ESR2 Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description estrogen receptor 2 (ER beta)|This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2100)
External Link http://www.ncbi.nlm.nih.gov/gene/2100
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Genes

419 target genes of the ESR2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD2 abhydrolase domain containing 2
ABHD8 abhydrolase domain containing 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ACER3 alkaline ceramidase 3
ACOT4 acyl-CoA thioesterase 4
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADGRE5 adhesion G protein-coupled receptor E5
ADORA1 adenosine A1 receptor
AFAP1L2 actin filament associated protein 1-like 2
AGAP11 ankyrin repeat and GTPase domain Arf GTPase activating protein 11
AGO2 argonaute RISC catalytic component 2
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C2 aldo-keto reductase family 1, member C2
ANGPTL4 angiopoietin-like 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANKRD13D ankyrin repeat domain 13 family, member D
ANKRD23 ankyrin repeat domain 23
ANKRD33 ankyrin repeat domain 33
APMAP adipocyte plasma membrane associated protein
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARID4B AT rich interactive domain 4B (RBP1-like)
ARRB1 arrestin, beta 1
ARRDC2 arrestin domain containing 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L2 autophagy related 16-like 2 (S. cerevisiae)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
ATXN1 ataxin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BACE1 beta-site APP-cleaving enzyme 1
BAG1 BCL2-associated athanogene
BANP BTG3 associated nuclear protein
BARD1 BRCA1 associated RING domain 1
BATF basic leucine zipper transcription factor, ATF-like
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL9L B-cell CLL/lymphoma 9-like
BDKRB2 bradykinin receptor B2
BMF Bcl2 modifying factor
BMP7 bone morphogenetic protein 7
BTBD11 BTB (POZ) domain containing 11
C14ORF132 chromosome 14 open reading frame 132
C16ORF74 chromosome 16 open reading frame 74
C17ORF58 chromosome 17 open reading frame 58
C1ORF122 chromosome 1 open reading frame 122
C1ORF21 chromosome 1 open reading frame 21
C1ORF216 chromosome 1 open reading frame 216
C1QTNF6 C1q and tumor necrosis factor related protein 6
C22ORF29 chromosome 22 open reading frame 29
C6ORF141 chromosome 6 open reading frame 141
C6ORF165 chromosome 6 open reading frame 165
CA12 carbonic anhydrase XII
CALCR calcitonin receptor
CALML5 calmodulin-like 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPN5 calpain 5
CAPN8 calpain 8
CCDC103 coiled-coil domain containing 103
CCDC64B coiled-coil domain containing 64B
CCDC74A coiled-coil domain containing 74A
CCDC92 coiled-coil domain containing 92
CCPG1 cell cycle progression 1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD82 CD82 molecule
CD9 CD9 molecule
CDC34 cell division cycle 34
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK6 cyclin-dependent kinase 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEMIP cell migration inducing protein, hyaluronan binding
CGN cingulin
CHD9 chromodomain helicase DNA binding protein 9
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLCF1 cardiotrophin-like cytokine factor 1
CLDN23 claudin 23
CLDN9 claudin 9
CMSS1 cms1 ribosomal small subunit homolog (yeast)
CNST consortin, connexin sorting protein
CNTD2 cyclin N-terminal domain containing 2
CREBRF CREB3 regulatory factor
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CROT carnitine O-octanoyltransferase
CSRNP1 cysteine-serine-rich nuclear protein 1
CSRP1 cysteine and glycine-rich protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
CTSD cathepsin D
CYB5A cytochrome b5 type A (microsomal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYSRT1 cysteine-rich tail protein 1
DCAF4 DDB1 and CUL4 associated factor 4
DCDC2 doublecortin domain containing 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DENND2C DENN/MADD domain containing 2C
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIO1 deiodinase, iodothyronine, type I
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DLL1 delta-like 1 (Drosophila)
DNAAF1 dynein, axonemal, assembly factor 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DOCK1 dedicator of cytokinesis 1
DOCK8 dedicator of cytokinesis 8
DOK7 docking protein 7
DOPEY2 dopey family member 2
DSCAM Down syndrome cell adhesion molecule
EDC3 enhancer of mRNA decapping 3
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EFR3B EFR3 homolog B (S. cerevisiae)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8
EPHA2 EPH receptor A2
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERC2 ELKS/RAB6-interacting/CAST family member 2
ESR2 estrogen receptor 2 (ER beta)
FAM174B family with sequence similarity 174, member B
FAM213A family with sequence similarity 213, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FCAR Fc fragment of IgA receptor
FKBP4 FK506 binding protein 4, 59kDa
FLNB filamin B, beta
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FREM2 FRAS1 related extracellular matrix protein 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GAB2 GRB2-associated binding protein 2
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16
GDF15 growth differentiation factor 15
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GFRA1 GDNF family receptor alpha 1
GLA galactosidase, alpha
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR37L1 G protein-coupled receptor 37 like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPSM1 G-protein signaling modulator 1
GRAMD1A GRAM domain containing 1A
GRB10 growth factor receptor-bound protein 10
GREB1 growth regulation by estrogen in breast cancer 1
GREB1L growth regulation by estrogen in breast cancer-like
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2IRD1 GTF2I repeat domain containing 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HCAR1 hydroxycarboxylic acid receptor 1
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIPK2 homeodomain interacting protein kinase 2
HK1 hexokinase 1
HOMER2 homer scaffolding protein 2
HOXC13 homeobox C13
HPDL 4-hydroxyphenylpyruvate dioxygenase-like
HS6ST2 heparan sulfate 6-O-sulfotransferase 2
HSPA4 heat shock 70kDa protein 4
HSPB8 heat shock 22kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IFT122 intraflagellar transport 122
IGDCC3 immunoglobulin superfamily, DCC subclass, member 3
IGFBP4 insulin-like growth factor binding protein 4
IGFL1 IGF-like family member 1
IGSF9 immunoglobulin superfamily, member 9
IL17RB interleukin 17 receptor B
INSIG2 insulin induced gene 2
IRF2BPL interferon regulatory factor 2 binding protein-like
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAK2 Janus kinase 2
JPH3 junctophilin 3
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KIAA1467 KIAA1467
KLF9 Kruppel-like factor 9
KLHDC9 kelch domain containing 9
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LATS2 large tumor suppressor kinase 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDHD lactate dehydrogenase D
LMCD1 LIM and cysteine-rich domains 1
LOC145837
LOC284379 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 pseudogene
LOC285696 uncharacterized LOC285696
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC8D leucine rich repeat containing 8 family, member D
MACF1 microtubule-actin crosslinking factor 1
MAOA monoamine oxidase A
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
MB21D2 Mab-21 domain containing 2
MBNL2 muscleblind-like splicing regulator 2
MBOAT1 membrane bound O-acyltransferase domain containing 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
METTL2A methyltransferase like 2A
MICB MHC class I polypeptide-related sequence B
MID1IP1 MID1 interacting protein 1
MIDN midnolin
MITF microphthalmia-associated transcription factor
MREG melanoregulin
MTCP1 mature T-cell proliferation 1
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYEOV myeloma overexpressed
MYH9 myosin, heavy chain 9, non-muscle
MYPN myopalladin
N4BP3 NEDD4 binding protein 3
NANS N-acetylneuraminic acid synthase
NAV2 neuron navigator 2
NBEA neurobeachin
NBPF1 neuroblastoma breakpoint family, member 1
NDRG1 N-myc downstream regulated 1
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NKD2 naked cuticle homolog 2 (Drosophila)
NOP16 NOP16 nucleolar protein
NOTCH3 notch 3
NPAS3 neuronal PAS domain protein 3
NPNT nephronectin
NRIP1 nuclear receptor interacting protein 1
NT5C2 5'-nucleotidase, cytosolic II
NUAK1 NUAK family, SNF1-like kinase, 1
OGFR opioid growth factor receptor
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OPRL1 opiate receptor-like 1
OSBPL7 oxysterol binding protein-like 7
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PALM paralemmin
PARM1 prostate androgen-regulated mucin-like protein 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PCTP phosphatidylcholine transfer protein
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PID1 phosphotyrosine interaction domain containing 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G16 phospholipase A2, group XVI
PLAC1 placenta-specific 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLEKHN1 pleckstrin homology domain containing, family N member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNPLA7 patatin-like phospholipase domain containing 7
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPL periplakin
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PRKCD protein kinase C, delta
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRRT2 proline-rich transmembrane protein 2
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES prostaglandin E synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
PVT1 Pvt1 oncogene (non-protein coding)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB15 RAB15, member RAS oncogene family
RAB26 RAB26, member RAS oncogene family
RAB37 RAB37, member RAS oncogene family
RAB4B RAB4B, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASA3 RAS p21 protein activator 3
RASEF RAS and EF-hand domain containing
RCAN1 regulator of calcineurin 1
RET ret proto-oncogene
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RHPN2 rhophilin, Rho GTPase binding protein 2
RIMS3 regulating synaptic membrane exocytosis 3
RIPK4 receptor-interacting serine-threonine kinase 4
RNF170 ring finger protein 170
RPL13 ribosomal protein L13
RPL23AP42 ribosomal protein L23a pseudogene 42
RUSC2 RUN and SH3 domain containing 2
S100P S100 calcium binding protein P
S1PR3 sphingosine-1-phosphate receptor 3
SASH1 SAM and SH3 domain containing 1
SDCBP syndecan binding protein (syntenin)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SELT selenoprotein T
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEPT9 septin 9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFXN2 sideroflexin 2
SGK1 serum/glucocorticoid regulated kinase 1
SGK3 serum/glucocorticoid regulated kinase family, member 3
SH3BP4 SH3-domain binding protein 4
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHROOM2 shroom family member 2
SIDT2 SID1 transmembrane family, member 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A23 solute carrier family 22, member 23
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC37A3 solute carrier family 37, member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLITRK4 SLIT and NTRK-like family, member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNX29 sorting nexin 29
SOCS3 suppressor of cytokine signaling 3
SOX13 SRY (sex determining region Y)-box 13
SOX18 SRY (sex determining region Y)-box 18
SOX3 SRY (sex determining region Y)-box 3
SOX9 SRY (sex determining region Y)-box 9
SPATS2 spermatogenesis associated, serine-rich 2
SPIRE2 spire-type actin nucleation factor 2
SPTBN2 spectrin, beta, non-erythrocytic 2
SQSTM1 sequestosome 1
SRPK1 SRSF protein kinase 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STC2 stanniocalcin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SVIL supervillin
SYBU syntabulin (syntaxin-interacting)
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCF12 transcription factor 12
TDRD1 tudor domain containing 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFB2 transforming growth factor, beta 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLN2 talin 2
TMEM63A transmembrane protein 63A
TMEM79 transmembrane protein 79
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TOM1L2 target of myb1-like 2 (chicken)
TOP1 topoisomerase (DNA) I
TPD52L1 tumor protein D52-like 1
TRAK1 trafficking protein, kinesin binding 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UBTD1 ubiquitin domain containing 1
UGDH UDP-glucose 6-dehydrogenase
UNKL unkempt family zinc finger-like
USP10 ubiquitin specific peptidase 10
VAMP5 vesicle-associated membrane protein 5
VASN vasorin
VAV2 vav 2 guanine nucleotide exchange factor
VPS9D1 VPS9 domain containing 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WBP4 WW domain binding protein 4
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WISP2 WNT1 inducible signaling pathway protein 2
WNT7B wingless-type MMTV integration site family, member 7B
WSB1 WD repeat and SOCS box containing 1
WWC3 WWC family member 3
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XBP1 X-box binding protein 1
ZBED4 zinc finger, BED-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF217 zinc finger protein 217
ZNF365 zinc finger protein 365
ZNF385A zinc finger protein 385A
ZNF462 zinc finger protein 462
ZNF703 zinc finger protein 703
ZNF823 zinc finger protein 823