| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.151613 |
| VGF | VGF nerve growth factor inducible | 0.131454 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.123494 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.113537 |
| NRG1 | neuregulin 1 | 0.102841 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0939466 |
| NCKAP5 | NCK-associated protein 5 | 0.0871978 |
| INHBA | inhibin, beta A | 0.0764304 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0731026 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0731002 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0717802 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0693639 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0653834 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0630661 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0580619 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0576345 |
| ASPH | aspartate beta-hydroxylase | 0.0575949 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0567417 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0567263 |
| RORA | RAR-related orphan receptor A | 0.0560823 |
| DTNA | dystrobrevin, alpha | 0.0554183 |
| MAP1B | microtubule-associated protein 1B | 0.0538187 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0529764 |
| SMYD3 | SET and MYND domain containing 3 | 0.0527229 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0515823 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0514099 |
| CNKSR3 | CNKSR family member 3 | 0.0503012 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | 0.0499878 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0486637 |
| NDRG1 | N-myc downstream regulated 1 | 0.0482402 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0468318 |
| SNTG1 | syntrophin, gamma 1 | 0.0465358 |
| KLHL29 | kelch-like family member 29 | 0.0453842 |
| RNF213 | ring finger protein 213 | 0.0446323 |
| EGR1 | early growth response 1 | 0.0443931 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0438981 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0426529 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0421465 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.042089 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0418759 |
| CHGB | chromogranin B | 0.0414489 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0408574 |
| FAM13A | family with sequence similarity 13, member A | 0.0406173 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0406066 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0405671 |
| MCL1 | myeloid cell leukemia 1 | 0.0404288 |
| NBEA | neurobeachin | 0.0403928 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0402795 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0401079 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0396547 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | 0.0389774 |
| ZFHX3 | zinc finger homeobox 3 | 0.0384095 |
| LSAMP | limbic system-associated membrane protein | 0.0379935 |
| TSPYL2 | TSPY-like 2 | 0.0375748 |
| TXNRD1 | thioredoxin reductase 1 | 0.0372383 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0372121 |
| KIF26B | kinesin family member 26B | 0.0372015 |
| EFNA5 | ephrin-A5 | 0.0363315 |
| SVIL | supervillin | 0.036248 |
| FGF14 | fibroblast growth factor 14 | 0.03612 |
| ACTG1 | actin gamma 1 | 0.0360628 |
| STC1 | stanniocalcin 1 | 0.0358393 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0358103 |
| RIT2 | Ras-like without CAAX 2 | 0.0357297 |
| TOX | thymocyte selection-associated high mobility group box | 0.0355954 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0353933 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0352883 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0351877 |
| FHIT | fragile histidine triad | 0.0349923 |
| GPC5 | glypican 5 | 0.0347717 |
| EGFR | epidermal growth factor receptor | 0.0347661 |
| APP | amyloid beta (A4) precursor protein | 0.0342006 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.033961 |
| RALYL | RALY RNA binding protein-like | 0.0339486 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0331874 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0330412 |
| NAV2 | neuron navigator 2 | 0.0329645 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.032799 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0327797 |
| SCFD2 | sec1 family domain containing 2 | 0.0324345 |
| WWOX | WW domain containing oxidoreductase | 0.0320055 |
| JUN | jun proto-oncogene | 0.0315913 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.031523 |
| TCF12 | transcription factor 12 | 0.0312208 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0311593 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0308419 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0302019 |
| ARFGEF3 | ARFGEF family member 3 | 0.0299248 |
| PTCHD4 | patched domain containing 4 | 0.0296532 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0294889 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0293431 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0289515 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0285655 |
| CPE | carboxypeptidase E | 0.028556 |
| TOP1 | topoisomerase (DNA) I | 0.0284791 |
| CALR | calreticulin | 0.0283088 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0282652 |
| HSPA8 | heat shock 70kDa protein 8 | 0.028219 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0281842 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.028146 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CENPF | centromere protein F, 350/400kDa | -0.105991 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0992127 |
| PTMA | prothymosin, alpha | -0.0881401 |
| TENM1 | teneurin transmembrane protein 1 | -0.0653284 |
| PDE10A | phosphodiesterase 10A | -0.0598604 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0522144 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0479068 |
| XPO1 | exportin 1 | -0.0432621 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0386143 |
| CALCA | calcitonin-related polypeptide alpha | -0.0378696 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0378219 |
| MKI67 | marker of proliferation Ki-67 | -0.0372182 |
| MATR3 | matrin 3 | -0.037032 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0370297 |
| RPS21 | ribosomal protein S21 | -0.036904 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.036497 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0356768 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0346094 |
| ZNF292 | zinc finger protein 292 | -0.0331876 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0327191 |
| ECT2 | epithelial cell transforming 2 | -0.0316228 |
| RPS2 | ribosomal protein S2 | -0.0311391 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0295183 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0293806 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.029196 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0291764 |
| KANTR | KDM5C adjacent non-coding transcript | -0.0284509 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0281398 |
| CDK8 | cyclin-dependent kinase 8 | -0.0279685 |
| AURKA | aurora kinase A | -0.02796 |
| PBK | PDZ binding kinase | -0.027401 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.027298 |
| TPX2 | TPX2, microtubule-associated | -0.0270075 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0260046 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0255489 |
| HMGB2 | high mobility group box 2 | -0.0255374 |
| PCM1 | pericentriolar material 1 | -0.025339 |
| RPL37A | ribosomal protein L37a | -0.0251576 |
| KIF2C | kinesin family member 2C | -0.0248257 |
| BUB3 | BUB3 mitotic checkpoint protein | -0.0239886 |
| RPL38 | ribosomal protein L38 | -0.0238223 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0237278 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0232234 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0230978 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | -0.0230661 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0230587 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0228038 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0227418 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.0224106 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0224005 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0221897 |
| CDCA2 | cell division cycle associated 2 | -0.0220235 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0211923 |
| RPS6 | ribosomal protein S6 | -0.0211225 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0210763 |
| ZFR | zinc finger RNA binding protein | -0.0210612 |
| KDM1A | lysine (K)-specific demethylase 1A | -0.0210585 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.020974 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0209021 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0207075 |
| KIF11 | kinesin family member 11 | -0.0206198 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0205368 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0205356 |
| CKAP2L | cytoskeleton associated protein 2-like | -0.0204883 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0204745 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0204343 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0203263 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0202912 |
| GOLIM4 | golgi integral membrane protein 4 | -0.0200555 |
| PPME1 | protein phosphatase methylesterase 1 | -0.019967 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0199552 |
| NKTR | natural killer cell triggering receptor | -0.0198778 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0198283 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.0197918 |
| RPS25 | ribosomal protein S25 | -0.0196511 |
| TTK | TTK protein kinase | -0.0195896 |
| PDS5B | PDS5 cohesin associated factor B | -0.0194892 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.01919 |
| RPL7 | ribosomal protein L7 | -0.01913 |
| H1-4 | H1.4 linker histone, cluster member | -0.0191 |
| KIF5B | kinesin family member 5B | -0.0189835 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0189498 |
| STMN1 | stathmin 1 | -0.0188914 |
| PRPF3 | pre-mRNA processing factor 3 | -0.0185629 |
| SPAG5 | sperm associated antigen 5 | -0.0184014 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0183054 |
| NCKAP1 | NCK-associated protein 1 | -0.0181403 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0178862 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | -0.0178176 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0177394 |
| CDC27 | cell division cycle 27 | -0.0177312 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.0176804 |
| CCNB1 | cyclin B1 | -0.0176522 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0175703 |
| KIF23 | kinesin family member 23 | -0.0175564 |
| NCAM1 | neural cell adhesion molecule 1 | -0.0175365 |
| CEP70 | centrosomal protein 70kDa | -0.0173881 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0173384 |
| CDCA8 | cell division cycle associated 8 | -0.0172765 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.017259 |
