Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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360 genes differentially expressed following the ESC_J1_UP_EARLY.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AAED1 AhpC/TSA antioxidant enzyme domain containing 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSS1 acyl-CoA synthetase short-chain family member 1
ADCK3 aarF domain containing kinase 3
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADM adrenomedullin
ADSSL1 adenylosuccinate synthase like 1
ADTRP androgen-dependent TFPI-regulating protein
AKR1C2 aldo-keto reductase family 1, member C2
ALX3 ALX homeobox 3
AMPH amphiphysin
ANGPTL7 angiopoietin-like 7
APOC4 apolipoprotein C-IV
AQP3 aquaporin 3 (Gill blood group)
ASCL2 achaete-scute family bHLH transcription factor 2
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AUP1 ancient ubiquitous protein 1
BCL2L2 BCL2-like 2
BMP7 bone morphogenetic protein 7
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BTN1A1 butyrophilin, subfamily 1, member A1
C10ORF35 chromosome 10 open reading frame 35
C10ORF54 chromosome 10 open reading frame 54
C10ORF82 chromosome 10 open reading frame 82
C14ORF132 chromosome 14 open reading frame 132
C14ORF37 chromosome 14 open reading frame 37
C16ORF62 chromosome 16 open reading frame 62
C19ORF66 chromosome 19 open reading frame 66
C1ORF210 chromosome 1 open reading frame 210
C4BPA complement component 4 binding protein, alpha
C9ORF89 chromosome 9 open reading frame 89
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD33 CD33 molecule
CD47 CD47 molecule
CD68 CD68 molecule
CD82 CD82 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDHR1 cadherin-related family member 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIDEB cell death-inducing DFFA-like effector b
COL26A1 collagen, type XXVI, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CORO2A coronin, actin binding protein, 2A
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPT1B carnitine palmitoyltransferase 1B (muscle)
CRELD1 cysteine-rich with EGF-like domains 1
CUBN cubilin (intrinsic factor-cobalamin receptor)
CUL4A cullin 4A
CXCL12 chemokine (C-X-C motif) ligand 12
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DENND6A DENN/MADD domain containing 6A
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIDO1 death inducer-obliterator 1
DLL1 delta-like 1 (Drosophila)
DPP7 dipeptidyl-peptidase 7
DRAM2 DNA-damage regulated autophagy modulator 2
DSCAM Down syndrome cell adhesion molecule
ECE2 endothelin converting enzyme 2
EDARADD EDAR-associated death domain
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
EPHB3 EPH receptor B3
EVPL envoplakin
FAM134B family with sequence similarity 134, member B
FGF14 fibroblast growth factor 14
FGFRL1 fibroblast growth factor receptor-like 1
FLT3 fms-related tyrosine kinase 3
FMNL3 formin-like 3
FOSL1 FOS-like antigen 1
FSCN3 fascin actin-bundling protein 3, testicular
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GDE1 glycerophosphodiester phosphodiesterase 1
GIMAP3P GTPase, IMAP family member 3 pseudogene
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX6 glutathione peroxidase 6
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HES6 hes family bHLH transcription factor 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMX2 H6 family homeobox 2
HOMER1 homer scaffolding protein 1
HPGDS hematopoietic prostaglandin D synthase
ICE2 interactor of little elongation complex ELL subunit 2
IL15 interleukin 15
IL36RN interleukin 36 receptor antagonist
IRX2 iroquois homeobox 2
KANK3 KN motif and ankyrin repeat domains 3
KIAA0195 KIAA0195
KRT13 keratin 13, type I
KRT7 keratin 7, type II
KRTAP13-1 keratin associated protein 13-1
LHX3 LIM homeobox 3
LMBRD1 LMBR1 domain containing 1
LOXL2 lysyl oxidase-like 2
LYRM5 LYR motif containing 5
MAG myelin associated glycoprotein
MEP1B meprin A, beta
METTL20 methyltransferase like 20
MKL2 MKL/myocardin-like 2
MOCS1 molybdenum cofactor synthesis 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MYB v-myb avian myeloblastosis viral oncogene homolog
NAAA N-acylethanolamine acid amidase
NAGA N-acetylgalactosaminidase, alpha-
NAGLU N-acetylglucosaminidase, alpha
NAGS N-acetylglutamate synthase
NANOS1 nanos homolog 1 (Drosophila)
NARF nuclear prelamin A recognition factor
NCF1 neutrophil cytosolic factor 1
NDRG1 N-myc downstream regulated 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NEK2 NIMA-related kinase 2
NGLY1 N-glycanase 1
NHSL1 NHS-like 1
NLRP3 NLR family, pyrin domain containing 3
NME3 NME/NM23 nucleoside diphosphate kinase 3
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSG1 neuron specific gene family member 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCSK4 proprotein convertase subtilisin/kexin type 4
PCTP phosphatidylcholine transfer protein
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDPN podoplanin
PHF21A PHD finger protein 21A
PHOX2B paired-like homeobox 2b
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLH polymerase (DNA directed), eta
PPAP2B phosphatidic acid phosphatase type 2B
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS8 protease, serine, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASL11B RAS-like, family 11, member B
RB1 retinoblastoma 1
RPL22 ribosomal protein L22
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCRN3 secernin 3
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN3 sestrin 3
SIL1 SIL1 nucleotide exchange factor
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SOX15 SRY (sex determining region Y)-box 15
ST5 suppression of tumorigenicity 5
STC1 stanniocalcin 1
TEX101 testis expressed 101
TEX264 testis expressed 264
TFF3 trefoil factor 3 (intestinal)
THRA thyroid hormone receptor, alpha
TLE6 transducin-like enhancer of split 6
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM106C transmembrane protein 106C
TMEM38A transmembrane protein 38A
TPGS1 tubulin polyglutamylase complex subunit 1
TRAFD1 TRAF-type zinc finger domain containing 1
TRIB2 tribbles pseudokinase 2
TSHZ1 teashirt zinc finger homeobox 1
TSPAN1 tetraspanin 1
TTR transthyretin
TXNDC16 thioredoxin domain containing 16
TYMP thymidine phosphorylase
WBSCR27 Williams Beuren syndrome chromosome region 27
ZBTB16 zinc finger and BTB domain containing 16
ZBTB7C zinc finger and BTB domain containing 7C
ZFPM2 zinc finger protein, FOG family member 2
ZIC2 Zic family member 2

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADAM23 ADAM metallopeptidase domain 23
ADAP2 ArfGAP with dual PH domains 2
AMH anti-Mullerian hormone
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
ANXA3 annexin A3
ANXA5 annexin A5
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOBR apolipoprotein B receptor
ARHGAP35 Rho GTPase activating protein 35
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATF5 activating transcription factor 5
ATP9B ATPase, class II, type 9B
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
BAG5 BCL2-associated athanogene 5
BCL3 B-cell CLL/lymphoma 3
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
BMP1 bone morphogenetic protein 1
BMP4 bone morphogenetic protein 4
BMS1 BMS1 ribosome biogenesis factor
BRWD1 bromodomain and WD repeat domain containing 1
C11ORF24 chromosome 11 open reading frame 24
C16ORF74 chromosome 16 open reading frame 74
C17ORF96 chromosome 17 open reading frame 96
C19ORF48 chromosome 19 open reading frame 48
CA7 carbonic anhydrase VII
CCDC59 coiled-coil domain containing 59
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPB centromere protein B, 80kDa
CIRBP cold inducible RNA binding protein
CNN1 calponin 1, basic, smooth muscle
CRYL1 crystallin, lambda 1
CTRB1 chymotrypsinogen B1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DCLRE1B DNA cross-link repair 1B
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30
DPYSL5 dihydropyrimidinase-like 5
DRD4 dopamine receptor D4
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EMP2 epithelial membrane protein 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERAS ES cell expressed Ras
ERF Ets2 repressor factor
ETV4 ets variant 4
FAM118B family with sequence similarity 118, member B
FBXO33 F-box protein 33
FETUB fetuin B
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FKBPL FK506 binding protein like
FOXD3 forkhead box D3
GAP43 growth associated protein 43
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GBX2 gastrulation brain homeobox 2
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPATCH4 G patch domain containing 4
GSG2 germ cell associated 2 (haspin)
GSPT2 G1 to S phase transition 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H2BC histone cluster 1, H2bc
HYAL2 hyaluronoglucosaminidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
INHBB inhibin, beta B
JUNB jun B proto-oncogene
KLF1 Kruppel-like factor 1 (erythroid)
KLF13 Kruppel-like factor 13
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae)
LALBA lactalbumin, alpha-
LAMA1 laminin, alpha 1
LAMC2 laminin, gamma 2
LIMS2 LIM and senescent cell antigen-like domains 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LPP LIM domain containing preferred translocation partner in lipoma
LTB lymphotoxin beta (TNF superfamily, member 3)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MDN1 MDN1, midasin homolog (yeast)
MED6 mediator complex subunit 6
METTL13 methyltransferase like 13
MRAS muscle RAS oncogene homolog
MRPS11 mitochondrial ribosomal protein S11
MTG2 mitochondrial ribosome-associated GTPase 2
MVK mevalonate kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL9 myosin, light chain 9, regulatory
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NAPSA napsin A aspartic peptidase
NIFK nucleolar protein interacting with the FHA domain of MKI67
NINJ2 ninjurin 2
NOL12 nucleolar protein 12
NSUN4 NOP2/Sun domain family, member 4
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PACRGL PARK2 co-regulated-like
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PHB prohibitin
PPCS phosphopantothenoylcysteine synthetase
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PQLC2 PQ loop repeat containing 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
QSER1 glutamine and serine rich 1
RAB33A RAB33A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RECQL RecQ helicase-like
REEP6 receptor accessory protein 6
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REM2 RAS (RAD and GEM)-like GTP binding 2
RIOK2 RIO kinase 2
RNASE4 ribonuclease, RNase A family, 4
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPP25 ribonuclease P/MRP 25kDa subunit
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAP30BP SAP30 binding protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35G3 solute carrier family 35, member G3
SOCS3 suppressor of cytokine signaling 3
SPRY4 sprouty homolog 4 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK4 serine/threonine kinase 4
SYT12 synaptotagmin XII
TAGLN transgelin
TCF15 transcription factor 15 (basic helix-loop-helix)
TFEB transcription factor EB
TGM1 transglutaminase 1
TGM3 transglutaminase 3
TLE4 transducin-like enhancer of split 4
TLR9 toll-like receptor 9
TMC6 transmembrane channel-like 6
TMEM121 transmembrane protein 121
TMEM98 transmembrane protein 98
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52L3 tumor protein D52-like 3
TRAIP TRAF interacting protein
TREM2 triggering receptor expressed on myeloid cells 2
TREX1 three prime repair exonuclease 1
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSPYL4 TSPY-like 4
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UHRF1BP1L UHRF1 binding protein 1-like
USP38 ubiquitin specific peptidase 38
UXT ubiquitously-expressed, prefoldin-like chaperone
VAX2 ventral anterior homeobox 2
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VWA5A von Willebrand factor A domain containing 5A
WSB1 WD repeat and SOCS box containing 1
ZBP1 Z-DNA binding protein 1
ZBTB21 zinc finger and BTB domain containing 21
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP57 ZFP57 zinc finger protein
ZNF35 zinc finger protein 35
ZNF423 zinc finger protein 423
ZNF48 zinc finger protein 48
ZNF808 zinc finger protein 808