ERK5-IN-2_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in SW1417 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ERK5-IN-2_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.101744
FTL ferritin, light polypeptide 0.100802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100241
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0981924
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0882145
EEF2 eukaryotic translation elongation factor 2 0.0780971
CEMIP cell migration inducing protein, hyaluronan binding 0.0641326
RPS3 ribosomal protein S3 0.0508177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0454218
PCBP2 poly(rC) binding protein 2 0.0450576
FLNA filamin A, alpha 0.0431856
RPS12 ribosomal protein S12 0.0428847
GOLGA4 golgin A4 0.0402386
DSPP dentin sialophosphoprotein 0.0400618
EEF1G eukaryotic translation elongation factor 1 gamma 0.0400263
NEBL nebulette 0.0386121
AKAP13 A kinase (PRKA) anchor protein 13 0.0383375
ASPH aspartate beta-hydroxylase 0.0378597
DIAPH1 diaphanous-related formin 1 0.0358086
RPLP2 ribosomal protein, large, P2 0.0350061
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0345109
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342284
KMT2E lysine (K)-specific methyltransferase 2E 0.0338635
APLP2 amyloid beta (A4) precursor-like protein 2 0.0335206
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0333683
RPL18 ribosomal protein L18 0.0323424
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0316795
FAT1 FAT atypical cadherin 1 0.0315992
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0314907
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0313482
SRRM2 serine/arginine repetitive matrix 2 0.0304976
BRD2 bromodomain containing 2 0.0300198
LOC102724023 ES1 protein homolog, mitochondrial 0.0295927
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.029516
YAP1 Yes-associated protein 1 0.0292885
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0292752
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0292259
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0290302
NKD1 naked cuticle homolog 1 (Drosophila) 0.02896
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.028683
VEGFA vascular endothelial growth factor A 0.0285534
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0280674
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0279263
AKAP9 A kinase (PRKA) anchor protein 9 0.0275859
RPL13A ribosomal protein L13a 0.0273768
TXNRD1 thioredoxin reductase 1 0.026993
KRT18 keratin 18, type I 0.0269668
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0262768
KTN1 kinectin 1 (kinesin receptor) 0.0259931
RPS19 ribosomal protein S19 0.0259855
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0254613
IQGAP1 IQ motif containing GTPase activating protein 1 0.0253151
NAV2 neuron navigator 2 0.0252141
MACF1 microtubule-actin crosslinking factor 1 0.0251985
CALR calreticulin 0.0250603
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0250124
TPM3 tropomyosin 3 0.0242758
PNN pinin, desmosome associated protein 0.0240412
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0239022
RPL21 ribosomal protein L21 0.0233189
TRA2B transformer 2 beta homolog (Drosophila) 0.0229228
MKI67 marker of proliferation Ki-67 0.022572
CCNL1 cyclin L1 0.0225094
RPS6 ribosomal protein S6 0.0224018
TSC22D2 TSC22 domain family, member 2 0.0223192
ZNF292 zinc finger protein 292 0.0222353
MED15 mediator complex subunit 15 0.0216889
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0216608
TMF1 TATA element modulatory factor 1 0.0215582
RPL12 ribosomal protein L12 0.0215267
RTN4 reticulon 4 0.0212583
LENG8 leukocyte receptor cluster (LRC) member 8 0.0211734
DPY19L1 dpy-19-like 1 (C. elegans) 0.0210169
NRP1 neuropilin 1 0.0208831
HSPA8 heat shock 70kDa protein 8 0.0208502
APP amyloid beta (A4) precursor protein 0.0208451
CLDN4 claudin 4 0.0207773
LMTK2 lemur tyrosine kinase 2 0.020772
MYH9 myosin, heavy chain 9, non-muscle 0.0207707
GSTP1 glutathione S-transferase pi 1 0.020764
ITGA6 integrin, alpha 6 0.0206442
KLF10 Kruppel-like factor 10 0.0206336
RPL37A ribosomal protein L37a 0.0204709
CENPF centromere protein F, 350/400kDa 0.0202997
SON SON DNA binding protein 0.019949
ADM adrenomedullin 0.0198547
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0198054
RPS18 ribosomal protein S18 0.0196883
ANKRD12 ankyrin repeat domain 12 0.0196734
RPS17 ribosomal protein S17 0.0192798
SHB Src homology 2 domain containing adaptor protein B 0.0192795
L1CAM L1 cell adhesion molecule 0.0189589
CPLX2 complexin 2 0.0189245
ADAM19 ADAM metallopeptidase domain 19 0.0188044
SET SET nuclear proto-oncogene 0.0187535
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0186315
OSBPL8 oxysterol binding protein-like 8 0.0186156
PRRC2C proline-rich coiled-coil 2C 0.0186057
MYO10 myosin X 0.0182132
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0180978

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.10504
MAML2 mastermind-like 2 (Drosophila) -0.0628201
VCL vinculin -0.0614162
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0597795
BCL2L1 BCL2-like 1 -0.0595379
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0589837
AHNAK AHNAK nucleoprotein -0.0536126
EPCAM epithelial cell adhesion molecule -0.0529217
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.050208
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0455775
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0435518
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0435268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0430695
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0424593
RPS24 ribosomal protein S24 -0.0423476
CCND1 cyclin D1 -0.0411115
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0409745
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0378682
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.036865
TAS2R14 taste receptor, type 2, member 14 -0.0361776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0359692
TMEM123 transmembrane protein 123 -0.035262
CUX1 cut-like homeobox 1 -0.0341635
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0309559
EHBP1 EH domain binding protein 1 -0.0304144
SERINC5 serine incorporator 5 -0.0301406
IFRD1 interferon-related developmental regulator 1 -0.0300556
NFIA nuclear factor I/A -0.0296418
LARP4B La ribonucleoprotein domain family, member 4B -0.0296353
H1-0 H1.0 linker histone -0.0295705
NCOA3 nuclear receptor coactivator 3 -0.0280679
PATJ PATJ crumbs cell polarity complex component -0.0278834
GNAS GNAS complex locus -0.0275224
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0264233
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.02625
CD2AP CD2-associated protein -0.0261492
RAD21 RAD21 homolog (S. pombe) -0.02612
SDC4 syndecan 4 -0.0260321
STAU1 staufen double-stranded RNA binding protein 1 -0.0257642
MYO1E myosin IE -0.0256387
SQSTM1 sequestosome 1 -0.0254612
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0253966
SENP5 SUMO1/sentrin specific peptidase 5 -0.0252474
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0247197
SMAD2 SMAD family member 2 -0.0246223
DLG1 discs, large homolog 1 (Drosophila) -0.024287
CANX calnexin -0.0241423
PERP PERP, TP53 apoptosis effector -0.0240365
KLF5 Kruppel-like factor 5 (intestinal) -0.0239712
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0238228
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0237247
IER3 immediate early response 3 -0.0236873
RPS21 ribosomal protein S21 -0.0234888
ZNF217 zinc finger protein 217 -0.0233478
ZMYND8 zinc finger, MYND-type containing 8 -0.0231218
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0228282
OGA O-GlcNAcase -0.0227446
KDM3A lysine (K)-specific demethylase 3A -0.0225338
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0223958
TPT1 tumor protein, translationally-controlled 1 -0.0221612
ACTN4 actinin, alpha 4 -0.0220937
ACTG1 actin gamma 1 -0.0219999
NT5C2 5'-nucleotidase, cytosolic II -0.021956
PLSCR1 phospholipid scramblase 1 -0.0218923
PRELID2 PRELI domain containing 2 -0.0217294
PCBP3 poly(rC) binding protein 3 -0.0213209
ZCCHC7 zinc finger, CCHC domain containing 7 -0.020959
PRPF6 pre-mRNA processing factor 6 -0.020806
RAB1A RAB1A, member RAS oncogene family -0.0206792
OSBPL3 oxysterol binding protein-like 3 -0.0206051
INTS6 integrator complex subunit 6 -0.0205977
KPNB1 karyopherin (importin) beta 1 -0.0205321
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.020447
ZBTB20 zinc finger and BTB domain containing 20 -0.0203846
BZW1 basic leucine zipper and W2 domains 1 -0.0203052
RAB10 RAB10, member RAS oncogene family -0.0201823
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0201375
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0200819
S100A6 S100 calcium binding protein A6 -0.0200801
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0199685
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.019762
UBAP2 ubiquitin associated protein 2 -0.0196118
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0192526
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0192309
GPATCH8 G patch domain containing 8 -0.0192307
OXSR1 oxidative stress responsive 1 -0.0192125
RPL35A ribosomal protein L35a -0.0191903
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0191714
LOC112694756 uncharaterized LOC112694756 -0.0190426
COTL1 coactosin-like F-actin binding protein 1 -0.0190409
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0190111
SAV1 salvador family WW domain containing protein 1 -0.0188207
ARHGAP5 Rho GTPase activating protein 5 -0.0187922
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0185835
RPL39 ribosomal protein L39 -0.0183441
KCMF1 potassium channel modulatory factor 1 -0.0179533
MED13L mediator complex subunit 13-like -0.0175397
PARD6B par-6 family cell polarity regulator beta -0.017338
KRT8 keratin 8, type II -0.0173293
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0171212