ERK5-IN-2_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ERK5-IN-2 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ERK5-IN-2_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.40424
VIM vimentin 0.263826
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108611
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104112
AKAP12 A kinase (PRKA) anchor protein 12 0.100585
INHBA inhibin, beta A 0.0914483
HLA-B major histocompatibility complex, class I, B 0.0904408
EEF2 eukaryotic translation elongation factor 2 0.0900808
COL6A1 collagen, type VI, alpha 1 0.0854953
B2M beta-2-microglobulin 0.0821761
TPT1 tumor protein, translationally-controlled 1 0.0816117
COL6A3 collagen, type VI, alpha 3 0.0714383
ASPH aspartate beta-hydroxylase 0.0705529
CXCL8 chemokine (C-X-C motif) ligand 8 0.0676087
CD44 CD44 molecule (Indian blood group) 0.0662218
MYO10 myosin X 0.0661361
CALR calreticulin 0.0644244
LIMS1 LIM and senescent cell antigen-like domains 1 0.0626775
NALF1 NALCN channel auxiliary factor 1 0.0623718
TGFBI transforming growth factor, beta-induced, 68kDa 0.0622497
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0611051
MYH9 myosin, heavy chain 9, non-muscle 0.0605172
TMSB10 thymosin beta 10 0.0600636
TRIO trio Rho guanine nucleotide exchange factor 0.0580157
MT2A metallothionein 2A 0.0569293
STC1 stanniocalcin 1 0.05635
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0554059
LDHA lactate dehydrogenase A 0.0544496
ENO1 enolase 1, (alpha) 0.0538016
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0537475
EIF1 eukaryotic translation initiation factor 1 0.0532469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0522497
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0522417
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0519025
COL6A2 collagen, type VI, alpha 2 0.0517347
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0515256
PRKG1 protein kinase, cGMP-dependent, type I 0.0493507
HMGA2 high mobility group AT-hook 2 0.0491669
NDRG1 N-myc downstream regulated 1 0.0474101
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0468488
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0457441
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0451751
RPS12 ribosomal protein S12 0.0444671
NAV1 neuron navigator 1 0.0442539
DST dystonin 0.0435546
FTL ferritin, light polypeptide 0.0435138
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0433161
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0421377
RPS8 ribosomal protein S8 0.0420014
JARID2 jumonji, AT rich interactive domain 2 0.0416162
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0410566
RPS6 ribosomal protein S6 0.0404353
TIMP1 TIMP metallopeptidase inhibitor 1 0.0383706
ANXA2 annexin A2 0.0383578
ADM adrenomedullin 0.0380892
VEGFA vascular endothelial growth factor A 0.0379432
PRRC2C proline-rich coiled-coil 2C 0.0374712
KTN1 kinectin 1 (kinesin receptor) 0.0371103
HLA-A major histocompatibility complex, class I, A 0.0369179
ACTG1 actin gamma 1 0.0367436
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0364493
ALCAM activated leukocyte cell adhesion molecule 0.0360954
RPL37A ribosomal protein L37a 0.0355934
FTH1 ferritin, heavy polypeptide 1 0.0352711
FBN1 fibrillin 1 0.0341356
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0332484
RPL23 ribosomal protein L23 0.0331341
RPS3 ribosomal protein S3 0.032658
HLA-E major histocompatibility complex, class I, E 0.032433
PKM pyruvate kinase, muscle 0.032109
PGK1 phosphoglycerate kinase 1 0.0320255
GLIS3 GLIS family zinc finger 3 0.0312778
TPM4 tropomyosin 4 0.0311646
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0308691
FAM13A family with sequence similarity 13, member A 0.0308515
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0307611
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0302058
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0300482
RPLP1 ribosomal protein, large, P1 0.0299838
CANX calnexin 0.0297687
APP amyloid beta (A4) precursor protein 0.0297236
SAMD4A sterile alpha motif domain containing 4A 0.0297163
PTMA prothymosin, alpha 0.0296376
LOX lysyl oxidase 0.0294712
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0291831
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0290749
MACF1 microtubule-actin crosslinking factor 1 0.0282997
TIMP2 TIMP metallopeptidase inhibitor 2 0.0282342
CTSB cathepsin B 0.0279365
RPS19 ribosomal protein S19 0.0278407
GOLGA4 golgin A4 0.0278041
FMNL2 formin-like 2 0.0277345
RPL31 ribosomal protein L31 0.0276719
CDH13 cadherin 13 0.0276357
HIPK2 homeodomain interacting protein kinase 2 0.0273991
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0273058
CALU calumenin 0.027254
ZSWIM6 zinc finger, SWIM-type containing 6 0.0267364
ENO2 enolase 2 (gamma, neuronal) 0.0265455
RPL26 ribosomal protein L26 0.0264781

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.0170475
CDK17 cyclin-dependent kinase 17 -0.0132901
ZEB1 zinc finger E-box binding homeobox 1 -0.0115365
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0114768
PLPP3 phospholipid phosphatase 3 -0.0114011
ARHGAP21 Rho GTPase activating protein 21 -0.0113123
ADGRB3 adhesion G protein-coupled receptor B3 -0.0109029
H1-0 H1.0 linker histone -0.00969286
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.00957633
MMP1 matrix metallopeptidase 1 -0.00875204
ATP13A3 ATPase type 13A3 -0.00791895
COL5A3 collagen, type V, alpha 3 -0.00778179
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00766729
SOCS5 suppressor of cytokine signaling 5 -0.00735641
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.007337
ARHGAP24 Rho GTPase activating protein 24 -0.0072159
CEP95 centrosomal protein 95kDa -0.00707091
CCDC102B coiled-coil domain containing 102B -0.00704813
TSHZ3 teashirt zinc finger homeobox 3 -0.00667904
SASH1 SAM and SH3 domain containing 1 -0.0066478
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.00664709
SMOX spermine oxidase -0.0064741
RHOQ ras homolog family member Q -0.00646
SPRY4 sprouty homolog 4 (Drosophila) -0.00613572
RNF152 ring finger protein 152 -0.00573266
PAMR1 peptidase domain containing associated with muscle regeneration 1 -0.00573006
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.00558426
HHIP hedgehog interacting protein -0.00555168
RPL6 ribosomal protein L6 -0.00539567
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00530442
BRWD3 bromodomain and WD repeat domain containing 3 -0.00526406
MON2 MON2 homolog (S. cerevisiae) -0.00523953
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00510728
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.00503832
APAF1 apoptotic peptidase activating factor 1 -0.00500161
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00494674
RARS1 arginyl-tRNA synthetase 1 -0.00493803
CDC27 cell division cycle 27 -0.00484564
SPRED1 sprouty-related, EVH1 domain containing 1 -0.00483337
ECD ecdysoneless homolog (Drosophila) -0.00481826
EBF1 early B-cell factor 1 -0.00466304
TUBB6 tubulin, beta 6 class V -0.00465282
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.00461933
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.00457634
PARVA parvin, alpha -0.00446746
GRB2 growth factor receptor-bound protein 2 -0.00443376
EDNRA endothelin receptor type A -0.00440793
HAS2 hyaluronan synthase 2 -0.0042717
SYAP1 synapse associated protein 1 -0.00426301
LUC7L LUC7-like (S. cerevisiae) -0.00423436
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.00422632
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -0.00421635
PRMT9 protein arginine methyltransferase 9 -0.00421255
GOLT1B golgi transport 1B -0.00421036
HOXB3 homeobox B3 -0.00420959
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.00419815
SYNJ1 synaptojanin 1 -0.00416098
IREB2 iron-responsive element binding protein 2 -0.00415507
FBXO38 F-box protein 38 -0.0041498
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.00413863
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.00409117
ANLN anillin, actin binding protein -0.0040863
GLI2 GLI family zinc finger 2 -0.00403929
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00398093
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.00398004
ARID3B AT rich interactive domain 3B (BRIGHT-like) -0.00397159
MED23 mediator complex subunit 23 -0.00396432
USPL1 ubiquitin specific peptidase like 1 -0.00396302
MSI2 musashi RNA-binding protein 2 -0.0039509
SCLT1 sodium channel and clathrin linker 1 -0.00394687
SP3 Sp3 transcription factor -0.00393295
PRPF3 pre-mRNA processing factor 3 -0.00390679
NUP214 nucleoporin 214kDa -0.00386652
USP3 ubiquitin specific peptidase 3 -0.00386242
DUSP10 dual specificity phosphatase 10 -0.00384602
DDB2 damage-specific DNA binding protein 2, 48kDa -0.00380845
NEMF nuclear export mediator factor -0.00379818
KCTD10 potassium channel tetramerization domain containing 10 -0.00379403
TSLIG1 tRNA splicing ligase complex subunit 1 -0.00373122
TUBE1 tubulin, epsilon 1 -0.00371284
PTCHD4 patched domain containing 4 -0.00370942
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -0.00370075
NDFIP2 Nedd4 family interacting protein 2 -0.00369411
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -0.00367196
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -0.00362332
TBX18 T-box 18 -0.00360521
COL1A1 collagen, type I, alpha 1 -0.00357809
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.00354547
CAPNS1 calpain, small subunit 1 -0.0035452
ANKRD50 ankyrin repeat domain 50 -0.00353086
TENT2 terminal nucleotidyltransferase 2 -0.00352656
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -0.0035254
TMEM39A transmembrane protein 39A -0.00352354
DCP1B decapping mRNA 1B -0.00351706
VGLL3 vestigial-like family member 3 -0.00350817
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0035065
AARSD1 alanyl-tRNA synthetase domain containing 1 -0.00349687
PID1 phosphotyrosine interaction domain containing 1 -0.00349364
ZMYM6 zinc finger, MYM-type 6 -0.00347975
ETNK1 ethanolamine kinase 1 -0.00347842