ERK5-IN-2_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.211797
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.189962
IGFBP3 insulin-like growth factor binding protein 3 0.173022
EEF2 eukaryotic translation elongation factor 2 0.158862
FTH1 ferritin, heavy polypeptide 1 0.152434
GRB10 growth factor receptor-bound protein 10 0.113355
FTL ferritin, light polypeptide 0.112557
ANXA2 annexin A2 0.111607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109609
LDHA lactate dehydrogenase A 0.109379
PABPC1 poly(A) binding protein, cytoplasmic 1 0.101582
LAMB3 laminin, beta 3 0.0955998
LAMC2 laminin, gamma 2 0.0874477
FN1 fibronectin 1 0.0835484
SAMD4A sterile alpha motif domain containing 4A 0.0817347
ENO1 enolase 1, (alpha) 0.0811304
CALR calreticulin 0.0760682
TRIO trio Rho guanine nucleotide exchange factor 0.0755835
DSPP dentin sialophosphoprotein 0.0718408
VEGFA vascular endothelial growth factor A 0.0700499
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0688626
CTSB cathepsin B 0.0682815
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.067794
FAM13A family with sequence similarity 13, member A 0.0672936
ACTG1 actin gamma 1 0.0663418
RAB7A RAB7A, member RAS oncogene family 0.0655576
IFI27 interferon, alpha-inducible protein 27 0.0652652
TMSB4X thymosin beta 4, X-linked 0.0628711
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0623913
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0623012
G0S2 G0/G1 switch 2 0.0609722
ZFP36L1 ZFP36 ring finger protein-like 1 0.060367
PGK1 phosphoglycerate kinase 1 0.0602427
KRT7 keratin 7, type II 0.0595944
ARRDC3 arrestin domain containing 3 0.0587025
PCBP2 poly(rC) binding protein 2 0.0584452
PLEC plectin 0.0575494
POTEF POTE ankyrin domain family, member F 0.057141
HMGA1 high mobility group AT-hook 1 0.0560236
FNDC3B fibronectin type III domain containing 3B 0.0525622
APLP2 amyloid beta (A4) precursor-like protein 2 0.0507818
EGR1 early growth response 1 0.0505953
KRT8 keratin 8, type II 0.0490321
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0489876
CSTB cystatin B (stefin B) 0.0481728
EEF1G eukaryotic translation elongation factor 1 gamma 0.047963
FLNA filamin A, alpha 0.0477977
ZSWIM6 zinc finger, SWIM-type containing 6 0.0472477
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0472238
EXT1 exostosin glycosyltransferase 1 0.046919
VIM vimentin 0.0469179
CANX calnexin 0.0462939
RNF213 ring finger protein 213 0.0451132
RPS3 ribosomal protein S3 0.0446582
PKM pyruvate kinase, muscle 0.0442448
MX1 MX dynamin-like GTPase 1 0.0441836
EFNA5 ephrin-A5 0.0440016
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0437117
RPL23 ribosomal protein L23 0.0435276
SH3KBP1 SH3-domain kinase binding protein 1 0.0429765
TOP1 topoisomerase (DNA) I 0.0427768
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0425196
AHNAK2 AHNAK nucleoprotein 2 0.042109
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0421081
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0414107
EZR ezrin 0.0411158
MAP1B microtubule-associated protein 1B 0.0408267
GOLGB1 golgin B1 0.0407448
TPI1 triosephosphate isomerase 1 0.0406043
PLAU plasminogen activator, urokinase 0.0405281
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0404871
TMSB10 thymosin beta 10 0.040487
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.03997
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0398162
CD44 CD44 molecule (Indian blood group) 0.0390488
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0389618
EGFR epidermal growth factor receptor 0.0386369
TPM3 tropomyosin 3 0.0385646
NDRG1 N-myc downstream regulated 1 0.0384634
ALCAM activated leukocyte cell adhesion molecule 0.0380659
BHLHE40 basic helix-loop-helix family, member e40 0.0378134
PTPRF protein tyrosine phosphatase, receptor type, F 0.0371721
MYH9 myosin, heavy chain 9, non-muscle 0.0370413
IFI16 interferon, gamma-inducible protein 16 0.036215
CD109 CD109 molecule 0.0359979
CXCL8 chemokine (C-X-C motif) ligand 8 0.035672
HDAC9 histone deacetylase 9 0.0354844
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0350711
KRT18 keratin 18, type I 0.03505
RPL8 ribosomal protein L8 0.0349618
IFITM3 interferon induced transmembrane protein 3 0.0347976
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0341271
SOX4 SRY (sex determining region Y)-box 4 0.0340099
NAV2 neuron navigator 2 0.0335838
LIMCH1 LIM and calponin homology domains 1 0.0332448
CSNK1A1 casein kinase 1, alpha 1 0.0329111
IRF6 interferon regulatory factor 6 0.0327868
RACK1 receptor for activated C kinase 1 0.0327194
BSG basigin (Ok blood group) 0.0327148
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0325196

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.10226
NAMPT nicotinamide phosphoribosyltransferase -0.0764707
TFG TRK-fused gene -0.0377068
KDM3A lysine (K)-specific demethylase 3A -0.0355707
MARCHF6 membrane associated ring-CH-type finger 6 -0.0340228
RPL38 ribosomal protein L38 -0.0328789
RPS2 ribosomal protein S2 -0.0317226
RPL35A ribosomal protein L35a -0.0288135
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.027653
PAPOLA poly(A) polymerase alpha -0.0269851
MSMO1 methylsterol monooxygenase 1 -0.0263284
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0259811
H1-4 H1.4 linker histone, cluster member -0.0257257
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0253153
GOLT1B golgi transport 1B -0.0250012
HMGB2 high mobility group box 2 -0.024075
EPCAM epithelial cell adhesion molecule -0.0237661
SLMAP sarcolemma associated protein -0.0237636
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0229893
ANLN anillin, actin binding protein -0.0227086
CDK17 cyclin-dependent kinase 17 -0.0225912
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0225485
ZFAND6 zinc finger, AN1-type domain 6 -0.0224498
RPL6 ribosomal protein L6 -0.0221856
RPS29 ribosomal protein S29 -0.0216583
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0210872
H3-3B H3.3 histone B -0.0208606
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0201882
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0197806
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0195769
RBM39 RNA binding motif protein 39 -0.0193011
RPS21 ribosomal protein S21 -0.0188918
RPS24 ribosomal protein S24 -0.01869
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0180571
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0180506
RPL34 ribosomal protein L34 -0.0179187
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0178305
DSCAM Down syndrome cell adhesion molecule -0.0176501
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0176114
NCKAP1 NCK-associated protein 1 -0.0172978
CLINT1 clathrin interactor 1 -0.0168669
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.016854
UBQLN1 ubiquilin 1 -0.0167912
RYK receptor-like tyrosine kinase -0.016738
CKAP5 cytoskeleton associated protein 5 -0.0165801
CYRIB CYFIP related Rac1 interactor B -0.0165795
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0165362
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0164605
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0163765
TENT2 terminal nucleotidyltransferase 2 -0.0163202
FBXO34 F-box protein 34 -0.0162048
MIS18BP1 MIS18 binding protein 1 -0.0160725
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0160627
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0159684
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -0.015798
TRA2A transformer 2 alpha homolog (Drosophila) -0.0153007
PELI1 pellino E3 ubiquitin protein ligase 1 -0.015215
WSB1 WD repeat and SOCS box containing 1 -0.0148562
SELENOK selenoprotein K -0.014741
CCNL1 cyclin L1 -0.0147123
TMEM131L transmembrane 131 like -0.0146889
FAM3C family with sequence similarity 3, member C -0.0146758
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0146466
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0146282
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0145647
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0145139
HLA-B major histocompatibility complex, class I, B -0.014432
WDR36 WD repeat domain 36 -0.0143586
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0141801
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0137245
TMEM263 transmembrane protein 263 -0.0135812
C1ORF52 chromosome 1 open reading frame 52 -0.0135333
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0135111
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0134306
ETNK1 ethanolamine kinase 1 -0.0133776
RPS13 ribosomal protein S13 -0.0133669
FCHO2 FCH domain only 2 -0.0132108
FAR1 fatty acyl CoA reductase 1 -0.0131061
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0130873
WTAP Wilms tumor 1 associated protein -0.0130501
RAD21 RAD21 homolog (S. pombe) -0.0130413
AGFG1 ArfGAP with FG repeats 1 -0.0130241
TMEM39A transmembrane protein 39A -0.0128273
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0128165
EMB embigin -0.0125573
PUM2 pumilio RNA-binding family member 2 -0.012456
ZFR zinc finger RNA binding protein -0.012379
NEK7 NIMA-related kinase 7 -0.0123605
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0121348
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0120129
YBX3 Y box binding protein 3 -0.0119534
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0117967
MKI67 marker of proliferation Ki-67 -0.0117743
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0115772
NUP54 nucleoporin 54kDa -0.011428
AREG amphiregulin -0.0112079
ZFAND3 zinc finger, AN1-type domain 3 -0.0110835
UGCG UDP-glucose ceramide glucosyltransferase -0.0110739
PNISR PNN-interacting serine/arginine-rich protein -0.0110272
NPC2 Niemann-Pick disease, type C2 -0.0109721