| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0988888 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0912482 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0907887 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0841149 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0756414 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0720704 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0716784 |
| VEGFA | vascular endothelial growth factor A | 0.0695062 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0679765 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0649868 |
| B2M | beta-2-microglobulin | 0.0647701 |
| HLA-B | major histocompatibility complex, class I, B | 0.0645871 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0637882 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0592488 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0592007 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0586142 |
| CDH13 | cadherin 13 | 0.0579004 |
| HDAC9 | histone deacetylase 9 | 0.0565059 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0553831 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0553692 |
| EGR1 | early growth response 1 | 0.0545706 |
| ANXA2 | annexin A2 | 0.0532647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0528232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0525588 |
| LOXL2 | lysyl oxidase-like 2 | 0.0524744 |
| MMP2 | matrix metallopeptidase 2 | 0.0523369 |
| MCL1 | myeloid cell leukemia 1 | 0.0484629 |
| HLA-A | major histocompatibility complex, class I, A | 0.0478475 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.046874 |
| RND3 | Rho family GTPase 3 | 0.0457691 |
| EGFR | epidermal growth factor receptor | 0.0456534 |
| SP100 | SP100 nuclear antigen | 0.0454194 |
| FAT1 | FAT atypical cadherin 1 | 0.0448388 |
| CADM1 | cell adhesion molecule 1 | 0.043089 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0415372 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0393679 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0390657 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.038715 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0382884 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0379432 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0379349 |
| HLA-E | major histocompatibility complex, class I, E | 0.0378918 |
| COL5A1 | collagen, type V, alpha 1 | 0.0377506 |
| FAM20C | family with sequence similarity 20, member C | 0.0374646 |
| FNIP1 | folliculin interacting protein 1 | 0.0373399 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0370062 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0360595 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0356921 |
| FTL | ferritin, light polypeptide | 0.0356068 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0354656 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.035446 |
| NAV1 | neuron navigator 1 | 0.0353157 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0352622 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0347442 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0345669 |
| SQSTM1 | sequestosome 1 | 0.034317 |
| PDE10A | phosphodiesterase 10A | 0.0340529 |
| KYNU | kynureninase | 0.0325129 |
| CTSB | cathepsin B | 0.0325106 |
| FLNA | filamin A, alpha | 0.0325086 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0318629 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0314469 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0313171 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0311987 |
| SMAD3 | SMAD family member 3 | 0.0304064 |
| ADM | adrenomedullin | 0.0301226 |
| IRF1 | interferon regulatory factor 1 | 0.0299222 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0296051 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | 0.0292799 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.02888 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0288679 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0286126 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0283893 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0283794 |
| INTS6 | integrator complex subunit 6 | 0.0283416 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0281135 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0281078 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0277991 |
| GOLGB1 | golgin B1 | 0.0274271 |
| IFI44L | interferon-induced protein 44-like | 0.0273965 |
| FHIT | fragile histidine triad | 0.0272762 |
| JUN | jun proto-oncogene | 0.0265475 |
| BSG | basigin (Ok blood group) | 0.0264437 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0263713 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0261711 |
| CALR | calreticulin | 0.0260674 |
| LYST | lysosomal trafficking regulator | 0.0258833 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0255158 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0253565 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0252834 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.025138 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0248925 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0248835 |
| HLA-C | major histocompatibility complex, class I, C | 0.0247433 |
| PCBP3 | poly(rC) binding protein 3 | 0.0246487 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0245791 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0245358 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0242319 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0240176 |
| SFTPA2 | surfactant protein A2 | 0.0239202 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.132149 |
| MT2A | metallothionein 2A | -0.118186 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0807784 |
| ZNF292 | zinc finger protein 292 | -0.0730215 |
| CENPF | centromere protein F, 350/400kDa | -0.0697054 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0673286 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0556702 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0548609 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0535233 |
| SETD5 | SET domain containing 5 | -0.0501133 |
| ANLN | anillin, actin binding protein | -0.0499884 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0498643 |
| RBM39 | RNA binding motif protein 39 | -0.0495723 |
| VIM | vimentin | -0.049364 |
| TFG | TRK-fused gene | -0.0484064 |
| XPO1 | exportin 1 | -0.0469203 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0463129 |
| SEPTIN7 | septin 7 | -0.0453152 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0451745 |
| TPX2 | TPX2, microtubule-associated | -0.0435007 |
| POTEF | POTE ankyrin domain family, member F | -0.0434173 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0433084 |
| FN1 | fibronectin 1 | -0.0431943 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.041604 |
| NDRG1 | N-myc downstream regulated 1 | -0.041156 |
| GOLGA4 | golgin A4 | -0.0403052 |
| RRBP1 | ribosome binding protein 1 | -0.0402911 |
| MKI67 | marker of proliferation Ki-67 | -0.039077 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0389738 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0387231 |
| HMGB2 | high mobility group box 2 | -0.0382933 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0378177 |
| H1-0 | H1.0 linker histone | -0.0373434 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0369069 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.036562 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0362356 |
| MEF2A | myocyte enhancer factor 2A | -0.0359894 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0355675 |
| STC1 | stanniocalcin 1 | -0.0354467 |
| PTMA | prothymosin, alpha | -0.0353432 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0350617 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0350125 |
| AFAP1 | actin filament associated protein 1 | -0.0347655 |
| DIAPH3 | diaphanous-related formin 3 | -0.0333384 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0326899 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0324924 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0322763 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0315593 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0311043 |
| RTN4 | reticulon 4 | -0.0304279 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0301225 |
| CENPE | centromere protein E, 312kDa | -0.0295424 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0292944 |
| MSN | moesin | -0.0289853 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0287339 |
| NKTR | natural killer cell triggering receptor | -0.0273528 |
| FRMD4A | FERM domain containing 4A | -0.0269187 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0266505 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0257207 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0254083 |
| KIF4A | kinesin family member 4A | -0.0253101 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252275 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0250863 |
| KIF20B | kinesin family member 20B | -0.0245882 |
| COL1A1 | collagen, type I, alpha 1 | -0.0245725 |
| SGO2 | shugoshin 2 | -0.0245014 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0241887 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0238748 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0237772 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0236493 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0235873 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0234505 |
| ECT2 | epithelial cell transforming 2 | -0.0232639 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0231129 |
| GNAS | GNAS complex locus | -0.0230492 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0229835 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0228448 |
| TMEM39A | transmembrane protein 39A | -0.0228207 |
| FAM162A | family with sequence similarity 162, member A | -0.0227408 |
| ZNF148 | zinc finger protein 148 | -0.0227279 |
| RNF24 | ring finger protein 24 | -0.02268 |
| CKAP2L | cytoskeleton associated protein 2-like | -0.0226363 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0223786 |
| SUCO | SUN domain containing ossification factor | -0.0223222 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0221507 |
| PKM | pyruvate kinase, muscle | -0.0221018 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0220067 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0217598 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0216172 |
| CDC27 | cell division cycle 27 | -0.0214855 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.021469 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.021444 |
| CALD1 | caldesmon 1 | -0.021389 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0212899 |
| TMF1 | TATA element modulatory factor 1 | -0.0212241 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.021182 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0211302 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.0211216 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0210776 |
| PHF21A | PHD finger protein 21A | -0.0210407 |
