| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0853895 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0635264 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0628714 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0627583 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0610133 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0605502 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0600897 |
| VEGFA | vascular endothelial growth factor A | 0.0569867 |
| RNF145 | ring finger protein 145 | 0.0533119 |
| COPA | coatomer protein complex, subunit alpha | 0.0529072 |
| HELZ | helicase with zinc finger | 0.0514706 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0489145 |
| FAT1 | FAT atypical cadherin 1 | 0.0457871 |
| SUCO | SUN domain containing ossification factor | 0.0452905 |
| SMAD3 | SMAD family member 3 | 0.0438034 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0436789 |
| PCBP2 | poly(rC) binding protein 2 | 0.04229 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0422405 |
| TPR | translocated promoter region, nuclear basket protein | 0.0412425 |
| CD109 | CD109 molecule | 0.0409067 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0406811 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0406684 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0402429 |
| FAM13A | family with sequence similarity 13, member A | 0.0396472 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0386811 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0385482 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.038434 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0379338 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.037656 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0375652 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.037007 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0357238 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0351779 |
| TXNIP | thioredoxin interacting protein | 0.0346344 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0345424 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0341754 |
| FLNA | filamin A, alpha | 0.0340784 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0336251 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0327203 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0326908 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0322831 |
| GOLGA4 | golgin A4 | 0.0321791 |
| NUP58 | nucleoporin 58 | 0.0315488 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0313959 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0309196 |
| RBM39 | RNA binding motif protein 39 | 0.0308133 |
| SIK3 | SIK family kinase 3 | 0.0305417 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0305395 |
| TPM3 | tropomyosin 3 | 0.0304995 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0304179 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0299068 |
| OGA | O-GlcNAcase | 0.0298193 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0295276 |
| PTK2 | protein tyrosine kinase 2 | 0.0292842 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0288965 |
| NDRG1 | N-myc downstream regulated 1 | 0.028567 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0284977 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0284474 |
| COG5 | component of oligomeric golgi complex 5 | 0.0283316 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0281078 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0278654 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0277247 |
| YBX3 | Y box binding protein 3 | 0.0274614 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0273927 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0273698 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0271121 |
| CDC73 | cell division cycle 73 | 0.0270721 |
| CTBP2 | C-terminal binding protein 2 | 0.0270642 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0268969 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.026839 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0266768 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0265429 |
| EZR | ezrin | 0.0265302 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0265293 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0264628 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0261976 |
| CD44 | CD44 molecule (Indian blood group) | 0.0260882 |
| CCNL1 | cyclin L1 | 0.0258793 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0257955 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0257245 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0256847 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0255467 |
| INSIG2 | insulin induced gene 2 | 0.0255178 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0254966 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.025286 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0250246 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0250148 |
| ZNF292 | zinc finger protein 292 | 0.0249804 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0248806 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0247317 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0244935 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0243235 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0243216 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0241474 |
| GPATCH2L | G patch domain containing 2-like | 0.0240123 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0239821 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0238882 |
| SEPTIN9 | septin 9 | 0.0238306 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0237672 |
| TFG | TRK-fused gene | 0.0237541 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.23282 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.161552 |
| HMGA2 | high mobility group AT-hook 2 | -0.150214 |
| FN1 | fibronectin 1 | -0.149381 |
| PTMA | prothymosin, alpha | -0.136605 |
| SQSTM1 | sequestosome 1 | -0.131455 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.118672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114143 |
| ITGA1 | integrin, alpha 1 | -0.110314 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.104309 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.104288 |
| TMSB10 | thymosin beta 10 | -0.0991509 |
| HLA-B | major histocompatibility complex, class I, B | -0.0935687 |
| S100A6 | S100 calcium binding protein A6 | -0.089533 |
| FTL | ferritin, light polypeptide | -0.0773686 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0714832 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0621328 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0608393 |
| SYT1 | synaptotagmin I | -0.0603346 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0559014 |
| VCL | vinculin | -0.0548391 |
| TMSB4X | thymosin beta 4, X-linked | -0.0545519 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0531175 |
| RAI14 | retinoic acid induced 14 | -0.0524887 |
| ACTG1 | actin gamma 1 | -0.0510093 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0493669 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0484215 |
| RPL35A | ribosomal protein L35a | -0.0448799 |
| IER3 | immediate early response 3 | -0.0444125 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0438657 |
| VIM | vimentin | -0.0417064 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0408352 |
| PLIN2 | perilipin 2 | -0.039929 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0399095 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0396499 |
| TMEM156 | transmembrane protein 156 | -0.0388277 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0383729 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0371531 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0368134 |
| CANX | calnexin | -0.0367155 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0365785 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0361312 |
| MT2A | metallothionein 2A | -0.0360631 |
| RPS24 | ribosomal protein S24 | -0.0358176 |
| S100A10 | S100 calcium binding protein A10 | -0.0355779 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0353318 |
| KLHL5 | kelch-like family member 5 | -0.0348215 |
| H1-0 | H1.0 linker histone | -0.034094 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0332455 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0331524 |
| AHNAK | AHNAK nucleoprotein | -0.0329171 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0325598 |
| RPS21 | ribosomal protein S21 | -0.0316045 |
| S100A9 | S100 calcium binding protein A9 | -0.0310306 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0309671 |
| RPL38 | ribosomal protein L38 | -0.0309545 |
| EFNA5 | ephrin-A5 | -0.0307184 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0303395 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0302772 |
| TENM4 | teneurin transmembrane protein 4 | -0.0299012 |
| TGFA | transforming growth factor, alpha | -0.0296894 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0293592 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.02915 |
| HLA-A | major histocompatibility complex, class I, A | -0.029056 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0284164 |
| PALLD | palladin, cytoskeletal associated protein | -0.0283574 |
| ENO1 | enolase 1, (alpha) | -0.0273018 |
| RPS8 | ribosomal protein S8 | -0.0272914 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0272785 |
| ETV1 | ets variant 1 | -0.0263876 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0255397 |
| GNAS | GNAS complex locus | -0.0247224 |
| B2M | beta-2-microglobulin | -0.0243507 |
| TMEM165 | transmembrane protein 165 | -0.0242516 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0241924 |
| RPL26 | ribosomal protein L26 | -0.0239464 |
| RPS29 | ribosomal protein S29 | -0.0237063 |
| RPL34 | ribosomal protein L34 | -0.0236779 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.023621 |
| POTEF | POTE ankyrin domain family, member F | -0.0235599 |
| OXR1 | oxidation resistance 1 | -0.0235194 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0234319 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0234136 |
| TPM4 | tropomyosin 4 | -0.0232229 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0231085 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0226442 |
| AEBP2 | AE binding protein 2 | -0.0224322 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0224262 |
| HMGA1 | high mobility group AT-hook 1 | -0.0222642 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.022088 |
| DUSP6 | dual specificity phosphatase 6 | -0.0213819 |
| RPLP1 | ribosomal protein, large, P1 | -0.0213448 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0210425 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0210095 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0209686 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0207769 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0206981 |
| ASPH | aspartate beta-hydroxylase | -0.0204652 |
| CD63 | CD63 molecule | -0.0203178 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0200411 |
