| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.414434 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.160499 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0991555 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0947211 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0841755 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0787842 |
| PTMA | prothymosin, alpha | 0.0778021 |
| TMSB10 | thymosin beta 10 | 0.0775781 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0716108 |
| ANXA2 | annexin A2 | 0.0632947 |
| LDHA | lactate dehydrogenase A | 0.0602526 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0600003 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0589958 |
| RNF213 | ring finger protein 213 | 0.0554865 |
| GRAMD1B | GRAM domain containing 1B | 0.0541725 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0498435 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0496948 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.048473 |
| ENO1 | enolase 1, (alpha) | 0.0483727 |
| KRT18 | keratin 18, type I | 0.0472604 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0450623 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0445512 |
| S100A10 | S100 calcium binding protein A10 | 0.0444394 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0435276 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.042782 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0411907 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0401154 |
| RPS3 | ribosomal protein S3 | 0.0399269 |
| LMO7 | LIM domain 7 | 0.0399223 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0384998 |
| RPLP1 | ribosomal protein, large, P1 | 0.0365499 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0358205 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0356984 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0350129 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0343189 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0336745 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334926 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0324356 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0318978 |
| SMAD3 | SMAD family member 3 | 0.0315403 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.031299 |
| DSPP | dentin sialophosphoprotein | 0.0312781 |
| ASPH | aspartate beta-hydroxylase | 0.0312716 |
| FAM13A | family with sequence similarity 13, member A | 0.0308705 |
| INTS6 | integrator complex subunit 6 | 0.0305874 |
| ACTG1 | actin gamma 1 | 0.0305149 |
| MYOF | myoferlin | 0.0300747 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0295266 |
| RPS25 | ribosomal protein S25 | 0.0293088 |
| EGR1 | early growth response 1 | 0.029036 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0286465 |
| RPS8 | ribosomal protein S8 | 0.0286409 |
| HOMER1 | homer scaffolding protein 1 | 0.0277581 |
| ANXA1 | annexin A1 | 0.0277437 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0270032 |
| CALR | calreticulin | 0.0269225 |
| KRT7 | keratin 7, type II | 0.0268025 |
| FTL | ferritin, light polypeptide | 0.0260739 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0258959 |
| HDLBP | high density lipoprotein binding protein | 0.0256654 |
| EZR | ezrin | 0.0254997 |
| RPS27A | ribosomal protein S27a | 0.0253111 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.025081 |
| S100P | S100 calcium binding protein P | 0.0248342 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0244446 |
| RPL31 | ribosomal protein L31 | 0.0242897 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0241649 |
| MYO1E | myosin IE | 0.0240513 |
| RPL19 | ribosomal protein L19 | 0.0237688 |
| LAMB3 | laminin, beta 3 | 0.023765 |
| AHNAK | AHNAK nucleoprotein | 0.0237415 |
| SIK3 | SIK family kinase 3 | 0.0236645 |
| PGK1 | phosphoglycerate kinase 1 | 0.0233434 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0232938 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0230765 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0230597 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0230168 |
| RPL35A | ribosomal protein L35a | 0.0227451 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0225269 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0225146 |
| H1-0 | H1.0 linker histone | 0.0224445 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0223025 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0220534 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.02187 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0218483 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.021671 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0211573 |
| RPL23 | ribosomal protein L23 | 0.0209192 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.0206413 |
| RPS24 | ribosomal protein S24 | 0.0200657 |
| TPI1 | triosephosphate isomerase 1 | 0.0200568 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.020045 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0200293 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0198087 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0198042 |
| IER3 | immediate early response 3 | 0.0197581 |
| ITGB4 | integrin, beta 4 | 0.0197015 |
| JUN | jun proto-oncogene | 0.0196705 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0196189 |
| RPS17 | ribosomal protein S17 | 0.0195755 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.213469 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.102925 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0906455 |
| CES1 | carboxylesterase 1 | -0.0498656 |
| NDRG1 | N-myc downstream regulated 1 | -0.0469599 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0461111 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.046092 |
| MKI67 | marker of proliferation Ki-67 | -0.0436674 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0419945 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0388228 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0368934 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0367126 |
| JMJD1C | jumonji domain containing 1C | -0.0363133 |
| USP34 | ubiquitin specific peptidase 34 | -0.0353107 |
| RUNX1 | runt-related transcription factor 1 | -0.0348033 |
| RBM39 | RNA binding motif protein 39 | -0.0336537 |
| ZNF292 | zinc finger protein 292 | -0.0328889 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0328206 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0325812 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0322418 |
| CCNL1 | cyclin L1 | -0.0318344 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0305776 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0288181 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0282352 |
| OSMR | oncostatin M receptor | -0.0279066 |
| TMEM165 | transmembrane protein 165 | -0.0278305 |
| SPAG9 | sperm associated antigen 9 | -0.0278183 |
| PAPOLA | poly(A) polymerase alpha | -0.0273415 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0272673 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0271343 |
| USP53 | ubiquitin specific peptidase 53 | -0.0270818 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0266454 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0262098 |
| TES | testin LIM domain protein | -0.0259545 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.025936 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0258201 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.025812 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0255326 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0251314 |
| CLTC | clathrin, heavy chain (Hc) | -0.0244519 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0236101 |
| RTN4 | reticulon 4 | -0.0235919 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0234822 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0233714 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0232779 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0232058 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0226194 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0225867 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0224506 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0222188 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0219612 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0217289 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0216164 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0214566 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0211269 |
| DTNA | dystrobrevin, alpha | -0.0210494 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0209253 |
| AGO2 | argonaute RISC catalytic component 2 | -0.020906 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0208621 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0207907 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0206721 |
| SEPTIN10 | septin 10 | -0.0205947 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.020465 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0199685 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.019948 |
| RPS2 | ribosomal protein S2 | -0.0198205 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0196398 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0196009 |
| MYO1B | myosin IB | -0.0193964 |
| TMF1 | TATA element modulatory factor 1 | -0.0193678 |
| FAM193A | family with sequence similarity 193, member A | -0.0193551 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0192917 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0192877 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0191438 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0190751 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.01902 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0189476 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0188665 |
| VMP1 | vacuole membrane protein 1 | -0.0188113 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0185242 |
| NGLY1 | N-glycanase 1 | -0.018345 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0183202 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0182063 |
| JAK1 | Janus kinase 1 | -0.01815 |
| SYAP1 | synapse associated protein 1 | -0.0180335 |
| CTTN | cortactin | -0.0179379 |
| OGA | O-GlcNAcase | -0.0177573 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0176988 |
| SETD5 | SET domain containing 5 | -0.0176772 |
| CPE | carboxypeptidase E | -0.0174598 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.0174138 |
| ZNF638 | zinc finger protein 638 | -0.0173106 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0170821 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0170498 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0170496 |
| FRMD4B | FERM domain containing 4B | -0.0169619 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0169532 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.016928 |
| NEK7 | NIMA-related kinase 7 | -0.0168949 |
| WDR26 | WD repeat domain 26 | -0.0168384 |
