| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.110893 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0825323 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0686124 |
| TPM3 | tropomyosin 3 | 0.0459685 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0358697 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0352268 |
| APP | amyloid beta (A4) precursor protein | 0.0346938 |
| CALR | calreticulin | 0.0289396 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0280027 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0279113 |
| PCBP2 | poly(rC) binding protein 2 | 0.0278185 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.027661 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.027465 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0272431 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0270015 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0261023 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0254731 |
| ANXA2 | annexin A2 | 0.0252719 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0252529 |
| FLNA | filamin A, alpha | 0.0241135 |
| RPS12 | ribosomal protein S12 | 0.0240181 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0233304 |
| MT2A | metallothionein 2A | 0.0226721 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0221631 |
| RPS3 | ribosomal protein S3 | 0.0221188 |
| ASPH | aspartate beta-hydroxylase | 0.0220419 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0219474 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0214814 |
| KIF5B | kinesin family member 5B | 0.0211976 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0211472 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0208026 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0207858 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0204639 |
| MCL1 | myeloid cell leukemia 1 | 0.0202603 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0199223 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0197564 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0196476 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0191235 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0190575 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.01876 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0181066 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0180986 |
| EZR | ezrin | 0.0179848 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0179296 |
| MYOF | myoferlin | 0.0175505 |
| RPS18 | ribosomal protein S18 | 0.0174167 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0173754 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0172842 |
| ADM | adrenomedullin | 0.0167448 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0167053 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0166019 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0164565 |
| GOLGA4 | golgin A4 | 0.0161425 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0160447 |
| ANXA1 | annexin A1 | 0.0160346 |
| RUNX1 | runt-related transcription factor 1 | 0.015808 |
| RPS17 | ribosomal protein S17 | 0.0157866 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.015765 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0156596 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0156249 |
| RPL3 | ribosomal protein L3 | 0.0154763 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0153851 |
| FAM107B | family with sequence similarity 107, member B | 0.0153072 |
| RPL37A | ribosomal protein L37a | 0.0152608 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0147673 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0147546 |
| RPL13A | ribosomal protein L13a | 0.0144867 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0143864 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0143496 |
| HYOU1 | hypoxia up-regulated 1 | 0.0141799 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.014131 |
| NDRG1 | N-myc downstream regulated 1 | 0.0140835 |
| RPS27 | ribosomal protein S27 | 0.0138203 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0138123 |
| SIK3 | SIK family kinase 3 | 0.0137623 |
| LDHA | lactate dehydrogenase A | 0.0137049 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0136846 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.013502 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0134776 |
| LAMC2 | laminin, gamma 2 | 0.013463 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0134609 |
| MATR3 | matrin 3 | 0.0134335 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.013369 |
| FNBP1L | formin binding protein 1-like | 0.0132797 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0132235 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.013154 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0131518 |
| RPL29 | ribosomal protein L29 | 0.0130046 |
| SFPQ | splicing factor proline/glutamine-rich | 0.01294 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.012868 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0127719 |
| PLEC | plectin | 0.0127636 |
| HELZ | helicase with zinc finger | 0.0127301 |
| ACTN1 | actinin, alpha 1 | 0.0125222 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0124165 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0120522 |
| NCKAP1 | NCK-associated protein 1 | 0.0120303 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0118071 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0117654 |
| CLU | clusterin | 0.0117639 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125836 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.113795 |
| TMSB10 | thymosin beta 10 | -0.077819 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0714501 |
| GRAMD1B | GRAM domain containing 1B | -0.0559379 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0549191 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0500529 |
| IGF2 | insulin-like growth factor 2 | -0.0486443 |
| TXNRD1 | thioredoxin reductase 1 | -0.0388605 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0381691 |
| ACTG1 | actin gamma 1 | -0.0354168 |
| BICC1 | BicC family RNA binding protein 1 | -0.02901 |
| RPS21 | ribosomal protein S21 | -0.0284493 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0282498 |
| EGR1 | early growth response 1 | -0.0246287 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0232704 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0230195 |
| EFNA5 | ephrin-A5 | -0.0220222 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.02168 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0214849 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0208628 |
| S100A6 | S100 calcium binding protein A6 | -0.0205759 |
| RPL35A | ribosomal protein L35a | -0.0201388 |
| NEGR1 | neuronal growth regulator 1 | -0.01897 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0186192 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.018107 |
| STC1 | stanniocalcin 1 | -0.0175376 |
| TPM4 | tropomyosin 4 | -0.0173913 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0171105 |
| PTMA | prothymosin, alpha | -0.0168578 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0168559 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0167562 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0166947 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0160783 |
| AK1 | adenylate kinase 1 | -0.0160123 |
| PYGL | phosphorylase, glycogen, liver | -0.015856 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0153339 |
| OSMR | oncostatin M receptor | -0.0150202 |
| CMIP | c-Maf inducing protein | -0.0148556 |
| PFN1 | profilin 1 | -0.0147987 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0145441 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0142529 |
| RAD51B | RAD51 paralog B | -0.0141976 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0141251 |
| GLIS3 | GLIS family zinc finger 3 | -0.0139184 |
| POTEF | POTE ankyrin domain family, member F | -0.0137604 |
| CFDP1 | craniofacial development protein 1 | -0.0136805 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.013477 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.013316 |
| NRG1 | neuregulin 1 | -0.0131604 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0128481 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0127518 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0125211 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0124791 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0124561 |
| HDAC9 | histone deacetylase 9 | -0.0124353 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0123675 |
| HMGA1 | high mobility group AT-hook 1 | -0.0122587 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0121161 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.011992 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0119805 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0119092 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0117871 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0117069 |
| ERBIN | erbb2 interacting protein | -0.0115613 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0114869 |
| NNMT | nicotinamide N-methyltransferase | -0.0114192 |
| HMGB1 | high mobility group box 1 | -0.0113899 |
| VIM | vimentin | -0.011372 |
| RPS24 | ribosomal protein S24 | -0.0112973 |
| TUBB | tubulin, beta class I | -0.0111198 |
| PLS3 | plastin 3 | -0.0107909 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0106202 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0105484 |
| RPLP0 | ribosomal protein, large, P0 | -0.0103725 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0102069 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0100214 |
| ZNF804A | zinc finger protein 804A | -0.009947 |
| ANKRD12 | ankyrin repeat domain 12 | -0.00990306 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.00979715 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00975014 |
| NHSL1 | NHS-like 1 | -0.00970308 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.00969226 |
| EHBP1 | EH domain binding protein 1 | -0.0096641 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.00956842 |
| KYNU | kynureninase | -0.00935235 |
| S100A9 | S100 calcium binding protein A9 | -0.00926796 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.00923404 |
| VCL | vinculin | -0.00921599 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.00915253 |
| CA2 | carbonic anhydrase II | -0.00895595 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | -0.00894597 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00892614 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00889837 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.00888603 |
| HMGA2 | high mobility group AT-hook 2 | -0.00887752 |
| TBC1D5 | TBC1 domain family, member 5 | -0.00883968 |
| GNAS | GNAS complex locus | -0.00882678 |
| SRGN | serglycin | -0.00864209 |
| TPM1 | tropomyosin 1 (alpha) | -0.00861231 |
