ESC_J1_UP_LATE.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/ESC_J1_UP_LATE.V1_UP
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Genes

377 genes differentially expressed following the ESC_J1_UP_LATE.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABHD5 abhydrolase domain containing 5
ADAM10 ADAM metallopeptidase domain 10
AFP alpha-fetoprotein
AMN amnion associated transmembrane protein
AMOT angiomotin
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATF3 activating transcription factor 3
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2
BGN biglycan
BICC1 BicC family RNA binding protein 1
BMP2 bone morphogenetic protein 2
C1ORF210 chromosome 1 open reading frame 210
CA4 carbonic anhydrase IV
CAPN6 calpain 6
CBX4 chromobox homolog 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CIDEB cell death-inducing DFFA-like effector b
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN7 claudin 7
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CTSC cathepsin C
CTSH cathepsin H
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAZL deleted in azoospermia-like
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
EFNA1 ephrin-A1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
ESX1 ESX homeobox 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM134B family with sequence similarity 134, member B
FAM213A family with sequence similarity 213, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGB fibrinogen beta chain
FGF5 fibroblast growth factor 5
FHL2 four and a half LIM domains 2
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXA2 forkhead box A2
FOXQ1 forkhead box Q1
FRZB frizzled-related protein
FST follistatin
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GGTA1P glycoprotein, alpha-galactosyltransferase 1 pseudogene
GKN1 gastrokine 1
GKN2 gastrokine 2
GLIPR1 GLI pathogenesis-related 1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPC3 glypican 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPX3 glutathione peroxidase 3
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSN gelsolin
GYG1 glycogenin 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HKDC1 hexokinase domain containing 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HTRA1 HtrA serine peptidase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF2 insulin-like growth factor 2
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
KLB klotho beta
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMA1 laminin, alpha 1
LAMB1 laminin, beta 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGMN legumain
LMBRD1 LMBR1 domain containing 1
LMO7 LIM domain 7
LOXL2 lysyl oxidase-like 2
LPAR3 lysophosphatidic acid receptor 3
LXN latexin
MOGAT2 monoacylglycerol O-acyltransferase 2
MORC4 MORC family CW-type zinc finger 4
MTTP microsomal triglyceride transfer protein
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYO5B myosin VB
MYO6 myosin VI
MYO7A myosin VIIA
NAGA N-acetylgalactosaminidase, alpha-
NEU1 sialidase 1 (lysosomal sialidase)
NRK Nik related kinase
OAF OAF homolog (Drosophila)
OCLN occludin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PARM1 prostate androgen-regulated mucin-like protein 1
PARVA parvin, alpha
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCDH1 protocadherin 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA5 protein disulfide isomerase family A, member 5
PEG3 paternally expressed 3
PGA5 pepsinogen 5, group I (pepsinogen A)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G12B phospholipase A2, group XIIB
PLXNB2 plexin B2
PODXL podocalyxin-like
PRG1 p53-responsive gene 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS8 protease, serine, 8
PTH1R parathyroid hormone 1 receptor
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB33B RAB33B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RBP4 retinol binding protein 4, plasma
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RHOU ras homolog family member U
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF130 ring finger protein 130
S100A1 S100 calcium binding protein A1
S100G S100 calcium binding protein G
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPN1 selenoprotein N, 1
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN3 sestrin 3
SGCE sarcoglycan, epsilon
SHROOM3 shroom family member 3
SLC22A23 solute carrier family 22, member 23
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAI1 snail family zinc finger 1
SOAT2 sterol O-acyltransferase 2
SOX17 SRY (sex determining region Y)-box 17
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP2 secreted phosphoprotein 2, 24kDa
ST5 suppression of tumorigenicity 5
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN2 transcobalamin II
TDRD7 tudor domain containing 7
TEX101 testis expressed 101
TEX264 testis expressed 264
TFEC transcription factor EC
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMED3 transmembrane emp24 protein transport domain containing 3
TMPRSS2 transmembrane protease, serine 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNNT1 troponin T type 1 (skeletal, slow)
TPCN1 two pore segment channel 1
TTR transthyretin
TUFT1 tuftelin 1
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UNC5B unc-5 homolog B (C. elegans)
VAMP8 vesicle-associated membrane protein 8
VIL1 villin 1
WBSCR27 Williams Beuren syndrome chromosome region 27
WLS wntless Wnt ligand secretion mediator
ZDHHC9 zinc finger, DHHC-type containing 9
ZFPM1 zinc finger protein, FOG family member 1

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM23 ADAM metallopeptidase domain 23
AMH anti-Mullerian hormone
ANGPTL4 angiopoietin-like 4
ANKRD10 ankyrin repeat domain 10
AOAH acyloxyacyl hydrolase (neutrophil)
ARMC6 armadillo repeat containing 6
ATG2A autophagy related 2A
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BMS1 BMS1 ribosome biogenesis factor
CALML4 calmodulin-like 4
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD1D CD1d molecule
CIRBP cold inducible RNA binding protein
CLTB clathrin, light chain B
CORO1A coronin, actin binding protein, 1A
CRCP CGRP receptor component
CRMP1 collapsin response mediator protein 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DHODH dihydroorotate dehydrogenase (quinone)
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNASE2 deoxyribonuclease II, lysosomal
DOC2A double C2-like domains, alpha
DPYS dihydropyrimidinase
E2F8 E2F transcription factor 8
ECH1 enoyl CoA hydratase 1, peroxisomal
EDN1 endothelin 1
EGR1 early growth response 1
ENDOG endonuclease G
ERAS ES cell expressed Ras
ERCC6L excision repair cross-complementation group 6-like
ETAA1 Ewing tumor-associated antigen 1
ETV4 ets variant 4
EVC Ellis van Creveld protein
EXOSC1 exosome component 1
FAM129A family with sequence similarity 129, member A
FAM169A family with sequence similarity 169, member A
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FOXN4 forkhead box N4
GAP43 growth associated protein 43
GBX2 gastrulation brain homeobox 2
GEMIN2 gem (nuclear organelle) associated protein 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH4 G patch domain containing 4
GPX2 glutathione peroxidase 2
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GSPT2 G1 to S phase transition 2
GYS1 glycogen synthase 1 (muscle)
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HCK HCK proto-oncogene, Src family tyrosine kinase
HELB helicase (DNA) B
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
HOOK2 hook microtubule-tethering protein 2
ICAM1 intercellular adhesion molecule 1
INA internexin neuronal intermediate filament protein, alpha
INTS6 integrator complex subunit 6
ITGB7 integrin, beta 7
JAM2 junctional adhesion molecule 2
KLF4 Kruppel-like factor 4 (gut)
KNOP1 lysine-rich nucleolar protein 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LMNB2 lamin B2
MAPK7 mitogen-activated protein kinase 7
MCF2 MCF.2 cell line derived transforming sequence
MDN1 MDN1, midasin homolog (yeast)
MED11 mediator complex subunit 11
MMP11 matrix metallopeptidase 11
MORC1 MORC family CW-type zinc finger 1
MRAS muscle RAS oncogene homolog
MRPL18 mitochondrial ribosomal protein L18
MRPL19 mitochondrial ribosomal protein L19
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSANTD3 Myb/SANT-like DNA-binding domain containing 3
MSRB2 methionine sulfoxide reductase B2
MTG2 mitochondrial ribosome-associated GTPase 2
MVK mevalonate kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NAPSA napsin A aspartic peptidase
NEFH neurofilament, heavy polypeptide
NGFR nerve growth factor receptor
NIFK nucleolar protein interacting with the FHA domain of MKI67
NNAT neuronatin
NOBOX NOBOX oogenesis homeobox
NOTUM notum pectinacetylesterase homolog (Drosophila)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NSUN4 NOP2/Sun domain family, member 4
NTN1 netrin 1
NXF1 nuclear RNA export factor 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PASK PAS domain containing serine/threonine kinase
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFC platelet derived growth factor C
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHB prohibitin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIH1D1 PIH1 domain containing 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLA2G1B phospholipase A2, group IB (pancreas)
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPCS phosphopantothenoylcysteine synthetase
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4
PPP4R1 protein phosphatase 4, regulatory subunit 1
PRMT6 protein arginine methyltransferase 6
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PTCH2 patched 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTRF polymerase I and transcript release factor
PUS7 pseudouridylate synthase 7 (putative)
QSER1 glutamine and serine rich 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASIP1 Ras interacting protein 1
RIOK2 RIO kinase 2
RNPC3 RNA-binding region (RNP1, RRM) containing 3
RPP25 ribonuclease P/MRP 25kDa subunit
RPP40 ribonuclease P/MRP 40kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SALL1 spalt-like transcription factor 1
SFN stratifin
SI sucrase-isomaltase (alpha-glucosidase)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SPRY4 sprouty homolog 4 (Drosophila)
STAT4 signal transducer and activator of transcription 4
STK4 serine/threonine kinase 4
SULT4A1 sulfotransferase family 4A, member 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBCE tubulin folding cofactor E
TCEA3 transcription elongation factor A (SII), 3
TCF15 transcription factor 15 (basic helix-loop-helix)
TDGF1 teratocarcinoma-derived growth factor 1
TET1 tet methylcytosine dioxygenase 1
TEX40 testis expressed 40
TFEB transcription factor EB
TGM1 transglutaminase 1
TGM3 transglutaminase 3
TLE4 transducin-like enhancer of split 4
TMEM121 transmembrane protein 121
TRAIP TRAF interacting protein
TRH thyrotropin-releasing hormone
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRPS1 trichorhinophalangeal syndrome I
TSPAN17 tetraspanin 17
TTC27 tetratricopeptide repeat domain 27
TTPA tocopherol (alpha) transfer protein
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
UXT ubiquitously-expressed, prefoldin-like chaperone
VEGFC vascular endothelial growth factor C
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR75 WD repeat domain 75
WDR83 WD repeat domain 83
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZCCHC10 zinc finger, CCHC domain containing 10
ZFP62 ZFP62 zinc finger protein
ZNF423 zinc finger protein 423
ZNF428 zinc finger protein 428