ERK5-IN-2_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.145928
FRMD6 FERM domain containing 6 0.109238
HDAC9 histone deacetylase 9 0.104983
PABPC1 poly(A) binding protein, cytoplasmic 1 0.103131
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0979847
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0876797
MT2A metallothionein 2A 0.0745003
RPS6 ribosomal protein S6 0.0670902
FLNB filamin B, beta 0.0668908
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0660568
EXT1 exostosin glycosyltransferase 1 0.0591315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0585456
MCL1 myeloid cell leukemia 1 0.0574222
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0566462
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0530026
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0512767
NAV2 neuron navigator 2 0.0501831
RPS3 ribosomal protein S3 0.0490359
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0487839
MCTP1 multiple C2 domains, transmembrane 1 0.0485319
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0479344
TRIO trio Rho guanine nucleotide exchange factor 0.0477648
RPL7A ribosomal protein L7a 0.0473958
EEF1G eukaryotic translation elongation factor 1 gamma 0.0472542
PGK1 phosphoglycerate kinase 1 0.0466814
SRRM2 serine/arginine repetitive matrix 2 0.0465296
TPT1 tumor protein, translationally-controlled 1 0.0453094
RPL8 ribosomal protein L8 0.0450723
NDRG1 N-myc downstream regulated 1 0.0440264
RPS8 ribosomal protein S8 0.0433044
CALR calreticulin 0.0423017
RPS12 ribosomal protein S12 0.0411319
ENO2 enolase 2 (gamma, neuronal) 0.0409779
ACTG1 actin gamma 1 0.0403584
PTMA prothymosin, alpha 0.0400764
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0400004
RPL23 ribosomal protein L23 0.0397794
RPL7 ribosomal protein L7 0.0397074
PBX3 pre-B-cell leukemia homeobox 3 0.0395841
ENO1 enolase 1, (alpha) 0.0395831
PKM pyruvate kinase, muscle 0.038874
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0384103
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0369667
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0369656
MACF1 microtubule-actin crosslinking factor 1 0.0365987
RPL13A ribosomal protein L13a 0.0365693
TPM4 tropomyosin 4 0.0365338
FNDC3B fibronectin type III domain containing 3B 0.0361913
SAMD4A sterile alpha motif domain containing 4A 0.0358793
RPL12 ribosomal protein L12 0.0344103
PCBP2 poly(rC) binding protein 2 0.0342018
RPLP1 ribosomal protein, large, P1 0.0340915
RPL37A ribosomal protein L37a 0.0337619
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0337464
HMGA2 high mobility group AT-hook 2 0.0336592
RPL3 ribosomal protein L3 0.0330221
FTL ferritin, light polypeptide 0.0328001
RPS19 ribosomal protein S19 0.0327315
ZSWIM6 zinc finger, SWIM-type containing 6 0.0325552
POTEF POTE ankyrin domain family, member F 0.0322531
RUNX1 runt-related transcription factor 1 0.0319944
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0318409
DGKI diacylglycerol kinase, iota 0.0314076
RPLP2 ribosomal protein, large, P2 0.0310199
CANX calnexin 0.0309207
KTN1 kinectin 1 (kinesin receptor) 0.0306572
FRMD4A FERM domain containing 4A 0.0304391
RAD51B RAD51 paralog B 0.0301427
RPS17 ribosomal protein S17 0.0299845
IARS1 isoleucyl-tRNA synthetase 1 0.0295208
RPL35A ribosomal protein L35a 0.0294852
OSBPL8 oxysterol binding protein-like 8 0.0293509
APLP2 amyloid beta (A4) precursor-like protein 2 0.0293184
TMSB10 thymosin beta 10 0.0292641
RPL11 ribosomal protein L11 0.0287029
ELL2 elongation factor, RNA polymerase II, 2 0.028615
RAB7A RAB7A, member RAS oncogene family 0.028415
HMGA1 high mobility group AT-hook 1 0.0282471
TTR transthyretin 0.0279301
LPP LIM domain containing preferred translocation partner in lipoma 0.0276009
EIF4A1 eukaryotic translation initiation factor 4A1 0.0276002
LDHA lactate dehydrogenase A 0.0273939
PDIA3 protein disulfide isomerase family A, member 3 0.0272718
RPS4X ribosomal protein S4, X-linked 0.0270412
SET SET nuclear proto-oncogene 0.0270113
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.026904
EIF1 eukaryotic translation initiation factor 1 0.026854
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0268232
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0266406
KMT2E lysine (K)-specific methyltransferase 2E 0.0266342
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0262177
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0261085
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0259295
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.025733
B2M beta-2-microglobulin 0.0255751
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0255528
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0254149
GOLGA4 golgin A4 0.0253857
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0253164
NAV3 neuron navigator 3 0.0252692

decreased expression

Symbol Name Standardized Value
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0505098
ZEB1 zinc finger E-box binding homeobox 1 -0.0480955
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0246505
CDK17 cyclin-dependent kinase 17 -0.0215524
RIGI RNA sensor RIG-I -0.020527
RBM25 RNA binding motif protein 25 -0.0197483
TEX10 testis expressed 10 -0.0195853
FHL2 four and a half LIM domains 2 -0.0191901
C2CD2 C2 calcium-dependent domain containing 2 -0.01617
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0158717
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.01548
TXNRD1 thioredoxin reductase 1 -0.0154396
TASOR2 transcription activation suppressor family member 2 -0.0153328
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0150438
TMEM156 transmembrane protein 156 -0.0147632
BMAL2 basic helix-loop-helix ARNT like 2 -0.014288
SPRED1 sprouty-related, EVH1 domain containing 1 -0.013674
CUL1 cullin 1 -0.0135308
ANTXR2 anthrax toxin receptor 2 -0.0134347
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0131594
DNAH14 dynein, axonemal, heavy chain 14 -0.0127468
DLC1 DLC1 Rho GTPase activating protein -0.0127112
BIRC2 baculoviral IAP repeat containing 2 -0.0122797
PLSCR1 phospholipid scramblase 1 -0.0120424
ZHX3 zinc fingers and homeoboxes 3 -0.0119555
TDRD7 tudor domain containing 7 -0.0118366
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0113262
FNDC3A fibronectin type III domain containing 3A -0.0112662
PAWR PRKC, apoptosis, WT1, regulator -0.0111469
CHIC2 cysteine-rich hydrophobic domain 2 -0.011108
RAD21 RAD21 homolog (S. pombe) -0.0108429
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0108077
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0107576
ADGRA3 adhesion G protein-coupled receptor A3 -0.0107396
NUP214 nucleoporin 214kDa -0.0105129
MX2 MX dynamin-like GTPase 2 -0.0103431
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0103159
SPIDR scaffolding protein involved in DNA repair -0.0103075
CBFB core-binding factor, beta subunit -0.0103029
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0101795
MAPK8 mitogen-activated protein kinase 8 -0.0101563
STK4 serine/threonine kinase 4 -0.0100015
PTBP2 polypyrimidine tract binding protein 2 -0.00991892
TASP1 taspase, threonine aspartase, 1 -0.00988118
NEMF nuclear export mediator factor -0.00977259
RASA3 RAS p21 protein activator 3 -0.00965384
FCHSD2 FCH and double SH3 domains 2 -0.00961335
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -0.00946186
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.00945896
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.00918379
FRS2 fibroblast growth factor receptor substrate 2 -0.00917976
FUBP3 far upstream element (FUSE) binding protein 3 -0.00913794
CAMKMT calmodulin-lysine N-methyltransferase -0.0091082
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.00906764
IFI16 interferon, gamma-inducible protein 16 -0.00903255
ERCC8 excision repair cross-complementation group 8 -0.00901839
STARD7 StAR-related lipid transfer (START) domain containing 7 -0.00901472
ZC3H12B zinc finger CCCH-type containing 12B -0.00900767
RBL1 retinoblastoma-like 1 -0.00893364
SAMD9 sterile alpha motif domain containing 9 -0.00889769
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00888049
FBXO30 F-box protein 30 -0.00883968
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.00881838
UCK2 uridine-cytidine kinase 2 -0.00881256
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.00880868
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0088081
PDS5A PDS5 cohesin associated factor A -0.00873737
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.00872736
ZNF267 zinc finger protein 267 -0.00869156
KLF10 Kruppel-like factor 10 -0.008619
MIPOL1 mirror-image polydactyly 1 -0.00858021
INVS inversin -0.00857276
ZNF655 zinc finger protein 655 -0.00852655
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -0.00839548
PRMT3 protein arginine methyltransferase 3 -0.00828748
CEP95 centrosomal protein 95kDa -0.00827823
ZFAND6 zinc finger, AN1-type domain 6 -0.00817913
CTTNBP2NL CTTNBP2 N-terminal like -0.00811303
ENOSF1 enolase superfamily member 1 -0.00807202
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.00793093
PAXBP1 PAX3 and PAX7 binding protein 1 -0.00787585
MX1 MX dynamin-like GTPase 1 -0.00784886
ZNFX1 zinc finger, NFX1-type containing 1 -0.0078453
STC1 stanniocalcin 1 -0.00777692
SMC5 structural maintenance of chromosomes 5 -0.00774421
ZC3H13 zinc finger CCCH-type containing 13 -0.00773844
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.00773404
BICD1 bicaudal D homolog 1 (Drosophila) -0.00771732
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.00770049
SCLT1 sodium channel and clathrin linker 1 -0.00766466
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.00758918
TRAF3 TNF receptor-associated factor 3 -0.00751126
SENP5 SUMO1/sentrin specific peptidase 5 -0.00747239
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.00745351
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.00744513
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -0.00742622
TCF12 transcription factor 12 -0.00740908
PHACTR4 phosphatase and actin regulator 4 -0.00740097
RHEB Ras homolog enriched in brain -0.00739592
BZW1 basic leucine zipper and W2 domains 1 -0.00734261