| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.1544 |
| FAM20C | family with sequence similarity 20, member C | 0.124474 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.120956 |
| VIM | vimentin | 0.114487 |
| LOX | lysyl oxidase | 0.101657 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.101135 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0946973 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0944396 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0922626 |
| PCBP2 | poly(rC) binding protein 2 | 0.0899982 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.077383 |
| LDHA | lactate dehydrogenase A | 0.0672939 |
| HMGA2 | high mobility group AT-hook 2 | 0.064618 |
| AADAC | arylacetamide deacetylase | 0.0643224 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0630425 |
| ASPH | aspartate beta-hydroxylase | 0.0590249 |
| GRB10 | growth factor receptor-bound protein 10 | 0.054228 |
| INTS6 | integrator complex subunit 6 | 0.0538703 |
| PKM | pyruvate kinase, muscle | 0.0538521 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0520473 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0503895 |
| TGFB1 | transforming growth factor, beta 1 | 0.0493132 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0487969 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0463777 |
| ENO1 | enolase 1, (alpha) | 0.0461474 |
| LOXL2 | lysyl oxidase-like 2 | 0.0461061 |
| CA12 | carbonic anhydrase XII | 0.0458957 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0454885 |
| VEGFA | vascular endothelial growth factor A | 0.0450336 |
| SEPTIN9 | septin 9 | 0.0432606 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0414903 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0410226 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0400889 |
| CDH13 | cadherin 13 | 0.0397518 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0395244 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0392165 |
| SP100 | SP100 nuclear antigen | 0.0373451 |
| ANXA2 | annexin A2 | 0.0371247 |
| EGFR | epidermal growth factor receptor | 0.0371026 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0360848 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0360674 |
| IFI44L | interferon-induced protein 44-like | 0.0354837 |
| ANGPTL4 | angiopoietin-like 4 | 0.0353203 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0332975 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.033183 |
| RNF213 | ring finger protein 213 | 0.0329206 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0323058 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0321956 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | 0.0319014 |
| PLIN2 | perilipin 2 | 0.0318683 |
| NTN4 | netrin 4 | 0.031099 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0309271 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0308486 |
| PLEC | plectin | 0.0304012 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0302338 |
| PGK1 | phosphoglycerate kinase 1 | 0.0301328 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0294804 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0291802 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0289979 |
| RPL13A | ribosomal protein L13a | 0.0286301 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0286224 |
| FLNA | filamin A, alpha | 0.0283923 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0283737 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0282478 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0282022 |
| SQSTM1 | sequestosome 1 | 0.0279469 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0279355 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0278614 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0277467 |
| JUN | jun proto-oncogene | 0.0276607 |
| NAV2 | neuron navigator 2 | 0.0274026 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0271428 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0269951 |
| VCL | vinculin | 0.0269451 |
| RPL31 | ribosomal protein L31 | 0.0266536 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0266209 |
| EGR1 | early growth response 1 | 0.026545 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0262503 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0255428 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0252972 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0240708 |
| FTL | ferritin, light polypeptide | 0.0240305 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0234509 |
| NDRG1 | N-myc downstream regulated 1 | 0.0232667 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0232401 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0231607 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0231456 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0230847 |
| MCL1 | myeloid cell leukemia 1 | 0.0230769 |
| WLS | wntless Wnt ligand secretion mediator | 0.0229238 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.022796 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0227629 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0227238 |
| RPS17 | ribosomal protein S17 | 0.0227083 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0225784 |
| RPS3 | ribosomal protein S3 | 0.0224435 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0220163 |
| RPL23 | ribosomal protein L23 | 0.0220061 |
| GPATCH2L | G patch domain containing 2-like | 0.0219925 |
| FBN1 | fibrillin 1 | 0.0219804 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.283134 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.129617 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0991722 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0885973 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0854949 |
| RBM39 | RNA binding motif protein 39 | -0.0847236 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0757548 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0720166 |
| OSMR | oncostatin M receptor | -0.0719538 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0650356 |
| USP34 | ubiquitin specific peptidase 34 | -0.063783 |
| GOLGA4 | golgin A4 | -0.0589195 |
| EFNA5 | ephrin-A5 | -0.0566427 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0534997 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0507687 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0507158 |
| JMJD1C | jumonji domain containing 1C | -0.0482219 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0480345 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0474064 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.047397 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.046867 |
| ETV6 | ets variant 6 | -0.0426967 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0422731 |
| OGA | O-GlcNAcase | -0.0417619 |
| NRP1 | neuropilin 1 | -0.041307 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0411076 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.04099 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0398251 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0392124 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0392009 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0368584 |
| SETD5 | SET domain containing 5 | -0.036627 |
| SBF2 | SET binding factor 2 | -0.0358371 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0350541 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0349304 |
| MT2A | metallothionein 2A | -0.0346135 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0345208 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0344026 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0343965 |
| ATP13A3 | ATPase type 13A3 | -0.0342585 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0342254 |
| RNF24 | ring finger protein 24 | -0.0339949 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0339397 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0335427 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0334225 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0333173 |
| ZNF292 | zinc finger protein 292 | -0.033015 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0329675 |
| GPC6 | glypican 6 | -0.0326417 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0325985 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0323849 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0323771 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0318704 |
| SNX9 | sorting nexin 9 | -0.0318056 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0317662 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0317483 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0315944 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0313209 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.0312202 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0311285 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0309251 |
| RNF149 | ring finger protein 149 | -0.0307809 |
| COG5 | component of oligomeric golgi complex 5 | -0.0305229 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0301467 |
| PCNX1 | pecanex 1 | -0.0296546 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0291027 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0290951 |
| KYNU | kynureninase | -0.0288447 |
| CDK17 | cyclin-dependent kinase 17 | -0.0288445 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0287719 |
| XPO1 | exportin 1 | -0.0286806 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0285053 |
| FNBP1 | formin binding protein 1 | -0.0281126 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0280088 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0275297 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.027432 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0273371 |
| NEK7 | NIMA-related kinase 7 | -0.0272104 |
| NF1 | neurofibromin 1 | -0.026978 |
| DUSP5 | dual specificity phosphatase 5 | -0.0269034 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0268338 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0267308 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0267255 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0265174 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0264425 |
| FAM3C | family with sequence similarity 3, member C | -0.0264306 |
| AHR | aryl hydrocarbon receptor | -0.0263982 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0263475 |
| VRK2 | vaccinia related kinase 2 | -0.0261967 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0258928 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0258275 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0257541 |
| DENND4A | DENN/MADD domain containing 4A | -0.0257115 |
| TMEM165 | transmembrane protein 165 | -0.0256327 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0255772 |
| PDE8A | phosphodiesterase 8A | -0.0255743 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0255549 |
| VMP1 | vacuole membrane protein 1 | -0.0255375 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0253842 |
| HAS2 | hyaluronan synthase 2 | -0.0250715 |
