| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.107622 |
| VIM | vimentin | 0.104593 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0996768 |
| EFNA5 | ephrin-A5 | 0.0942575 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0939909 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0785499 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0720468 |
| ASPH | aspartate beta-hydroxylase | 0.0697884 |
| DTNA | dystrobrevin, alpha | 0.066456 |
| LDHA | lactate dehydrogenase A | 0.0648446 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0610465 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0608589 |
| RUNX1 | runt-related transcription factor 1 | 0.0586253 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0569447 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0558282 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0546032 |
| RPS6 | ribosomal protein S6 | 0.0542459 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.046246 |
| FLNA | filamin A, alpha | 0.0450477 |
| GPC6 | glypican 6 | 0.0449555 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0439644 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0435501 |
| PGK1 | phosphoglycerate kinase 1 | 0.0408226 |
| RPL23 | ribosomal protein L23 | 0.0393756 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0374482 |
| DST | dystonin | 0.0373263 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0359516 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0359205 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0352793 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.035169 |
| MYO10 | myosin X | 0.0349961 |
| PKM | pyruvate kinase, muscle | 0.0348703 |
| RPS3 | ribosomal protein S3 | 0.0345384 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0345338 |
| RPS12 | ribosomal protein S12 | 0.0343359 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0330664 |
| PCBP2 | poly(rC) binding protein 2 | 0.0328322 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0327866 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0320094 |
| PRKCE | protein kinase C, epsilon | 0.0309513 |
| MSN | moesin | 0.0305001 |
| MCL1 | myeloid cell leukemia 1 | 0.0302032 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0301906 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0298948 |
| ACTG1 | actin gamma 1 | 0.0296797 |
| NDRG1 | N-myc downstream regulated 1 | 0.0294846 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0294211 |
| CD44 | CD44 molecule (Indian blood group) | 0.0290259 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0289681 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0287753 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0287549 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0284932 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0283964 |
| KIAA1549L | KIAA1549-like | 0.0279465 |
| ENO1 | enolase 1, (alpha) | 0.0278617 |
| TPM3 | tropomyosin 3 | 0.0277729 |
| RPL12 | ribosomal protein L12 | 0.0276264 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0271779 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0270399 |
| ANXA2 | annexin A2 | 0.0269556 |
| CDK6 | cyclin-dependent kinase 6 | 0.0268241 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0267883 |
| NAV1 | neuron navigator 1 | 0.0267009 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0263707 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0263539 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0262731 |
| FTL | ferritin, light polypeptide | 0.026144 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.025911 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0255847 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0252394 |
| CALD1 | caldesmon 1 | 0.0251816 |
| RPS17 | ribosomal protein S17 | 0.025052 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0247287 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0244214 |
| RPL13A | ribosomal protein L13a | 0.024323 |
| CDH13 | cadherin 13 | 0.0241634 |
| PTMA | prothymosin, alpha | 0.0241148 |
| RPL7 | ribosomal protein L7 | 0.0237394 |
| RPS8 | ribosomal protein S8 | 0.0236643 |
| ITGA6 | integrin, alpha 6 | 0.0236086 |
| RPS18 | ribosomal protein S18 | 0.0234679 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0233073 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0231664 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0228615 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0225772 |
| RPL21 | ribosomal protein L21 | 0.0223401 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.02223 |
| RPL37A | ribosomal protein L37a | 0.0220263 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0220122 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0217803 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0216417 |
| RPS2 | ribosomal protein S2 | 0.020769 |
| PLEC | plectin | 0.0207376 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0207171 |
| PTK2 | protein tyrosine kinase 2 | 0.0207125 |
| ATXN1 | ataxin 1 | 0.0204931 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0202355 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0200967 |
| JUN | jun proto-oncogene | 0.0198662 |
| RPL4 | ribosomal protein L4 | 0.0198398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDK17 | cyclin-dependent kinase 17 | -0.0209392 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0136624 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0136053 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0125638 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0112176 |
| RBM39 | RNA binding motif protein 39 | -0.0110305 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0103097 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0102222 |
| WDR43 | WD repeat domain 43 | -0.0101468 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00973705 |
| VCL | vinculin | -0.00947081 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0093575 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00934887 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.00905321 |
| KYNU | kynureninase | -0.00878392 |
| PTCHD4 | patched domain containing 4 | -0.00872133 |
| H1-0 | H1.0 linker histone | -0.00844719 |
| ZNF292 | zinc finger protein 292 | -0.00835968 |
| TEX10 | testis expressed 10 | -0.0077648 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.00775039 |
| CFAP251 | cilia and flagella associated protein 251 | -0.00749167 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.00747874 |
| RBM25 | RNA binding motif protein 25 | -0.0067429 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00663769 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00647203 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.00633366 |
| GNAS | GNAS complex locus | -0.00610671 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.00606913 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00606786 |
| HAS2 | hyaluronan synthase 2 | -0.00597529 |
| RHEB | Ras homolog enriched in brain | -0.00588905 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.00584494 |
| YBX3 | Y box binding protein 3 | -0.00583212 |
| RAB1A | RAB1A, member RAS oncogene family | -0.00575859 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.00570709 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.00569382 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.00558794 |
| WTAP | Wilms tumor 1 associated protein | -0.00539613 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00527948 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.00527173 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.00520729 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.00514307 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.00508376 |
| RIGI | RNA sensor RIG-I | -0.00502343 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.00497598 |
| GLMN | glomulin, FKBP associated protein | -0.00492848 |
| PCNX4 | pecanex 4 | -0.00492734 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.00488484 |
| MT1X | metallothionein 1X | -0.00486943 |
| OGA | O-GlcNAcase | -0.00482448 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00480593 |
| GPATCH8 | G patch domain containing 8 | -0.0047901 |
| WDR45B | WD repeat domain 45B | -0.00468928 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00467958 |
| HDAC3 | histone deacetylase 3 | -0.00464385 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.00462342 |
| CUL3 | cullin 3 | -0.00460701 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0045331 |
| NOP58 | NOP58 ribonucleoprotein | -0.00450372 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.00445537 |
| ZNF654 | zinc finger protein 654 | -0.00444063 |
| RPL6 | ribosomal protein L6 | -0.00439985 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.00437394 |
| BTG3 | BTG family, member 3 | -0.00427671 |
| THOC2 | THO complex 2 | -0.00423382 |
| STK17A | serine/threonine kinase 17a | -0.00422367 |
| FOXJ3 | forkhead box J3 | -0.00417214 |
| TBC1D15 | TBC1 domain family, member 15 | -0.00412474 |
| RNF145 | ring finger protein 145 | -0.00409498 |
| TTK | TTK protein kinase | -0.00398555 |
| PATL1 | protein associated with topoisomerase II homolog 1 (yeast) | -0.00389574 |
| USP15 | ubiquitin specific peptidase 15 | -0.00387786 |
| ABI1 | abl-interactor 1 | -0.00385811 |
| IP6K1 | inositol hexakisphosphate kinase 1 | -0.0038316 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.00378296 |
| PLAG1 | pleiomorphic adenoma gene 1 | -0.00374034 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.00373899 |
| PUM2 | pumilio RNA-binding family member 2 | -0.00370776 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00367752 |
| ALPK2 | alpha-kinase 2 | -0.00367655 |
| EED | embryonic ectoderm development | -0.00367494 |
| SETD5 | SET domain containing 5 | -0.00366194 |
| ATXN3 | ataxin 3 | -0.00364236 |
| QKI | QKI, KH domain containing, RNA binding | -0.00361888 |
| EZH1 | enhancer of zeste 1 polycomb repressive complex 2 subunit | -0.00361497 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.00356413 |
| BRD8 | bromodomain containing 8 | -0.00353476 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00351865 |
| AEBP2 | AE binding protein 2 | -0.00349304 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.00345777 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.00344998 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.00343788 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | -0.00341658 |
| HBP1 | HMG-box transcription factor 1 | -0.0034053 |
| MIS18BP1 | MIS18 binding protein 1 | -0.00340313 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.00338442 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.00338147 |
| MAP3K7CL | MAP3K7 C-terminal like | -0.00338035 |
| TLK2 | tousled-like kinase 2 | -0.00336356 |
| RANBP9 | RAN binding protein 9 | -0.00333798 |
