| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.200995 |
| VCL | vinculin | 0.137752 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.124188 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.119934 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0842362 |
| SEPTIN9 | septin 9 | 0.0782458 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0770465 |
| MAP1B | microtubule-associated protein 1B | 0.0706296 |
| EGFR | epidermal growth factor receptor | 0.0669136 |
| SMAD3 | SMAD family member 3 | 0.06561 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0653035 |
| DST | dystonin | 0.063723 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0636918 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0632854 |
| EGR1 | early growth response 1 | 0.0617458 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0611116 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0601491 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0579776 |
| MYO1E | myosin IE | 0.0575245 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0560057 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0519826 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0511859 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0508192 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0498405 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0494865 |
| TNS3 | tensin 3 | 0.045142 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0450333 |
| SIK3 | SIK family kinase 3 | 0.0442558 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0441924 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0435353 |
| NAV2 | neuron navigator 2 | 0.0433183 |
| LDHA | lactate dehydrogenase A | 0.042926 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0427599 |
| HMGA2 | high mobility group AT-hook 2 | 0.0404596 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0393674 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0392036 |
| JMJD1C | jumonji domain containing 1C | 0.038152 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0373441 |
| PTK2 | protein tyrosine kinase 2 | 0.0362137 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0359115 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0358684 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.035817 |
| DOCK1 | dedicator of cytokinesis 1 | 0.03556 |
| HDAC9 | histone deacetylase 9 | 0.0351803 |
| SFTPA2 | surfactant protein A2 | 0.0351169 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0350548 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0346915 |
| GOLGB1 | golgin B1 | 0.033267 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0332534 |
| CTBP2 | C-terminal binding protein 2 | 0.032987 |
| FLNA | filamin A, alpha | 0.0328705 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0321272 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0321251 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0320087 |
| TPM1 | tropomyosin 1 (alpha) | 0.0316635 |
| MSN | moesin | 0.0312826 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.0305512 |
| MYO10 | myosin X | 0.0304041 |
| MYOF | myoferlin | 0.030363 |
| ADM | adrenomedullin | 0.0300383 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0298349 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0298194 |
| TPM3 | tropomyosin 3 | 0.0297402 |
| PLEC | plectin | 0.029679 |
| ANO6 | anoctamin 6 | 0.029535 |
| FNIP1 | folliculin interacting protein 1 | 0.0293704 |
| RPS12 | ribosomal protein S12 | 0.0292641 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.029091 |
| FAT1 | FAT atypical cadherin 1 | 0.0290313 |
| RPL3 | ribosomal protein L3 | 0.0286378 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0283698 |
| MCL1 | myeloid cell leukemia 1 | 0.0281108 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0280902 |
| L1CAM | L1 cell adhesion molecule | 0.0280026 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0277033 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0275392 |
| ATXN1 | ataxin 1 | 0.0274994 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0273835 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0270976 |
| PRKCE | protein kinase C, epsilon | 0.0270512 |
| RPS17 | ribosomal protein S17 | 0.0268656 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.026364 |
| NUP98 | nucleoporin 98kDa | 0.0263396 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0262611 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0262147 |
| RPS2 | ribosomal protein S2 | 0.025764 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.025706 |
| RPS18 | ribosomal protein S18 | 0.0255657 |
| CMIP | c-Maf inducing protein | 0.0251013 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0250455 |
| RPL21 | ribosomal protein L21 | 0.0249886 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0249858 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0249344 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0249194 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0249159 |
| BMP6 | bone morphogenetic protein 6 | 0.0247129 |
| PCBP2 | poly(rC) binding protein 2 | 0.024327 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0241138 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0238623 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0237597 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101886 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.087512 |
| PTMA | prothymosin, alpha | -0.0805216 |
| OGA | O-GlcNAcase | -0.0640847 |
| VIM | vimentin | -0.0628582 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0500421 |
| RPS16 | ribosomal protein S16 | -0.0494936 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0494882 |
| ZNF292 | zinc finger protein 292 | -0.0481908 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.048104 |
| RPLP0 | ribosomal protein, large, P0 | -0.0455102 |
| SNX14 | sorting nexin 14 | -0.0444943 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0435796 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0435212 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0427472 |
| SPAG9 | sperm associated antigen 9 | -0.0413329 |
| TMSB10 | thymosin beta 10 | -0.0400655 |
| S100A6 | S100 calcium binding protein A6 | -0.0368191 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0366429 |
| WDR45B | WD repeat domain 45B | -0.0364049 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0360825 |
| RPL35A | ribosomal protein L35a | -0.0358793 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0355611 |
| THOC2 | THO complex 2 | -0.0353684 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0332754 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0330044 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0327765 |
| TXNRD1 | thioredoxin reductase 1 | -0.0313569 |
| NOP58 | NOP58 ribonucleoprotein | -0.031134 |
| ANLN | anillin, actin binding protein | -0.0310625 |
| RBM25 | RNA binding motif protein 25 | -0.0309349 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.030762 |
| TMEM123 | transmembrane protein 123 | -0.030643 |
| PERP | PERP, TP53 apoptosis effector | -0.0303169 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0299795 |
| S100A10 | S100 calcium binding protein A10 | -0.0297867 |
| RBM39 | RNA binding motif protein 39 | -0.0297752 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0295695 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0295316 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0293129 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0287182 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0281778 |
| AFAP1 | actin filament associated protein 1 | -0.0280463 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0280347 |
| USP3 | ubiquitin specific peptidase 3 | -0.0274862 |
| SEPTIN7 | septin 7 | -0.027486 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0274296 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0273609 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0272665 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0270893 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0266114 |
| TMEM41B | transmembrane protein 41B | -0.0262463 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0262228 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0261956 |
| YBX1 | Y box binding protein 1 | -0.0246042 |
| FBL | fibrillarin | -0.0245605 |
| CD44 | CD44 molecule (Indian blood group) | -0.0245106 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0244968 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244657 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0244042 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0242281 |
| RLF | rearranged L-myc fusion | -0.0240258 |
| CANX | calnexin | -0.0238933 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0238114 |
| IER3 | immediate early response 3 | -0.0235564 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0234794 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0228555 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0227386 |
| RAD21 | RAD21 homolog (S. pombe) | -0.022629 |
| RNF145 | ring finger protein 145 | -0.0221071 |
| H1-0 | H1.0 linker histone | -0.0220924 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0219161 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0217784 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.021599 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0215392 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0215358 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0212577 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -0.021212 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.02121 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0211305 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0208996 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.02088 |
| FOXJ3 | forkhead box J3 | -0.0208615 |
| CCNL1 | cyclin L1 | -0.0201848 |
| ZFR | zinc finger RNA binding protein | -0.0200829 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0200137 |
| TFRC | transferrin receptor | -0.0198483 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0198414 |
| TPR | translocated promoter region, nuclear basket protein | -0.0196326 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0193519 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0190447 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0187515 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0183551 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0182813 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0182712 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0182205 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0181014 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0180713 |
| B2M | beta-2-microglobulin | -0.017961 |
| SQLE | squalene epoxidase | -0.0179535 |
