| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.16624 |
| EZR | ezrin | 0.100998 |
| ANXA2 | annexin A2 | 0.0993651 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0977755 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0952029 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0882737 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.079752 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0739419 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0719674 |
| ATXN1 | ataxin 1 | 0.0718397 |
| MYOF | myoferlin | 0.0678993 |
| ASPH | aspartate beta-hydroxylase | 0.06721 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0653633 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0589101 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.05851 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0582193 |
| EMP1 | epithelial membrane protein 1 | 0.058163 |
| KLHL29 | kelch-like family member 29 | 0.0578992 |
| ANXA1 | annexin A1 | 0.0575027 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0574557 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0543456 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0541147 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0536621 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0513242 |
| GDA | guanine deaminase | 0.0474274 |
| SMAD3 | SMAD family member 3 | 0.0471503 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0467362 |
| SEPTIN9 | septin 9 | 0.0462837 |
| LCN2 | lipocalin 2 | 0.0460398 |
| MYO1E | myosin IE | 0.044811 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0447845 |
| PLEC | plectin | 0.0445605 |
| TJP1 | tight junction protein 1 | 0.044278 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0442492 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0438248 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0430774 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0423797 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0423651 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0417835 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0396384 |
| COBL | cordon-bleu WH2 repeat protein | 0.0391658 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0390618 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0381407 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0374497 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0368015 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0364397 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0363839 |
| SQSTM1 | sequestosome 1 | 0.0362953 |
| FTL | ferritin, light polypeptide | 0.0362488 |
| RPL23 | ribosomal protein L23 | 0.035462 |
| SIK3 | SIK family kinase 3 | 0.0352675 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0349573 |
| VCL | vinculin | 0.0348574 |
| EFNB2 | ephrin-B2 | 0.0344691 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0343091 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.033944 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0329035 |
| EFNA5 | ephrin-A5 | 0.0326724 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0324455 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0321293 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0320593 |
| FNIP1 | folliculin interacting protein 1 | 0.0318678 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0316701 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0314613 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.031458 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0313685 |
| HDAC9 | histone deacetylase 9 | 0.0313213 |
| LAMA4 | laminin, alpha 4 | 0.0312144 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0309737 |
| INTS6 | integrator complex subunit 6 | 0.030532 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0300157 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.02992 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299156 |
| ACTN4 | actinin, alpha 4 | 0.0297135 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0296228 |
| RPS12 | ribosomal protein S12 | 0.02949 |
| RASEF | RAS and EF-hand domain containing | 0.0294042 |
| GOLGB1 | golgin B1 | 0.0292572 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0291405 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0290696 |
| RPL26 | ribosomal protein L26 | 0.0283485 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0282029 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0279991 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0279077 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0269908 |
| KRT8 | keratin 8, type II | 0.0264987 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0264957 |
| TXNRD1 | thioredoxin reductase 1 | 0.0264886 |
| ATP11A | ATPase, class VI, type 11A | 0.0264705 |
| SGMS2 | sphingomyelin synthase 2 | 0.0263156 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0262726 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0260783 |
| CTBP2 | C-terminal binding protein 2 | 0.0259355 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0258289 |
| KLF6 | Kruppel-like factor 6 | 0.025819 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0257217 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0256623 |
| RPLP1 | ribosomal protein, large, P1 | 0.0256514 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0250978 |
| FRMD5 | FERM domain containing 5 | 0.0250734 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.152566 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0865498 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0716254 |
| S100A6 | S100 calcium binding protein A6 | -0.0542456 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0525006 |
| H1-0 | H1.0 linker histone | -0.0507791 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0471589 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0438245 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0414046 |
| LYZ | lysozyme | -0.041186 |
| CLDN7 | claudin 7 | -0.0373237 |
| INSIG1 | insulin induced gene 1 | -0.03725 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0372288 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0370172 |
| WDR45B | WD repeat domain 45B | -0.0352753 |
| TMEM123 | transmembrane protein 123 | -0.0305493 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0303828 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0301338 |
| RNF43 | ring finger protein 43 | -0.0293465 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0279955 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0269059 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0267667 |
| GPX2 | glutathione peroxidase 2 | -0.0265847 |
| PLS1 | plastin 1 | -0.0252269 |
| MUC17 | mucin 17, cell surface associated | -0.0250271 |
| THOC2 | THO complex 2 | -0.0247578 |
| MUC1 | mucin 1, cell surface associated | -0.0243657 |
| TRIM31 | tripartite motif containing 31 | -0.0243628 |
| RAB6A | RAB6A, member RAS oncogene family | -0.024096 |
| EPCAM | epithelial cell adhesion molecule | -0.0237968 |
| XPO1 | exportin 1 | -0.0236369 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0235686 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0235381 |
| FASN | fatty acid synthase | -0.0233125 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.023271 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0231214 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0222192 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0217671 |
| GAN | gigaxonin | -0.0215421 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0214081 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0209556 |
| CD2AP | CD2-associated protein | -0.0207029 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0204287 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0201687 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0201303 |
| MSMO1 | methylsterol monooxygenase 1 | -0.019984 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | -0.0196769 |
| PRSS3 | protease, serine, 3 | -0.0196365 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0195088 |
| EHF | ets homologous factor | -0.0194305 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0190715 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0189274 |
| PFN1 | profilin 1 | -0.0186019 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0185291 |
| ZNF292 | zinc finger protein 292 | -0.0184287 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.0183996 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0183857 |
| KLK10 | kallikrein-related peptidase 10 | -0.018259 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0182546 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0180805 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0178726 |
| ATM | ATM serine/threonine kinase | -0.0178398 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.0177575 |
| CLINT1 | clathrin interactor 1 | -0.0172995 |
| SRP54 | signal recognition particle 54kDa | -0.0171771 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0171107 |
| POTEF | POTE ankyrin domain family, member F | -0.0167692 |
| ZNRF3 | zinc and ring finger 3 | -0.0167488 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0163869 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0163867 |
| S100A11 | S100 calcium binding protein A11 | -0.0160714 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0159554 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0159225 |
| CEP57 | centrosomal protein 57kDa | -0.0158875 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0155906 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0154984 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0154042 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0153841 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.015359 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0152786 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0151842 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0148667 |
| AFTPH | aftiphilin | -0.0148568 |
| PDS5B | PDS5 cohesin associated factor B | -0.0147602 |
| WASF2 | WAS protein family, member 2 | -0.0147488 |
| GOLM2 | golgi membrane protein 2 | -0.014729 |
| SRPK2 | SRSF protein kinase 2 | -0.0145997 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0143739 |
| SNX13 | sorting nexin 13 | -0.0142766 |
| PDCD10 | programmed cell death 10 | -0.0141176 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0140798 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | -0.0139413 |
| APOL6 | apolipoprotein L, 6 | -0.0139301 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -0.0138641 |
| TMEM45B | transmembrane protein 45B | -0.0138074 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0136736 |
| ITM2B | integral membrane protein 2B | -0.0135048 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0134879 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0134724 |
| KRT7 | keratin 7, type II | -0.0133528 |
