ESC_V6.5_UP_LATE.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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376 genes differentially expressed following the ESC_V6.5_UP_LATE.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AFP alpha-fetoprotein
AMOT angiomotin
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
APLNR apelin receptor
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
ARF5 ADP-ribosylation factor 5
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAIAP2L1 BAI1-associated protein 2-like 1
BBX bobby sox homolog (Drosophila)
BMP2 bone morphogenetic protein 2
BVES blood vessel epicardial substance
C14ORF37 chromosome 14 open reading frame 37
CA14 carbonic anhydrase XIV
CA4 carbonic anhydrase IV
CAPN6 calpain 6
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLDND1 claudin domain containing 1
CMTM8 CKLF-like MARVEL transmembrane domain containing 8
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSH cathepsin H
CUBN cubilin (intrinsic factor-cobalamin receptor)
CYBA cytochrome b-245, alpha polypeptide
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCXR dicarbonyl/L-xylulose reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EOMES eomesodermin
EPB41 erythrocyte membrane protein band 4.1
EVX1 even-skipped homeobox 1
FAM107B family with sequence similarity 107, member B
FAM134B family with sequence similarity 134, member B
FAM213A family with sequence similarity 213, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXL20 F-box and leucine-rich repeat protein 20
FGB fibrinogen beta chain
FGF5 fibroblast growth factor 5
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFRL1 fibroblast growth factor receptor-like 1
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXQ1 forkhead box Q1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FRZB frizzled-related protein
FXYD2 FXYD domain containing ion transport regulator 2
FZD2 frizzled class receptor 2
FZD8 frizzled class receptor 8
G6PC3 glucose 6 phosphatase, catalytic, 3
GAS1 growth arrest-specific 1
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GATAD2B GATA zinc finger domain containing 2B
GATS GATS, stromal antigen 3 opposite strand
GPC3 glypican 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPX3 glutathione peroxidase 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSC goosecoid homeobox
GYG1 glycogenin 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H1F0 H1 histone family, member 0
HBE1 hemoglobin, epsilon 1
HBG2 hemoglobin, gamma G
HBZ hemoglobin, zeta
HEXA hexosaminidase A (alpha polypeptide)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNF1B HNF1 homeobox B
HPN hepsin
IER5 immediate early response 5
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IMPAD1 inositol monophosphatase domain containing 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0930 KIAA0930
KIF21A kinesin family member 21A
KRT7 keratin 7, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGMN legumain
LHX1 LIM homeobox 1
LIMD2 LIM domain containing 2
LMBRD1 LMBR1 domain containing 1
LOXL2 lysyl oxidase-like 2
LPIN2 lipin 2
MACROD1 MACRO domain containing 1
MFAP2 microfibrillar-associated protein 2
MICU1 mitochondrial calcium uptake 1
MOGAT2 monoacylglycerol O-acyltransferase 2
MOSPD1 motile sperm domain containing 1
MSX2 msh homeobox 2
MTTP microsomal triglyceride transfer protein
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NAGLU N-acetylglucosaminidase, alpha
NARF nuclear prelamin A recognition factor
NDRG1 N-myc downstream regulated 1
NENF neudesin neurotrophic factor
NEPNP nephrocan, pseudogene
NRK Nik related kinase
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OCLN occludin
OPN3 opsin 3
OTX2 orthodenticle homeobox 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PARM1 prostate androgen-regulated mucin-like protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDLIM3 PDZ and LIM domain 3
PDZRN3 PDZ domain containing ring finger 3
PITX2 paired-like homeodomain 2
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PKDCC protein kinase domain containing, cytoplasmic
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNB2 plexin B2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRG1 p53-responsive gene 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS8 protease, serine, 8
PTH1R parathyroid hormone 1 receptor
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PURG purine-rich element binding protein G
RAI1 retinoic acid induced 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RASAL2 RAS protein activator like 2
RBP4 retinol binding protein 4, plasma
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RHOU ras homolog family member U
RIPK4 receptor-interacting serine-threonine kinase 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF130 ring finger protein 130
S100G S100 calcium binding protein G
SAMD8 sterile alpha motif domain containing 8
SATB1 SATB homeobox 1
SCCPDH saccharopine dehydrogenase (putative)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPN1 selenoprotein N, 1
SEPP1 selenoprotein P, plasma, 1
SGCE sarcoglycan, epsilon
SH3RF1 SH3 domain containing ring finger 1
SIL1 SIL1 nucleotide exchange factor
SIX5 SIX homeobox 5
SLC22A23 solute carrier family 22, member 23
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLIT3 slit homolog 3 (Drosophila)
SMIM14 small integral membrane protein 14
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOAT2 sterol O-acyltransferase 2
SOX17 SRY (sex determining region Y)-box 17
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPP2 secreted phosphoprotein 2, 24kDa
STX2 syntaxin 2
STX7 syntaxin 7
TCN2 transcobalamin II
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM98 transmembrane protein 98
TMPRSS2 transmembrane protease, serine 2
TNNC1 troponin C type 1 (slow)
TNNT2 troponin T type 2 (cardiac)
TRAPPC6A trafficking protein particle complex 6A
TSPAN7 tetraspanin 7
TTR transthyretin
UNC5B unc-5 homolog B (C. elegans)
VAMP8 vesicle-associated membrane protein 8
VEGFB vascular endothelial growth factor B
VIL1 villin 1
WLS wntless Wnt ligand secretion mediator
ZDHHC9 zinc finger, DHHC-type containing 9
ZFPM1 zinc finger protein, FOG family member 1
ZNF521 zinc finger protein 521

decreased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACACB acetyl-CoA carboxylase beta
ACOT8 acyl-CoA thioesterase 8
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADA adenosine deaminase
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
AOAH acyloxyacyl hydrolase (neutrophil)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARMC6 armadillo repeat containing 6
ATF1 activating transcription factor 1
AVPI1 arginine vasopressin-induced 1
BCL3 B-cell CLL/lymphoma 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BGN biglycan
BID BH3 interacting domain death agonist
BIRC6 baculoviral IAP repeat containing 6
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C11ORF24 chromosome 11 open reading frame 24
C16ORF74 chromosome 16 open reading frame 74
C16ORF89 chromosome 16 open reading frame 89
C17ORF96 chromosome 17 open reading frame 96
C19ORF48 chromosome 19 open reading frame 48
CAAP1 caspase activity and apoptosis inhibitor 1
CALML4 calmodulin-like 4
CBR3 carbonyl reductase 3
CBX7 chromobox homolog 7
CBY1 chibby homolog 1 (Drosophila)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD38 CD38 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLTB clathrin, light chain B
CRCP CGRP receptor component
CRMP1 collapsin response mediator protein 1
CTH cystathionine gamma-lyase
CYCTP cytochrome c, testis, pseudogene
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DCLRE1B DNA cross-link repair 1B
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEDD2 death effector domain containing 2
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DPPA2 developmental pluripotency associated 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F8 E2F transcription factor 8
ECH1 enoyl CoA hydratase 1, peroxisomal
EMP1 epithelial membrane protein 1
ERAS ES cell expressed Ras
ESRRB estrogen-related receptor beta
ETV4 ets variant 4
EXOSC1 exosome component 1
FAM169A family with sequence similarity 169, member A
FAM208B family with sequence similarity 208, member B
FASTKD2 FAST kinase domains 2
FBLN2 fibulin 2
FBXO15 F-box protein 15
FGF17 fibroblast growth factor 17
FOXD3 forkhead box D3
FTSJ3 FtsJ homolog 3 (E. coli)
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GBX2 gastrulation brain homeobox 2
GDF3 growth differentiation factor 3
GEMIN2 gem (nuclear organelle) associated protein 2
GGCT gamma-glutamylcyclotransferase
GIMAP3P GTPase, IMAP family member 3 pseudogene
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GPA33 glycoprotein A33 (transmembrane)
GPATCH4 G patch domain containing 4
GPX2 glutathione peroxidase 2
GYS1 glycogen synthase 1 (muscle)
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HES7 hes family bHLH transcription factor 7
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
ICAM1 intercellular adhesion molecule 1
INHBA inhibin, beta A
INHBB inhibin, beta B
ITGB7 integrin, beta 7
JAM2 junctional adhesion molecule 2
KAT2B K(lysine) acetyltransferase 2B
KAT6B K(lysine) acetyltransferase 6B
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIF18A kinesin family member 18A
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
MANBA mannosidase, beta A, lysosomal
MDN1 MDN1, midasin homolog (yeast)
MED29 mediator complex subunit 29
MGP matrix Gla protein
MORC1 MORC family CW-type zinc finger 1
MPC1 mitochondrial pyruvate carrier 1
MRAS muscle RAS oncogene homolog
MSC musculin
MSRB2 methionine sulfoxide reductase B2
MTG2 mitochondrial ribosome-associated GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT2 N-6 adenine-specific DNA methyltransferase 2 (putative)
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NOL12 nucleolar protein 12
NOTUM notum pectinacetylesterase homolog (Drosophila)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLIG2 oligodendrocyte lineage transcription factor 2
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE12 phosphodiesterase 12
PDGFC platelet derived growth factor C
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHB prohibitin
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PLK3 polo-like kinase 3
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PRADC1 protease-associated domain containing 1
PRCC papillary renal cell carcinoma (translocation-associated)
PRX periaxin
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PTCD1 pentatricopeptide repeat domain 1
PTRF polymerase I and transcript release factor
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASIP1 Ras interacting protein 1
RBM43 RNA binding motif protein 43
RIOK2 RIO kinase 2
RPP25 ribonuclease P/MRP 25kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SEPT1 septin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SOCS3 suppressor of cytokine signaling 3
SPP1 secreted phosphoprotein 1
SPRY4 sprouty homolog 4 (Drosophila)
SPTBN4 spectrin, beta, non-erythrocytic 4
SULT4A1 sulfotransferase family 4A, member 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCEA3 transcription elongation factor A (SII), 3
TCF15 transcription factor 15 (basic helix-loop-helix)
TEX14 testis expressed 14
TEX19 testis expressed 19
TFEB transcription factor EB
TGM1 transglutaminase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TMEM79 transmembrane protein 79
TRIB3 tribbles pseudokinase 3
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TTC39B tetratricopeptide repeat domain 39B
TTYH2 tweety family member 2
TUBB3 tubulin, beta 3 class III
UFM1 ubiquitin-fold modifier 1
VAC14 Vac14 homolog (S. cerevisiae)
WDR46 WD repeat domain 46
WDR75 WD repeat domain 75
ZBTB21 zinc finger and BTB domain containing 21
ZBTB32 zinc finger and BTB domain containing 32
ZBTB45 zinc finger and BTB domain containing 45
ZBTB8A zinc finger and BTB domain containing 8A
ZC3H8 zinc finger CCCH-type containing 8
ZCCHC10 zinc finger, CCHC domain containing 10
ZFP1 ZFP1 zinc finger protein
ZFP42 ZFP42 zinc finger protein
ZFP57 ZFP57 zinc finger protein
ZMYM3 zinc finger, MYM-type 3
ZNF274 zinc finger protein 274
ZNF423 zinc finger protein 423
ZNF428 zinc finger protein 428
ZNF566 zinc finger protein 566