| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.234819 |
| LMO7 | LIM domain 7 | 0.190267 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.102553 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0997334 |
| EXPH5 | exophilin 5 | 0.0969122 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0937752 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0932462 |
| TJP1 | tight junction protein 1 | 0.0887338 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0849809 |
| SMAD3 | SMAD family member 3 | 0.0830721 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0747617 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0734725 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0724789 |
| MYO1E | myosin IE | 0.0695838 |
| ATXN1 | ataxin 1 | 0.0663934 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0661363 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0621604 |
| FTL | ferritin, light polypeptide | 0.0620295 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0591419 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0572924 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0558009 |
| INTS6 | integrator complex subunit 6 | 0.0535837 |
| SGMS2 | sphingomyelin synthase 2 | 0.0534724 |
| EMP1 | epithelial membrane protein 1 | 0.0530124 |
| SIK3 | SIK family kinase 3 | 0.0520565 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0496724 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0492473 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0483527 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0480297 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.045716 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0452736 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0441027 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0439353 |
| GOLGB1 | golgin B1 | 0.0434344 |
| TLE4 | transducin-like enhancer of split 4 | 0.0433576 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0430368 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0427633 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0420284 |
| KRT20 | keratin 20, type I | 0.0414287 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0412087 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0403226 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0402976 |
| POF1B | premature ovarian failure, 1B | 0.0392084 |
| PDZD8 | PDZ domain containing 8 | 0.0387324 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0386114 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0385058 |
| TMEM65 | transmembrane protein 65 | 0.038241 |
| CTBP2 | C-terminal binding protein 2 | 0.0379285 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0378678 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0377763 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.037487 |
| MYADM | myeloid-associated differentiation marker | 0.0370819 |
| CCNYL1 | cyclin Y-like 1 | 0.0370301 |
| KRT18 | keratin 18, type I | 0.0364009 |
| TRIB1 | tribbles pseudokinase 1 | 0.0355822 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0353685 |
| RPL23 | ribosomal protein L23 | 0.0350202 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0349325 |
| NTN4 | netrin 4 | 0.0344803 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0341135 |
| RASEF | RAS and EF-hand domain containing | 0.0339144 |
| NEBL | nebulette | 0.0338067 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0338014 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0335931 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0329947 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0327701 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.032576 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0323542 |
| RPS12 | ribosomal protein S12 | 0.0320552 |
| RTN3 | reticulon 3 | 0.0318914 |
| RPS3 | ribosomal protein S3 | 0.031684 |
| MYO5B | myosin VB | 0.0312245 |
| PRR5L | proline rich 5 like | 0.0305423 |
| ANXA1 | annexin A1 | 0.0303646 |
| RND3 | Rho family GTPase 3 | 0.0303462 |
| KRT8 | keratin 8, type II | 0.030142 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0297444 |
| FBXO32 | F-box protein 32 | 0.0289322 |
| RPS16 | ribosomal protein S16 | 0.028847 |
| ATF3 | activating transcription factor 3 | 0.0288171 |
| VEGFA | vascular endothelial growth factor A | 0.0285848 |
| TUFT1 | tuftelin 1 | 0.0282045 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0277127 |
| DST | dystonin | 0.0276634 |
| FAT1 | FAT atypical cadherin 1 | 0.0274431 |
| RPL11 | ribosomal protein L11 | 0.0272714 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0268651 |
| RPL21 | ribosomal protein L21 | 0.026821 |
| LAMA4 | laminin, alpha 4 | 0.0263142 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0261602 |
| KLF6 | Kruppel-like factor 6 | 0.0261084 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0260447 |
| EFNB2 | ephrin-B2 | 0.0260271 |
| RPL3 | ribosomal protein L3 | 0.0258971 |
| EGFR | epidermal growth factor receptor | 0.0255365 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0250047 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.0249843 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0248744 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0247829 |
| LDHA | lactate dehydrogenase A | 0.0246093 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.0867814 |
| PTMA | prothymosin, alpha | -0.0800024 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0741727 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0677852 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0638621 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0600885 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0596233 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.054946 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0487028 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.048345 |
| ZNF292 | zinc finger protein 292 | -0.0449113 |
| STK24 | serine/threonine kinase 24 | -0.044806 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0445969 |
| LYZ | lysozyme | -0.0440151 |
| PTK2 | protein tyrosine kinase 2 | -0.0420973 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0399465 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.03957 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0375906 |
| PGK1 | phosphoglycerate kinase 1 | -0.0372142 |
| THOC2 | THO complex 2 | -0.0371614 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0369291 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0364487 |
| CD2AP | CD2-associated protein | -0.0361928 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0358742 |
| NF1 | neurofibromin 1 | -0.0355613 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0351113 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0321442 |
| CENPF | centromere protein F, 350/400kDa | -0.0314138 |
| PRELID2 | PRELI domain containing 2 | -0.0310975 |
| ASPH | aspartate beta-hydroxylase | -0.0306391 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0302379 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0294302 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0294018 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.02923 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0290303 |
| MKI67 | marker of proliferation Ki-67 | -0.0286203 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0281111 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0279957 |
| CDK19 | cyclin-dependent kinase 19 | -0.0274117 |
| RTN4 | reticulon 4 | -0.0273362 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0271254 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0270452 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0270431 |
| RPS6 | ribosomal protein S6 | -0.026723 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0264358 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0263049 |
| POMP | proteasome maturation protein | -0.0262079 |
| MYO6 | myosin VI | -0.0259799 |
| JUP | junction plakoglobin | -0.0257955 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0256909 |
| OGA | O-GlcNAcase | -0.0254106 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0251697 |
| VIM | vimentin | -0.0250408 |
| SETD5 | SET domain containing 5 | -0.0249942 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0247376 |
| TMEM123 | transmembrane protein 123 | -0.0247353 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0240051 |
| WASF2 | WAS protein family, member 2 | -0.0237561 |
| RBM39 | RNA binding motif protein 39 | -0.023372 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0233475 |
| ACTN4 | actinin, alpha 4 | -0.0231366 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0231097 |
| HMGB1 | high mobility group box 1 | -0.0228578 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0226838 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0226358 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0225591 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.022516 |
| DEK | DEK proto-oncogene | -0.0223752 |
| DIAPH2 | diaphanous-related formin 2 | -0.0220689 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0220146 |
| MSN | moesin | -0.0217606 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0217514 |
| WDR45B | WD repeat domain 45B | -0.0217078 |
| TMEM87A | transmembrane protein 87A | -0.021565 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.021506 |
| DENND4C | DENN/MADD domain containing 4C | -0.021496 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0214704 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0212915 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0210396 |
| KRT19 | keratin 19, type I | -0.0208546 |
| CEP95 | centrosomal protein 95kDa | -0.0207885 |
| H1-0 | H1.0 linker histone | -0.0207843 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0206374 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.020458 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0204312 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0203623 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | -0.0202213 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0201691 |
| GNAS | GNAS complex locus | -0.0200185 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0199081 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0198409 |
| RNF213 | ring finger protein 213 | -0.0197961 |
| TCF12 | transcription factor 12 | -0.0197806 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0197512 |
| DNM2 | dynamin 2 | -0.0196728 |
| CLTC | clathrin, heavy chain (Hc) | -0.0196699 |
| TJP2 | tight junction protein 2 | -0.0195731 |
| RAB20 | RAB20, member RAS oncogene family | -0.0195196 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.019508 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.019491 |
