| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the ERK5-IN-2_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.116324 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.106581 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0939277 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0818824 |
| PKM | pyruvate kinase, muscle | 0.0816409 |
| INTS6 | integrator complex subunit 6 | 0.0789295 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0736855 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0716415 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0706045 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0700014 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0685171 |
| ASPH | aspartate beta-hydroxylase | 0.0653382 |
| FMNL2 | formin-like 2 | 0.0588531 |
| LDHA | lactate dehydrogenase A | 0.0579814 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0575047 |
| ENO1 | enolase 1, (alpha) | 0.0546364 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0536232 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0497024 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0492089 |
| SQSTM1 | sequestosome 1 | 0.0487839 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0480856 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0478717 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0466167 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0444798 |
| CALR | calreticulin | 0.043995 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.043359 |
| RPS12 | ribosomal protein S12 | 0.041923 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0415775 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0414842 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0412397 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0407155 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0395877 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0387743 |
| GOLGB1 | golgin B1 | 0.0382592 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0380171 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0369302 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0368947 |
| FLNA | filamin A, alpha | 0.036748 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0366544 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.03665 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0365054 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0364395 |
| PGK1 | phosphoglycerate kinase 1 | 0.0363604 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0361282 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0360115 |
| ANXA2 | annexin A2 | 0.0357365 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.034881 |
| SETX | senataxin | 0.0340366 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0335749 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0328186 |
| PCBP2 | poly(rC) binding protein 2 | 0.0327236 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0325096 |
| USP34 | ubiquitin specific peptidase 34 | 0.0324186 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0321792 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0318081 |
| ZNF638 | zinc finger protein 638 | 0.0314218 |
| PHF3 | PHD finger protein 3 | 0.0311353 |
| CAVIN1 | caveolae associated protein 1 | 0.0307871 |
| SMYD3 | SET and MYND domain containing 3 | 0.0300616 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0299318 |
| SET | SET nuclear proto-oncogene | 0.0297977 |
| CPNE1 | copine I | 0.0295942 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0295181 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0293812 |
| AEBP2 | AE binding protein 2 | 0.0293334 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0291392 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0290505 |
| RPS3 | ribosomal protein S3 | 0.0288251 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0287361 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0286678 |
| FUS | FUS RNA binding protein | 0.0285806 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0284429 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.028354 |
| BRD2 | bromodomain containing 2 | 0.0282908 |
| B2M | beta-2-microglobulin | 0.0282434 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0282123 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0282112 |
| TUT7 | terminal uridylyl transferase 7 | 0.0281619 |
| IRF1 | interferon regulatory factor 1 | 0.0279539 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0279209 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0278917 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0277168 |
| TLE4 | transducin-like enhancer of split 4 | 0.0273831 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0272936 |
| FNIP1 | folliculin interacting protein 1 | 0.0271598 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0270679 |
| GPATCH2L | G patch domain containing 2-like | 0.0269887 |
| RBM25 | RNA binding motif protein 25 | 0.0268304 |
| RPL26 | ribosomal protein L26 | 0.0265271 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0259416 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0257245 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0256727 |
| HMGA2 | high mobility group AT-hook 2 | 0.025635 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0254544 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0253838 |
| CDCP1 | CUB domain containing protein 1 | 0.0250736 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0250243 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0248655 |
| RPL37A | ribosomal protein L37a | 0.0248359 |
| IER3 | immediate early response 3 | 0.0247211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0409133 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0367138 |
| ECT2 | epithelial cell transforming 2 | -0.0301756 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0291122 |
| RIGI | RNA sensor RIG-I | -0.028068 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0259845 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0250139 |
| DIAPH3 | diaphanous-related formin 3 | -0.0245421 |
| PTMA | prothymosin, alpha | -0.024466 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0236313 |
| TPX2 | TPX2, microtubule-associated | -0.0235346 |
| KIAA1328 | KIAA1328 | -0.0218005 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0217764 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0211556 |
| PHF20 | PHD finger protein 20 | -0.0206258 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0204053 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0203616 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0201249 |
| IGF2 | insulin-like growth factor 2 | -0.01996 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0198547 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.019348 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0189332 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.018692 |
| DNER | delta/notch-like EGF repeat containing | -0.0186385 |
| CEP170 | centrosomal protein 170kDa | -0.0182022 |
| ANLN | anillin, actin binding protein | -0.0180013 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0177028 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0175405 |
| HMGB1 | high mobility group box 1 | -0.0174594 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0173029 |
| VMP1 | vacuole membrane protein 1 | -0.017059 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.01704 |
| NALCN | sodium leak channel, non selective | -0.0167464 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | -0.0167461 |
| RPS21 | ribosomal protein S21 | -0.0164866 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0164781 |
| FAM3C | family with sequence similarity 3, member C | -0.016453 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0164273 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0161999 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.016061 |
| H1-0 | H1.0 linker histone | -0.0158324 |
| HLA-B | major histocompatibility complex, class I, B | -0.0157667 |
| CENPF | centromere protein F, 350/400kDa | -0.0157484 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0155071 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.015438 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0153633 |
| CEP95 | centrosomal protein 95kDa | -0.0152227 |
| RRBP1 | ribosome binding protein 1 | -0.0150182 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0148282 |
| RAD51B | RAD51 paralog B | -0.0147686 |
| TRIM33 | tripartite motif containing 33 | -0.0147601 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0146083 |
| TTK | TTK protein kinase | -0.0144845 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.014462 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0143636 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0142378 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0141972 |
| ZNF438 | zinc finger protein 438 | -0.0141898 |
| KIF4A | kinesin family member 4A | -0.0141112 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0139588 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -0.0139547 |
| BBX | bobby sox homolog (Drosophila) | -0.013914 |
| RPL35A | ribosomal protein L35a | -0.0138948 |
| JMJD1C | jumonji domain containing 1C | -0.0137242 |
| RPS28 | ribosomal protein S28 | -0.0137203 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0136977 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.0136582 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0135734 |
| FANCI | Fanconi anemia, complementation group I | -0.0135679 |
| MT2A | metallothionein 2A | -0.0133243 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0132613 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.013259 |
| CRBN | cereblon | -0.01312 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0130467 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.0130099 |
| SRPK2 | SRSF protein kinase 2 | -0.0129879 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0129299 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0128468 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0128221 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.0128177 |
| SMAD5 | SMAD family member 5 | -0.0127549 |
| CUL5 | cullin 5 | -0.0126632 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0125873 |
| HMGB2 | high mobility group box 2 | -0.0125546 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0125074 |
| SSH2 | slingshot protein phosphatase 2 | -0.0124922 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0124775 |
| S100A6 | S100 calcium binding protein A6 | -0.0124499 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0124376 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0123098 |
| ATXN1 | ataxin 1 | -0.012299 |
| DEK | DEK proto-oncogene | -0.0122677 |
| BCL2L1 | BCL2-like 1 | -0.0122435 |
| TXNIP | thioredoxin interacting protein | -0.0121095 |
| ZNF267 | zinc finger protein 267 | -0.0120971 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0120877 |
| SUMF1 | sulfatase modifying factor 1 | -0.012074 |
| ZBTB10 | zinc finger and BTB domain containing 10 | -0.0120711 |
| CLEC2D | C-type lectin domain family 2, member D | -0.0120614 |
| NRG1 | neuregulin 1 | -0.0120537 |
