ESPL1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description extra spindle pole bodies homolog 1 (S. cerevisiae)|Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010] (NCBI Entrez Gene Database, 9700)
External Link http://www.ncbi.nlm.nih.gov/gene/9700
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186 interacting proteins for ESPL1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AHCTF1 AT hook containing transcription factor 1
AHNAK AHNAK nucleoprotein
AKAP2 A kinase (PRKA) anchor protein 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC7 anaphase promoting complex subunit 7
ANXA4 annexin A4
ANXA8 annexin A8
ANXA8L1 annexin A8-like 1
APITD1 apoptosis-inducing, TAF9-like domain 1
ARF4 ADP-ribosylation factor 4
AURKB aurora kinase B
B9D2 B9 protein domain 2
BIRC5 baculoviral IAP repeat containing 5
BSG basigin (Ok blood group)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C1QBP complement component 1, q subcomponent binding protein
CA2 carbonic anhydrase II
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASC5 cancer susceptibility candidate 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNO cyclin O
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDCA5 cell division cycle associated 5
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK17 cyclin-dependent kinase 17
CDK5 cyclin-dependent kinase 5
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPI centromere protein I
CENPK centromere protein K
CENPL centromere protein L
CENPM centromere protein M
CENPN centromere protein N
CENPO centromere protein O
CENPP centromere protein P
CENPQ centromere protein Q
CENPT centromere protein T
CKAP5 cytoskeleton associated protein 5
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLIP1 CAP-GLY domain containing linker protein 1
CORO1C coronin, actin binding protein, 1C
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4A1 eukaryotic translation initiation factor 4A1
ERCC6L excision repair cross-complementation group 6-like
EZR ezrin
FOLR1 folate receptor 1 (adult)
GDI2 GDP dissociation inhibitor 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
IDE insulin-degrading enzyme
INCENP inner centromere protein antigens 135/155kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF18A kinesin family member 18A
KIF24 kinesin family member 24
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KNTC1 kinetochore associated 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MIS12 MIS12 kinetochore complex component
MISP mitotic spindle positioning
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NEXN nexilin (F actin binding protein)
NSL1 NSL1, MIS12 kinetochore complex component
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NUDC nudC nuclear distribution protein
NUF2 NUF2, NDC80 kinetochore complex component
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDLIM7 PDZ and LIM domain 7 (enigma)
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKM pyruvate kinase, muscle
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPL periplakin
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRPF8 pre-mRNA processing factor 8
PTTG1 pituitary tumor-transforming 1
RAD21 RAD21 homolog (S. pombe)
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RPS27 ribosomal protein S27
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGOL1 shugoshin-like 1 (S. pombe)
SGOL2 shugoshin-like 2 (S. pombe)
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SPC24 SPC24, NDC80 kinetochore complex component
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPRR2A small proline-rich protein 2A
SPRR2B small proline-rich protein 2B
SPRR2E small proline-rich protein 2E
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAG1 stromal antigen 1
STAG2 stromal antigen 2
SVIL supervillin
TAOK1 TAO kinase 1
TJP1 tight junction protein 1
TMOD3 tropomodulin 3 (ubiquitous)
TRIM29 tripartite motif containing 29
TRIM55 tripartite motif containing 55
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TYMP thymidine phosphorylase
UBC ubiquitin C
USP21 ubiquitin specific peptidase 21
USP28 ubiquitin specific peptidase 28
VCP valosin containing protein
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
XPO1 exportin 1
ZW10 zw10 kinetochore protein
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein