ERK5-IN-2_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.174737
AKAP12 A kinase (PRKA) anchor protein 12 0.156742
MT2A metallothionein 2A 0.155443
IGFBP1 insulin-like growth factor binding protein 1 0.108915
SVIL supervillin 0.0780915
TIMP1 TIMP metallopeptidase inhibitor 1 0.0755095
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0691445
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0566252
EXT1 exostosin glycosyltransferase 1 0.0563719
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0539405
SAMD4A sterile alpha motif domain containing 4A 0.0501433
ATXN1 ataxin 1 0.0475209
ASPH aspartate beta-hydroxylase 0.0466395
RPL37A ribosomal protein L37a 0.0442324
RPL11 ribosomal protein L11 0.0375556
NDRG1 N-myc downstream regulated 1 0.0356631
GRB10 growth factor receptor-bound protein 10 0.0355678
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0349911
RPLP1 ribosomal protein, large, P1 0.0347866
RPLP2 ribosomal protein, large, P2 0.0342114
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0338331
KYNU kynureninase 0.032166
KIAA1217 KIAA1217 0.0318682
RPL26 ribosomal protein L26 0.0318531
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0308026
TPT1 tumor protein, translationally-controlled 1 0.0294373
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0288515
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0287449
RPL23 ribosomal protein L23 0.0275809
CTSB cathepsin B 0.0274654
LPP LIM domain containing preferred translocation partner in lipoma 0.0267253
ACTG1 actin gamma 1 0.0258697
VCL vinculin 0.0258187
RPS6 ribosomal protein S6 0.0254306
RPL31 ribosomal protein L31 0.025212
RPL35A ribosomal protein L35a 0.0249306
RPS19 ribosomal protein S19 0.024473
RPS12 ribosomal protein S12 0.0241947
TMSB10 thymosin beta 10 0.0240075
FAT1 FAT atypical cadherin 1 0.0237811
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0229148
FAM107B family with sequence similarity 107, member B 0.0228794
GPC6 glypican 6 0.022645
RAD51B RAD51 paralog B 0.0219545
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0218053
RPS10 ribosomal protein S10 0.0215511
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0214472
CRY1 cryptochrome circadian clock 1 0.0208605
TRIO trio Rho guanine nucleotide exchange factor 0.0207782
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0205457
DST dystonin 0.0200965
RPL32 ribosomal protein L32 0.0199265
RPL36 ribosomal protein L36 0.0198086
FLNA filamin A, alpha 0.0197241
PAWR PRKC, apoptosis, WT1, regulator 0.0191985
ISG15 ISG15 ubiquitin-like modifier 0.0191709
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0188079
FNIP1 folliculin interacting protein 1 0.0185454
RPS14 ribosomal protein S14 0.0176723
FOXP1 forkhead box P1 0.0175658
PLIN2 perilipin 2 0.0175043
RPS21 ribosomal protein S21 0.0174708
RPL21 ribosomal protein L21 0.0173829
RPS8 ribosomal protein S8 0.0168499
RPS23 ribosomal protein S23 0.0168189
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0167167
DTNA dystrobrevin, alpha 0.0166754
SIK3 SIK family kinase 3 0.0166521
RPL7A ribosomal protein L7a 0.0166252
HMGA1 high mobility group AT-hook 1 0.0164469
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0162519
RPS13 ribosomal protein S13 0.0162161
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0161844
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0160568
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.015998
JAK1 Janus kinase 1 0.0159937
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0159646
DSPP dentin sialophosphoprotein 0.0159629
RASA2 RAS p21 protein activator 2 0.0158875
ANXA5 annexin A5 0.0157963
SOX5 SRY (sex determining region Y)-box 5 0.015377
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0152137
EEF2 eukaryotic translation elongation factor 2 0.0152084
ZSWIM6 zinc finger, SWIM-type containing 6 0.0150131
GOLGB1 golgin B1 0.0149633
EGR1 early growth response 1 0.014861
TLE4 transducin-like enhancer of split 4 0.0148026
ESYT2 extended synaptotagmin-like protein 2 0.0147362
FHL2 four and a half LIM domains 2 0.0147078
STC2 stanniocalcin 2 0.0146346
RPS3 ribosomal protein S3 0.0146176
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0145936
RPL38 ribosomal protein L38 0.0144961
RPL37 ribosomal protein L37 0.0142942
MALRD1 MAM and LDL receptor class A domain containing 1 0.01425
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0141573
EGFR epidermal growth factor receptor 0.0141271
RPL27 ribosomal protein L27 0.0140864
AKAP13 A kinase (PRKA) anchor protein 13 0.0139378
KIF21A kinesin family member 21A 0.0139012

decreased expression

Symbol Name Standardized Value
FBF1 Fas (TNFRSF6) binding factor 1 -0.206628
APOB apolipoprotein B -0.170535
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.1627
GPC3 glypican 3 -0.085906
TRIM26 tripartite motif containing 26 -0.0710079
A2M alpha-2-macroglobulin -0.0608354
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.058854
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0492301
CP ceruloplasmin (ferroxidase) -0.0474508
EML4 echinoderm microtubule associated protein like 4 -0.0471315
UBC ubiquitin C -0.0469107
TM4SF1 transmembrane 4 L six family member 1 -0.0459322
TF transferrin -0.0445979
AHSG alpha-2-HS-glycoprotein -0.0433953
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0427142
NKD1 naked cuticle homolog 1 (Drosophila) -0.0422346
C3 complement component 3 -0.0378217
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0356753
LYZ lysozyme -0.0356315
ENO1 enolase 1, (alpha) -0.0356068
SELENOP selenoprotein P -0.0355028
SOD2 superoxide dismutase 2, mitochondrial -0.0349588
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347047
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0343676
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0343397
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0341476
SDC4 syndecan 4 -0.0340241
TMEM123 transmembrane protein 123 -0.0339344
NAP1L1 nucleosome assembly protein 1-like 1 -0.0337192
PTPRM protein tyrosine phosphatase, receptor type, M -0.0334502
RBM39 RNA binding motif protein 39 -0.031311
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0307513
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0302032
SESTD1 SEC14 and spectrin domains 1 -0.0301109
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0290324
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0288029
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0286158
APOE apolipoprotein E -0.0282993
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0278976
SLC38A2 solute carrier family 38, member 2 -0.0275698
FNDC3B fibronectin type III domain containing 3B -0.0272319
IGF1R insulin-like growth factor 1 receptor -0.026888
BIRC6 baculoviral IAP repeat containing 6 -0.0261242
ELL2 elongation factor, RNA polymerase II, 2 -0.0257048
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0247683
VMP1 vacuole membrane protein 1 -0.0247309
PEG3 paternally expressed 3 -0.0240498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0237639
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0234557
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0233796
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0233791
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0232369
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0230574
NIPBL Nipped-B homolog (Drosophila) -0.0222526
CPE carboxypeptidase E -0.0222111
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0222075
PDIA3 protein disulfide isomerase family A, member 3 -0.0220288
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0217669
PTBP3 polypyrimidine tract binding protein 3 -0.0216624
GNAS GNAS complex locus -0.0210348
AMBP alpha-1-microglobulin/bikunin precursor -0.020974
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0208383
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0206703
MBNL3 muscleblind-like splicing regulator 3 -0.020427
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.020397
PRRC2B proline-rich coiled-coil 2B -0.0202391
PTCHD4 patched domain containing 4 -0.0201384
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0199865
JUN jun proto-oncogene -0.0199068
USP34 ubiquitin specific peptidase 34 -0.0197886
STAU1 staufen double-stranded RNA binding protein 1 -0.0197511
RPS27A ribosomal protein S27a -0.0195486
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0194404
UBASH3B ubiquitin associated and SH3 domain containing B -0.0192203
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0190039
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0188542
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0186951
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0182645
ZFAND3 zinc finger, AN1-type domain 3 -0.0181256
H1-0 H1.0 linker histone -0.0176674
QKI QKI, KH domain containing, RNA binding -0.0176239
UGP2 UDP-glucose pyrophosphorylase 2 -0.0175036
GK glycerol kinase -0.0174564
TOP1 topoisomerase (DNA) I -0.0173594
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0170971
ITGA1 integrin, alpha 1 -0.017006
OLA1 Obg-like ATPase 1 -0.0167466
MALT1 MALT1 paracaspase -0.0167094
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0165391
LITAF lipopolysaccharide-induced TNF factor -0.0164689
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.016393
XPO1 exportin 1 -0.0162524
FABP1 fatty acid binding protein 1, liver -0.0161963
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0161822
MATN3 matrilin 3 -0.0157306
PERP PERP, TP53 apoptosis effector -0.0156904
AGXT alanine-glyoxylate aminotransferase -0.0155911
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0154676
GSK3B glycogen synthase kinase 3 beta -0.0154079
FCHSD2 FCH and double SH3 domains 2 -0.0153774