| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.22665 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.164631 |
| COL6A3 | collagen, type VI, alpha 3 | 0.145988 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.105303 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0950591 |
| NDRG1 | N-myc downstream regulated 1 | 0.0780995 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0701494 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0692932 |
| CALR | calreticulin | 0.0688852 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0664162 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0652132 |
| FN1 | fibronectin 1 | 0.0608027 |
| COL5A1 | collagen, type V, alpha 1 | 0.058624 |
| ANXA2 | annexin A2 | 0.0545751 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0545046 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0536234 |
| FAM13A | family with sequence similarity 13, member A | 0.053612 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.052777 |
| CD44 | CD44 molecule (Indian blood group) | 0.0512304 |
| HDLBP | high density lipoprotein binding protein | 0.0494476 |
| PRELID2 | PRELI domain containing 2 | 0.0490332 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0475126 |
| CANX | calnexin | 0.0471547 |
| KYNU | kynureninase | 0.0471134 |
| VEGFA | vascular endothelial growth factor A | 0.0460729 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0446104 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0444509 |
| GOLGB1 | golgin B1 | 0.0421041 |
| FLNA | filamin A, alpha | 0.0417895 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0417769 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0409963 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0409308 |
| NRXN3 | neurexin 3 | 0.0400922 |
| LOXL2 | lysyl oxidase-like 2 | 0.0392456 |
| FNIP1 | folliculin interacting protein 1 | 0.0383623 |
| ENO1 | enolase 1, (alpha) | 0.0375888 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0373445 |
| LDHA | lactate dehydrogenase A | 0.0366087 |
| EGFR | epidermal growth factor receptor | 0.0359027 |
| PTGES2 | prostaglandin E synthase 2 | 0.0353165 |
| PGK1 | phosphoglycerate kinase 1 | 0.0350664 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0339493 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0338202 |
| GLG1 | golgi glycoprotein 1 | 0.0335831 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0334836 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0333426 |
| EXT1 | exostosin glycosyltransferase 1 | 0.033209 |
| GOLGA4 | golgin A4 | 0.0322117 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0309427 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0300383 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0298548 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0298244 |
| CALU | calumenin | 0.0298041 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0296819 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0296201 |
| BSG | basigin (Ok blood group) | 0.0293028 |
| MORF4L2 | mortality factor 4 like 2 | 0.0292818 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0288219 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0282257 |
| ARRDC3 | arrestin domain containing 3 | 0.0280028 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0276325 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0270359 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0270291 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0269536 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0268435 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.026639 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0266216 |
| AHNAK | AHNAK nucleoprotein | 0.0264931 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0264629 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0262565 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0260992 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0259648 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0259541 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.025922 |
| SEC24D | SEC24 family member D | 0.0255505 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0254066 |
| PGM3 | phosphoglucomutase 3 | 0.0251632 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0250212 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0249307 |
| MCL1 | myeloid cell leukemia 1 | 0.0244169 |
| ZNF395 | zinc finger protein 395 | 0.0241608 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0239963 |
| RND3 | Rho family GTPase 3 | 0.023814 |
| COPA | coatomer protein complex, subunit alpha | 0.0237553 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0236976 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0236663 |
| GSE1 | Gse1 coiled-coil protein | 0.0235318 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0235229 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0234627 |
| INTS6 | integrator complex subunit 6 | 0.0232686 |
| CTSB | cathepsin B | 0.0232144 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.023067 |
| TNS3 | tensin 3 | 0.0229669 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0223242 |
| PLEC | plectin | 0.0221975 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0220239 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0218881 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0218 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0217656 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0213716 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.0688267 |
| COL1A2 | collagen, type I, alpha 2 | -0.0489155 |
| TMSB10 | thymosin beta 10 | -0.044647 |
| COL1A1 | collagen, type I, alpha 1 | -0.0329201 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0315115 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0286572 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0219362 |
| MAP1B | microtubule-associated protein 1B | -0.0218161 |
| S100A6 | S100 calcium binding protein A6 | -0.0209927 |
| TPM1 | tropomyosin 1 (alpha) | -0.020982 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0204899 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0188927 |
| HLA-B | major histocompatibility complex, class I, B | -0.01878 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0186794 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0186066 |
| LOX | lysyl oxidase | -0.0179156 |
| GPC6 | glypican 6 | -0.0175709 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0171201 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0169897 |
| PFN1 | profilin 1 | -0.0168151 |
| MT1X | metallothionein 1X | -0.0161524 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0156003 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0152689 |
| INHBA | inhibin, beta A | -0.0151199 |
| TXNRD1 | thioredoxin reductase 1 | -0.0142656 |
| FOSL1 | FOS-like antigen 1 | -0.0139991 |
| EGR1 | early growth response 1 | -0.0132265 |
| PLAT | plasminogen activator, tissue | -0.0126467 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0122106 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0119473 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.011877 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0118659 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0116838 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | -0.0116218 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | -0.0115066 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0114334 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0112386 |
| USP12 | ubiquitin specific peptidase 12 | -0.0112339 |
| ACTG1 | actin gamma 1 | -0.0111186 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0110515 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0110305 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0109192 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0108356 |
| NEK7 | NIMA-related kinase 7 | -0.010811 |
| USP3 | ubiquitin specific peptidase 3 | -0.0108029 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0107841 |
| CEP290 | centrosomal protein 290kDa | -0.0106294 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0106138 |
| NUCB2 | nucleobindin 2 | -0.0104704 |
| MYO6 | myosin VI | -0.0104418 |
| PDE10A | phosphodiesterase 10A | -0.0102421 |
| SNX6 | sorting nexin 6 | -0.0101813 |
| RTN4 | reticulon 4 | -0.0101337 |
| SMIM14 | small integral membrane protein 14 | -0.0101217 |
| NRG1 | neuregulin 1 | -0.010038 |
| CD109 | CD109 molecule | -0.0100303 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0100282 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.00996454 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.00989724 |
| PHKB | phosphorylase kinase, beta | -0.00987878 |
| RPL36 | ribosomal protein L36 | -0.00984121 |
| SMIM44 | small integral membrane protein 44 | -0.00979736 |
| RPL19 | ribosomal protein L19 | -0.00974304 |
| RNF11 | ring finger protein 11 | -0.00970464 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.00970265 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.00963371 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00949664 |
| RFX7 | regulatory factor X, 7 | -0.00943098 |
| ETV3 | ets variant 3 | -0.00942033 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0093671 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.00931937 |
| DTNA | dystrobrevin, alpha | -0.00924701 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.00921652 |
| PLCB4 | phospholipase C, beta 4 | -0.00920245 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00915197 |
| NUP153 | nucleoporin 153kDa | -0.00911345 |
| LUZP1 | leucine zipper protein 1 | -0.00906937 |
| RPL27 | ribosomal protein L27 | -0.00906197 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.00905611 |
| NUP58 | nucleoporin 58 | -0.00905295 |
| TES | testin LIM domain protein | -0.00901897 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.00900652 |
| YBX3 | Y box binding protein 3 | -0.00899918 |
| NFIA | nuclear factor I/A | -0.00896593 |
| JAK1 | Janus kinase 1 | -0.00896137 |
| LRRC8C | leucine rich repeat containing 8 family, member C | -0.008947 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.00892172 |
| CARD16 | caspase recruitment domain family, member 16 | -0.00890124 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.00887228 |
| ZFP36 | ZFP36 ring finger protein | -0.00883058 |
| PDE8A | phosphodiesterase 8A | -0.00882939 |
| HBS1L | HBS1-like translational GTPase | -0.00882062 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00879727 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.00879036 |
| GRB2 | growth factor receptor-bound protein 2 | -0.00874092 |
| TENM2 | teneurin transmembrane protein 2 | -0.00873878 |
| FNBP1L | formin binding protein 1-like | -0.0087011 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.00869537 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0086744 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00864391 |
