| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | 0.0818183 |
| VIM | vimentin | 0.0811819 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0788462 |
| NAV2 | neuron navigator 2 | 0.0758806 |
| SFTPA2 | surfactant protein A2 | 0.0637842 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0620004 |
| ENO1 | enolase 1, (alpha) | 0.0603338 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.058385 |
| LSAMP | limbic system-associated membrane protein | 0.0563976 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0540086 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0533027 |
| PKM | pyruvate kinase, muscle | 0.0515537 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0500411 |
| LDHA | lactate dehydrogenase A | 0.0492933 |
| SPAG9 | sperm associated antigen 9 | 0.0487304 |
| PGK1 | phosphoglycerate kinase 1 | 0.0458317 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0435083 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0429541 |
| PMEL | premelanosome protein | 0.0402286 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0400946 |
| CCND1 | cyclin D1 | 0.0386388 |
| MKI67 | marker of proliferation Ki-67 | 0.0380024 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0371846 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0370294 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0352914 |
| TXNRD1 | thioredoxin reductase 1 | 0.0351353 |
| SQSTM1 | sequestosome 1 | 0.0347942 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0344694 |
| CENPF | centromere protein F, 350/400kDa | 0.0343075 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0339001 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0337978 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0334285 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0331993 |
| RPS6 | ribosomal protein S6 | 0.0328614 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0319443 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0318113 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0311181 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0308791 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0307642 |
| NDRG1 | N-myc downstream regulated 1 | 0.0305723 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0305325 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0305246 |
| RHOA | ras homolog family member A | 0.0304873 |
| FLNA | filamin A, alpha | 0.0299854 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0299008 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0298404 |
| CD44 | CD44 molecule (Indian blood group) | 0.029805 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0296109 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.029532 |
| NRG3 | neuregulin 3 | 0.0294193 |
| CANX | calnexin | 0.028836 |
| UBC | ubiquitin C | 0.0287797 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0286129 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0274083 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0274062 |
| MCL1 | myeloid cell leukemia 1 | 0.0273022 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0268128 |
| CLTC | clathrin, heavy chain (Hc) | 0.026506 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0264141 |
| GOLGA4 | golgin A4 | 0.0263867 |
| ANXA2 | annexin A2 | 0.0263208 |
| SSH1 | slingshot protein phosphatase 1 | 0.0262694 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0260279 |
| FRMD5 | FERM domain containing 5 | 0.02565 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0254779 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0252724 |
| ANXA5 | annexin A5 | 0.0252085 |
| MATR3 | matrin 3 | 0.0248984 |
| RPLP1 | ribosomal protein, large, P1 | 0.0247869 |
| PRRC2B | proline-rich coiled-coil 2B | 0.024579 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0245787 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0241373 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0240959 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0240929 |
| OGA | O-GlcNAcase | 0.0238337 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0237056 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0236251 |
| RPS8 | ribosomal protein S8 | 0.0234553 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0233313 |
| FUS | FUS RNA binding protein | 0.0230245 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0229959 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0229235 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0228638 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0227898 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0226934 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0225456 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0224909 |
| PCBP2 | poly(rC) binding protein 2 | 0.0223391 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0222142 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0222131 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0221036 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0221011 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0218909 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0218889 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0217444 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0217036 |
| ANLN | anillin, actin binding protein | 0.0214542 |
| EP300 | E1A binding protein p300 | 0.0212321 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0208238 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0205285 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0863338 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0276524 |
| ANGPTL4 | angiopoietin-like 4 | -0.0245691 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0225458 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0208997 |
| ASPH | aspartate beta-hydroxylase | -0.0205432 |
| RASAL2 | RAS protein activator like 2 | -0.0201718 |
| CFAP20DC | CFAP20 domain containing | -0.0200174 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0194473 |
| EHBP1 | EH domain binding protein 1 | -0.0181072 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0176352 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.017556 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0171262 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0166704 |
| AUTS2 | autism susceptibility candidate 2 | -0.0158898 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.015064 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.014203 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0129407 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0120575 |
| ANO6 | anoctamin 6 | -0.0113851 |
| PLAT | plasminogen activator, tissue | -0.011332 |
| WWC1 | WW and C2 domain containing 1 | -0.0111417 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0107728 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0106854 |
| FAM78B | family with sequence similarity 78, member B | -0.0105888 |
| DPP6 | dipeptidyl-peptidase 6 | -0.0103395 |
| TNS1 | tensin 1 | -0.010331 |
| FLNB | filamin B, beta | -0.0101826 |
| NLGN1 | neuroligin 1 | -0.0101056 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0100586 |
| CADM1 | cell adhesion molecule 1 | -0.00996476 |
| RNF150 | ring finger protein 150 | -0.00946586 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.00929328 |
| ZNF704 | zinc finger protein 704 | -0.00919968 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0090712 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.00879892 |
| NAV1 | neuron navigator 1 | -0.00867066 |
| TNNC1 | troponin C type 1 (slow) | -0.00864806 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.00863214 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.00863012 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00847538 |
| ATP11C | ATPase, class VI, type 11C | -0.00847372 |
| SMAD3 | SMAD family member 3 | -0.00838117 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0082405 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.00823409 |
| SON | SON DNA binding protein | -0.00810994 |
| HPSE2 | heparanase 2 (inactive) | -0.00810976 |
| SUMF1 | sulfatase modifying factor 1 | -0.00808373 |
| ANO4 | anoctamin 4 | -0.00807801 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00802331 |
| SFMBT2 | Scm-like with four mbt domains 2 | -0.0080065 |
| KCNC4 | potassium channel, voltage gated Shaw related subfamily C, member 4 | -0.00798006 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.00795778 |
| ENTHD1 | ENTH domain containing 1 | -0.00793648 |
| SCFD2 | sec1 family domain containing 2 | -0.00789672 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.00786048 |
| MSI2 | musashi RNA-binding protein 2 | -0.00781046 |
| ZNF827 | zinc finger protein 827 | -0.00769926 |
| CEP83 | centrosomal protein 83kDa | -0.00766194 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00761573 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00757363 |
| AGRN | agrin | -0.00755882 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.00743032 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00740777 |
| FRMD6 | FERM domain containing 6 | -0.00736107 |
| RAD51B | RAD51 paralog B | -0.0073137 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.00726962 |
| ZNF841 | zinc finger protein 841 | -0.0072145 |
| YOD1 | YOD1 deubiquitinase | -0.00717582 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.00705771 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.00701777 |
| IFI44L | interferon-induced protein 44-like | -0.00696502 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00692918 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.00690822 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00688703 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.0068657 |
| WDR25 | WD repeat domain 25 | -0.00683288 |
| MAMLD1 | mastermind-like domain containing 1 | -0.0068214 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.00681586 |
| GPATCH2L | G patch domain containing 2-like | -0.00680605 |
| MLPH | melanophilin | -0.00673997 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | -0.00671493 |
| WASL | Wiskott-Aldrich syndrome-like | -0.00669684 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.00664868 |
| DHFR | dihydrofolate reductase | -0.00659474 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.00656541 |
| MX2 | MX dynamin-like GTPase 2 | -0.00647504 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0064599 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | -0.00641121 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.00637663 |
| RALGDS | ral guanine nucleotide dissociation stimulator | -0.00635389 |
| OSBPL6 | oxysterol binding protein-like 6 | -0.00634263 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.00634003 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.00633696 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.00630471 |
| PRR16 | proline rich 16 | -0.00617992 |
| TBC1D22A | TBC1 domain family, member 22A | -0.00615207 |
| SDC2 | syndecan 2 | -0.00614979 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.00614215 |
| TOB2 | transducer of ERBB2, 2 | -0.00613571 |
