| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | estrogen receptor 1|This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 2099) |
| External Link | https://ncbi.nlm.nih.gov/gene/2099 |
| Similar Terms | |
| Downloads & Tools |
496 genes differentially expressed following the ESR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LTF | lactotransferrin | 0.0151502 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0148216 |
| FABP7 | fatty acid binding protein 7, brain | 0.0142506 |
| RGCC | regulator of cell cycle | 0.0142329 |
| MYBPC1 | myosin binding protein C, slow type | 0.0142032 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0141314 |
| S100A9 | S100 calcium binding protein A9 | 0.0138607 |
| S100A7 | S100 calcium binding protein A7 | 0.0135523 |
| ANXA1 | annexin A1 | 0.0132654 |
| KRT23 | keratin 23, type I | 0.0128842 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0123644 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0123339 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.0116923 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.0116655 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0114761 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0114373 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.0114341 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.0111917 |
| AK4 | adenylate kinase 4 | 0.0110418 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0110391 |
| EMP1 | epithelial membrane protein 1 | 0.0106616 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0105382 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.0104349 |
| LCN2 | lipocalin 2 | 0.010299 |
| INHBB | inhibin, beta B | 0.0102012 |
| MMP7 | matrix metallopeptidase 7 | 0.0101052 |
| CHI3L2 | chitinase 3-like 2 | 0.00989402 |
| KRT15 | keratin 15, type I | 0.00982169 |
| S100A8 | S100 calcium binding protein A8 | 0.00978119 |
| PEG3 | paternally expressed 3 | 0.00965965 |
| MYO1C | myosin IC | 0.00932306 |
| TFRC | transferrin receptor | 0.00928097 |
| KRT14 | keratin 14, type I | 0.00927826 |
| CSTA | cystatin A (stefin A) | 0.00917673 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00916341 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00908232 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00895836 |
| S100A10 | S100 calcium binding protein A10 | 0.00883511 |
| MUC16 | mucin 16, cell surface associated | 0.00879621 |
| CD14 | CD14 molecule | 0.00877609 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00874406 |
| XIC | X chromosome inactivation center | 0.0086741 |
| REEP5 | receptor accessory protein 5 | 0.00862886 |
| BCL2A1 | BCL2-related protein A1 | 0.00862535 |
| EPCAM | epithelial cell adhesion molecule | 0.00861029 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.0085796 |
| KLK10 | kallikrein-related peptidase 10 | 0.00857596 |
| IQCG | IQ motif containing G | 0.00854819 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00848033 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00844217 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00842544 |
| PITX3 | paired-like homeodomain 3 | 0.00823544 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00819353 |
| LY96 | lymphocyte antigen 96 | 0.00818511 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00815994 |
| SLN | sarcolipin | 0.0081314 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00810892 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00805905 |
| PLK2 | polo-like kinase 2 | 0.00798519 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00796632 |
| EGR2 | early growth response 2 | 0.00788433 |
| PADI2 | peptidyl arginine deiminase, type II | 0.00782186 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00779988 |
| IL32 | interleukin 32 | 0.00771707 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00764854 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00763912 |
| TAGLN2 | transgelin 2 | 0.00762675 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00759628 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00748346 |
| DOK5 | docking protein 5 | 0.00744212 |
| KRT5 | keratin 5, type II | 0.00739441 |
| ETHE1 | ethylmalonic encephalopathy 1 | 0.00739275 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00736291 |
| NRN1 | neuritin 1 | 0.00735501 |
| JUNB | jun B proto-oncogene | 0.0072979 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.00725027 |
| C3 | complement component 3 | 0.00724178 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00720989 |
| S100A2 | S100 calcium binding protein A2 | 0.00719709 |
| CNN3 | calponin 3, acidic | 0.00718084 |
| RNASET2 | ribonuclease T2 | 0.00716559 |
| HOPX | HOP homeobox | 0.00712978 |
| CLDN7 | claudin 7 | 0.00708464 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00704279 |
| TMC5 | transmembrane channel-like 5 | 0.00700006 |
| MB | myoglobin | 0.00691964 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00690683 |
| ABLIM1 | actin binding LIM protein 1 | 0.00690502 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0069028 |
| CLDN8 | claudin 8 | 0.00688961 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00687538 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00687008 |
| ACP6 | acid phosphatase 6, lysophosphatidic | 0.00685352 |
| TSPAN6 | tetraspanin 6 | 0.00684099 |
| IFI44L | interferon-induced protein 44-like | 0.00677658 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00676072 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00675411 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00672043 |
| HTRA1 | HtrA serine peptidase 1 | 0.0067023 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.00669878 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.00668551 |
| HOMER1 | homer scaffolding protein 1 | 0.00667371 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00666181 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | 0.00663937 |
| KRT81 | keratin 81, type II | 0.00663243 |
| KRT6A | keratin 6A, type II | 0.00662303 |
| NCOA4 | nuclear receptor coactivator 4 | 0.00660529 |
| RGS10 | regulator of G-protein signaling 10 | 0.00658722 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00657653 |
| ITGA6 | integrin, alpha 6 | 0.00657276 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00657168 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00656438 |
| PSAP | prosaposin | 0.00655693 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00655506 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.00654114 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00653219 |
| IER5 | immediate early response 5 | 0.00652229 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.0064937 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | 0.00649298 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00647357 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00646241 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00644101 |
| KRT17 | keratin 17, type I | 0.00643713 |
| CHPT1 | choline phosphotransferase 1 | 0.0064228 |
| NES | nestin | 0.00637639 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00636698 |
| FAM198B | family with sequence similarity 198, member B | 0.00636582 |
| CFI | complement factor I | 0.0063295 |
| RUNX1 | runt-related transcription factor 1 | 0.00632486 |
| KLF6 | Kruppel-like factor 6 | 0.00631775 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00631163 |
| TRIM29 | tripartite motif containing 29 | 0.00630111 |
| GPR65 | G protein-coupled receptor 65 | 0.00627455 |
| IFI44 | interferon-induced protein 44 | 0.00627022 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00626619 |
| CTSH | cathepsin H | 0.00625302 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.00624604 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00623719 |
| KLK6 | kallikrein-related peptidase 6 | 0.00621714 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.00620881 |
| TPM4 | tropomyosin 4 | 0.00620682 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00619376 |
| KLK8 | kallikrein-related peptidase 8 | 0.00619277 |
| NMD3 | NMD3 ribosome export adaptor | 0.00619002 |
| LDLR | low density lipoprotein receptor | 0.00613733 |
| MMP11 | matrix metallopeptidase 11 | 0.00606867 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.0060661 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00604497 |
| THBS2 | thrombospondin 2 | 0.00603684 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.00603531 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00601773 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00601751 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.00601732 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00600692 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00600331 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00599001 |
| TNNC2 | troponin C type 2 (fast) | 0.00595334 |
| STOM | stomatin | 0.00595111 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | 0.00594749 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00591553 |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.00591517 |
| CD53 | CD53 molecule | 0.00589302 |
| C9ORF16 | chromosome 9 open reading frame 16 | 0.00589098 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00588638 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0058807 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00585313 |
| HIST3H2A | histone cluster 3, H2a | 0.00584531 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.00583458 |
| ZNF706 | zinc finger protein 706 | 0.00583336 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.00583303 |
| IL1RN | interleukin 1 receptor antagonist | 0.0058279 |
| GPM6B | glycoprotein M6B | 0.00582541 |
| DAZAP2 | DAZ associated protein 2 | 0.0058231 |
| CANX | calnexin | 0.00581976 |
| TPM3 | tropomyosin 3 | 0.00581394 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | 0.00579893 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0057967 |
| TTN | titin | 0.00578827 |
| AZIN1 | antizyme inhibitor 1 | 0.00578237 |
| A2M | alpha-2-macroglobulin | 0.00578099 |
| NEK7 | NIMA-related kinase 7 | 0.0057747 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00577078 |
| USP18 | ubiquitin specific peptidase 18 | 0.00574549 |
| ATF3 | activating transcription factor 3 | 0.00574412 |
| FZD1 | frizzled class receptor 1 | 0.00573442 |
| CALML5 | calmodulin-like 5 | 0.00572431 |
| RFK | riboflavin kinase | 0.00572192 |
| GMFG | glia maturation factor, gamma | 0.00571771 |
| CLIC5 | chloride intracellular channel 5 | 0.00571432 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00571345 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.00570686 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00570278 |
| TNNC1 | troponin C type 1 (slow) | 0.00569681 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00568505 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0056722 |
| FZD6 | frizzled class receptor 6 | 0.0056603 |
| KLHL41 | kelch-like family member 41 | 0.00565195 |
| MAPK1 | mitogen-activated protein kinase 1 | 0.00564195 |
| COCH | cochlin | 0.00562016 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00561504 |
| IPO7 | importin 7 | 0.00560997 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.00560427 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00559558 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00558022 |
| BTG3 | BTG family, member 3 | 0.00557638 |
| SELL | selectin L | 0.00557382 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00556105 |
| RPL36 | ribosomal protein L36 | 0.00555216 |
| FOLR1 | folate receptor 1 (adult) | 0.00551763 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.0055165 |
| PLP1 | proteolipid protein 1 | 0.00551339 |
| PRKCQ | protein kinase C, theta | 0.00549221 |
| HNMT | histamine N-methyltransferase | 0.00547183 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00546111 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.00544369 |
| SFN | stratifin | 0.00543984 |
| STAC | SH3 and cysteine rich domain | 0.00542543 |
| DPH5 | diphthamide biosynthesis 5 | 0.00542299 |
| ASPN | asporin | 0.00540645 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00539664 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00539616 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00538607 |
| CAPN3 | calpain 3, (p94) | 0.0053844 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00538005 |
| IRS2 | insulin receptor substrate 2 | 0.00537565 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.0053562 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00534918 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00534456 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | 0.0053302 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00532827 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.00531155 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.0053099 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00530661 |
| C5AR1 | complement component 5a receptor 1 | 0.00530101 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00529772 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00529557 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00529529 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.00527895 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.00527331 |
| KRT7 | keratin 7, type II | 0.00527022 |
| PLBD1 | phospholipase B domain containing 1 | 0.00526791 |
| PRAME | preferentially expressed antigen in melanoma | 0.00526529 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.00525655 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00525569 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | 0.00524649 |
| SPRR1B | small proline-rich protein 1B | 0.00524424 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00522607 |
| PRKCH | protein kinase C, eta | 0.00522491 |
| CAST | calpastatin | 0.00522275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0218103 |
| MMP1 | matrix metallopeptidase 1 | -0.0116636 |
| HOXC6 | homeobox C6 | -0.0108612 |
| TFF1 | trefoil factor 1 | -0.0106948 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00986554 |
| BLNK | B-cell linker | -0.00967207 |
| LAMB1 | laminin, beta 1 | -0.00947635 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00945272 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00931941 |
| SCG5 | secretogranin V | -0.00913968 |
| HOXC10 | homeobox C10 | -0.00901505 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00895162 |
| CTBP2 | C-terminal binding protein 2 | -0.00877354 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00853191 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00848698 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00848203 |
| CTSZ | cathepsin Z | -0.0080363 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00800348 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00782222 |
| PDZK1 | PDZ domain containing 1 | -0.00780774 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0077658 |
| CSK | c-src tyrosine kinase | -0.0077433 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.00769793 |
| PROCR | protein C receptor, endothelial | -0.00768277 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00764477 |
| NDRG1 | N-myc downstream regulated 1 | -0.00760399 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00746412 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.0074444 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.00743705 |
| NVL | nuclear VCP-like | -0.00740198 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | -0.00731783 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00728072 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00719544 |
| TSPAN12 | tetraspanin 12 | -0.00716864 |
| OLFM1 | olfactomedin 1 | -0.00715433 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00715311 |
| RRBP1 | ribosome binding protein 1 | -0.00708715 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00708356 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00701038 |
| REG1A | regenerating islet-derived 1 alpha | -0.00700212 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.00696756 |
| ELN | elastin | -0.0069504 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00693994 |
| FBN2 | fibrillin 2 | -0.00693755 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00682679 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00675988 |
| SMTN | smoothelin | -0.00672168 |
| PRKCZ | protein kinase C, zeta | -0.00666574 |
| MYRF | myelin regulatory factor | -0.00663825 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00661438 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00659113 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00655349 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -0.00654162 |
| TBC1D16 | TBC1 domain family, member 16 | -0.00653435 |
| SEPTIN10 | septin 10 | -0.00652932 |
| EHD3 | EH-domain containing 3 | -0.00651321 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | -0.00650099 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0064864 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00643331 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00642814 |
| CALCA | calcitonin-related polypeptide alpha | -0.00637304 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00635679 |
| PLXNB2 | plexin B2 | -0.00635604 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00635505 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | -0.0063407 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00631871 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00629666 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00629238 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | -0.00627387 |
| KIAA0930 | KIAA0930 | -0.00623765 |
| CFD | complement factor D (adipsin) | -0.00621556 |
| BEX1 | brain expressed, X-linked 1 | -0.00613889 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00613009 |
| SETBP1 | SET binding protein 1 | -0.00612022 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.00610367 |
| ADIRF | adipogenesis regulatory factor | -0.00607643 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00607292 |
| ELAC2 | elaC ribonuclease Z 2 | -0.00606397 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0060401 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00601321 |
| CHGB | chromogranin B | -0.00599953 |
| CA12 | carbonic anhydrase XII | -0.00598113 |
| MTMR9 | myotubularin related protein 9 | -0.00592652 |
| NTS | neurotensin | -0.00591644 |
| INTS1 | integrator complex subunit 1 | -0.00588899 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00587891 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00587486 |
| METTL7A | methyltransferase like 7A | -0.00586768 |
| CBX5 | chromobox homolog 5 | -0.00585301 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -0.00582633 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00579422 |
| TMEM176B | transmembrane protein 176B | -0.00579193 |
| ALDOB | aldolase B, fructose-bisphosphate | -0.00578819 |
| DSE | dermatan sulfate epimerase | -0.00578314 |
| FAM13A | family with sequence similarity 13, member A | -0.00577831 |
| LAMA5 | laminin, alpha 5 | -0.00574823 |
| SPATA20 | spermatogenesis associated 20 | -0.00574655 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00574235 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00574176 |
| FBXO2 | F-box protein 2 | -0.00571229 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00571207 |
| DACH1 | dachshund family transcription factor 1 | -0.0057021 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00568259 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | -0.00566889 |
| TARDBP | TAR DNA binding protein | -0.00563158 |
| CTBP1 | C-terminal binding protein 1 | -0.00554987 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00554193 |
| NOTCH2 | notch 2 | -0.00553164 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00549159 |
| DDX39A | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A | -0.00547484 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.00546623 |
| MAOA | monoamine oxidase A | -0.00545639 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00541709 |
| FOXO4 | forkhead box O4 | -0.00541452 |
| CDC7 | cell division cycle 7 | -0.0053983 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00539658 |
| REEP1 | receptor accessory protein 1 | -0.00538977 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00538311 |
| PIAS3 | protein inhibitor of activated STAT, 3 | -0.00538107 |
| SUCO | SUN domain containing ossification factor | -0.0053644 |
| MOK | MOK protein kinase | -0.00530086 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00528565 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00527999 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00526884 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.00526601 |
| CLU | clusterin | -0.00525891 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00525144 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00525036 |
| HOXC4 | homeobox C4 | -0.00524747 |
| AOX1 | aldehyde oxidase 1 | -0.00524396 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.00522996 |
| CDC20 | cell division cycle 20 | -0.00521087 |
| SEPTIN2 | septin 2 | -0.00516385 |
| PLCB4 | phospholipase C, beta 4 | -0.00514576 |
| ANKRD11 | ankyrin repeat domain 11 | -0.00513889 |
| WDR6 | WD repeat domain 6 | -0.00513741 |
| L1CAM | L1 cell adhesion molecule | -0.00513135 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.00511896 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00511247 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00509432 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | -0.00508525 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00508019 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | -0.00507185 |
| G0S2 | G0/G1 switch 2 | -0.00503539 |
| HOXB6 | homeobox B6 | -0.00503149 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0050245 |
| RCAN2 | regulator of calcineurin 2 | -0.00500958 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | -0.00499347 |
| CLGN | calmegin | -0.00499003 |
| LEFTY1 | left-right determination factor 1 | -0.00498093 |
| TIMELESS | timeless circadian clock | -0.00496113 |
| ADCY9 | adenylate cyclase 9 | -0.00496018 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.00495057 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | -0.00494771 |
| ATMIN | ATM interactor | -0.00493374 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00492164 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.00492135 |
| HMG20B | high mobility group 20B | -0.00492046 |
| AURKB | aurora kinase B | -0.00491205 |
| UNC45A | unc-45 homolog A (C. elegans) | -0.00487885 |
| EFHD2 | EF-hand domain family, member D2 | -0.00487826 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00487803 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00487621 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.00487286 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.00486978 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00486698 |
| PBLD | phenazine biosynthesis-like protein domain containing | -0.00485963 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00485578 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00485477 |
| TRRAP | transformation/transcription domain-associated protein | -0.00484345 |
| MAEA | macrophage erythroblast attacher | -0.00482405 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | -0.00481517 |
| FANCL | Fanconi anemia, complementation group L | -0.00481223 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.00481045 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00481024 |
| FOXF1 | forkhead box F1 | -0.00479658 |
| STK25 | serine/threonine kinase 25 | -0.00479427 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00478867 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00478755 |
| APMAP | adipocyte plasma membrane associated protein | -0.0047752 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.00477345 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00476979 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0047662 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.00476615 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00476145 |
| EDRF1 | erythroid differentiation regulatory factor 1 | -0.00476028 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | -0.00475164 |
| HMGN5 | high mobility group nucleosome binding domain 5 | -0.00474226 |
| BRD4 | bromodomain containing 4 | -0.00473676 |
| FAM149A | family with sequence similarity 149, member A | -0.00473518 |
| SMAD7 | SMAD family member 7 | -0.0047346 |
| BMP6 | bone morphogenetic protein 6 | -0.00473331 |
| PNPLA6 | patatin-like phospholipase domain containing 6 | -0.00473184 |
| ANXA10 | annexin A10 | -0.00473067 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00472855 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00472795 |
| FOXM1 | forkhead box M1 | -0.00472065 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.00471079 |
| ATG4B | autophagy related 4B, cysteine peptidase | -0.0047021 |
| SIK2 | salt-inducible kinase 2 | -0.00470126 |
| EXOSC10 | exosome component 10 | -0.00469971 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -0.004693 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.00468645 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00468191 |
| FAM193A | family with sequence similarity 193, member A | -0.00467568 |
| SNX1 | sorting nexin 1 | -0.00467049 |
| RGS5 | regulator of G-protein signaling 5 | -0.00467021 |
| COL9A2 | collagen, type IX, alpha 2 | -0.0046691 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00466162 |
| NISCH | nischarin | -0.00465813 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00465536 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.00465066 |
| GPX3 | glutathione peroxidase 3 | -0.0046478 |
| RAD9A | RAD9 homolog A (S. pombe) | -0.00463308 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.00463172 |
| CTSK | cathepsin K | -0.00463112 |
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | -0.00462795 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00462296 |
| GOLGA8H | golgin A8 family, member H | -0.00461952 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.00461326 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.00460451 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00460072 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.00458744 |
| SRRT | serrate, RNA effector molecule | -0.00458708 |
| XYLT1 | xylosyltransferase I | -0.00458564 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.00457636 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00457481 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00456805 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00456034 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | -0.00455775 |
| HMGB3 | high mobility group box 3 | -0.00455321 |
| CDH16 | cadherin 16, KSP-cadherin | -0.00453668 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.00453505 |
| PDE10A | phosphodiesterase 10A | -0.00452514 |
| CCNF | cyclin F | -0.00450637 |
| CD320 | CD320 molecule | -0.00450598 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | -0.00450227 |
| LOXL1 | lysyl oxidase-like 1 | -0.00449282 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.00449042 |
| FEM1B | fem-1 homolog b (C. elegans) | -0.00447344 |
| GUSB | glucuronidase, beta | -0.0044599 |
| USP48 | ubiquitin specific peptidase 48 | -0.00445979 |
| SPAG5 | sperm associated antigen 5 | -0.00445952 |
| THAP9-AS1 | THAP9 antisense RNA 1 | -0.00445439 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.00443766 |
| BANP | BTG3 associated nuclear protein | -0.00443587 |
| C5 | complement component 5 | -0.00443294 |
