| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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91 genes differentially expressed following the ERK5-IN-2_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.191637 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.141359 |
| DSCAM | Down syndrome cell adhesion molecule | 0.139307 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.138054 |
| NDRG1 | N-myc downstream regulated 1 | 0.130578 |
| FN1 | fibronectin 1 | 0.125663 |
| MORF4L2 | mortality factor 4 like 2 | 0.110379 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.11028 |
| PRELID2 | PRELI domain containing 2 | 0.109789 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102145 |
| RPS6 | ribosomal protein S6 | 0.102073 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.099486 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0983341 |
| RPLP1 | ribosomal protein, large, P1 | 0.0961724 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0950573 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0856259 |
| FLNB | filamin B, beta | 0.0854752 |
| RPS12 | ribosomal protein S12 | 0.0807801 |
| RPLP0 | ribosomal protein, large, P0 | 0.0793981 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0790015 |
| RPL23 | ribosomal protein L23 | 0.0764255 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0723234 |
| TPM4 | tropomyosin 4 | 0.0699879 |
| GOLGA4 | golgin A4 | 0.0680774 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0519289 |
| ATXN1 | ataxin 1 | 0.0501682 |
| ANKRD11 | ankyrin repeat domain 11 | 0.050132 |
| BBX | bobby sox homolog (Drosophila) | 0.0443265 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0434379 |
| FNDC3B | fibronectin type III domain containing 3B | 0.038655 |
| RPL19 | ribosomal protein L19 | 0.0372809 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0370673 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0361126 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0279588 |
| TXNRD1 | thioredoxin reductase 1 | 0.0258834 |
| TMSB10 | thymosin beta 10 | 0.0214252 |
| APP | amyloid beta (A4) precursor protein | 0.0210609 |
| SRPK2 | SRSF protein kinase 2 | 0.0143226 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0121293 |
| RPS3 | ribosomal protein S3 | 0.0113324 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0102841 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0101721 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00992823 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00925423 |
| VIM | vimentin | 0.00924885 |
| PRKCA | protein kinase C, alpha | 0.00645548 |
| RIGI | RNA sensor RIG-I | 0.00323726 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.00255396 |
| SMYD3 | SET and MYND domain containing 3 | 8.75415E-5 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.441043 |
| PDE10A | phosphodiesterase 10A | -0.160254 |
| EFNA5 | ephrin-A5 | -0.14205 |
| RORA | RAR-related orphan receptor A | -0.125599 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.101051 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.100575 |
| CDH13 | cadherin 13 | -0.0981441 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0883645 |
| EGFR | epidermal growth factor receptor | -0.0815528 |
| ASPH | aspartate beta-hydroxylase | -0.0710605 |
| GPC6 | glypican 6 | -0.0707784 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.070701 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0685939 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0679653 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0658226 |
| PTMA | prothymosin, alpha | -0.064093 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0598379 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0547394 |
| DST | dystonin | -0.0532702 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0480185 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0466329 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0460549 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0455177 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0436275 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0429934 |
| SETD5 | SET domain containing 5 | -0.0396159 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0389238 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0362066 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0357018 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0352351 |
| MYO1E | myosin IE | -0.0248077 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0244743 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0239825 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0201751 |
| VCL | vinculin | -0.0165549 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00604943 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.00591144 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00543954 |
| PARD3 | par-3 family cell polarity regulator | -0.00450755 |
| TCF12 | transcription factor 12 | -0.00427712 |
| SLTM | SAFB-like, transcription modulator | -0.00203258 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -8.96237E-4 |
