| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.131341 |
| NDRG1 | N-myc downstream regulated 1 | 0.123886 |
| FNDC3B | fibronectin type III domain containing 3B | 0.116467 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.108655 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0893983 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0849138 |
| GOLGA4 | golgin A4 | 0.0838112 |
| FAM13A | family with sequence similarity 13, member A | 0.0832189 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0820163 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.078737 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0736863 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0725937 |
| PLEC | plectin | 0.0717021 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0711672 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0687857 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0679192 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0672054 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0654403 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0651276 |
| GRB10 | growth factor receptor-bound protein 10 | 0.064959 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0645545 |
| GPHN | gephyrin | 0.0642618 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0627702 |
| NBAS | neuroblastoma amplified sequence | 0.0625716 |
| MYO5B | myosin VB | 0.0613294 |
| RPL13A | ribosomal protein L13a | 0.059774 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0594675 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0592777 |
| ZNF292 | zinc finger protein 292 | 0.0578132 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0567905 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0564623 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0552678 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0549699 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0540449 |
| SNX25 | sorting nexin 25 | 0.0533964 |
| BBX | bobby sox homolog (Drosophila) | 0.0533446 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0516596 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.051224 |
| MTDH | metadherin | 0.0497042 |
| RNF149 | ring finger protein 149 | 0.0496635 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0494024 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0493376 |
| RPN1 | ribophorin I | 0.0487136 |
| HELZ | helicase with zinc finger | 0.0480954 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0478338 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0476323 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0469063 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0465215 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0464621 |
| FAT1 | FAT atypical cadherin 1 | 0.0460377 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0459682 |
| CLTC | clathrin, heavy chain (Hc) | 0.0456248 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0439318 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0427494 |
| RPL37A | ribosomal protein L37a | 0.0423765 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0416239 |
| VMP1 | vacuole membrane protein 1 | 0.0412492 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0408994 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0408145 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0401647 |
| ENO1 | enolase 1, (alpha) | 0.0401138 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0400482 |
| TMEM263 | transmembrane protein 263 | 0.0400438 |
| ANO6 | anoctamin 6 | 0.0396725 |
| RYBP | RING1 and YY1 binding protein | 0.0391978 |
| MED13L | mediator complex subunit 13-like | 0.0391949 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0391306 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0390339 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0389618 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0386389 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0383276 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0379574 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.037559 |
| VCL | vinculin | 0.037429 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0372582 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0370899 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.037082 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0365152 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0365057 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0364176 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0363553 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0362516 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.035783 |
| NABP1 | nucleic acid binding protein 1 | 0.0357499 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0355781 |
| SPAG9 | sperm associated antigen 9 | 0.0352858 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0351602 |
| ACTN4 | actinin, alpha 4 | 0.0350097 |
| RBM39 | RNA binding motif protein 39 | 0.0345998 |
| AHNAK | AHNAK nucleoprotein | 0.0343131 |
| RPL26 | ribosomal protein L26 | 0.0338565 |
| RIOK3 | RIO kinase 3 | 0.0337133 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0334478 |
| MSI2 | musashi RNA-binding protein 2 | 0.0333818 |
| PAPOLA | poly(A) polymerase alpha | 0.0330994 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0329055 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0326186 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0326046 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0325329 |
| XPO1 | exportin 1 | 0.0324414 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT17 | keratin 17, type I | -0.180018 |
| ATOSA | atos homolog A | -0.132754 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.128773 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.110937 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.105365 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0928241 |
| MUC16 | mucin 16, cell surface associated | -0.0919842 |
| TMSB10 | thymosin beta 10 | -0.0872645 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0837601 |
| IGF2 | insulin-like growth factor 2 | -0.0835098 |
| LMO7 | LIM domain 7 | -0.079543 |
| ACTG1 | actin gamma 1 | -0.0776595 |
| LAMB3 | laminin, beta 3 | -0.075983 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0757362 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0718237 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0712635 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0700074 |
| VIM | vimentin | -0.0696135 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0675098 |
| FLNB | filamin B, beta | -0.0666863 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0658506 |
| CDK13 | cyclin-dependent kinase 13 | -0.0651203 |
| SLMAP | sarcolemma associated protein | -0.0627133 |
| QKI | QKI, KH domain containing, RNA binding | -0.0616941 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0615928 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0612538 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0604959 |
| SVIL | supervillin | -0.0603583 |
| RND3 | Rho family GTPase 3 | -0.0596197 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0595796 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0590945 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0590067 |
| MYO9A | myosin IXA | -0.0581865 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0560104 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.055968 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0548556 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0530544 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0530496 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0520445 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.051712 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0516861 |
| STC1 | stanniocalcin 1 | -0.0508503 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0505003 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0503925 |
| CDH13 | cadherin 13 | -0.0500371 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0491033 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0490842 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0484678 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0484042 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0483949 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0479021 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0478981 |
| SON | SON DNA binding protein | -0.04779 |
| S100A11 | S100 calcium binding protein A11 | -0.0475639 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0472785 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0455529 |
| MAP7 | microtubule-associated protein 7 | -0.0447754 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0445377 |
| RPL37 | ribosomal protein L37 | -0.0443892 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0438838 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0437935 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0434773 |
| CMIP | c-Maf inducing protein | -0.0431157 |
| RAB10 | RAB10, member RAS oncogene family | -0.043111 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0429292 |
| OSMR | oncostatin M receptor | -0.0428827 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0427135 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0425883 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0420809 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0420454 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0419576 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0419514 |
| S100A9 | S100 calcium binding protein A9 | -0.0419036 |
| PTEN | phosphatase and tensin homolog | -0.0418579 |
| HLA-B | major histocompatibility complex, class I, B | -0.0417736 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0415398 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0411728 |
| POTEF | POTE ankyrin domain family, member F | -0.041026 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0407024 |
| B2M | beta-2-microglobulin | -0.040066 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0398704 |
| PKM | pyruvate kinase, muscle | -0.0398652 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0398538 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0391518 |
| MACC1 | metastasis associated in colon cancer 1 | -0.039095 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0383338 |
| RPL31 | ribosomal protein L31 | -0.0381984 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0378746 |
| CA12 | carbonic anhydrase XII | -0.037601 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0373919 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0367139 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0362027 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0359727 |
| CD44 | CD44 molecule (Indian blood group) | -0.0354932 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0354619 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.035284 |
| GLIS3 | GLIS family zinc finger 3 | -0.0350548 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.0349836 |
| DST | dystonin | -0.0349134 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0345181 |
