| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | 0.143463 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118327 |
| LAMB3 | laminin, beta 3 | 0.111609 |
| LAMC2 | laminin, gamma 2 | 0.104998 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0973682 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0968352 |
| SMAD3 | SMAD family member 3 | 0.0933893 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0854847 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0836729 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0793799 |
| ACTG1 | actin gamma 1 | 0.0778353 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0761042 |
| VEGFA | vascular endothelial growth factor A | 0.0749805 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0702029 |
| SQSTM1 | sequestosome 1 | 0.0660021 |
| NAV2 | neuron navigator 2 | 0.0657812 |
| TJP1 | tight junction protein 1 | 0.0642223 |
| ANXA2 | annexin A2 | 0.0636333 |
| MYO5B | myosin VB | 0.0626866 |
| RPS6 | ribosomal protein S6 | 0.0624475 |
| RPS8 | ribosomal protein S8 | 0.0620473 |
| RPS3 | ribosomal protein S3 | 0.0605065 |
| TMSB4X | thymosin beta 4, X-linked | 0.0599033 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0597625 |
| RPL37A | ribosomal protein L37a | 0.0597268 |
| RPS12 | ribosomal protein S12 | 0.0597029 |
| RPL23 | ribosomal protein L23 | 0.0580378 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0573152 |
| CD44 | CD44 molecule (Indian blood group) | 0.0567598 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.05617 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0555514 |
| PLEC | plectin | 0.054508 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0538295 |
| SVIL | supervillin | 0.0531783 |
| RNF213 | ring finger protein 213 | 0.0507332 |
| RPS17 | ribosomal protein S17 | 0.0498554 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0493992 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0489168 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0482463 |
| FAM107B | family with sequence similarity 107, member B | 0.0482194 |
| HDAC9 | histone deacetylase 9 | 0.0482116 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0478536 |
| RPL37 | ribosomal protein L37 | 0.0476843 |
| INTS6 | integrator complex subunit 6 | 0.0476207 |
| DSPP | dentin sialophosphoprotein | 0.0475102 |
| RPL13A | ribosomal protein L13a | 0.0473484 |
| FN1 | fibronectin 1 | 0.0472433 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.046974 |
| RPL12 | ribosomal protein L12 | 0.0455229 |
| MYO1E | myosin IE | 0.0437796 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0433717 |
| BRD2 | bromodomain containing 2 | 0.0430679 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0430023 |
| RPS19 | ribosomal protein S19 | 0.042889 |
| SEPTIN9 | septin 9 | 0.0428246 |
| FLNA | filamin A, alpha | 0.0424937 |
| RPL31 | ribosomal protein L31 | 0.042161 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0420348 |
| FMNL2 | formin-like 2 | 0.0417614 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0415988 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0405854 |
| MUC16 | mucin 16, cell surface associated | 0.0405528 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0404507 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0403294 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0400365 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0397976 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0395718 |
| GOLGB1 | golgin B1 | 0.0394524 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0393183 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0391993 |
| EGFR | epidermal growth factor receptor | 0.0390814 |
| RPL26 | ribosomal protein L26 | 0.0388705 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0387835 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0384796 |
| RPS27A | ribosomal protein S27a | 0.0384056 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.038035 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0380336 |
| RPS18 | ribosomal protein S18 | 0.0372941 |
| ATF3 | activating transcription factor 3 | 0.0364041 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0363103 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0361494 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.035775 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0357518 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0352917 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0352389 |
| RPL19 | ribosomal protein L19 | 0.0350137 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.034954 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.0341464 |
| LMO7 | LIM domain 7 | 0.0334667 |
| SIK3 | SIK family kinase 3 | 0.033271 |
| DIAPH1 | diaphanous-related formin 1 | 0.0332028 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0328681 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0325583 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.032512 |
| KIAA1671 | KIAA1671 | 0.0325017 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0322147 |
| PLSCR1 | phospholipid scramblase 1 | 0.0320222 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0320191 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0319588 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0315442 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.256684 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0999745 |
| ANLN | anillin, actin binding protein | -0.0814308 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0724794 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0720142 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0586969 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0567323 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0551786 |
| MKI67 | marker of proliferation Ki-67 | -0.0462657 |
| DIAPH3 | diaphanous-related formin 3 | -0.0450717 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.042723 |
| FAM3C | family with sequence similarity 3, member C | -0.0414701 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0405142 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0403382 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0399756 |
| PLAT | plasminogen activator, tissue | -0.0398892 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0397681 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.039088 |
| RIOK3 | RIO kinase 3 | -0.0374802 |
| TMEM123 | transmembrane protein 123 | -0.0372251 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0354297 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0345172 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0340186 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0337667 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0334207 |
| AHNAK | AHNAK nucleoprotein | -0.0333534 |
| CENPF | centromere protein F, 350/400kDa | -0.0330095 |
| CD2AP | CD2-associated protein | -0.0325491 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0318926 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.031056 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0309677 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0301339 |
| ECT2 | epithelial cell transforming 2 | -0.0292763 |
| BCL2L1 | BCL2-like 1 | -0.0290599 |
| TMSB10 | thymosin beta 10 | -0.0281967 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0275979 |
| FOSL1 | FOS-like antigen 1 | -0.0272868 |
| VCL | vinculin | -0.0271371 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0268521 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0264752 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0262092 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0261024 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0256868 |
| RBM25 | RNA binding motif protein 25 | -0.024862 |
| TFG | TRK-fused gene | -0.0245175 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0238613 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0238467 |
| LIMA1 | LIM domain and actin binding 1 | -0.0238141 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0235602 |
| WDR45B | WD repeat domain 45B | -0.0233529 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0231069 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.022565 |
| CCNL1 | cyclin L1 | -0.0224444 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.022417 |
| PRR11 | proline rich 11 | -0.0223071 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0221045 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0219286 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0219264 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0218582 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0216176 |
| FRMD5 | FERM domain containing 5 | -0.0215841 |
| PLAC8 | placenta-specific 8 | -0.0215445 |
| EPCAM | epithelial cell adhesion molecule | -0.0212463 |
| TPX2 | TPX2, microtubule-associated | -0.0210921 |
| XPO1 | exportin 1 | -0.0210459 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0207815 |
| PDCD10 | programmed cell death 10 | -0.0206788 |
| HMGB2 | high mobility group box 2 | -0.0206319 |
| NFIB | nuclear factor I/B | -0.0205359 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0203784 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0203718 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0201885 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0199332 |
| NF1 | neurofibromin 1 | -0.0199121 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0195444 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0193624 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0193194 |
| H3-3B | H3.3 histone B | -0.0192458 |
| TXNIP | thioredoxin interacting protein | -0.019143 |
| TXNRD1 | thioredoxin reductase 1 | -0.0187462 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0185946 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0185461 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0185135 |
| CENPE | centromere protein E, 312kDa | -0.0184392 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0183374 |
| PERP | PERP, TP53 apoptosis effector | -0.0180398 |
| CCNI | cyclin I | -0.0180194 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0179638 |
| MTF2 | metal response element binding transcription factor 2 | -0.0177891 |
| OGA | O-GlcNAcase | -0.017578 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0175678 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0175112 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0175065 |
| VIM | vimentin | -0.0174659 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0174576 |
| PTMA | prothymosin, alpha | -0.0174025 |
| KRT19 | keratin 19, type I | -0.0172045 |
| CMTM7 | CKLF-like MARVEL transmembrane domain containing 7 | -0.0170591 |
| CACUL1 | CDK2-associated, cullin domain 1 | -0.0170553 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0166659 |
