| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.417973 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.156246 |
| COL6A3 | collagen, type VI, alpha 3 | 0.136573 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.122438 |
| CALR | calreticulin | 0.114976 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0945718 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0925262 |
| CADM1 | cell adhesion molecule 1 | 0.0868315 |
| FNDC3B | fibronectin type III domain containing 3B | 0.077831 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0774577 |
| VEGFA | vascular endothelial growth factor A | 0.0753265 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0749183 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0737778 |
| LDHA | lactate dehydrogenase A | 0.0675347 |
| GOLGB1 | golgin B1 | 0.0642489 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0623079 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0611048 |
| ENO1 | enolase 1, (alpha) | 0.0583644 |
| CDH13 | cadherin 13 | 0.0582043 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0530658 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0525684 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0515103 |
| FLNA | filamin A, alpha | 0.0498813 |
| APP | amyloid beta (A4) precursor protein | 0.0475528 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0466052 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0463082 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0445554 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0444582 |
| EGFR | epidermal growth factor receptor | 0.0442449 |
| PLEC | plectin | 0.0442302 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0440326 |
| ANXA2 | annexin A2 | 0.0427139 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0408375 |
| SQSTM1 | sequestosome 1 | 0.0403893 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0389955 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0371649 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.036754 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0367123 |
| HDLBP | high density lipoprotein binding protein | 0.0349296 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0341219 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0329309 |
| RPL13A | ribosomal protein L13a | 0.0326908 |
| ASPH | aspartate beta-hydroxylase | 0.0325335 |
| RPS3 | ribosomal protein S3 | 0.0324225 |
| HYOU1 | hypoxia up-regulated 1 | 0.0314142 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0309189 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0297157 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0293165 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0289907 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0288563 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0286608 |
| PGK1 | phosphoglycerate kinase 1 | 0.028443 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0284096 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0281494 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0279301 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0278356 |
| CALU | calumenin | 0.0274315 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0273915 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.027226 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0269323 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0269012 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0268244 |
| FBN1 | fibrillin 1 | 0.0267832 |
| CANX | calnexin | 0.026431 |
| COL3A1 | collagen, type III, alpha 1 | 0.0261214 |
| GOLGA4 | golgin A4 | 0.0259923 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0256477 |
| INTS6 | integrator complex subunit 6 | 0.0255953 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0255338 |
| SP100 | SP100 nuclear antigen | 0.0251108 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.025088 |
| CLINT1 | clathrin interactor 1 | 0.0244685 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0243476 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0240943 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0240002 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0239527 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.023947 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0239405 |
| COL5A1 | collagen, type V, alpha 1 | 0.0238658 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0238541 |
| BSG | basigin (Ok blood group) | 0.0238381 |
| FAT1 | FAT atypical cadherin 1 | 0.0238183 |
| TLE4 | transducin-like enhancer of split 4 | 0.0237687 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0237115 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0234392 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0234156 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0229884 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0229763 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0228691 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0224654 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0223061 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0220585 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0220187 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0219243 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0214079 |
| FNIP1 | folliculin interacting protein 1 | 0.0213197 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0212166 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0212135 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0211533 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.021098 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170067 |
| COL1A1 | collagen, type I, alpha 1 | -0.161265 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.134112 |
| MT2A | metallothionein 2A | -0.123099 |
| COL1A2 | collagen, type I, alpha 2 | -0.0956866 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.075995 |
| TMSB10 | thymosin beta 10 | -0.0754398 |
| STC1 | stanniocalcin 1 | -0.0733483 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0732425 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0633676 |
| VIM | vimentin | -0.0621572 |
| S100A9 | S100 calcium binding protein A9 | -0.0488609 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0467451 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0439362 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0415371 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0413459 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0405319 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0397856 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0377874 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0370799 |
| MT1X | metallothionein 1X | -0.0366593 |
| HAS2 | hyaluronan synthase 2 | -0.0360977 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.035362 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0344486 |
| PTMA | prothymosin, alpha | -0.0322719 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0312513 |
| MAP1B | microtubule-associated protein 1B | -0.0297064 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0292007 |
| HLA-B | major histocompatibility complex, class I, B | -0.0290496 |
| MTSS1 | metastasis suppressor 1 | -0.0282926 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282739 |
| CD44 | CD44 molecule (Indian blood group) | -0.0275104 |
| ATP13A3 | ATPase type 13A3 | -0.0269105 |
| HMGA2 | high mobility group AT-hook 2 | -0.0265588 |
| S100A6 | S100 calcium binding protein A6 | -0.0258849 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0256483 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.025347 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.025266 |
| B2M | beta-2-microglobulin | -0.0248522 |
| POSTN | periostin, osteoblast specific factor | -0.0247008 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0245295 |
| IL6 | interleukin 6 | -0.0240958 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0235389 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0232038 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0229003 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0223947 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0214025 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0212584 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0209609 |
| CLMP | CXADR-like membrane protein | -0.0209197 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0208603 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.020532 |
| NRP1 | neuropilin 1 | -0.0203979 |
| LOXL2 | lysyl oxidase-like 2 | -0.0203767 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0199484 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0196641 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0185671 |
| S100A10 | S100 calcium binding protein A10 | -0.0177691 |
| RPS21 | ribosomal protein S21 | -0.0177299 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0173785 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0170895 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0169018 |
| OSMR | oncostatin M receptor | -0.0163556 |
| RPL35A | ribosomal protein L35a | -0.0162841 |
| POTEF | POTE ankyrin domain family, member F | -0.0161815 |
| STK38L | serine/threonine kinase 38 like | -0.0161759 |
| CENPF | centromere protein F, 350/400kDa | -0.016098 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.016011 |
| TUBB6 | tubulin, beta 6 class V | -0.0157426 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0156636 |
| PFN1 | profilin 1 | -0.0152391 |
| LMO4 | LIM domain only 4 | -0.0152243 |
| CD99 | CD99 molecule | -0.0149993 |
| ECE1 | endothelin converting enzyme 1 | -0.0149841 |
| VEGFC | vascular endothelial growth factor C | -0.0149777 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0149658 |
| GLIS3 | GLIS family zinc finger 3 | -0.0148987 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0147591 |
| HLA-A | major histocompatibility complex, class I, A | -0.0146728 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0146381 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0145602 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0143984 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0143795 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0139694 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0138994 |
| TPM1 | tropomyosin 1 (alpha) | -0.0138966 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0137597 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0137539 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0136285 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0135623 |
| THY1 | Thy-1 cell surface antigen | -0.0135373 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0135306 |
| TMEM165 | transmembrane protein 165 | -0.0134961 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0134308 |
| RPS6 | ribosomal protein S6 | -0.0134159 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0133981 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.013393 |
| CFAP96 | cilia and flagella associated protein 96 | -0.0133047 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0131998 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0131601 |
