ERK5 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase 7|The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5598)
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100 substrates of the kinase ERK5 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
GPRIN1 G protein regulated inducer of neurite outgrowth 1
CHAMP1 chromosome alignment maintaining phosphoprotein 1
ZNF205 zinc finger protein 205
SIK3 SIK family kinase 3
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
AHNAK AHNAK nucleoprotein
NKX2-2 NK2 homeobox 2
NKX2-4 NK2 homeobox 4
BCL9L B-cell CLL/lymphoma 9-like
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
MAP7D1 MAP7 domain containing 1
TPST2 tyrosylprotein sulfotransferase 2
DAB2IP DAB2 interacting protein
ISCU iron-sulfur cluster assembly enzyme
TNS1 tensin 1
SH3RF1 SH3 domain containing ring finger 1
RGL3 ral guanine nucleotide dissociation stimulator-like 3
FMN1 formin 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
WASF1 WAS protein family, member 1
NCOR2 nuclear receptor corepressor 2
ERBB2IP erbb2 interacting protein
BICD1 bicaudal D homolog 1 (Drosophila)
NEURL4 neuralized E3 ubiquitin protein ligase 4
HTRA2 HtrA serine peptidase 2
LIN9 lin-9 DREAM MuvB core complex component
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7 myosin, heavy chain 7, cardiac muscle, beta
UBN2 ubinuclein 2
ZNF524 zinc finger protein 524
ARID1A AT rich interactive domain 1A (SWI-like)
MDC1 mediator of DNA-damage checkpoint 1
PTH1R parathyroid hormone 1 receptor
SRP72 signal recognition particle 72kDa
LSM11 LSM11, U7 small nuclear RNA associated
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
ZIC5 Zic family member 5
BRSK2 BR serine/threonine kinase 2
BRSK1 BR serine/threonine kinase 1
RANBP2 RAN binding protein 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
C2CD3 C2 calcium-dependent domain containing 3
WIPF3 WAS/WASL interacting protein family, member 3
CASKIN1 CASK interacting protein 1
TRIP10 thyroid hormone receptor interactor 10
FOXK1 forkhead box K1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
PHOX2A paired-like homeobox 2a
LRP2 low density lipoprotein receptor-related protein 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
TSLIG2 tRNA splicing ligase complex subunit 2
CDCA2 cell division cycle associated 2
PTGR2 prostaglandin reductase 2
MTUS1 microtubule associated tumor suppressor 1
RGCC regulator of cell cycle
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
ZC3H12D zinc finger CCCH-type containing 12D
SYNPO2 synaptopodin 2
FXR2 fragile X mental retardation, autosomal homolog 2
MAP1S microtubule-associated protein 1S
EPB41L5 erythrocyte membrane protein band 4.1 like 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
KLHDC4 kelch domain containing 4
EDC4 enhancer of mRNA decapping 4
CSDC2 cold shock domain containing C2, RNA binding
MTX1 metaxin 1
AFF2 AF4/FMR2 family, member 2
KIAA0195 KIAA0195
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYNPO synaptopodin
AHCTF1 AT hook containing transcription factor 1
IRF2BP2 interferon regulatory factor 2 binding protein 2
TNRC18 trinucleotide repeat containing 18
NOS2 nitric oxide synthase 2, inducible
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
KIF1C kinesin family member 1C
MED4 mediator complex subunit 4
TOP2A topoisomerase (DNA) II alpha 170kDa
MYO9A myosin IXA
RAVER1 ribonucleoprotein, PTB-binding 1
FAM110D family with sequence similarity 110, member D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
TNRC6A trinucleotide repeat containing 6A
INCENP inner centromere protein antigens 135/155kDa
ZNF629 zinc finger protein 629
CNKSR1 connector enhancer of kinase suppressor of Ras 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
SOWAHC sosondowah ankyrin repeat domain family member C
AKIRIN2 akirin 2
SRRM2 serine/arginine repetitive matrix 2
ARHGAP27 Rho GTPase activating protein 27
NACAD NAC alpha domain containing
ESAM endothelial cell adhesion molecule
HSF1 heat shock transcription factor 1
SPEG SPEG complex locus