| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.1545 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0973327 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0904034 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0752239 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0712951 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.064153 |
| GOLGA4 | golgin A4 | 0.0638658 |
| APP | amyloid beta (A4) precursor protein | 0.0618544 |
| CALR | calreticulin | 0.0510048 |
| CANX | calnexin | 0.0426768 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0409058 |
| GOLGB1 | golgin B1 | 0.0359687 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0354505 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0343264 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0343204 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0336374 |
| FLNA | filamin A, alpha | 0.033592 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.032367 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321994 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0316659 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0316419 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0315404 |
| RPL13A | ribosomal protein L13a | 0.0312863 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0309698 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0307508 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0302259 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0295117 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0293698 |
| ANXA2 | annexin A2 | 0.0291681 |
| SMAD3 | SMAD family member 3 | 0.0291089 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.028606 |
| PLEC | plectin | 0.0279311 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.027644 |
| LDHA | lactate dehydrogenase A | 0.0276256 |
| SEC24D | SEC24 family member D | 0.0267801 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0266662 |
| HDLBP | high density lipoprotein binding protein | 0.0264283 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0262218 |
| SPAG9 | sperm associated antigen 9 | 0.0256533 |
| LAMB3 | laminin, beta 3 | 0.0246279 |
| ANXA1 | annexin A1 | 0.0244329 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0235936 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.02355 |
| HELZ | helicase with zinc finger | 0.0229726 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.022467 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0223187 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0222521 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0221974 |
| MLF1 | myeloid leukemia factor 1 | 0.0221728 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0221084 |
| RUNX1 | runt-related transcription factor 1 | 0.0218298 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0214062 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0210709 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0210451 |
| TMSB4X | thymosin beta 4, X-linked | 0.0210218 |
| DSG2 | desmoglein 2 | 0.0207791 |
| FNBP1L | formin binding protein 1-like | 0.0207674 |
| WWC1 | WW and C2 domain containing 1 | 0.0207205 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0206931 |
| ZNF292 | zinc finger protein 292 | 0.0206102 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0205557 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.020407 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0199627 |
| PCBP2 | poly(rC) binding protein 2 | 0.0197129 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0192711 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0192483 |
| DSPP | dentin sialophosphoprotein | 0.0192118 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0191454 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0191232 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0191197 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0190799 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0189768 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0185466 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0182446 |
| PGK1 | phosphoglycerate kinase 1 | 0.0182221 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0181443 |
| RPL29 | ribosomal protein L29 | 0.0179231 |
| TMF1 | TATA element modulatory factor 1 | 0.0176842 |
| ITGB8 | integrin, beta 8 | 0.0174342 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0173588 |
| KIF5B | kinesin family member 5B | 0.0173407 |
| RLF | rearranged L-myc fusion | 0.0172953 |
| SQSTM1 | sequestosome 1 | 0.0171321 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0164394 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0163724 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0163581 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0163298 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0162384 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0161697 |
| TPD52 | tumor protein D52 | 0.0160233 |
| HYOU1 | hypoxia up-regulated 1 | 0.0160221 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0159707 |
| COG6 | component of oligomeric golgi complex 6 | 0.0158714 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0158558 |
| RPS3 | ribosomal protein S3 | 0.0157665 |
| TFG | TRK-fused gene | 0.0157583 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0157579 |
| IRF1 | interferon regulatory factor 1 | 0.0156553 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0155762 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0154734 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.164208 |
| MT2A | metallothionein 2A | -0.102599 |
| HMGA1 | high mobility group AT-hook 1 | -0.0637206 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0634547 |
| POTEF | POTE ankyrin domain family, member F | -0.0631637 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0570064 |
| RPL35A | ribosomal protein L35a | -0.0568047 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0542352 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0510916 |
| VCL | vinculin | -0.0496997 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0488215 |
| TPM4 | tropomyosin 4 | -0.0464322 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0451339 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0435004 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0416448 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0410508 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0409611 |
| DIAPH3 | diaphanous-related formin 3 | -0.0403722 |
| PFN1 | profilin 1 | -0.0394865 |
| PTMA | prothymosin, alpha | -0.0392702 |
| HMGA2 | high mobility group AT-hook 2 | -0.0392445 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0383137 |
| S100A9 | S100 calcium binding protein A9 | -0.0355598 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0353834 |
| PCED1B | PC-esterase domain containing 1B | -0.0347929 |
| RAD51B | RAD51 paralog B | -0.0343706 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0337517 |
| ASPH | aspartate beta-hydroxylase | -0.0329861 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0325945 |
| ATG7 | autophagy related 7 | -0.0318241 |
| FHIT | fragile histidine triad | -0.0316159 |
| PKM | pyruvate kinase, muscle | -0.0314396 |
| CCND1 | cyclin D1 | -0.0311696 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.030838 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0307851 |
| ITGA6 | integrin, alpha 6 | -0.0303588 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0299124 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0296572 |
| RBM25 | RNA binding motif protein 25 | -0.0291992 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0288798 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0286345 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0272891 |
| S100A6 | S100 calcium binding protein A6 | -0.0269723 |
| RPS21 | ribosomal protein S21 | -0.0266886 |
| CD44 | CD44 molecule (Indian blood group) | -0.0263001 |
| NF1 | neurofibromin 1 | -0.0262615 |
| SETD5 | SET domain containing 5 | -0.0258557 |
| SMYD3 | SET and MYND domain containing 3 | -0.0258075 |
| TUBA1B | tubulin, alpha 1b | -0.0257882 |
| SVIL | supervillin | -0.0254384 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0252356 |
| CENPF | centromere protein F, 350/400kDa | -0.025038 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0249139 |
| TCERG1 | transcription elongation regulator 1 | -0.0246709 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0245465 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0243842 |
| PTK2 | protein tyrosine kinase 2 | -0.0243538 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0242537 |
| PRR11 | proline rich 11 | -0.0240646 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0239721 |
| CBX3 | chromobox homolog 3 | -0.0237599 |
| RPS24 | ribosomal protein S24 | -0.0236158 |
| ZNF148 | zinc finger protein 148 | -0.0235559 |
| RPS6 | ribosomal protein S6 | -0.0235489 |
| ANXA3 | annexin A3 | -0.023511 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0232507 |
| RPL9 | ribosomal protein L9 | -0.0228262 |
| HMGB1 | high mobility group box 1 | -0.0228222 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0225871 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0225194 |
| MACROH2A1 | macroH2A.1 histone | -0.0225109 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0224443 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0223757 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0222929 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0218659 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0217964 |
| SSH2 | slingshot protein phosphatase 2 | -0.0217368 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0216554 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0216277 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0215761 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.021508 |
| BPTF | bromodomain PHD finger transcription factor | -0.0212523 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.021216 |
| KRT19 | keratin 19, type I | -0.0211878 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0210197 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0209673 |
| PCNX4 | pecanex 4 | -0.0209673 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0208679 |
| THOC2 | THO complex 2 | -0.0207735 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0203356 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0199974 |
| PRELID2 | PRELI domain containing 2 | -0.019746 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0197159 |
| MACROD2 | MACRO domain containing 2 | -0.0194094 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0193601 |
| ERBIN | erbb2 interacting protein | -0.0192556 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.0192427 |
| WWOX | WW domain containing oxidoreductase | -0.0189719 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0188978 |
| S100A4 | S100 calcium binding protein A4 | -0.0188826 |
