| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.168649 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.117974 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0799458 |
| NAV2 | neuron navigator 2 | 0.0641348 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0519148 |
| ANXA1 | annexin A1 | 0.0514139 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0456938 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0448337 |
| EGFR | epidermal growth factor receptor | 0.0403403 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0392887 |
| FLNA | filamin A, alpha | 0.0381508 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0376097 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0364533 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0338371 |
| FAM107B | family with sequence similarity 107, member B | 0.0336987 |
| SMAD3 | SMAD family member 3 | 0.0327224 |
| MLF1 | myeloid leukemia factor 1 | 0.0317729 |
| RUNX1 | runt-related transcription factor 1 | 0.0315597 |
| ANXA2 | annexin A2 | 0.0310359 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0305394 |
| RPL21 | ribosomal protein L21 | 0.0304642 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0300671 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0295003 |
| ADM | adrenomedullin | 0.028491 |
| NDRG1 | N-myc downstream regulated 1 | 0.0283259 |
| LDHA | lactate dehydrogenase A | 0.0278778 |
| EZR | ezrin | 0.027326 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0268317 |
| ARRDC3 | arrestin domain containing 3 | 0.0257568 |
| KRT18 | keratin 18, type I | 0.0253667 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0249256 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0248581 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0246773 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0244531 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0240925 |
| TPM3 | tropomyosin 3 | 0.0238838 |
| KRT8 | keratin 8, type II | 0.0232728 |
| VEGFA | vascular endothelial growth factor A | 0.0231929 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0227951 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0226537 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0222384 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220977 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.02138 |
| DTNA | dystrobrevin, alpha | 0.0212091 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.021207 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0208274 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0206958 |
| L1CAM | L1 cell adhesion molecule | 0.0206225 |
| TLE4 | transducin-like enhancer of split 4 | 0.0205115 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0201886 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0198511 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0194371 |
| MYOF | myoferlin | 0.0194144 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0193341 |
| BSG | basigin (Ok blood group) | 0.0191896 |
| CRY1 | cryptochrome circadian clock 1 | 0.0190082 |
| NRXN3 | neurexin 3 | 0.0189544 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0185415 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0181617 |
| NCOR2 | nuclear receptor corepressor 2 | 0.017907 |
| COL5A1 | collagen, type V, alpha 1 | 0.0177939 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0177719 |
| RPL29 | ribosomal protein L29 | 0.0175114 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0174239 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0173733 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0171063 |
| APP | amyloid beta (A4) precursor protein | 0.0169158 |
| ATXN1 | ataxin 1 | 0.0168505 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0168082 |
| ZNF841 | zinc finger protein 841 | 0.0162431 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0162188 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0162149 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0161185 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0161006 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0160985 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0159196 |
| FAM13A | family with sequence similarity 13, member A | 0.0158489 |
| SIK3 | SIK family kinase 3 | 0.0157155 |
| PCBP2 | poly(rC) binding protein 2 | 0.0155465 |
| ANO6 | anoctamin 6 | 0.015498 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.015472 |
| MSN | moesin | 0.0153569 |
| MED15 | mediator complex subunit 15 | 0.0149103 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.014696 |
| HELZ | helicase with zinc finger | 0.0146053 |
| SEPTIN9 | septin 9 | 0.0145673 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.01447 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0144154 |
| MYO10 | myosin X | 0.0144045 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0143035 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.0142344 |
| DSPP | dentin sialophosphoprotein | 0.0140877 |
| RPL13A | ribosomal protein L13a | 0.0138502 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0138182 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0137926 |
| CTBP2 | C-terminal binding protein 2 | 0.0137786 |
| DIAPH1 | diaphanous-related formin 1 | 0.0137342 |
| CADM1 | cell adhesion molecule 1 | 0.0136546 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0134179 |
| YBX3 | Y box binding protein 3 | 0.0133625 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | -0.199298 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.177943 |
| FN1 | fibronectin 1 | -0.0969074 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0905139 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.089172 |
| AHNAK | AHNAK nucleoprotein | -0.0842948 |
| EXT1 | exostosin glycosyltransferase 1 | -0.078808 |
| FTL | ferritin, light polypeptide | -0.0729215 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0706293 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.07007 |
| UBC | ubiquitin C | -0.0631471 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0615891 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0613129 |
| ENO1 | enolase 1, (alpha) | -0.0600814 |
| CANX | calnexin | -0.0559774 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0530196 |
| HLA-A | major histocompatibility complex, class I, A | -0.0472454 |
| DEK | DEK proto-oncogene | -0.0459637 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.045685 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0442345 |
| PTMA | prothymosin, alpha | -0.0438109 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0427664 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0427328 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0416184 |
| VIM | vimentin | -0.0406628 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.039522 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0391923 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0379432 |
| B2M | beta-2-microglobulin | -0.0375723 |
| PLIN2 | perilipin 2 | -0.0367216 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0364836 |
| TXNRD1 | thioredoxin reductase 1 | -0.0364368 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0349076 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0344399 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.034418 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0340238 |
| CD44 | CD44 molecule (Indian blood group) | -0.0340056 |
| IL6ST | interleukin 6 signal transducer | -0.0333523 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0330739 |
| TMSB10 | thymosin beta 10 | -0.0327408 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0319061 |
| CAVIN1 | caveolae associated protein 1 | -0.0317034 |
| MT1X | metallothionein 1X | -0.0317002 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0315542 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0314023 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0312279 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0306902 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.03057 |
| POSTN | periostin, osteoblast specific factor | -0.0294399 |
| RPL35A | ribosomal protein L35a | -0.0290597 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0289495 |
| GNAS | GNAS complex locus | -0.0287362 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0286902 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0284153 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0279928 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.027539 |
| TPM4 | tropomyosin 4 | -0.0275339 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0268001 |
| CALU | calumenin | -0.0264034 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0257478 |
| RAI14 | retinoic acid induced 14 | -0.0257158 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0250079 |
| ASPH | aspartate beta-hydroxylase | -0.0242162 |
| S100A6 | S100 calcium binding protein A6 | -0.02416 |
| RBM25 | RNA binding motif protein 25 | -0.0238246 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.023686 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0235552 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0234509 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0234178 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0233567 |
| MTDH | metadherin | -0.0233334 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0229965 |
| LOX | lysyl oxidase | -0.0226722 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0226327 |
| GLIS3 | GLIS family zinc finger 3 | -0.022367 |
| SNX14 | sorting nexin 14 | -0.022339 |
| HLA-E | major histocompatibility complex, class I, E | -0.0223196 |
| RPS27A | ribosomal protein S27a | -0.0221777 |
| RTN4 | reticulon 4 | -0.0221283 |
| IER3 | immediate early response 3 | -0.0218076 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0217984 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0213889 |
| SQSTM1 | sequestosome 1 | -0.021105 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0210055 |
| CLIC4 | chloride intracellular channel 4 | -0.0208503 |
| ZFR | zinc finger RNA binding protein | -0.0207857 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0207084 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0205454 |
| RPS24 | ribosomal protein S24 | -0.0204766 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0204726 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0204101 |
| ZXDC | ZXD family zinc finger C | -0.0201692 |
| RRBP1 | ribosome binding protein 1 | -0.0198538 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.0196648 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0195191 |
| BCL2L1 | BCL2-like 1 | -0.0193606 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0192633 |
| TUBB | tubulin, beta class I | -0.0191093 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0188839 |
| WDR45B | WD repeat domain 45B | -0.0188714 |
