ERK5-IN-2_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.168408
EEF2 eukaryotic translation elongation factor 2 0.113891
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.090578
RPS6 ribosomal protein S6 0.0783851
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.075907
KYNU kynureninase 0.066943
VIM vimentin 0.065008
PCBP2 poly(rC) binding protein 2 0.0643017
POTEF POTE ankyrin domain family, member F 0.0639192
MCL1 myeloid cell leukemia 1 0.0632639
PM20D1 peptidase M20 domain containing 1 0.061347
RPS12 ribosomal protein S12 0.0603371
LDHA lactate dehydrogenase A 0.0594236
DST dystonin 0.0587305
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0571193
ASPH aspartate beta-hydroxylase 0.0553007
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0534176
MYOF myoferlin 0.0534014
TMSB10 thymosin beta 10 0.0519334
SMOC1 SPARC related modular calcium binding 1 0.05165
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0508008
FTL ferritin, light polypeptide 0.0503117
PKM pyruvate kinase, muscle 0.0501654
COL8A1 collagen, type VIII, alpha 1 0.0497738
RPL23 ribosomal protein L23 0.0497133
FTH1 ferritin, heavy polypeptide 1 0.0492535
RPS8 ribosomal protein S8 0.0465258
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.045067
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0436575
RPL37A ribosomal protein L37a 0.0435944
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0435776
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0432902
RPL31 ribosomal protein L31 0.0429461
PTMA prothymosin, alpha 0.0429261
PGK1 phosphoglycerate kinase 1 0.0427265
RPS23 ribosomal protein S23 0.0425139
PSD3 pleckstrin and Sec7 domain containing 3 0.0420162
ZSWIM6 zinc finger, SWIM-type containing 6 0.0419426
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.041372
CTIF CBP80/20-dependent translation initiation factor 0.0404096
PRRC2C proline-rich coiled-coil 2C 0.0403523
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0400424
EIF1 eukaryotic translation initiation factor 1 0.0393288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0392558
RPS19 ribosomal protein S19 0.0388514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0386779
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0379083
RPS17 ribosomal protein S17 0.0377319
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0375974
RPL12 ribosomal protein L12 0.0371346
ENO1 enolase 1, (alpha) 0.0354913
B2M beta-2-microglobulin 0.0353775
IGFBP3 insulin-like growth factor binding protein 3 0.0346349
EEF1G eukaryotic translation elongation factor 1 gamma 0.0343606
TRIO trio Rho guanine nucleotide exchange factor 0.0342025
PDLIM5 PDZ and LIM domain 5 0.0340915
EIF4A1 eukaryotic translation initiation factor 4A1 0.0334168
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0334113
RPL19 ribosomal protein L19 0.0332815
RPS3 ribosomal protein S3 0.0332215
RPL26 ribosomal protein L26 0.0329354
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0328985
CENPF centromere protein F, 350/400kDa 0.0327938
ANXA2 annexin A2 0.0326687
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0326274
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0324659
RPL7A ribosomal protein L7a 0.032215
AKAP13 A kinase (PRKA) anchor protein 13 0.0321999
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0319309
CXCL8 chemokine (C-X-C motif) ligand 8 0.0317222
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0315721
ACTG1 actin gamma 1 0.0312658
VCL vinculin 0.0310744
BASP1 brain abundant, membrane attached signal protein 1 0.0308015
RPS4X ribosomal protein S4, X-linked 0.030756
MT2A metallothionein 2A 0.0305812
RPL9 ribosomal protein L9 0.0305223
EZR ezrin 0.0304779
PTEN phosphatase and tensin homolog 0.0301308
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0300567
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0297099
EXT1 exostosin glycosyltransferase 1 0.029498
TPM3 tropomyosin 3 0.0290001
MSN moesin 0.0288192
PRKN parkin RBR E3 ubiquitin protein ligase 0.0286985
RPL11 ribosomal protein L11 0.0283055
DOCK4 dedicator of cytokinesis 4 0.0282601
RPLP2 ribosomal protein, large, P2 0.0279895
RACK1 receptor for activated C kinase 1 0.0275434
HSPA8 heat shock 70kDa protein 8 0.0274741
RPS13 ribosomal protein S13 0.0274564
RPS25 ribosomal protein S25 0.0273878
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0272132
TGFBR1 transforming growth factor, beta receptor 1 0.0271472
CHD1 chromodomain helicase DNA binding protein 1 0.0271176
P3H2 prolyl 3-hydroxylase 2 0.0270359
RPL3 ribosomal protein L3 0.0269343
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0268781
GRAMD1B GRAM domain containing 1B 0.0266887
CALR calreticulin 0.0266665

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.183991
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0571934
NAMPT nicotinamide phosphoribosyltransferase -0.0570046
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0550354
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0462683
PCBP3 poly(rC) binding protein 3 -0.0422572
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0326645
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0275585
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0267552
NCKAP5 NCK-associated protein 5 -0.0255718
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0228747
TENM3 teneurin transmembrane protein 3 -0.022832
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0228081
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0225362
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0219655
COL4A5 collagen, type IV, alpha 5 -0.0216082
SMYD3 SET and MYND domain containing 3 -0.0201775
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.019811
SOX4 SRY (sex determining region Y)-box 4 -0.0197421
SLC16A6 solute carrier family 16, member 6 -0.0192113
OSMR oncostatin M receptor -0.0184939
AOPEP aminopeptidase O (putative) -0.0183452
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0177023
CCDC68 coiled-coil domain containing 68 -0.0176139
ZMYND8 zinc finger, MYND-type containing 8 -0.0174865
KDM3A lysine (K)-specific demethylase 3A -0.0170125
CRLF2 cytokine receptor-like factor 2 -0.016992
PCDH9 protocadherin 9 -0.0168355
IGF1R insulin-like growth factor 1 receptor -0.0166522
PTGR1 prostaglandin reductase 1 -0.0166001
CDH13 cadherin 13 -0.0164678
AGFG1 ArfGAP with FG repeats 1 -0.0161379
NPAS2 neuronal PAS domain protein 2 -0.0160256
TTC28 tetratricopeptide repeat domain 28 -0.0158525
NALF1 NALCN channel auxiliary factor 1 -0.0157453
RANBP17 RAN binding protein 17 -0.0151849
FOXC1 forkhead box C1 -0.0147477
PYGL phosphorylase, glycogen, liver -0.014676
ADGRB3 adhesion G protein-coupled receptor B3 -0.014668
TGFBI transforming growth factor, beta-induced, 68kDa -0.0144556
STC1 stanniocalcin 1 -0.0143687
SOX6 SRY (sex determining region Y)-box 6 -0.0143015
BZW1 basic leucine zipper and W2 domains 1 -0.0142985
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0142376
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0142143
NPEPPS aminopeptidase puromycin sensitive -0.0141309
CTSL cathepsin L -0.0139119
ESM1 endothelial cell-specific molecule 1 -0.0138368
NCOA7 nuclear receptor coactivator 7 -0.0136647
STEAP1B STEAP family member 1B -0.0134311
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0133442
KDM5B lysine (K)-specific demethylase 5B -0.0129694
TMX4 thioredoxin-related transmembrane protein 4 -0.0126932
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0124944
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0124935
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0124254
RAI14 retinoic acid induced 14 -0.0123853
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.01236
CLMP CXADR-like membrane protein -0.0123339
TBC1D19 TBC1 domain family, member 19 -0.012251
TGIF1 TGFB-induced factor homeobox 1 -0.0121772
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0118831
THSD4 thrombospondin, type I, domain containing 4 -0.011851
ADGRD1 adhesion G protein-coupled receptor D1 -0.0113229
BRWD3 bromodomain and WD repeat domain containing 3 -0.0112778
AKR1C1 aldo-keto reductase family 1, member C1 -0.011264
ENOSF1 enolase superfamily member 1 -0.0111715
CEP170 centrosomal protein 170kDa -0.011045
IER3 immediate early response 3 -0.0110318
ZNF33A zinc finger protein 33A -0.0109861
RIGI RNA sensor RIG-I -0.0107961
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0107813
WSB1 WD repeat and SOCS box containing 1 -0.0107173
UNC5D unc-5 homolog D (C. elegans) -0.0107099
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0106421
BMERB1 bMERB domain containing 1 -0.010603
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0104769
BABAM2 BRISC and BRCA1 A complex member 2 -0.0103955
CUL1 cullin 1 -0.0103828
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.0103532
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.0101338
IFIH1 interferon induced with helicase C domain 1 -0.0100932
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0100611
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0100502
AHNAK AHNAK nucleoprotein -0.00993828
CHL1 cell adhesion molecule L1-like -0.0098335
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00972469
USP40 ubiquitin specific peptidase 40 -0.00957272
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.00950812
LIN7A lin-7 homolog A (C. elegans) -0.00947249
DNAH11 dynein, axonemal, heavy chain 11 -0.00942154
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00941279
UNC13A unc-13 homolog A (C. elegans) -0.0093994
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.00939382
INHBA inhibin, beta A -0.00933734
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0090429
TFPI2 tissue factor pathway inhibitor 2 -0.00903051
MTAP methylthioadenosine phosphorylase -0.0089368
DISP1 dispatched homolog 1 (Drosophila) -0.00887708
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -0.00883528