| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.144527 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0864462 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0803903 |
| LMO7 | LIM domain 7 | 0.0799071 |
| EZR | ezrin | 0.0765474 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0762255 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.073419 |
| INTS6 | integrator complex subunit 6 | 0.0713412 |
| DSPP | dentin sialophosphoprotein | 0.0678186 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0621539 |
| PCBP2 | poly(rC) binding protein 2 | 0.0567402 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0546123 |
| RPS6 | ribosomal protein S6 | 0.0507372 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0507259 |
| RPL3 | ribosomal protein L3 | 0.0504667 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0503262 |
| LRRC23 | leucine rich repeat containing 23 | 0.0466578 |
| PKM | pyruvate kinase, muscle | 0.0462466 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0458516 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0435795 |
| CTBP2 | C-terminal binding protein 2 | 0.0434602 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0430757 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0427072 |
| BRD2 | bromodomain containing 2 | 0.0413039 |
| FRMD5 | FERM domain containing 5 | 0.0384437 |
| RPS12 | ribosomal protein S12 | 0.0378228 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0372628 |
| LDHA | lactate dehydrogenase A | 0.0368518 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0352277 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0348353 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0346478 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0339828 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0323995 |
| RPS18 | ribosomal protein S18 | 0.031247 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0311315 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0310181 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0309819 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0307382 |
| OXSR1 | oxidative stress responsive 1 | 0.0299979 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.029825 |
| MYO5B | myosin VB | 0.0296546 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0288743 |
| DIAPH1 | diaphanous-related formin 1 | 0.0284603 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0283725 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0282795 |
| NABP1 | nucleic acid binding protein 1 | 0.0282034 |
| ARRDC3 | arrestin domain containing 3 | 0.027089 |
| PLK2 | polo-like kinase 2 | 0.0270318 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.026892 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0268706 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0267165 |
| CFAP161 | cilia and flagella associated protein 161 | 0.0265643 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0265057 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0260615 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0260476 |
| MCL1 | myeloid cell leukemia 1 | 0.0252666 |
| RPL21 | ribosomal protein L21 | 0.0240627 |
| TXNIP | thioredoxin interacting protein | 0.0240303 |
| LOC105378220 | macrophage receptor MARCO-like | 0.0239963 |
| SVIL | supervillin | 0.0237861 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0237802 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0237759 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236389 |
| UBAP2 | ubiquitin associated protein 2 | 0.0235201 |
| ASPH | aspartate beta-hydroxylase | 0.0233582 |
| FBXO11 | F-box protein 11 | 0.0232936 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0229825 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0229216 |
| RCC1 | regulator of chromosome condensation 1 | 0.0227674 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0224297 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0223443 |
| RCOR1 | REST corepressor 1 | 0.0221449 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0220472 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0219937 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0219549 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.021468 |
| FUS | FUS RNA binding protein | 0.0214167 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0213282 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0211538 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0211375 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.021043 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0209025 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0208873 |
| AEBP2 | AE binding protein 2 | 0.0208559 |
| SLTM | SAFB-like, transcription modulator | 0.0207934 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207494 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0206396 |
| KRT18 | keratin 18, type I | 0.0205553 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0204755 |
| VEGFA | vascular endothelial growth factor A | 0.0202619 |
| IRF1 | interferon regulatory factor 1 | 0.0202519 |
| MYO1E | myosin IE | 0.0200962 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0196568 |
| GOLGB1 | golgin B1 | 0.0195711 |
| PDZD8 | PDZ domain containing 8 | 0.019421 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0193752 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0191603 |
| RPL29 | ribosomal protein L29 | 0.0191149 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0190506 |
| TUFT1 | tuftelin 1 | 0.018917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.182257 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.122 |
| FLNB | filamin B, beta | -0.120992 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.107225 |
| PKP2 | plakophilin 2 | -0.0879918 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0851337 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0838277 |
| PRSS3 | protease, serine, 3 | -0.0835463 |
| TXNRD1 | thioredoxin reductase 1 | -0.0830592 |
| PLAC8 | placenta-specific 8 | -0.0823594 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0760392 |
| TRIM2 | tripartite motif containing 2 | -0.0681954 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0676188 |
| ITGA6 | integrin, alpha 6 | -0.0672208 |
| SHROOM3 | shroom family member 3 | -0.0657897 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0626988 |
| ABHD17C | abhydrolase domain containing 17C | -0.0623562 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0595482 |
| FOXO1 | forkhead box O1 | -0.059495 |
| PCDHB16 | protocadherin beta 16 | -0.0582089 |
| MYOF | myoferlin | -0.0577275 |
| VCL | vinculin | -0.0575615 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0568576 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0551833 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0534751 |
| RAD51B | RAD51 paralog B | -0.05226 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0476491 |
| MYO1D | myosin ID | -0.047472 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.046938 |
| PRELID2 | PRELI domain containing 2 | -0.0466419 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0462738 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | -0.046207 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0453834 |
| FOXP1 | forkhead box P1 | -0.0450232 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.044155 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0439687 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0436162 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0435634 |
| TMSB10 | thymosin beta 10 | -0.0433784 |
| RIGI | RNA sensor RIG-I | -0.0433578 |
| RRBP1 | ribosome binding protein 1 | -0.0432958 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.043102 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0425358 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.041548 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0412197 |
| ETV6 | ets variant 6 | -0.0412122 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0403564 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0402856 |
| FAT1 | FAT atypical cadherin 1 | -0.0400914 |
| RPS24 | ribosomal protein S24 | -0.0400167 |
| WWC1 | WW and C2 domain containing 1 | -0.039961 |
| ETNK1 | ethanolamine kinase 1 | -0.0398834 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0394596 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0390418 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0387234 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0386178 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.0373436 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0368639 |
| MX2 | MX dynamin-like GTPase 2 | -0.0363729 |
| RPLP1 | ribosomal protein, large, P1 | -0.0356261 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0350225 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0349527 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0346951 |
| EREG | epiregulin | -0.0346282 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.034539 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0342844 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0341693 |
| RNF213 | ring finger protein 213 | -0.0338681 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0337413 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.033685 |
| SEPTIN10 | septin 10 | -0.0332815 |
| FERMT1 | fermitin family member 1 | -0.0332533 |
| EXOC4 | exocyst complex component 4 | -0.033232 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0330265 |
| MX1 | MX dynamin-like GTPase 1 | -0.0328404 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0321728 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | -0.0319654 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0317537 |
| MKI67 | marker of proliferation Ki-67 | -0.0312797 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0312647 |
| CALB1 | calbindin 1, 28kDa | -0.0312335 |
| BCL2L1 | BCL2-like 1 | -0.0310975 |
| TRIM31 | tripartite motif containing 31 | -0.030889 |
| FHL2 | four and a half LIM domains 2 | -0.0306537 |
| TMEM45B | transmembrane protein 45B | -0.0305312 |
| CXADR | coxsackie virus and adenovirus receptor | -0.030197 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.030085 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.030053 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0300073 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0298595 |
| SMYD3 | SET and MYND domain containing 3 | -0.0297804 |
| CEP95 | centrosomal protein 95kDa | -0.0296228 |
| RPS21 | ribosomal protein S21 | -0.0294509 |
| TLN2 | talin 2 | -0.0284254 |
| KLF6 | Kruppel-like factor 6 | -0.0282796 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0280362 |
| CLINT1 | clathrin interactor 1 | -0.0278155 |
| CCPG1 | cell cycle progression 1 | -0.0276636 |
| YBX3 | Y box binding protein 3 | -0.0272638 |
| NF1 | neurofibromin 1 | -0.0268575 |
