| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.102036 |
| EZR | ezrin | 0.0730402 |
| GOLGA4 | golgin A4 | 0.071179 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0540917 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0486726 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0466566 |
| ZNF292 | zinc finger protein 292 | 0.0456061 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0443865 |
| TXNIP | thioredoxin interacting protein | 0.0400161 |
| ZNF608 | zinc finger protein 608 | 0.0389901 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0386068 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0384651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0377179 |
| PCBP2 | poly(rC) binding protein 2 | 0.037616 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0375965 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0349529 |
| HELZ | helicase with zinc finger | 0.0333687 |
| PDGFC | platelet derived growth factor C | 0.0324302 |
| HDAC9 | histone deacetylase 9 | 0.0324262 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0322148 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0311123 |
| TJP1 | tight junction protein 1 | 0.0302932 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0297249 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0295884 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0279422 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0273453 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0272443 |
| MATR3 | matrin 3 | 0.0271781 |
| FAM13A | family with sequence similarity 13, member A | 0.0271118 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0266583 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0266511 |
| TFG | TRK-fused gene | 0.0265559 |
| LDHA | lactate dehydrogenase A | 0.0263764 |
| RPL3 | ribosomal protein L3 | 0.0259904 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0259374 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.025181 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0250239 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.02491 |
| PLK2 | polo-like kinase 2 | 0.0245204 |
| CCNL1 | cyclin L1 | 0.0243484 |
| NBAS | neuroblastoma amplified sequence | 0.0238636 |
| NUP58 | nucleoporin 58 | 0.0238235 |
| QKI | QKI, KH domain containing, RNA binding | 0.0231946 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0230463 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0226267 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0224238 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0221813 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0220648 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0220061 |
| ATOSA | atos homolog A | 0.0218726 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0215927 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0215375 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.021439 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0212697 |
| SGMS2 | sphingomyelin synthase 2 | 0.0212046 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0211529 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0210876 |
| COPA | coatomer protein complex, subunit alpha | 0.0209229 |
| SEC24D | SEC24 family member D | 0.0207216 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0205312 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0201723 |
| RAB6A | RAB6A, member RAS oncogene family | 0.019922 |
| RNF145 | ring finger protein 145 | 0.0199056 |
| GOLGB1 | golgin B1 | 0.0198798 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0198469 |
| FLNA | filamin A, alpha | 0.0197872 |
| USP47 | ubiquitin specific peptidase 47 | 0.0195323 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0194583 |
| FAT1 | FAT atypical cadherin 1 | 0.0194411 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0193512 |
| COG6 | component of oligomeric golgi complex 6 | 0.0192135 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0192131 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0188915 |
| SEC24A | SEC24 family member A | 0.0188904 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0188614 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.018708 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0187028 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0185869 |
| SRP54 | signal recognition particle 54kDa | 0.0185255 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0185235 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.018418 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0182811 |
| RLF | rearranged L-myc fusion | 0.0182797 |
| POTEF | POTE ankyrin domain family, member F | 0.0182712 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0182224 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0179984 |
| CABIN1 | calcineurin binding protein 1 | 0.0179614 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0176859 |
| RTN4 | reticulon 4 | 0.0174811 |
| SUCO | SUN domain containing ossification factor | 0.0172656 |
| JUN | jun proto-oncogene | 0.0171887 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.017001 |
| HM13 | histocompatibility (minor) 13 | 0.0169982 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0168769 |
| ECT2 | epithelial cell transforming 2 | 0.0168137 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0167119 |
| BRD2 | bromodomain containing 2 | 0.0167108 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0166315 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.016574 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0165546 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.259455 |
| AHNAK | AHNAK nucleoprotein | -0.15129 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.148414 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.13106 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126893 |
| VCL | vinculin | -0.106031 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.101868 |
| BMP10 | bone morphogenetic protein 10 | -0.0992351 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0941731 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0866261 |
| FOXP1 | forkhead box P1 | -0.0862602 |
| NBEA | neurobeachin | -0.0833181 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0819657 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0752873 |
| CCND1 | cyclin D1 | -0.0729334 |
| RPL35A | ribosomal protein L35a | -0.0686811 |
| GLI3 | GLI family zinc finger 3 | -0.0671812 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0655131 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.065272 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0555686 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0540813 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0531927 |
| RPL34 | ribosomal protein L34 | -0.0526385 |
| RPS6 | ribosomal protein S6 | -0.0518059 |
| RPS23 | ribosomal protein S23 | -0.0517977 |
| RPLP1 | ribosomal protein, large, P1 | -0.0497685 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0496385 |
| RPL19 | ribosomal protein L19 | -0.0488117 |
| RPL31 | ribosomal protein L31 | -0.0474741 |
| EFNA5 | ephrin-A5 | -0.0462773 |
| RPS24 | ribosomal protein S24 | -0.0456676 |
| ACTG1 | actin gamma 1 | -0.0455613 |
| RPS21 | ribosomal protein S21 | -0.0452924 |
| RPS13 | ribosomal protein S13 | -0.0451088 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0446002 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0445159 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0422775 |
| ZNF438 | zinc finger protein 438 | -0.0399954 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0391782 |
| NFIA | nuclear factor I/A | -0.0389929 |
| RPL26 | ribosomal protein L26 | -0.0385681 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0382093 |
| RPS27A | ribosomal protein S27a | -0.0381466 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0377919 |
| MYL12B | myosin, light chain 12B, regulatory | -0.037283 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0368815 |
| MKI67 | marker of proliferation Ki-67 | -0.0367078 |
| EGFR | epidermal growth factor receptor | -0.0364597 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0353388 |
| RPS8 | ribosomal protein S8 | -0.0352869 |
| S100A6 | S100 calcium binding protein A6 | -0.0350926 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0349546 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.03486 |
| GLI2 | GLI family zinc finger 2 | -0.0346868 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0343112 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0341398 |
| CUX1 | cut-like homeobox 1 | -0.0331006 |
| RPS19 | ribosomal protein S19 | -0.0330158 |
| FLNB | filamin B, beta | -0.0324207 |
| PDE7B | phosphodiesterase 7B | -0.031836 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0315925 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0313746 |
| PRELID2 | PRELI domain containing 2 | -0.0310534 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0307574 |
| PYGB | phosphorylase, glycogen; brain | -0.0305225 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0302707 |
| DIAPH2 | diaphanous-related formin 2 | -0.0302413 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0301879 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0301303 |
| RPL9 | ribosomal protein L9 | -0.0299676 |
| RPS25 | ribosomal protein S25 | -0.0298773 |
| SMYD3 | SET and MYND domain containing 3 | -0.0297154 |
| S100A9 | S100 calcium binding protein A9 | -0.0296615 |
| S100A4 | S100 calcium binding protein A4 | -0.0295797 |
| RPL38 | ribosomal protein L38 | -0.0293252 |
| RPL23 | ribosomal protein L23 | -0.0292217 |
| RPLP2 | ribosomal protein, large, P2 | -0.0289797 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0287257 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0285426 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | -0.0285021 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0283687 |
| S100A10 | S100 calcium binding protein A10 | -0.0279552 |
| RPL37A | ribosomal protein L37a | -0.0273887 |
| RPS29 | ribosomal protein S29 | -0.0273143 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0272107 |
| TXNRD1 | thioredoxin reductase 1 | -0.0272069 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0271742 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0270184 |
| PARD3 | par-3 family cell polarity regulator | -0.0267729 |
| DIAPH3 | diaphanous-related formin 3 | -0.0267438 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0263206 |
| RPLP0 | ribosomal protein, large, P0 | -0.0258255 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0254178 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0252884 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0245174 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0240486 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0234576 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0233474 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0228829 |
| GPATCH8 | G patch domain containing 8 | -0.02276 |
