| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.183805 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.162164 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.154912 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.141618 |
| MTSS1 | metastasis suppressor 1 | 0.116327 |
| EXT1 | exostosin glycosyltransferase 1 | 0.115107 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.11116 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.106166 |
| SLC35F3 | solute carrier family 35, member F3 | 0.103988 |
| CD44 | CD44 molecule (Indian blood group) | 0.101871 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0878895 |
| SULF2 | sulfatase 2 | 0.0804629 |
| PODXL | podocalyxin-like | 0.0771837 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0762214 |
| PDLIM5 | PDZ and LIM domain 5 | 0.073834 |
| PLEC | plectin | 0.0716793 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0671725 |
| ANXA1 | annexin A1 | 0.0659728 |
| SIK3 | SIK family kinase 3 | 0.0654733 |
| RAI14 | retinoic acid induced 14 | 0.0649291 |
| LAMC2 | laminin, gamma 2 | 0.0647563 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0581712 |
| RASAL2 | RAS protein activator like 2 | 0.0570668 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0559122 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0543549 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0541259 |
| ANXA2 | annexin A2 | 0.0537833 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0534827 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0517304 |
| FAM107B | family with sequence similarity 107, member B | 0.0514767 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0509059 |
| FLNA | filamin A, alpha | 0.0499217 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0498473 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0496808 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0495598 |
| NAV2 | neuron navigator 2 | 0.0494321 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0484823 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.047989 |
| ITGB4 | integrin, beta 4 | 0.0464165 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0459755 |
| EFNA5 | ephrin-A5 | 0.0458519 |
| LDHA | lactate dehydrogenase A | 0.0454109 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.045293 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0451762 |
| JMJD1C | jumonji domain containing 1C | 0.0445952 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0442437 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0440946 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0440831 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.043713 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0431756 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0429681 |
| EGFR | epidermal growth factor receptor | 0.0427814 |
| PGK1 | phosphoglycerate kinase 1 | 0.0421713 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0420921 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0415325 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0414213 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0404947 |
| EZR | ezrin | 0.0403098 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0402185 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0401844 |
| KIAA1671 | KIAA1671 | 0.0398944 |
| DOK5 | docking protein 5 | 0.0394571 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0392629 |
| RAD51B | RAD51 paralog B | 0.0389395 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0386485 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0380979 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.037742 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0376887 |
| FNDC3B | fibronectin type III domain containing 3B | 0.03721 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0365152 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0361914 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0359774 |
| RNF217 | ring finger protein 217 | 0.0358167 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.035746 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0355713 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.035397 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0353206 |
| APP | amyloid beta (A4) precursor protein | 0.0352398 |
| DIAPH1 | diaphanous-related formin 1 | 0.0351081 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0347184 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0346888 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.034376 |
| HDAC9 | histone deacetylase 9 | 0.0341969 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0340566 |
| IFI44L | interferon-induced protein 44-like | 0.0337474 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0329103 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0327421 |
| ASPH | aspartate beta-hydroxylase | 0.0326186 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0326058 |
| AMOTL1 | angiomotin like 1 | 0.0322352 |
| TGM2 | transglutaminase 2 | 0.0320095 |
| RAB7A | RAB7A, member RAS oncogene family | 0.031706 |
| RIGI | RNA sensor RIG-I | 0.0316025 |
| ACTN4 | actinin, alpha 4 | 0.0312813 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.031105 |
| SVIL | supervillin | 0.0301291 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0300627 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0300026 |
| CALB1 | calbindin 1, 28kDa | 0.029842 |
| MT1E | metallothionein 1E | 0.0294479 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CLU | clusterin | -0.134667 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.116343 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0784556 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0687373 |
| STC1 | stanniocalcin 1 | -0.0679434 |
| CUL4B | cullin 4B | -0.0678744 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0604251 |
| FLNB | filamin B, beta | -0.0571356 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0569967 |
| ANLN | anillin, actin binding protein | -0.0566449 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0544905 |
| GOLGA4 | golgin A4 | -0.0536215 |
| RBM39 | RNA binding motif protein 39 | -0.0535018 |
| RPS21 | ribosomal protein S21 | -0.0498942 |
| H1-0 | H1.0 linker histone | -0.0487087 |
| BCL2L1 | BCL2-like 1 | -0.0480638 |
| PTMA | prothymosin, alpha | -0.0449873 |
| PLAT | plasminogen activator, tissue | -0.0441268 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0436926 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0428438 |
| ZNF292 | zinc finger protein 292 | -0.0427966 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0426965 |
| TPX2 | TPX2, microtubule-associated | -0.0417094 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0408227 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0401753 |
| OGA | O-GlcNAcase | -0.0390918 |
| POTEF | POTE ankyrin domain family, member F | -0.0379234 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0372277 |
| RPS8 | ribosomal protein S8 | -0.0368797 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0356193 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0354582 |
| KRT17 | keratin 17, type I | -0.034962 |
| RPS2 | ribosomal protein S2 | -0.034889 |
| RPS6 | ribosomal protein S6 | -0.0347943 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0339363 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0335845 |
| MEF2A | myocyte enhancer factor 2A | -0.0320185 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0318907 |
| ITGA6 | integrin, alpha 6 | -0.0318593 |
| DSTN | destrin (actin depolymerizing factor) | -0.0315482 |
| CAPRIN2 | caprin family member 2 | -0.0314468 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0309306 |
| HM13 | histocompatibility (minor) 13 | -0.0305171 |
| PDLIM1 | PDZ and LIM domain 1 | -0.0303973 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0289164 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0285818 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0279071 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0276192 |
| EFHD2 | EF-hand domain family, member D2 | -0.0275915 |
| AHNAK | AHNAK nucleoprotein | -0.0275208 |
| LIMA1 | LIM domain and actin binding 1 | -0.0268966 |
| TMSB10 | thymosin beta 10 | -0.0262198 |
| B2M | beta-2-microglobulin | -0.0261023 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0260818 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0260736 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0260347 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0258828 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0258091 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0256353 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0255944 |
| GNAS | GNAS complex locus | -0.0255351 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0255066 |
| SRP54 | signal recognition particle 54kDa | -0.0255041 |
| SETD5 | SET domain containing 5 | -0.0253305 |
| SERINC3 | serine incorporator 3 | -0.0250629 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0249733 |
| COG5 | component of oligomeric golgi complex 5 | -0.0249565 |
| METTL15 | methyltransferase like 15 | -0.024851 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0246871 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0245673 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0244369 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0243181 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0239427 |
| IGF2 | insulin-like growth factor 2 | -0.0237673 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0235275 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0231825 |
| CANX | calnexin | -0.0231362 |
| YBX3 | Y box binding protein 3 | -0.0228772 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0228515 |
| SERTAD2 | SERTA domain containing 2 | -0.0224359 |
| S100A2 | S100 calcium binding protein A2 | -0.0223625 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0222784 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0222373 |
| S100A9 | S100 calcium binding protein A9 | -0.0219603 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0219284 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0217833 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0217662 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0216974 |
| CLINT1 | clathrin interactor 1 | -0.0214955 |
| GOLT1B | golgi transport 1B | -0.0214688 |
| NKTR | natural killer cell triggering receptor | -0.0213363 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0212548 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0212189 |
| RPS24 | ribosomal protein S24 | -0.0211613 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0211173 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0210743 |
| RPL7 | ribosomal protein L7 | -0.0209155 |
| SUCO | SUN domain containing ossification factor | -0.0208637 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0207971 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0204715 |
