ERK5-IN-2_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.118227
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117417
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0764731
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.059031
HDLBP high density lipoprotein binding protein 0.0505156
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0487088
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.048397
HELZ helicase with zinc finger 0.0465813
LDHA lactate dehydrogenase A 0.043028
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0427362
CANX calnexin 0.0415501
GOLGA4 golgin A4 0.0407461
MYH9 myosin, heavy chain 9, non-muscle 0.0402389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0401755
PCBP2 poly(rC) binding protein 2 0.0383247
PRELID2 PRELI domain containing 2 0.0366895
FAT1 FAT atypical cadherin 1 0.0363221
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.036243
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354501
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347739
ZNF292 zinc finger protein 292 0.0346006
PDIA4 protein disulfide isomerase family A, member 4 0.0333136
GOLGB1 golgin B1 0.0326212
YEATS2 YEATS domain containing 2 0.0312743
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0310454
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0304683
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0300837
ERRFI1 ERBB receptor feedback inhibitor 1 0.0296348
RPL3 ribosomal protein L3 0.0289326
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0285663
VEGFA vascular endothelial growth factor A 0.0276368
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0275361
FNIP1 folliculin interacting protein 1 0.0274981
NUP58 nucleoporin 58 0.0274424
HSPA8 heat shock 70kDa protein 8 0.0273452
EZR ezrin 0.0269445
LOC112694756 uncharaterized LOC112694756 0.0268863
EIF4H eukaryotic translation initiation factor 4H 0.0264078
ANXA2 annexin A2 0.0255088
FTH1 ferritin, heavy polypeptide 1 0.0253794
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0251989
TMF1 TATA element modulatory factor 1 0.025129
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0245601
DSPP dentin sialophosphoprotein 0.0245541
PLEC plectin 0.0244512
AFF4 AF4/FMR2 family, member 4 0.0242427
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0240672
MACF1 microtubule-actin crosslinking factor 1 0.0237355
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235172
TXNRD1 thioredoxin reductase 1 0.0229254
IARS1 isoleucyl-tRNA synthetase 1 0.022618
TPM3 tropomyosin 3 0.0219031
SEC24A SEC24 family member A 0.0216594
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0216426
RPS18 ribosomal protein S18 0.0215796
FLNA filamin A, alpha 0.021492
ZC3H11A zinc finger CCCH-type containing 11A 0.0213851
SEC24D SEC24 family member D 0.0213058
KMT2C lysine (K)-specific methyltransferase 2C 0.0207285
RUNX1 runt-related transcription factor 1 0.0205694
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0205601
RAB7A RAB7A, member RAS oncogene family 0.0202821
TAC4 tachykinin 4 (hemokinin) 0.0199835
CSDE1 cold shock domain containing E1, RNA-binding 0.0199371
APLP2 amyloid beta (A4) precursor-like protein 2 0.0199312
IQGAP1 IQ motif containing GTPase activating protein 1 0.0198351
ARL5B ADP-ribosylation factor-like 5B 0.0198017
ARCN1 archain 1 0.0197512
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0194237
SUCO SUN domain containing ossification factor 0.0194066
TENM3 teneurin transmembrane protein 3 0.0193927
KDM4C lysine (K)-specific demethylase 4C 0.0191017
WDR26 WD repeat domain 26 0.019074
EIF4B eukaryotic translation initiation factor 4B 0.0189779
RLF rearranged L-myc fusion 0.0188597
WWC2 WW and C2 domain containing 2 0.0188542
KRT8 keratin 8, type II 0.0188395
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0187297
ZNF638 zinc finger protein 638 0.0186823
KIF5B kinesin family member 5B 0.0186421
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0185884
RNF24 ring finger protein 24 0.0185729
SEPTIN2 septin 2 0.0180906
CLTC clathrin, heavy chain (Hc) 0.0180598
DDIT4 DNA-damage-inducible transcript 4 0.0179978
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0179365
CTBP2 C-terminal binding protein 2 0.017908
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.017882
SPAG9 sperm associated antigen 9 0.0177108
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0177056
EGFR epidermal growth factor receptor 0.0174739
ARRDC3 arrestin domain containing 3 0.0174405
MATR3 matrin 3 0.017269
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0172208
PHF3 PHD finger protein 3 0.0171996
NBAS neuroblastoma amplified sequence 0.0171463
ATXN1 ataxin 1 0.0168735
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0168121
SON SON DNA binding protein 0.0167145
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0167029

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.28272
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162181
TMSB10 thymosin beta 10 -0.157396
TPT1 tumor protein, translationally-controlled 1 -0.132253
RPL35A ribosomal protein L35a -0.123356
RPS6 ribosomal protein S6 -0.118162
RPS8 ribosomal protein S8 -0.0945647
RPLP1 ribosomal protein, large, P1 -0.0766497
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0762096
RPLP2 ribosomal protein, large, P2 -0.0709425
RPL34 ribosomal protein L34 -0.0685419
RPS24 ribosomal protein S24 -0.0644727
RPS13 ribosomal protein S13 -0.0614545
RPL37A ribosomal protein L37a -0.0586106
RPS19 ribosomal protein S19 -0.0561227
RPS29 ribosomal protein S29 -0.0554115
RPS3 ribosomal protein S3 -0.0505975
RPL11 ribosomal protein L11 -0.0504279
MT2A metallothionein 2A -0.0497387
RPL31 ribosomal protein L31 -0.0489267
RPS27A ribosomal protein S27a -0.0463589
PKM pyruvate kinase, muscle -0.0462851
RPS12 ribosomal protein S12 -0.0459305
RPS25 ribosomal protein S25 -0.0454034
RPL26 ribosomal protein L26 -0.0450161
S100A9 S100 calcium binding protein A9 -0.0447651
RPL23 ribosomal protein L23 -0.0444317
RPLP0 ribosomal protein, large, P0 -0.0438726
ACTG1 actin gamma 1 -0.0436369
RPL38 ribosomal protein L38 -0.0435965
S100A10 S100 calcium binding protein A10 -0.0429273
EGR1 early growth response 1 -0.0412817
RPS15 ribosomal protein S15 -0.040511
RPL19 ribosomal protein L19 -0.0392129
RPS21 ribosomal protein S21 -0.0380113
RPS14 ribosomal protein S14 -0.0372475
HLA-A major histocompatibility complex, class I, A -0.0362225
LDHB lactate dehydrogenase B -0.0357672
RPS10 ribosomal protein S10 -0.0356409
RPS16 ribosomal protein S16 -0.0355483
RPS23 ribosomal protein S23 -0.0350265
RPL36 ribosomal protein L36 -0.0347706
RPL7A ribosomal protein L7a -0.0336107
RPL12 ribosomal protein L12 -0.0334155
RPL37 ribosomal protein L37 -0.0333683
RPS17 ribosomal protein S17 -0.0322488
CCND1 cyclin D1 -0.03214
RPL28 ribosomal protein L28 -0.031751
HLA-B major histocompatibility complex, class I, B -0.0316311
RPL9 ribosomal protein L9 -0.0312694
RPL35 ribosomal protein L35 -0.0312691
RPL36A ribosomal protein L36a -0.0308943
RPL15 ribosomal protein L15 -0.0305908
GNAS GNAS complex locus -0.0304663
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0301499
TPI1 triosephosphate isomerase 1 -0.0299773
RPL5 ribosomal protein L5 -0.0299085
S100A6 S100 calcium binding protein A6 -0.0297847
RPS11 ribosomal protein S11 -0.0297169
RPL27 ribosomal protein L27 -0.0295554
KPNB1 karyopherin (importin) beta 1 -0.0293318
RBM25 RNA binding motif protein 25 -0.0293008
RACK1 receptor for activated C kinase 1 -0.0292316
PNISR PNN-interacting serine/arginine-rich protein -0.0291524
TPM4 tropomyosin 4 -0.0285841
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0284582
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0283992
TUBB4B tubulin, beta 4B class IVb -0.0280828
RPL8 ribosomal protein L8 -0.0278277
RPS20 ribosomal protein S20 -0.027586
HMGB1 high mobility group box 1 -0.0275094
RPL32 ribosomal protein L32 -0.026348
RPS5 ribosomal protein S5 -0.0259283
FTL ferritin, light polypeptide -0.0259035
PRDX2 peroxiredoxin 2 -0.02565
WSB1 WD repeat and SOCS box containing 1 -0.0249246
RPL27A ribosomal protein L27a -0.0246438
KRT19 keratin 19, type I -0.02456
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0243422
IFITM3 interferon induced transmembrane protein 3 -0.0239793
CELF1 CUGBP, Elav-like family member 1 -0.0238822
RPL30 ribosomal protein L30 -0.0235469
EIF5B eukaryotic translation initiation factor 5B -0.0231961
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0230925
RPL10A ribosomal protein L10a -0.0228703
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0228274
RPL18 ribosomal protein L18 -0.0228085
RPS27 ribosomal protein S27 -0.0226592
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0226356
SLC38A2 solute carrier family 38, member 2 -0.0226263
TBCA tubulin folding cofactor A -0.0224331
PERP PERP, TP53 apoptosis effector -0.0222881
CD63 CD63 molecule -0.021427
NOP56 NOP56 ribonucleoprotein -0.0213412
PABPN1 poly(A) binding protein, nuclear 1 -0.021275
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0211154
CCAR1 cell division cycle and apoptosis regulator 1 -0.0205811
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0199846
HMGA2 high mobility group AT-hook 2 -0.0198271
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0197059