| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.247011 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.11374 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0934319 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.088116 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0807958 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0793623 |
| OSMR | oncostatin M receptor | 0.0765414 |
| MCL1 | myeloid cell leukemia 1 | 0.0688531 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0686687 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.06484 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0630706 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.058241 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.056954 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0551328 |
| ATXN1 | ataxin 1 | 0.0548182 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0534104 |
| EGR1 | early growth response 1 | 0.0525142 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0525113 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0521367 |
| RAD51B | RAD51 paralog B | 0.0511952 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0486317 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0468343 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0465261 |
| GOLGB1 | golgin B1 | 0.0447729 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0445554 |
| ACTG1 | actin gamma 1 | 0.0439126 |
| PYGL | phosphorylase, glycogen, liver | 0.0425143 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0420752 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0420549 |
| VCL | vinculin | 0.0419102 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.041208 |
| CRY1 | cryptochrome circadian clock 1 | 0.0406662 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0400196 |
| TMSB10 | thymosin beta 10 | 0.0394636 |
| RPS3 | ribosomal protein S3 | 0.0381866 |
| PDE10A | phosphodiesterase 10A | 0.0378657 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0378301 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.037463 |
| PRKCE | protein kinase C, epsilon | 0.0371347 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0370071 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0367612 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0347333 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0347282 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0330878 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0329965 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0329616 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0328759 |
| HDLBP | high density lipoprotein binding protein | 0.0320118 |
| JUN | jun proto-oncogene | 0.031484 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.03118 |
| XPOT | exportin, tRNA | 0.0310878 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0309911 |
| HMGA2 | high mobility group AT-hook 2 | 0.0305535 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0299745 |
| TPM3 | tropomyosin 3 | 0.029725 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0293058 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0291761 |
| IGF1R | insulin-like growth factor 1 receptor | 0.029021 |
| RNF213 | ring finger protein 213 | 0.028827 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0285888 |
| EXOC4 | exocyst complex component 4 | 0.0285755 |
| WWOX | WW domain containing oxidoreductase | 0.0285506 |
| DST | dystonin | 0.0284663 |
| SIK3 | SIK family kinase 3 | 0.0283377 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0282923 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0281879 |
| RPS12 | ribosomal protein S12 | 0.027895 |
| FMNL2 | formin-like 2 | 0.0278453 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0277503 |
| ANXA2 | annexin A2 | 0.0276495 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0276054 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0273112 |
| COPA | coatomer protein complex, subunit alpha | 0.0271503 |
| LOXL2 | lysyl oxidase-like 2 | 0.0271228 |
| RPS18 | ribosomal protein S18 | 0.0270395 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0269001 |
| HDAC4 | histone deacetylase 4 | 0.0266456 |
| LDHA | lactate dehydrogenase A | 0.026534 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0264642 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0263674 |
| SVIL | supervillin | 0.0263502 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0261075 |
| TCIM | transcriptional and immune response regulator | 0.0260918 |
| INTS6 | integrator complex subunit 6 | 0.0260586 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0256703 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0254762 |
| GOLGA3 | golgin A3 | 0.0253335 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0253283 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0252261 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0250514 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0250156 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0240776 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0240368 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0239806 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0237091 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0235737 |
| MAP4 | microtubule-associated protein 4 | 0.0235646 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0234289 |
| ACTN1 | actinin, alpha 1 | 0.0232913 |
| R3HDM2 | R3H domain containing 2 | 0.0231526 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.141778 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0796349 |
| TXNRD1 | thioredoxin reductase 1 | -0.0776884 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0577158 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0575511 |
| PHIP | pleckstrin homology domain interacting protein | -0.0515303 |
| XPO1 | exportin 1 | -0.0474609 |
| BBX | bobby sox homolog (Drosophila) | -0.0455778 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0454457 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0439027 |
| RTN4 | reticulon 4 | -0.0429763 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0424495 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.042074 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0387092 |
| RPLP0 | ribosomal protein, large, P0 | -0.0374123 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0370053 |
| SEPTIN7 | septin 7 | -0.0359594 |
| CCNL1 | cyclin L1 | -0.0356467 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0351175 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0348099 |
| PFN1 | profilin 1 | -0.034097 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0338273 |
| ZFR | zinc finger RNA binding protein | -0.0321481 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0320634 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0313442 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0311151 |
| RBM25 | RNA binding motif protein 25 | -0.0306599 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0304069 |
| RNF145 | ring finger protein 145 | -0.0303439 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0301943 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0300692 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0299795 |
| FLOT1 | flotillin 1 | -0.0294899 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0291896 |
| WASF2 | WAS protein family, member 2 | -0.0290784 |
| OGA | O-GlcNAcase | -0.0290569 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0287494 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0286042 |
| RAP1A | RAP1A, member of RAS oncogene family | -0.0285337 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.027929 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0265651 |
| ZNF292 | zinc finger protein 292 | -0.0263915 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0261467 |
| ZNF638 | zinc finger protein 638 | -0.0257698 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0257477 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0255443 |
| RNF38 | ring finger protein 38 | -0.0254085 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0253621 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0253505 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0250787 |
| TNPO3 | transportin 3 | -0.0249539 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0249299 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0249025 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0248957 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0242831 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0238624 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0237985 |
| HMGA1 | high mobility group AT-hook 1 | -0.023774 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0234401 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0232511 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0229315 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0228089 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0224763 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0224734 |
| PPHLN1 | periphilin 1 | -0.022432 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0223035 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0222043 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0221294 |
| TPR | translocated promoter region, nuclear basket protein | -0.0220694 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0220437 |
| SPPL3 | signal peptide peptidase like 3 | -0.0219935 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0218151 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0217358 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0214925 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0213765 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0213271 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0211884 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0211263 |
| ERBIN | erbb2 interacting protein | -0.0209939 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0208843 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0207563 |
| NEK7 | NIMA-related kinase 7 | -0.020623 |
| PCM1 | pericentriolar material 1 | -0.020523 |
| LDHB | lactate dehydrogenase B | -0.0205044 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0204216 |
| WDR45B | WD repeat domain 45B | -0.0203006 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0202042 |
| FBXO11 | F-box protein 11 | -0.0200224 |
| NEMF | nuclear export mediator factor | -0.0200174 |
| ETNK1 | ethanolamine kinase 1 | -0.0196869 |
| MTF2 | metal response element binding transcription factor 2 | -0.0196723 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0196112 |
| DIAPH3 | diaphanous-related formin 3 | -0.0195415 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0194842 |
| AFTPH | aftiphilin | -0.0193983 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0193713 |
| BRD8 | bromodomain containing 8 | -0.0193697 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0193178 |
| HNRNPLL | heterogeneous nuclear ribonucleoprotein L-like | -0.0191361 |
| CENPE | centromere protein E, 312kDa | -0.0190785 |
