| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ERK5-IN-2 perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ERK5-IN-2_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.106684 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0875582 |
| ASPH | aspartate beta-hydroxylase | 0.0831017 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0766594 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.069507 |
| EZR | ezrin | 0.0597189 |
| LDHA | lactate dehydrogenase A | 0.057671 |
| DST | dystonin | 0.057304 |
| KRT18 | keratin 18, type I | 0.0552812 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0544632 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0534695 |
| ANXA2 | annexin A2 | 0.0529406 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0525813 |
| NAV2 | neuron navigator 2 | 0.0480144 |
| PGK1 | phosphoglycerate kinase 1 | 0.0459807 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0438479 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0438038 |
| ENO1 | enolase 1, (alpha) | 0.0435683 |
| CDH13 | cadherin 13 | 0.0413115 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0406315 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0400957 |
| DSPP | dentin sialophosphoprotein | 0.0400301 |
| VCL | vinculin | 0.0390603 |
| SPATA13 | spermatogenesis associated 13 | 0.0370985 |
| FLNB | filamin B, beta | 0.036744 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0366808 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0354353 |
| ITGA6 | integrin, alpha 6 | 0.0353423 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0352171 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0333042 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0332466 |
| MYOF | myoferlin | 0.0323336 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0321509 |
| VIM | vimentin | 0.0320107 |
| CANX | calnexin | 0.0314086 |
| ACTN1 | actinin, alpha 1 | 0.031311 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0308134 |
| GOLGA4 | golgin A4 | 0.0306276 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0299791 |
| LMO7 | LIM domain 7 | 0.0296454 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.029285 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.02859 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.028439 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0282952 |
| INTS6 | integrator complex subunit 6 | 0.027968 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0278377 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0274544 |
| KRT8 | keratin 8, type II | 0.0270198 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0269547 |
| PCBP2 | poly(rC) binding protein 2 | 0.0267952 |
| TMSB4X | thymosin beta 4, X-linked | 0.0258851 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0258134 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.025767 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0251664 |
| ITGB4 | integrin, beta 4 | 0.0251591 |
| PLEC | plectin | 0.024674 |
| RPS3 | ribosomal protein S3 | 0.0245017 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0244065 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.024066 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0231966 |
| TPM3 | tropomyosin 3 | 0.0230998 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0229974 |
| CALR | calreticulin | 0.0225954 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0225781 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.022542 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0224455 |
| COPA | coatomer protein complex, subunit alpha | 0.0222967 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0220326 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0220038 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.021967 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0219569 |
| SMAD3 | SMAD family member 3 | 0.0217397 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0217197 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0215112 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0214464 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.021413 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0213646 |
| GLG1 | golgi glycoprotein 1 | 0.0213357 |
| LAMA4 | laminin, alpha 4 | 0.0211802 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0209967 |
| KIZ | kizuna centrosomal protein | 0.020976 |
| SEPTIN9 | septin 9 | 0.0208238 |
| CDK6 | cyclin-dependent kinase 6 | 0.0207675 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0206458 |
| EFNB2 | ephrin-B2 | 0.0205722 |
| FLNA | filamin A, alpha | 0.0202931 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0201941 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0201716 |
| GOLGB1 | golgin B1 | 0.0199721 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0197848 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0196958 |
| TPM4 | tropomyosin 4 | 0.0195691 |
| COBL | cordon-bleu WH2 repeat protein | 0.0195604 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0195421 |
| SKAP1 | src kinase associated phosphoprotein 1 | 0.0194287 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0193151 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0192077 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.019093 |
| MYO1E | myosin IE | 0.0190815 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0190777 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107003 |
| RPL35A | ribosomal protein L35a | -0.0786192 |
| TMSB10 | thymosin beta 10 | -0.0499279 |
| RPS19 | ribosomal protein S19 | -0.0401329 |
| RPLP1 | ribosomal protein, large, P1 | -0.0395042 |
| RPS6 | ribosomal protein S6 | -0.0391131 |
| RPS21 | ribosomal protein S21 | -0.0365878 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0321305 |
| MT2A | metallothionein 2A | -0.0316169 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.030386 |
| SYT1 | synaptotagmin I | -0.0291685 |
| RPS23 | ribosomal protein S23 | -0.0264852 |
| RPL34 | ribosomal protein L34 | -0.0253024 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0243665 |
| RPLP2 | ribosomal protein, large, P2 | -0.0240449 |
| HMGB1 | high mobility group box 1 | -0.0209741 |
| RPL28 | ribosomal protein L28 | -0.0208649 |
| RPL23 | ribosomal protein L23 | -0.0207365 |
| RPL32 | ribosomal protein L32 | -0.0204937 |
| RPL19 | ribosomal protein L19 | -0.0204164 |
| RPS13 | ribosomal protein S13 | -0.0199782 |
| RPL35 | ribosomal protein L35 | -0.0198183 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0191216 |
| RPS5 | ribosomal protein S5 | -0.0183981 |
| RNF43 | ring finger protein 43 | -0.0183959 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0182426 |
| RPL38 | ribosomal protein L38 | -0.018207 |
| RPS15 | ribosomal protein S15 | -0.0180899 |
| RPS29 | ribosomal protein S29 | -0.0179413 |
| CENPF | centromere protein F, 350/400kDa | -0.0175946 |
| RPL11 | ribosomal protein L11 | -0.0175121 |
| CCND1 | cyclin D1 | -0.0174868 |
| RPS24 | ribosomal protein S24 | -0.0171976 |
| ZNRF3 | zinc and ring finger 3 | -0.0169076 |
| RPS16 | ribosomal protein S16 | -0.0166764 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0162154 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0161135 |
| RPS11 | ribosomal protein S11 | -0.0159602 |
| RBM39 | RNA binding motif protein 39 | -0.0154399 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0153662 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.0151249 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0151166 |
| OXR1 | oxidation resistance 1 | -0.0148899 |
| DIAPH3 | diaphanous-related formin 3 | -0.0144882 |
| RPL39 | ribosomal protein L39 | -0.0144153 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0143909 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0143274 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0140041 |
| RBMX | RNA binding motif protein, X-linked | -0.0139616 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0139536 |
| RPS14 | ribosomal protein S14 | -0.0137532 |
| RPL5 | ribosomal protein L5 | -0.0136649 |
| DEK | DEK proto-oncogene | -0.0136635 |
| MT1X | metallothionein 1X | -0.0135038 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | -0.0133681 |
| RPL27A | ribosomal protein L27a | -0.0133668 |
| TNS4 | tensin 4 | -0.0132951 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0132194 |
| RPL31 | ribosomal protein L31 | -0.0131197 |
| S100A9 | S100 calcium binding protein A9 | -0.0131107 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.013072 |
| HDAC8 | histone deacetylase 8 | -0.0130165 |
| RPS20 | ribosomal protein S20 | -0.0129184 |
| TXNIP | thioredoxin interacting protein | -0.0125389 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0124643 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0123854 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.012289 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.012173 |
| MKI67 | marker of proliferation Ki-67 | -0.0120121 |
| MYO1D | myosin ID | -0.0119679 |
| RBM25 | RNA binding motif protein 25 | -0.0119185 |
| RPL30 | ribosomal protein L30 | -0.0118119 |
| BCL2L1 | BCL2-like 1 | -0.0117643 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0116452 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0115488 |
| SGO2 | shugoshin 2 | -0.0112902 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0112338 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.011204 |
| FOXP1 | forkhead box P1 | -0.0111755 |
| OLA1 | Obg-like ATPase 1 | -0.0110806 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0110192 |
| HMGB2 | high mobility group box 2 | -0.0109541 |
| CBFB | core-binding factor, beta subunit | -0.0109429 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0109232 |
| TASP1 | taspase, threonine aspartase, 1 | -0.0107629 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0106867 |
| MSI2 | musashi RNA-binding protein 2 | -0.0106551 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.010519 |
| RBL1 | retinoblastoma-like 1 | -0.010467 |
| RPL36 | ribosomal protein L36 | -0.0104438 |
| CBX3 | chromobox homolog 3 | -0.010363 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0103544 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0103479 |
| RPL9 | ribosomal protein L9 | -0.010182 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0101818 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0101536 |
| RPL37A | ribosomal protein L37a | -0.00998814 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | -0.00991526 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0098901 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.00987268 |
