ERK5-IN-2_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.104487
EEF2 eukaryotic translation elongation factor 2 0.100047
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0958783
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0904123
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0685013
EZR ezrin 0.0671586
DST dystonin 0.0626445
TMSB4X thymosin beta 4, X-linked 0.0618313
LDHA lactate dehydrogenase A 0.060214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0583139
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0572454
FMNL2 formin-like 2 0.0503609
TM4SF1 transmembrane 4 L six family member 1 0.0479211
KLF6 Kruppel-like factor 6 0.0468307
CAPRIN2 caprin family member 2 0.0467009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0448088
PGK1 phosphoglycerate kinase 1 0.0430696
APP amyloid beta (A4) precursor protein 0.0426309
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0424922
MACF1 microtubule-actin crosslinking factor 1 0.0418312
SPAG9 sperm associated antigen 9 0.0417942
PLK2 polo-like kinase 2 0.0366429
PRRC2C proline-rich coiled-coil 2C 0.036211
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0341002
BIRC3 baculoviral IAP repeat containing 3 0.0335973
PSD3 pleckstrin and Sec7 domain containing 3 0.0317681
FTH1 ferritin, heavy polypeptide 1 0.0312893
RUNX1 runt-related transcription factor 1 0.0310055
HSPA8 heat shock 70kDa protein 8 0.030822
HOOK2 hook microtubule-tethering protein 2 0.0303692
JMJD1C jumonji domain containing 1C 0.0303446
CALR calreticulin 0.0301028
CXCL8 chemokine (C-X-C motif) ligand 8 0.0293322
EREG epiregulin 0.0289181
KMT2E lysine (K)-specific methyltransferase 2E 0.0288607
KTN1 kinectin 1 (kinesin receptor) 0.0286615
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285691
JUN jun proto-oncogene 0.0277497
TXNIP thioredoxin interacting protein 0.0277255
CANX calnexin 0.0273606
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0269005
LOC112694756 uncharaterized LOC112694756 0.0267684
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0266898
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0264852
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0258815
SON SON DNA binding protein 0.0258465
HDLBP high density lipoprotein binding protein 0.0251809
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0242879
TPM3 tropomyosin 3 0.0241881
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0240073
RAB7A RAB7A, member RAS oncogene family 0.0235073
ZBTB38 zinc finger and BTB domain containing 38 0.0234771
PTPRF protein tyrosine phosphatase, receptor type, F 0.0234339
TRIO trio Rho guanine nucleotide exchange factor 0.0233792
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0233234
ANXA1 annexin A1 0.0232481
SRRM2 serine/arginine repetitive matrix 2 0.0232428
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0231282
RPS18 ribosomal protein S18 0.0230191
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0229952
PUM1 pumilio RNA-binding family member 1 0.0224875
WWTR1 WW domain containing transcription regulator 1 0.0221903
RAI1 retinoic acid induced 1 0.0221797
RLF rearranged L-myc fusion 0.022142
ZEB1 zinc finger E-box binding homeobox 1 0.0221114
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0220365
AFF4 AF4/FMR2 family, member 4 0.0217208
KDM3A lysine (K)-specific demethylase 3A 0.0216297
DSCAM Down syndrome cell adhesion molecule 0.0212468
NPAS2 neuronal PAS domain protein 2 0.0211025
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210515
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0209399
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0206976
PDIA4 protein disulfide isomerase family A, member 4 0.0206306
MYOF myoferlin 0.0206022
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020559
TAC4 tachykinin 4 (hemokinin) 0.020422
ANGPTL4 angiopoietin-like 4 0.0203601
NUP58 nucleoporin 58 0.0202547
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0201994
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0198115
CSNK1A1 casein kinase 1, alpha 1 0.019673
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0196343
ENO1 enolase 1, (alpha) 0.0193992
EMP1 epithelial membrane protein 1 0.0193937
EIF4A1 eukaryotic translation initiation factor 4A1 0.0193297
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0192207
GOLGB1 golgin B1 0.0192075
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0191748
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0190932
EIF4H eukaryotic translation initiation factor 4H 0.019045
CSDE1 cold shock domain containing E1, RNA-binding 0.0189517
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0189495
IQGAP1 IQ motif containing GTPase activating protein 1 0.0188312
RGS4 regulator of G-protein signaling 4 0.0187683
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0187624
MYH9 myosin, heavy chain 9, non-muscle 0.0184872
MATR3 matrin 3 0.0184185
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0183739
OSBPL8 oxysterol binding protein-like 8 0.0183651

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109771
RPL35A ribosomal protein L35a -0.0950107
HLA-B major histocompatibility complex, class I, B -0.0766431
TMSB10 thymosin beta 10 -0.0628627
RPL31 ribosomal protein L31 -0.056709
POTEF POTE ankyrin domain family, member F -0.0543077
FTL ferritin, light polypeptide -0.049927
PTMA prothymosin, alpha -0.0466229
RPS23 ribosomal protein S23 -0.0454772
RPS29 ribosomal protein S29 -0.0418646
RPS8 ribosomal protein S8 -0.0409179
RPL28 ribosomal protein L28 -0.0401162
RPL37A ribosomal protein L37a -0.0399458
RPS6 ribosomal protein S6 -0.0373282
RPS13 ribosomal protein S13 -0.0372378
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0365955
RPL38 ribosomal protein L38 -0.0324648
HLA-A major histocompatibility complex, class I, A -0.0308578
RPS10 ribosomal protein S10 -0.0304093
HMGA1 high mobility group AT-hook 1 -0.0299938
RPS19 ribosomal protein S19 -0.029495
RPS24 ribosomal protein S24 -0.0289968
RPLP2 ribosomal protein, large, P2 -0.027798
RPS27A ribosomal protein S27a -0.027134
TP63 tumor protein p63 -0.0262417
RPS25 ribosomal protein S25 -0.0260618
RPL9 ribosomal protein L9 -0.0254301
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0252281
RPS21 ribosomal protein S21 -0.0248153
ISG15 ISG15 ubiquitin-like modifier -0.0233299
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0232864
RPLP1 ribosomal protein, large, P1 -0.0228788
DLG1 discs, large homolog 1 (Drosophila) -0.0225019
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0223353
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0221784
CADM2 cell adhesion molecule 2 -0.0214441
RPS14 ribosomal protein S14 -0.0214075
VIM vimentin -0.0213406
IFI6 interferon, alpha-inducible protein 6 -0.0211643
RPS27 ribosomal protein S27 -0.0206912
WARS1 tryptophanyl-tRNA synthetase 1 -0.0199131
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0195498
RPS15 ribosomal protein S15 -0.0195188
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.019238
RPL34 ribosomal protein L34 -0.0185257
B2M beta-2-microglobulin -0.0175492
RPL37 ribosomal protein L37 -0.017337
TNS3 tensin 3 -0.0170988
RPL27 ribosomal protein L27 -0.0170734
EFNA5 ephrin-A5 -0.01692
RPL7A ribosomal protein L7a -0.0163065
EGR1 early growth response 1 -0.0162758
ENO2 enolase 2 (gamma, neuronal) -0.0161332
RPS28 ribosomal protein S28 -0.0161071
ANKRD12 ankyrin repeat domain 12 -0.0160019
RPL36 ribosomal protein L36 -0.0159239
RPL36A ribosomal protein L36a -0.0155077
RPS17 ribosomal protein S17 -0.0155057
RPL23 ribosomal protein L23 -0.015421
AEBP2 AE binding protein 2 -0.0151458
RPS5 ribosomal protein S5 -0.0145771
WASF2 WAS protein family, member 2 -0.0139339
RIGI RNA sensor RIG-I -0.013889
EPB41 erythrocyte membrane protein band 4.1 -0.013879
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0138413
S100A9 S100 calcium binding protein A9 -0.0132899
PDCD5 programmed cell death 5 -0.01298
RPS16 ribosomal protein S16 -0.0127821
RPS20 ribosomal protein S20 -0.0126654
RPS11 ribosomal protein S11 -0.0125695
CCDC91 coiled-coil domain containing 91 -0.0123966
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0122736
CFDP1 craniofacial development protein 1 -0.0121682
PLIN3 perilipin 3 -0.0120821
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0120196
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0119437
HSPG2 heparan sulfate proteoglycan 2 -0.0115889
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0115528
IFITM1 interferon induced transmembrane protein 1 -0.0114783
CD44 CD44 molecule (Indian blood group) -0.0113142
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0111549
CFAP299 cilia and flagella associated protein 299 -0.0110708
CALD1 caldesmon 1 -0.0109621
AGRN agrin -0.010918
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0106523
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0105092
TPT1 tumor protein, translationally-controlled 1 -0.0104305
CSMD3 CUB and Sushi multiple domains 3 -0.0104062
RPL27A ribosomal protein L27a -0.0102253
DPH6 diphthamine biosynthesis 6 -0.0101294
VDAC1 voltage-dependent anion channel 1 -0.00990999
RPL11 ribosomal protein L11 -0.00989853
ZDHHC14 zinc finger, DHHC-type containing 14 -0.00984213
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00980349
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0097613
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -0.00969454
ECE1 endothelin converting enzyme 1 -0.00968652
TTC3 tetratricopeptide repeat domain 3 -0.00964341
RPL39 ribosomal protein L39 -0.00960486
RSF1 remodeling and spacing factor 1 -0.00959856