ESC_V6.5_UP_EARLY.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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342 genes differentially expressed following the ESC_V6.5_UP_EARLY.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACSS1 acyl-CoA synthetase short-chain family member 1
AGER advanced glycosylation end product-specific receptor
AIRE autoimmune regulator
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AQP2 aquaporin 2 (collecting duct)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP27 Rho GTPase activating protein 27
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2
BBX bobby sox homolog (Drosophila)
BMP10 bone morphogenetic protein 10
C9 complement component 9
CA4 carbonic anhydrase IV
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CBWD1 COBW domain containing 1
CCDC114 coiled-coil domain containing 114
CCNK cyclin K
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP131 centrosomal protein 131kDa
CGNL1 cingulin-like 1
CHD7 chromodomain helicase DNA binding protein 7
CLEC11A C-type lectin domain family 11, member A
CORT cortistatin
CRAT carnitine O-acetyltransferase
CSN1S2BP casein alpha s2-like B, pseudogene
CSNK1G1 casein kinase 1, gamma 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DLC1 DLC1 Rho GTPase activating protein
DLL3 delta-like 3 (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOC2A double C2-like domains, alpha
DRC1 dynein regulatory complex subunit 1
ECE1 endothelin converting enzyme 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41 erythrocyte membrane protein band 4.1
ERCC2 excision repair cross-complementation group 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM189B family with sequence similarity 189, member B
FBP1 fructose-1,6-bisphosphatase 1
FGF19 fibroblast growth factor 19
FGF5 fibroblast growth factor 5
FOXQ1 forkhead box Q1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GATAD2B GATA zinc finger domain containing 2B
GATS GATS, stromal antigen 3 opposite strand
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GPA33 glycoprotein A33 (transmembrane)
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPR153 G protein-coupled receptor 153
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRM8 glutamate receptor, metabotropic 8
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HDAC11 histone deacetylase 11
HES6 hes family bHLH transcription factor 6
HIGD1C HIG1 hypoxia inducible domain family, member 1C
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTRA2 HtrA serine peptidase 2
IFNA2 interferon, alpha 2
IGSF8 immunoglobulin superfamily, member 8
IRX2 iroquois homeobox 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KIF21A kinesin family member 21A
KLC2 kinesin light chain 2
KLF13 Kruppel-like factor 13
LEF1 lymphoid enhancer-binding factor 1
LIMD2 LIM domain containing 2
LIPF lipase, gastric
LPAR4 lysophosphatidic acid receptor 4
LPP-AS2 LPP antisense RNA 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MARCH9 membrane-associated ring finger (C3HC4) 9
MAST3 microtubule associated serine/threonine kinase 3
MBD4 methyl-CpG binding domain protein 4
MBOAT1 membrane bound O-acyltransferase domain containing 1
MDFI MyoD family inhibitor
METTL20 methyltransferase like 20
MGA MGA, MAX dimerization protein
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NARF nuclear prelamin A recognition factor
NCOA2 nuclear receptor coactivator 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NRL neural retina leucine zipper
OCLN occludin
OPRD1 opioid receptor, delta 1
OTUD7A OTU deubiquitinase 7A
OTX2 orthodenticle homeobox 2
PARP6 poly (ADP-ribose) polymerase family, member 6
PCP4 Purkinje cell protein 4
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDZK1 PDZ domain containing 1
PHF21A PHD finger protein 21A
PKDREJ polycystin (PKD) family receptor for egg jelly
PMFBP1 polyamine modulated factor 1 binding protein 1
POU3F1 POU class 3 homeobox 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTK7 protein tyrosine kinase 7 (inactive)
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PURB purine-rich element binding protein B
RAI1 retinoic acid induced 1
RASAL2 RAS protein activator like 2
RNF123 ring finger protein 123
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RUNX1 runt-related transcription factor 1
RYR3 ryanodine receptor 3
SASH1 SAM and SH3 domain containing 1
SATB1 SATB homeobox 1
SCAP SREBF chaperone
SEPP1 selenoprotein P, plasma, 1
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
SH3RF1 SH3 domain containing ring finger 1
SIMC1 SUMO-interacting motifs containing 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4
SLC35G3 solute carrier family 35, member G3
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX11 SRY (sex determining region Y)-box 11
SP1 Sp1 transcription factor
SPEF1 sperm flagellar 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STIM1 stromal interaction molecule 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYT3 synaptotagmin III
SYT8 synaptotagmin VIII
SYTL2 synaptotagmin-like 2
TCEAL1 transcription elongation factor A (SII)-like 1
TERT telomerase reverse transcriptase
TEX2 testis expressed 2
TEX9 testis expressed 9
TMCO4 transmembrane and coiled-coil domains 4
TMEM121 transmembrane protein 121
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM186 transmembrane protein 186
TMEM42 transmembrane protein 42
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNRC6B trinucleotide repeat containing 6B
TTPA tocopherol (alpha) transfer protein
VEGFB vascular endothelial growth factor B
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDFY3 WD repeat and FYVE domain containing 3
WIPF1 WAS/WASL interacting protein family, member 1
WNT3A wingless-type MMTV integration site family, member 3A
WT1 Wilms tumor 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZG16 zymogen granule protein 16
ZMAT5 zinc finger, matrin-type 5
ZNF286A zinc finger protein 286A
ZNF322 zinc finger protein 322
ZNF771 zinc finger protein 771
ZNF865 zinc finger protein 865
ZPBP zona pellucida binding protein

decreased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTA1 actin, alpha 1, skeletal muscle
ADAM21 ADAM metallopeptidase domain 21
AEBP1 AE binding protein 1
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
ALX3 ALX homeobox 3
ANXA1 annexin A1
ANXA2 annexin A2
ANXA3 annexin A3
ANXA5 annexin A5
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
AXL AXL receptor tyrosine kinase
B2M beta-2-microglobulin
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BAG5 BCL2-associated athanogene 5
BCAN brevican
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
BTNL10 butyrophilin-like 10
C16ORF74 chromosome 16 open reading frame 74
C16ORF89 chromosome 16 open reading frame 89
C3ORF70 chromosome 3 open reading frame 70
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS Ca++-dependent secretion activator
CALD1 caldesmon 1
CALML4 calmodulin-like 4
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN2 calpain 2, (m/II) large subunit
CARD14 caspase recruitment domain family, member 14
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC34 coiled-coil domain containing 34
CCDC80 coiled-coil domain containing 80
CD37 CD37 molecule
CD44 CD44 molecule (Indian blood group)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CFB complement factor B
CIZ1 CDKN1A interacting zinc finger protein 1
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
COL11A1 collagen, type XI, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPE carboxypeptidase E
CRY2 cryptochrome circadian clock 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDHD1 DDHD domain containing 1
DEGS2 delta(4)-desaturase, sphingolipid 2
DSP desmoplakin
EMP1 epithelial membrane protein 1
ESRRA estrogen-related receptor alpha
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM198B family with sequence similarity 198, member B
FAP fibroblast activation protein, alpha
FBLN2 fibulin 2
FBXO28 F-box protein 28
FBXO6 F-box protein 6
FGF17 fibroblast growth factor 17
FGF2 fibroblast growth factor 2 (basic)
FHL2 four and a half LIM domains 2
FZD5 frizzled class receptor 5
GAP43 growth associated protein 43
GBP2 guanylate binding protein 2, interferon-inducible
GBX2 gastrulation brain homeobox 2
GIMAP3P GTPase, IMAP family member 3 pseudogene
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
GPX2 glutathione peroxidase 2
GSN gelsolin
GYS1 glycogen synthase 1 (muscle)
HBEGF heparin-binding EGF-like growth factor
HES7 hes family bHLH transcription factor 7
HTRA1 HtrA serine peptidase 1
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
INHBB inhibin, beta B
JUNB jun B proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIF18A kinesin family member 18A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
KRTAP13-2 keratin associated protein 13-2
LAMA1 laminin, alpha 1
LAMC2 laminin, gamma 2
LBP lipopolysaccharide binding protein
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LTBP3 latent transforming growth factor beta binding protein 3
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MOGAT2 monoacylglycerol O-acyltransferase 2
MRAS muscle RAS oncogene homolog
MYO7B myosin VIIB
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NID1 nidogen 1
NTN1 netrin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAF OAF homolog (Drosophila)
PARVA parvin, alpha
PBX1 pre-B-cell leukemia homeobox 1
PCOLCE procollagen C-endopeptidase enhancer
PKD1L3 polycystic kidney disease 1-like 3
PLAU plasminogen activator, urokinase
PLCL2 phospholipase C-like 2
PMP22 peripheral myelin protein 22
PNRC2 proline-rich nuclear receptor coactivator 2
PRCC papillary renal cell carcinoma (translocation-associated)
PTRF polymerase I and transcript release factor
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCARA3 scavenger receptor class A, member 3
SDPR serum deprivation response
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFN stratifin
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC41A3 solute carrier family 41, member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNTG1 syntrophin, gamma 1
SOCS3 suppressor of cytokine signaling 3
SP5 Sp5 transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
STARD8 StAR-related lipid transfer (START) domain containing 8
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
T T, brachyury homolog (mouse)
TAGLN transgelin
TAS2R4 taste receptor, type 2, member 4
TFCP2L1 transcription factor CP2-like 1
TFEB transcription factor EB
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM1 transglutaminase 1
TIMP2 TIMP metallopeptidase inhibitor 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM54 tripartite motif containing 54
TSHZ2 teashirt zinc finger homeobox 2
TTYH2 tweety family member 2
TUBB6 tubulin, beta 6 class V
UBD ubiquitin D
UTS2 urotensin 2
VAC14 Vac14 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZADH2 zinc binding alcohol dehydrogenase domain containing 2
ZBTB32 zinc finger and BTB domain containing 32
ZFP36L1 ZFP36 ring finger protein-like 1