ERK5-IN-2_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ERK5-IN-2_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.248876
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.215887
CD44 CD44 molecule (Indian blood group) 0.159595
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.142979
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.13571
FN1 fibronectin 1 0.122715
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114949
MT2A metallothionein 2A 0.114896
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.109469
EEF2 eukaryotic translation elongation factor 2 0.0973862
ENO1 enolase 1, (alpha) 0.0939541
LDHA lactate dehydrogenase A 0.0843952
TRIO trio Rho guanine nucleotide exchange factor 0.0843258
ASPH aspartate beta-hydroxylase 0.0838894
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0793193
ANXA2 annexin A2 0.0780347
COL6A1 collagen, type VI, alpha 1 0.0742595
TPT1 tumor protein, translationally-controlled 1 0.0738457
RPS6 ribosomal protein S6 0.0690736
AKAP12 A kinase (PRKA) anchor protein 12 0.066729
PGK1 phosphoglycerate kinase 1 0.064959
RPL12 ribosomal protein L12 0.0643374
COL5A1 collagen, type V, alpha 1 0.0620314
VEGFA vascular endothelial growth factor A 0.0613905
SEPTIN9 septin 9 0.0598199
NDRG1 N-myc downstream regulated 1 0.0594138
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0540932
RPS8 ribosomal protein S8 0.0531129
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.052908
PTPRM protein tyrosine phosphatase, receptor type, M 0.0521533
PLEC plectin 0.0510411
CXCL8 chemokine (C-X-C motif) ligand 8 0.0508684
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0478152
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0469883
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0469564
NAV1 neuron navigator 1 0.0462167
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.046024
HSPA8 heat shock 70kDa protein 8 0.0442833
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0434984
RPL23 ribosomal protein L23 0.0432418
MYH9 myosin, heavy chain 9, non-muscle 0.0431797
CALR calreticulin 0.0429292
IGFBP3 insulin-like growth factor binding protein 3 0.0424235
CDCP1 CUB domain containing protein 1 0.0419171
JARID2 jumonji, AT rich interactive domain 2 0.0417234
EEF1G eukaryotic translation elongation factor 1 gamma 0.041637
EIF1 eukaryotic translation initiation factor 1 0.0416046
FTH1 ferritin, heavy polypeptide 1 0.0409602
RPS3 ribosomal protein S3 0.0408786
FLNA filamin A, alpha 0.0393521
SMAD3 SMAD family member 3 0.0391771
MAP1B microtubule-associated protein 1B 0.0388776
TAC4 tachykinin 4 (hemokinin) 0.0387908
NAV2 neuron navigator 2 0.0382585
FAM13A family with sequence similarity 13, member A 0.0380989
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.036588
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0360881
RPS12 ribosomal protein S12 0.0360545
PKM pyruvate kinase, muscle 0.035966
TPM3 tropomyosin 3 0.0356065
CAPN2 calpain 2, (m/II) large subunit 0.0354997
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0351092
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0350905
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0350143
DST dystonin 0.0348685
RPL31 ribosomal protein L31 0.03436
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0339974
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0339577
RPLP1 ribosomal protein, large, P1 0.0339313
GOLGB1 golgin B1 0.0338695
RPL37A ribosomal protein L37a 0.0337236
LAMB3 laminin, beta 3 0.0334764
APP amyloid beta (A4) precursor protein 0.0326093
ANGPTL4 angiopoietin-like 4 0.032062
RPS17 ribosomal protein S17 0.0319195
TPI1 triosephosphate isomerase 1 0.0317381
G0S2 G0/G1 switch 2 0.0316568
KTN1 kinectin 1 (kinesin receptor) 0.0314188
RPS19 ribosomal protein S19 0.0312495
PRRC2C proline-rich coiled-coil 2C 0.0312454
PCBP2 poly(rC) binding protein 2 0.0310545
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.03067
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303711
ANKRD28 ankyrin repeat domain 28 0.0300628
RPL7 ribosomal protein L7 0.0300188
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.029998
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0297821
RPL11 ribosomal protein L11 0.0297512
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0288008
SRRM2 serine/arginine repetitive matrix 2 0.0287718
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0285266
CTSB cathepsin B 0.0284538
ENO2 enolase 2 (gamma, neuronal) 0.0284318
MT1E metallothionein 1E 0.0284288
LOXL2 lysyl oxidase-like 2 0.0281859
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0281601
RPLP2 ribosomal protein, large, P2 0.0281247
RUNX1 runt-related transcription factor 1 0.0278372
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0278188
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.027446

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.0471084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0429018
IGF2 insulin-like growth factor 2 -0.0309514
VCL vinculin -0.0307907
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0262298
FMN1 formin 1 -0.0196515
HMGA2 high mobility group AT-hook 2 -0.0177769
WSB1 WD repeat and SOCS box containing 1 -0.0167493
APOLD1 apolipoprotein L domain containing 1 -0.0162145
SBF2 SET binding factor 2 -0.0149286
MARCHF6 membrane associated ring-CH-type finger 6 -0.0149174
USP3 ubiquitin specific peptidase 3 -0.0147633
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0147387
OGA O-GlcNAcase -0.0146613
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0146443
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0146173
SETD5 SET domain containing 5 -0.0143701
WDR45B WD repeat domain 45B -0.0143613
MAML3 mastermind-like 3 (Drosophila) -0.0142146
RRBP1 ribosome binding protein 1 -0.0138227
COL1A1 collagen, type I, alpha 1 -0.0138215
NABP1 nucleic acid binding protein 1 -0.0129625
LCORL ligand dependent nuclear receptor corepressor-like -0.0129195
TENM2 teneurin transmembrane protein 2 -0.0127799
TMEM263 transmembrane protein 263 -0.0123932
PRELID2 PRELI domain containing 2 -0.0119375
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0119171
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0117531
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0117431
KDM3A lysine (K)-specific demethylase 3A -0.011672
SPAG9 sperm associated antigen 9 -0.0116058
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0115855
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0115323
MIS18BP1 MIS18 binding protein 1 -0.0110746
NPEPPS aminopeptidase puromycin sensitive -0.0106415
QKI QKI, KH domain containing, RNA binding -0.010556
NLK nemo-like kinase -0.00998818
TSC22D2 TSC22 domain family, member 2 -0.00994629
TFG TRK-fused gene -0.00989144
TAS2R14 taste receptor, type 2, member 14 -0.00984186
VEPH1 ventricular zone expressed PH domain-containing 1 -0.00969023
ZNF292 zinc finger protein 292 -0.009579
NAMPT nicotinamide phosphoribosyltransferase -0.00933193
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00927511
ADARB1 adenosine deaminase, RNA-specific, B1 -0.00908146
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00888942
DIAPH2 diaphanous-related formin 2 -0.00888782
RBM39 RNA binding motif protein 39 -0.00884855
ELL2 elongation factor, RNA polymerase II, 2 -0.00883523
COL7A1 collagen, type VII, alpha 1 -0.00883397
KDM5B lysine (K)-specific demethylase 5B -0.00870109
FOXO3 forkhead box O3 -0.00861688
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00848687
SNX14 sorting nexin 14 -0.008336
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.00830603
VASP vasodilator-stimulated phosphoprotein -0.00822409
ZNF207 zinc finger protein 207 -0.008213
FOXJ3 forkhead box J3 -0.008144
PLS3 plastin 3 -0.00802804
TENT4A terminal nucleotidyltransferase 4A -0.00799249
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00775985
KIF14 kinesin family member 14 -0.00774812
CEP95 centrosomal protein 95kDa -0.0077146
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.00767916
SH2B3 SH2B adaptor protein 3 -0.00767109
CD109 CD109 molecule -0.00743294
MARCKS myristoylated alanine-rich protein kinase C substrate -0.00741237
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0073811
WDFY2 WD repeat and FYVE domain containing 2 -0.00736971
SAR1A secretion associated, Ras related GTPase 1A -0.00736216
CDC27 cell division cycle 27 -0.00736064
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00733465
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00725683
TAOK1 TAO kinase 1 -0.00725098
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.00720992
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00717147
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.00711772
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.00709883
GLIPR1 GLI pathogenesis-related 1 -0.00701659
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00700374
IER3 immediate early response 3 -0.00687731
FBXO11 F-box protein 11 -0.0067254
PCNX4 pecanex 4 -0.00654512
MBD5 methyl-CpG binding domain protein 5 -0.00652329
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00646051
SCLT1 sodium channel and clathrin linker 1 -0.00644713
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0062564
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.00622782
SAMD3 sterile alpha motif domain containing 3 -0.00615327
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.00610235
FSTL1 follistatin-like 1 -0.00609795
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0060286
KCTD9 potassium channel tetramerization domain containing 9 -0.00601995
TRPS1 trichorhinophalangeal syndrome I -0.00599963
STRN3 striatin, calmodulin binding protein 3 -0.00589921
HP1BP3 heterochromatin protein 1, binding protein 3 -0.00587952
CDK14 cyclin-dependent kinase 14 -0.00587147
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00581866
ETNK1 ethanolamine kinase 1 -0.00580759
NSD2 nuclear receptor binding SET domain protein 2 -0.00577115