ERK5-IN-2_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.170904
EEF2 eukaryotic translation elongation factor 2 0.154049
MYH9 myosin, heavy chain 9, non-muscle 0.106157
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105096
TRIO trio Rho guanine nucleotide exchange factor 0.0819105
LDHA lactate dehydrogenase A 0.0723934
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0687799
PGK1 phosphoglycerate kinase 1 0.0601587
FLNA filamin A, alpha 0.0580948
NAV2 neuron navigator 2 0.057034
ANXA2 annexin A2 0.0567639
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0566706
FNIP1 folliculin interacting protein 1 0.0552495
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0517109
HDAC9 histone deacetylase 9 0.0483626
PHF3 PHD finger protein 3 0.0469224
FN1 fibronectin 1 0.0463916
ZSWIM6 zinc finger, SWIM-type containing 6 0.0463221
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0459862
MYOF myoferlin 0.0448962
GOLGB1 golgin B1 0.0433248
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0427097
ADM adrenomedullin 0.0425811
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0412299
ZMIZ1 zinc finger, MIZ-type containing 1 0.0410108
APP amyloid beta (A4) precursor protein 0.0407468
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.040094
PDE10A phosphodiesterase 10A 0.040063
SPAG9 sperm associated antigen 9 0.0396754
PRELID2 PRELI domain containing 2 0.038674
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0380169
KYNU kynureninase 0.0372894
SQSTM1 sequestosome 1 0.0372887
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.036029
CALR calreticulin 0.0356164
OGA O-GlcNAcase 0.0347855
ENO1 enolase 1, (alpha) 0.0336748
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0334803
USP9X ubiquitin specific peptidase 9, X-linked 0.0333509
VCL vinculin 0.0333157
DST dystonin 0.0330495
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0324293
RPS3 ribosomal protein S3 0.0318896
INTS6 integrator complex subunit 6 0.0315976
MORF4L2 mortality factor 4 like 2 0.0298778
DSCAM Down syndrome cell adhesion molecule 0.029771
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0292687
EEF1G eukaryotic translation elongation factor 1 gamma 0.0290499
TPT1 tumor protein, translationally-controlled 1 0.0287605
RAB7A RAB7A, member RAS oncogene family 0.0286065
SRRM2 serine/arginine repetitive matrix 2 0.0285138
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0284738
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0277338
MLPH melanophilin 0.0275905
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0271804
AKAP9 A kinase (PRKA) anchor protein 9 0.0270683
RB1CC1 RB1-inducible coiled-coil 1 0.0269798
RND3 Rho family GTPase 3 0.0268911
DUSP10 dual specificity phosphatase 10 0.0268805
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.02624
SFTPA2 surfactant protein A2 0.0260062
LAMP2 lysosomal-associated membrane protein 2 0.025839
NAP1L1 nucleosome assembly protein 1-like 1 0.0257102
IGF2R insulin-like growth factor 2 receptor 0.0253831
COL4A2 collagen, type IV, alpha 2 0.0245851
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0243467
HELZ helicase with zinc finger 0.0242736
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0235292
ASPH aspartate beta-hydroxylase 0.0233008
VEGFA vascular endothelial growth factor A 0.0232431
EIF4B eukaryotic translation initiation factor 4B 0.0230654
GOLGA4 golgin A4 0.0229034
RPL13A ribosomal protein L13a 0.0226435
MXI1 MAX interactor 1, dimerization protein 0.0225895
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0224983
CANX calnexin 0.0220017
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219307
CTSB cathepsin B 0.0219058
KDM3A lysine (K)-specific demethylase 3A 0.0218753
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0217373
TMSB4X thymosin beta 4, X-linked 0.0217361
HSPA8 heat shock 70kDa protein 8 0.0214152
OPTN optineurin 0.021358
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0213421
AHR aryl hydrocarbon receptor 0.021182
FLOT1 flotillin 1 0.0209993
ARRDC3 arrestin domain containing 3 0.0209728
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0208182
MKI67 marker of proliferation Ki-67 0.0206251
EPAS1 endothelial PAS domain protein 1 0.0205864
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0203976
RPS12 ribosomal protein S12 0.0203797
PRRC2C proline-rich coiled-coil 2C 0.0203678
MBNL1 muscleblind-like splicing regulator 1 0.0203412
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0200602
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0199841
RHOBTB3 Rho-related BTB domain containing 3 0.0199651
CLTC clathrin, heavy chain (Hc) 0.0198323
JMJD1C jumonji domain containing 1C 0.0197547
CEP250 centrosomal protein 250kDa 0.0197219

decreased expression

Symbol Name Standardized Value
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0809274
IGFBP3 insulin-like growth factor binding protein 3 -0.0761632
VIM vimentin -0.0731671
AKAP12 A kinase (PRKA) anchor protein 12 -0.0700222
TMSB10 thymosin beta 10 -0.0670479
GLIS3 GLIS family zinc finger 3 -0.0611702
HLA-B major histocompatibility complex, class I, B -0.0555409
NAMPT nicotinamide phosphoribosyltransferase -0.0471415
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0423411
ZMYND8 zinc finger, MYND-type containing 8 -0.0412387
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0381974
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0366613
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.035404
FTL ferritin, light polypeptide -0.0336206
CLMP CXADR-like membrane protein -0.0308382
IFI6 interferon, alpha-inducible protein 6 -0.0279354
CD44 CD44 molecule (Indian blood group) -0.0268267
EFNA5 ephrin-A5 -0.0251867
MT2A metallothionein 2A -0.0250946
RAI14 retinoic acid induced 14 -0.0248497
TPM4 tropomyosin 4 -0.0240924
HLA-A major histocompatibility complex, class I, A -0.0239687
ADAM12 ADAM metallopeptidase domain 12 -0.0233768
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0228381
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0223728
S100A9 S100 calcium binding protein A9 -0.0222892
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0216195
RPL35A ribosomal protein L35a -0.0213716
IFITM1 interferon induced transmembrane protein 1 -0.0213473
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0212077
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0210329
HMGA2 high mobility group AT-hook 2 -0.0209507
C3 complement component 3 -0.0199611
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0184749
ISG15 ISG15 ubiquitin-like modifier -0.0183827
IFITM3 interferon induced transmembrane protein 3 -0.0182736
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0181227
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0180782
NAV1 neuron navigator 1 -0.017833
MT1X metallothionein 1X -0.0176585
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0175342
SOX5 SRY (sex determining region Y)-box 5 -0.0175336
NRP1 neuropilin 1 -0.0175317
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0170813
RPS19 ribosomal protein S19 -0.0170424
TPM1 tropomyosin 1 (alpha) -0.017015
DLG1 discs, large homolog 1 (Drosophila) -0.0169957
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0169301
RPS21 ribosomal protein S21 -0.0168937
EGR1 early growth response 1 -0.0167711
RTN4 reticulon 4 -0.0166077
MAML2 mastermind-like 2 (Drosophila) -0.0165399
HMGA1 high mobility group AT-hook 1 -0.0159781
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0158688
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0155205
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.015466
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0152102
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0147602
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0145943
SAMD3 sterile alpha motif domain containing 3 -0.0145752
FRMD4A FERM domain containing 4A -0.0145148
SLC38A1 solute carrier family 38, member 1 -0.0143901
PTMA prothymosin, alpha -0.0142233
S100A6 S100 calcium binding protein A6 -0.0141742
RRBP1 ribosome binding protein 1 -0.0135217
IER2 immediate early response 2 -0.01337
SOX4 SRY (sex determining region Y)-box 4 -0.0131183
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0129522
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0128312
RPL36 ribosomal protein L36 -0.0128073
PTBP3 polypyrimidine tract binding protein 3 -0.0127769
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0127712
RPLP1 ribosomal protein, large, P1 -0.0126044
RIGI RNA sensor RIG-I -0.0125568
FOSL1 FOS-like antigen 1 -0.0124466
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.012432
NRN1 neuritin 1 -0.0123046
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0122722
CUX1 cut-like homeobox 1 -0.0122697
BNC2 basonuclin 2 -0.0122654
INHBA inhibin, beta A -0.0118495
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0117185
ARF4 ADP-ribosylation factor 4 -0.0116823
TMEM41B transmembrane protein 41B -0.0116174
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.011412
MAP4 microtubule-associated protein 4 -0.0113997
PFN1 profilin 1 -0.0113525
FBXO11 F-box protein 11 -0.0113452
ASTN2 astrotactin 2 -0.0112499
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0111708
ATP13A3 ATPase type 13A3 -0.0111146
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0109605
CDCP1 CUB domain containing protein 1 -0.0109573
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.01094
RGS17 regulator of G-protein signaling 17 -0.010891
KRT19 keratin 19, type I -0.0106569
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0106487
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0106285
RPS6 ribosomal protein S6 -0.0105063
COL1A1 collagen, type I, alpha 1 -0.0105021