| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.124803 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110707 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0824411 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0793131 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0692866 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0642922 |
| FAT1 | FAT atypical cadherin 1 | 0.0585436 |
| LDHA | lactate dehydrogenase A | 0.0571826 |
| CALR | calreticulin | 0.0508389 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0493109 |
| DSPP | dentin sialophosphoprotein | 0.0476146 |
| EREG | epiregulin | 0.0412002 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0411368 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.040563 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0375176 |
| LMO7 | LIM domain 7 | 0.0372972 |
| GOLGA4 | golgin A4 | 0.036142 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0355758 |
| VEGFA | vascular endothelial growth factor A | 0.0351827 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.03331 |
| RPL13A | ribosomal protein L13a | 0.0328206 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0323108 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0308412 |
| HDLBP | high density lipoprotein binding protein | 0.0294785 |
| PDZD8 | PDZ domain containing 8 | 0.0274992 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0271922 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0269789 |
| RPS3 | ribosomal protein S3 | 0.026821 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0265014 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0263137 |
| PGK1 | phosphoglycerate kinase 1 | 0.025546 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0253912 |
| GOLGB1 | golgin B1 | 0.025054 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0248001 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0245618 |
| BRD2 | bromodomain containing 2 | 0.0245121 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0240565 |
| NEBL | nebulette | 0.0239191 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0235528 |
| PHF3 | PHD finger protein 3 | 0.0234848 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0234368 |
| OGA | O-GlcNAcase | 0.0226091 |
| FTL | ferritin, light polypeptide | 0.0225633 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0222439 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0220389 |
| RPL26 | ribosomal protein L26 | 0.02203 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0211635 |
| TPM3 | tropomyosin 3 | 0.0209029 |
| PCBP2 | poly(rC) binding protein 2 | 0.0208738 |
| ASPH | aspartate beta-hydroxylase | 0.0204302 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0203973 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0203066 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.020268 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0201544 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0199237 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0198495 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0196134 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0195069 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0192791 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.019257 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0191982 |
| APP | amyloid beta (A4) precursor protein | 0.0190757 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0188656 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0185562 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0184519 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0184484 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0182964 |
| RPS12 | ribosomal protein S12 | 0.0182423 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0181094 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0178291 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0178013 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0177959 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0174935 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.017447 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0173897 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0171891 |
| RNF145 | ring finger protein 145 | 0.017176 |
| MUC13 | mucin 13, cell surface associated | 0.017121 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0170767 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0170412 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0169267 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0168017 |
| CANX | calnexin | 0.0167299 |
| SQSTM1 | sequestosome 1 | 0.0167197 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0167131 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0165799 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0164793 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0162826 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0159325 |
| SETD2 | SET domain containing 2 | 0.0159217 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0159128 |
| JAK1 | Janus kinase 1 | 0.0158998 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.015855 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0158014 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0156966 |
| RPS18 | ribosomal protein S18 | 0.0156922 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0156209 |
| RPL29 | ribosomal protein L29 | 0.01558 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0155396 |
| RPL3 | ribosomal protein L3 | 0.0154755 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.258179 |
| TMSB10 | thymosin beta 10 | -0.20385 |
| PTMA | prothymosin, alpha | -0.176973 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.145121 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0974398 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.093807 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0875904 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0846858 |
| RPS6 | ribosomal protein S6 | -0.079452 |
| S100A6 | S100 calcium binding protein A6 | -0.0745164 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0734305 |
| ITGA6 | integrin, alpha 6 | -0.0687258 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0669782 |
| RPL35A | ribosomal protein L35a | -0.0610763 |
| FLNB | filamin B, beta | -0.0603628 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0582457 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0554338 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0547084 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0522048 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0495926 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0490743 |
| RNF217 | ring finger protein 217 | -0.0469455 |
| CALB1 | calbindin 1, 28kDa | -0.0461106 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0442811 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0439748 |
| POTEF | POTE ankyrin domain family, member F | -0.0436397 |
| TNS4 | tensin 4 | -0.0434462 |
| S100A9 | S100 calcium binding protein A9 | -0.0433797 |
| GPHN | gephyrin | -0.0419356 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0417164 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0410235 |
| TFF1 | trefoil factor 1 | -0.0409847 |
| AHNAK | AHNAK nucleoprotein | -0.0400008 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0396839 |
| RPL34 | ribosomal protein L34 | -0.0386253 |
| RPS21 | ribosomal protein S21 | -0.0372578 |
| ACTG1 | actin gamma 1 | -0.0371666 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0369756 |
| HMGA1 | high mobility group AT-hook 1 | -0.0362922 |
| TPM4 | tropomyosin 4 | -0.0345781 |
| FERMT1 | fermitin family member 1 | -0.0338876 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0338649 |
| DIAPH2 | diaphanous-related formin 2 | -0.0334314 |
| FHIT | fragile histidine triad | -0.033363 |
| RIN2 | Ras and Rab interactor 2 | -0.0333198 |
| FOSL1 | FOS-like antigen 1 | -0.0328731 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0328664 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0327222 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.032704 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0321105 |
| SH3D19 | SH3 domain containing 19 | -0.0319772 |
| PRSS3 | protease, serine, 3 | -0.0318432 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0315958 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0312639 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0304716 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0300209 |
| ABHD2 | abhydrolase domain containing 2 | -0.0295947 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0295258 |
| LSAMP | limbic system-associated membrane protein | -0.0294349 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0293962 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0289437 |
| KLK10 | kallikrein-related peptidase 10 | -0.0287903 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0281642 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0280639 |
| EHBP1 | EH domain binding protein 1 | -0.0280497 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0275733 |
| FRMD5 | FERM domain containing 5 | -0.0274687 |
| MUC17 | mucin 17, cell surface associated | -0.0274569 |
| MT2A | metallothionein 2A | -0.0273469 |
| SBF2 | SET binding factor 2 | -0.0270388 |
| SMYD3 | SET and MYND domain containing 3 | -0.026875 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0263534 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0262478 |
| CCND1 | cyclin D1 | -0.0260939 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0257813 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0257386 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0253114 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0249846 |
| MYO1E | myosin IE | -0.0249489 |
| RREB1 | ras responsive element binding protein 1 | -0.0249451 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0247785 |
| HMGB1 | high mobility group box 1 | -0.024627 |
| RPS19 | ribosomal protein S19 | -0.0245946 |
| ITGB4 | integrin, beta 4 | -0.0245316 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0244704 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0241487 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0241014 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0238165 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0237168 |
| RAD51B | RAD51 paralog B | -0.0233361 |
| PFN1 | profilin 1 | -0.0224847 |
| ACTN4 | actinin, alpha 4 | -0.0224775 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0224087 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0222866 |
| ARHGAP6 | Rho GTPase activating protein 6 | -0.022252 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0222282 |
| S100A10 | S100 calcium binding protein A10 | -0.0219412 |
| ONECUT3 | one cut homeobox 3 | -0.0218316 |
| NDRG1 | N-myc downstream regulated 1 | -0.021636 |
| IER3 | immediate early response 3 | -0.0214618 |
