ERK5-IN-2_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0934495
TSC22D2 TSC22 domain family, member 2 0.0857892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0840139
ANKRD33B ankyrin repeat domain 33B 0.080571
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0732955
EEF2 eukaryotic translation elongation factor 2 0.0705643
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0685097
KMT2E lysine (K)-specific methyltransferase 2E 0.0588128
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.058758
PGAP1 post-GPI attachment to proteins 1 0.0555546
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.055381
DST dystonin 0.0539367
APP amyloid beta (A4) precursor protein 0.049244
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0480221
COL5A2 collagen, type V, alpha 2 0.0478929
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.047841
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0462119
ZNF292 zinc finger protein 292 0.0457475
CALR calreticulin 0.0423934
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0423702
DSCAM Down syndrome cell adhesion molecule 0.0417193
RYBP RING1 and YY1 binding protein 0.0416021
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0396509
NOP58 NOP58 ribonucleoprotein 0.038353
PUM1 pumilio RNA-binding family member 1 0.0382434
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0381593
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0378786
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0375745
GLS2 glutaminase 2 (liver, mitochondrial) 0.037516
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.037076
AKAP9 A kinase (PRKA) anchor protein 9 0.0369974
RLF rearranged L-myc fusion 0.036957
MATR3 matrin 3 0.0359948
KMT2C lysine (K)-specific methyltransferase 2C 0.0356109
GPBP1 GC-rich promoter binding protein 1 0.0354312
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0342797
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0340877
FNDC3B fibronectin type III domain containing 3B 0.0335325
PHF3 PHD finger protein 3 0.0334176
CSDE1 cold shock domain containing E1, RNA-binding 0.0328639
WDR43 WD repeat domain 43 0.0327903
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0318534
TPM3 tropomyosin 3 0.031629
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0315704
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0310877
KDM5B lysine (K)-specific demethylase 5B 0.0308112
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0305417
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0292623
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.029234
SFPQ splicing factor proline/glutamine-rich 0.0291055
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0290871
SETD5 SET domain containing 5 0.0289695
WAC WW domain containing adaptor with coiled-coil 0.0287858
ENAH enabled homolog (Drosophila) 0.0287419
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0286429
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0285398
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0284842
CDH19 cadherin 19, type 2 0.0284337
CENPF centromere protein F, 350/400kDa 0.0283231
TLK2 tousled-like kinase 2 0.0276365
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.027543
ZNF608 zinc finger protein 608 0.0272909
EIF4B eukaryotic translation initiation factor 4B 0.0266848
PRTG protogenin 0.0266444
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02652
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0265126
QKI QKI, KH domain containing, RNA binding 0.0263646
NCKAP1 NCK-associated protein 1 0.0262998
MARCHF7 membrane associated ring-CH-type finger 7 0.0262298
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0261031
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0258506
ANXA2 annexin A2 0.0256877
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0255982
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0255181
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0252562
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0250735
RBM25 RNA binding motif protein 25 0.0250556
PCBP2 poly(rC) binding protein 2 0.0250473
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248628
ADAM9 ADAM metallopeptidase domain 9 0.0248129
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0247306
EEF1G eukaryotic translation elongation factor 1 gamma 0.0246784
CCNL1 cyclin L1 0.0245997
MEIS2 Meis homeobox 2 0.0242022
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.02368
RBM5 RNA binding motif protein 5 0.0233591
SCAF8 SR-related CTD-associated factor 8 0.0233019
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0232576
BRD2 bromodomain containing 2 0.0232548
CEP350 centrosomal protein 350kDa 0.0230685
COLEC11 collectin sub-family member 11 0.0229478
CUL3 cullin 3 0.0228422
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.022824
NUP58 nucleoporin 58 0.0225492
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0225398
U2SURP U2 snRNP-associated SURP domain containing 0.0225102
CDC73 cell division cycle 73 0.02248
DENND4C DENN/MADD domain containing 4C 0.0223147
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0222672
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0221472

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190171
COL11A1 collagen, type XI, alpha 1 -0.168142
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.152079
CADM2 cell adhesion molecule 2 -0.118009
TMSB10 thymosin beta 10 -0.0998905
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0957625
PCDH9 protocadherin 9 -0.0917449
COL3A1 collagen, type III, alpha 1 -0.0911562
COL1A2 collagen, type I, alpha 2 -0.0892727
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0791139
GPC3 glypican 3 -0.0768483
PTMA prothymosin, alpha -0.0689677
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0579146
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0548736
PCLO piccolo presynaptic cytomatrix protein -0.0531129
MDK midkine (neurite growth-promoting factor 2) -0.0521148
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0495824
H1-0 H1.0 linker histone -0.0495068
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0491062
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.048304
KCTD16 potassium channel tetramerization domain containing 16 -0.0473659
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0471812
PLPP1 phospholipid phosphatase 1 -0.0469589
TPT1 tumor protein, translationally-controlled 1 -0.0440074
NCAM2 neural cell adhesion molecule 2 -0.0431925
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0431477
PRELID2 PRELI domain containing 2 -0.0426505
ADGRL2 adhesion G protein-coupled receptor L2 -0.0421152
GNAS GNAS complex locus -0.0416624
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0400035
WSB1 WD repeat and SOCS box containing 1 -0.0393025
MAP4 microtubule-associated protein 4 -0.0381381
ACTG1 actin gamma 1 -0.0366418
CSMD3 CUB and Sushi multiple domains 3 -0.0362803
RPS8 ribosomal protein S8 -0.0361888
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0354105
RPL35A ribosomal protein L35a -0.0334115
LRRC4C leucine rich repeat containing 4C -0.0329496
ITGAV integrin, alpha V -0.0328063
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0325138
RAD51B RAD51 paralog B -0.0324729
ISG15 ISG15 ubiquitin-like modifier -0.0319694
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0316732
RPS21 ribosomal protein S21 -0.0307798
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.030576
AHNAK AHNAK nucleoprotein -0.030553
EMP1 epithelial membrane protein 1 -0.0305477
HMCN1 hemicentin 1 -0.0304494
ZC3H12B zinc finger CCCH-type containing 12B -0.0297989
KLHL5 kelch-like family member 5 -0.0297777
ZNF385D zinc finger protein 385D -0.0296866
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0295809
BCAS3 breast carcinoma amplified sequence 3 -0.0289189
ARHGAP24 Rho GTPase activating protein 24 -0.0288731
TTC28 tetratricopeptide repeat domain 28 -0.0287904
MYL12B myosin, light chain 12B, regulatory -0.0284236
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0281891
ADGRV1 adhesion G protein-coupled receptor V1 -0.0277316
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.027707
FTL ferritin, light polypeptide -0.0274511
NPAS3 neuronal PAS domain protein 3 -0.0272251
SAMD11 sterile alpha motif domain containing 11 -0.0271554
SOX2 SRY (sex determining region Y)-box 2 -0.0264494
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0262836
B2M beta-2-microglobulin -0.0259313
NRG1 neuregulin 1 -0.0254259
CNRIP1 cannabinoid receptor interacting protein 1 -0.0250086
USH2A Usher syndrome 2A (autosomal recessive, mild) -0.0248951
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0247886
PEG10 paternally expressed 10 -0.0247123
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0244058
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0236866
GSE1 Gse1 coiled-coil protein -0.0236853
FST follistatin -0.0236841
DARS1 aspartyl-tRNA synthetase 1 -0.0231156
RAD21 RAD21 homolog (S. pombe) -0.0230077
SLC44A5 solute carrier family 44, member 5 -0.0227539
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0226814
LYST lysosomal trafficking regulator -0.0226143
S100A10 S100 calcium binding protein A10 -0.0221209
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0219386
HSPB1 heat shock 27kDa protein 1 -0.0218862
RPS24 ribosomal protein S24 -0.021868
RPS6 ribosomal protein S6 -0.0218464
CAVIN1 caveolae associated protein 1 -0.0216774
METAP2 methionyl aminopeptidase 2 -0.0216032
MRPS30 mitochondrial ribosomal protein S30 -0.0215156
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0214232
ZMYND8 zinc finger, MYND-type containing 8 -0.0211008
CAPNS1 calpain, small subunit 1 -0.0208376
PROS1 protein S (alpha) -0.020837
ATP5F1E ATP synthase F1 subunit epsilon -0.0207935
UBE2B ubiquitin-conjugating enzyme E2B -0.0205667
KHSRP KH-type splicing regulatory protein -0.0205115
LOC112694756 uncharaterized LOC112694756 -0.0201774
EIF1 eukaryotic translation initiation factor 1 -0.020012
CFDP1 craniofacial development protein 1 -0.0200103
PRR16 proline rich 16 -0.019918
MRPS6 mitochondrial ribosomal protein S6 -0.0196697
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0196069