ESR1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description estrogen receptor 1|This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 2099)
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Genes

272 genes differentially expressed following the ESR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CBLIF cobalamin binding intrinsic factor 2.74069
AGR2 anterior gradient 2 2.74069
PKD2L1 polycystic kidney disease 2-like 1 2.74069
USP26 ubiquitin specific peptidase 26 2.74069
OPN4 opsin 4 2.74069
CELA3A chymotrypsin-like elastase family, member 3A 2.74069
NLRP7 NLR family, pyrin domain containing 7 2.74069
IMPG1 interphotoreceptor matrix proteoglycan 1 2.74069
ANGPTL3 angiopoietin-like 3 2.74069
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.74069
TMEM176A transmembrane protein 176A 2.74069
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.74069
PEAK3 PEAK family member 3 2.74069
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.74069
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.74069
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.74069
HBA2 hemoglobin, alpha 2 2.68699
PLIN1 perilipin 1 2.68699
UCN urocortin 2.68699
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.68699
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.68699
TMPRSS11A transmembrane protease, serine 11A 2.68699
LAX1 lymphocyte transmembrane adaptor 1 2.68699
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.68699
KLRC2 killer cell lectin-like receptor subfamily C, member 2 2.68699
ELF5 E74-like factor 5 (ets domain transcription factor) 2.68699
NANOS3 nanos homolog 3 (Drosophila) 2.68699
CAMP cathelicidin antimicrobial peptide 2.68699
MOGAT2 monoacylglycerol O-acyltransferase 2 2.68699
BSX brain-specific homeobox 2.68699
ANKRD34A ankyrin repeat domain 34A 2.68699
SSTR4 somatostatin receptor 4 2.68699
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2.68699
GDE1 glycerophosphodiester phosphodiesterase 1 2.68699
PLCH2 phospholipase C, eta 2 2.68699
AJM1 apical junction component 1 homolog 2.68699
PAX2 paired box 2 2.68699
SH2D7 SH2 domain containing 7 2.68699
AFM afamin 2.68699
GPR151 G protein-coupled receptor 151 2.68699
PRSS41 protease, serine, 41 2.68699
RIMBP3C RIMS binding protein 3C 2.68699
ZNF99 zinc finger protein 99 2.68699
FRMD7 FERM domain containing 7 2.68699
MYEOV myeloma overexpressed 2.68699
SAG S-antigen; retina and pineal gland (arrestin) 2.68699
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.68699
MLN motilin 2.68699
VN1R5 vomeronasal 1 receptor 5 (gene/pseudogene) 2.68699
CES4A carboxylesterase 4A 2.68699
DEPP1 DEPP autophagy regulator 1 2.68699
CCDC198 coiled-coil domain containing 198 2.68699
GSTT4 glutathione S-transferase theta 4 2.68699
CCDC197 coiled-coil domain containing 197 2.68699
CIBAR2 CBY1 interacting BAR domain containing 2 2.68699
H2AC19 H2A clustered histone 19 2.68699
LINC02268 long intergenic non-protein coding RNA 2268 2.68699
SPEGNB SPEG neighbor 2.68699
SPMIP1 sperm microtubule inner protein 1 2.68699
FOXC2 forkhead box C2 2.68699
CNTN6 contactin 6 2.68699
LTK leukocyte receptor tyrosine kinase 2.68699
RAB44 RAB44, member RAS oncogene family 2.68699
PCDHA7 protocadherin alpha 7 2.68699
CLDN2 claudin 2 2.68699
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.68699
SNIP1 Smad nuclear interacting protein 1 2.68699
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.68699
PGC progastricsin (pepsinogen C) 2.68699
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.68699
GSC goosecoid homeobox 2.68699
SASH3 SAM and SH3 domain containing 3 2.68699
C6 complement component 6 2.68699
SAMD11 sterile alpha motif domain containing 11 2.68699
GDF9 growth differentiation factor 9 2.68699
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.68699
SOAT2 sterol O-acyltransferase 2 2.68699
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.68699
CNGB1 cyclic nucleotide gated channel beta 1 2.68699
SHISA8 shisa family member 8 2.68699
WFDC9 WAP four-disulfide core domain 9 2.68699
BPIFB1 BPI fold containing family B, member 1 2.68699
TAS2R50 taste receptor, type 2, member 50 2.68699
EDN2 endothelin 2 2.68699
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 2.68699
NT5C1A 5'-nucleotidase, cytosolic IA 2.68699
LRRC46 leucine rich repeat containing 46 2.68699
ZMYND10 zinc finger, MYND-type containing 10 2.68699
HEMGN hemogen 2.68699
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.68699
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.68699
SLITRK2 SLIT and NTRK-like family, member 2 2.68699
MCCD1 mitochondrial coiled-coil domain 1 2.68699
MUC15 mucin 15, cell surface associated 2.68699
CXORF58 chromosome X open reading frame 58 2.68699
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.68699
CLEC1B C-type lectin domain family 1, member B 2.68699
IZUMO1R IZUMO1 receptor, JUNO 2.68699
F13B coagulation factor XIII, B polypeptide 2.68699
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.68699
LYZ lysozyme 2.68699
DLX6 distal-less homeobox 6 2.68699
DEFA5 defensin, alpha 5, Paneth cell-specific 2.68699
GSTA2 glutathione S-transferase alpha 2 2.68699
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.68699
C8ORF89 chromosome 8 open reading frame 89 2.68699
SLC22A24 solute carrier family 22, member 24 2.68699
GLT6D1 glycosyltransferase 6 domain containing 1 2.68699
CD84 CD84 molecule 2.68699
SNTN sentan, cilia apical structure protein 2.68699
TEX36 testis expressed 36 2.68699
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.68699
ST18 suppression of tumorigenicity 18, zinc finger 2.68699
IL2RA interleukin 2 receptor, alpha 2.68699
KRTAP5-8 keratin associated protein 5-8 2.68699
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.68699
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.68699
ZNF648 zinc finger protein 648 2.68699
FGF7 fibroblast growth factor 7 2.68699
CLCNKA chloride channel, voltage-sensitive Ka 2.68699
RFX6 regulatory factor X, 6 2.68699
LRRC31 leucine rich repeat containing 31 2.68699
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.68699
NNMT nicotinamide N-methyltransferase 2.68699
R3HDML R3H domain containing-like 2.68699
CRYGC crystallin, gamma C 2.68699
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 2.68699
ASCL1 achaete-scute family bHLH transcription factor 1 2.68699
KY kyphoscoliosis peptidase 2.64516
RTN4R reticulon 4 receptor 2.6199
ZNF644 zinc finger protein 644 2.61985
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.61691
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.61691
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.61691
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 2.61691
SYN3 synapsin III 2.59583
EIF2D eukaryotic translation initiation factor 2D 2.59583
ACTN2 actinin, alpha 2 2.5607
RAD51B RAD51 paralog B 2.51253
FOXP1 forkhead box P1 2.4988
RUFY1 RUN and FYVE domain containing 1 2.46285
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.45482
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.44512
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.42653
POU2AF3 POU class 2 homeobox associating factor 3 2.3841
RARS2 arginyl-tRNA synthetase 2, mitochondrial 2.3841
RALGDS ral guanine nucleotide dissociation stimulator 2.36889
DNA2 DNA replication helicase/nuclease 2 2.36889
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.35968
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.35968
ANGPTL6 angiopoietin-like 6 2.30708
NREP neuronal regeneration related protein 2.30708
ANAPC4 anaphase promoting complex subunit 4 2.30026
OVOL3 ovo-like zinc finger 3 2.25363
ISOC1 isochorismatase domain containing 1 2.24213
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.22486
MATR3 matrin 3 2.19226
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.17115
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 2.15407
QKI QKI, KH domain containing, RNA binding 2.09162
TSPAN3 tetraspanin 3 2.08712
PPAN peter pan homolog (Drosophila) 2.07975
FOXO4 forkhead box O4 2.07122
CA4 carbonic anhydrase IV 2.06995
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.05875
UNC13B unc-13 homolog B (C. elegans) 2.05875
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.05859
SMIM29 small integral membrane protein 29 2.05125
ARL11 ADP-ribosylation factor-like 11 2.04387
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 2.02224
MRAS muscle RAS oncogene homolog 2.02224
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 2.01858
HPS3 Hermansky-Pudlak syndrome 3 2.0108
PGAP3 post-GPI attachment to proteins 3 2.0108
GAS1 growth arrest-specific 1 2.0036
MYL12B myosin, light chain 12B, regulatory 2.0036

decreased expression

Symbol Name Standardized Value
EBF2 early B-cell factor 2 -2.74069
KCTD21 potassium channel tetramerization domain containing 21 -2.74069
IL15RA interleukin 15 receptor, alpha -2.74069
MMP28 matrix metallopeptidase 28 -2.74069
OIT3 oncoprotein induced transcript 3 -2.68934
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.68934
ACE2 angiotensin I converting enzyme 2 -2.68934
GJC3 gap junction protein, gamma 3, 30.2kDa -2.68934
PDCD1LG2 programmed cell death 1 ligand 2 -2.68934
PNMA2 paraneoplastic Ma antigen 2 -2.68699
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.68699
SCARB2 scavenger receptor class B, member 2 -2.68699
FZD7 frizzled class receptor 7 -2.68699
OXCT2 3-oxoacid CoA transferase 2 -2.68699
FAM133A family with sequence similarity 133, member A -2.68699
BBS5 Bardet-Biedl syndrome 5 -2.68699
CFAP157 cilia and flagella associated protein 157 -2.68699
ZBED1 zinc finger, BED-type containing 1 -2.61731
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.61691
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.61691
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.61691
PITX3 paired-like homeodomain 3 -2.61691
AREG amphiregulin -2.61691
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.61691
TCEAL7 transcription elongation factor A (SII)-like 7 -2.61691
FPR2 formyl peptide receptor 2 -2.61691
BIRC2 baculoviral IAP repeat containing 2 -2.61691
TPBGL trophoblast glycoprotein-like -2.61691
GGT5 gamma-glutamyltransferase 5 -2.61691
C10ORF67 chromosome 10 open reading frame 67 -2.61691
IL5RA interleukin 5 receptor, alpha -2.61691
ARHGAP36 Rho GTPase activating protein 36 -2.61691
ZNF189 zinc finger protein 189 -2.61691
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.61691
NLRP14 NLR family, pyrin domain containing 14 -2.61691
TRAF3IP3 TRAF3 interacting protein 3 -2.61691
IFITM10 interferon induced transmembrane protein 10 -2.61691
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) -2.61691
AMIGO1 adhesion molecule with Ig-like domain 1 -2.61691
ALOXE3 arachidonate lipoxygenase 3 -2.61691
UBXN10 UBX domain protein 10 -2.61691
PCDHGB4 protocadherin gamma subfamily B, 4 -2.61691
EFCC1 EF-hand and coiled-coil domain containing 1 -2.61691
ERVV-2 endogenous retrovirus group V, member 2 -2.61691
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4 -2.61691
LRRC24 leucine rich repeat containing 24 -2.61691
BIN2 bridging integrator 2 -2.61691
BPHL biphenyl hydrolase-like (serine hydrolase) -2.54435
RASD1 RAS, dexamethasone-induced 1 -2.53164
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.53164
LRRC61 leucine rich repeat containing 61 -2.53164
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.52308
NTPCR nucleoside-triphosphatase, cancer-related -2.52151
AHSG alpha-2-HS-glycoprotein -2.4988
LYNX1 Ly6/neurotoxin 1 -2.4988
PLAAT5 phospholipase A and acyltransferase 5 -2.45584
IQCK IQ motif containing K -2.44182
OTUD3 OTU deubiquitinase 3 -2.42653
DLAT dihydrolipoamide S-acetyltransferase -2.38335
MTX1 metaxin 1 -2.37274
ALKAL1 ALK and LTK ligand 1 -2.37274
AMBP alpha-1-microglobulin/bikunin precursor -2.37274
SOSTDC1 sclerostin domain containing 1 -2.37274
SOWAHD sosondowah ankyrin repeat domain family member D -2.33694
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.32681
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.30026
SFMBT2 Scm-like with four mbt domains 2 -2.29863
GPRC5B G protein-coupled receptor, class C, group 5, member B -2.29544
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 -2.29544
FXN frataxin -2.28898
GKAP1 G kinase anchoring protein 1 -2.28724
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.24213
SLK STE20-like kinase -2.23388
KIF4A kinesin family member 4A -2.22543
VRK3 vaccinia related kinase 3 -2.21478
LRP4 low density lipoprotein receptor-related protein 4 -2.21289
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.17793
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.17479
ZC3H12B zinc finger CCCH-type containing 12B -2.17115
ZNF852 zinc finger protein 852 -2.1499
NOD1 nucleotide-binding oligomerization domain containing 1 -2.12131
STARD13 StAR-related lipid transfer (START) domain containing 13 -2.12071
MYOT myotilin -2.08712
PANX2 pannexin 2 -2.08419
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.08068
POR P450 (cytochrome) oxidoreductase -2.05125
NES nestin -2.04387
ZFP42 ZFP42 zinc finger protein -2.04387
GLRX2 glutaredoxin 2 -2.04326
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.02486
CER1 cerberus 1, DAN family BMP antagonist -2.01858
ZNF860 zinc finger protein 860 -2.01858
SPAG6 sperm associated antigen 6 -2.01858
SESN1 sestrin 1 -2.0167
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.00151
LHFPL1 lipoma HMGIC fusion partner-like 1 -2.00025