ESR2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description estrogen receptor 2 (ER beta)|This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2100)
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Genes

222 genes differentially expressed following the ESR2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.65575
SPINK4 serine peptidase inhibitor, Kazal type 4 2.65575
IGFL2 IGF-like family member 2 2.65575
ZNF503 zinc finger protein 503 2.65575
PCDHA8 protocadherin alpha 8 2.65575
CDX2 caudal type homeobox 2 2.65575
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.65575
PRB4 proline-rich protein BstNI subfamily 4 2.65575
C4ORF17 chromosome 4 open reading frame 17 2.65575
CLDN9 claudin 9 2.65575
CLDN2 claudin 2 2.65575
IRF5 interferon regulatory factor 5 2.65575
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.65575
IL4 interleukin 4 2.65575
TPTE transmembrane phosphatase with tensin homology 2.65575
TBX4 T-box 4 2.65575
PGAM4 phosphoglycerate mutase family member 4 2.65575
PDYN prodynorphin 2.65575
MAGED4 melanoma antigen family D4 2.65575
CD69 CD69 molecule 2.65575
C1ORF146 chromosome 1 open reading frame 146 2.65575
SIX2 SIX homeobox 2 2.65575
ADAMTSL5 ADAMTS-like 5 2.65575
BRS3 bombesin-like receptor 3 2.65575
ZNF232 zinc finger protein 232 2.65575
PLXNB3 plexin B3 2.65575
SSTR5 somatostatin receptor 5 2.65575
SNX5 sorting nexin 5 2.65575
OR6M1 olfactory receptor, family 6, subfamily M, member 1 2.65575
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.65575
FFAR4 free fatty acid receptor 4 2.65575
LRRC52 leucine rich repeat containing 52 2.65575
INSM2 insulinoma-associated 2 2.65575
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.65575
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.65575
MACO1 macoilin 1 2.65575
TMEM271 transmembrane protein 271 2.65575
CCDC187 coiled-coil domain containing 187 2.65575
H4C9 H4 clustered histone 9 2.65575
GARIN6 golgi associated RAB2 interactor family member 6 2.65575
MEIOSIN meiosis initiator 2.65575
CFAP276 cilia and flagella associated protein 276 2.65575
DEFB131A defensin beta 131A 2.65575
H2AC19 H2A clustered histone 19 2.65575
H3C3 H3 clustered histone 3 2.65575
REELD1 reeler domain containing 1 2.65575
ANKRD42-DT ANKRD42 divergent transcript 2.65575
DRC5 dynein regulatory complex subunit 5 2.65575
SPMIP10 sperm microtubule inner protein 10 2.65575
FAM90A12 family with sequence similarity 90 member A12 2.65575
RAX2 retina and anterior neural fold homeobox 2 2.65575
TCERG1L transcription elongation regulator 1-like 2.65575
ARMS2 age-related maculopathy susceptibility 2 2.65575
CCR4 chemokine (C-C motif) receptor 4 2.65575
CLDN24 claudin 24 2.65575
UTS2 urotensin 2 2.65575
LRTM3 leucine rich repeat transmembrane protein 3 2.65575
CNTRL centriolin 2.65575
ASIC5 acid sensing (proton gated) ion channel family member 5 2.65575
ROPN1 rhophilin associated tail protein 1 2.65575
SOAT2 sterol O-acyltransferase 2 2.65575
ZG16B zymogen granule protein 16B 2.65575
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.65575
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.65575
C15ORF62 chromosome 15 open reading frame 62 2.65575
SPATA25 spermatogenesis associated 25 2.65575
OR9G4 olfactory receptor, family 9, subfamily G, member 4 2.65575
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.65575
MUC15 mucin 15, cell surface associated 2.65575
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.65575
CST4 cystatin S 2.65575
CST5 cystatin D 2.65575
CABP5 calcium binding protein 5 2.65575
POU3F2 POU class 3 homeobox 2 2.65575
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.65575
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.65575
GFRAL GDNF family receptor alpha like 2.65575
MAPK11 mitogen-activated protein kinase 11 2.65575
FOXP3 forkhead box P3 2.65575
AQP6 aquaporin 6, kidney specific 2.65575
TLE7 TLE family member 7 2.65575
TEKT1 tektin 1 2.65575
AGXT2 alanine--glyoxylate aminotransferase 2 2.65575
NUPR1 nuclear protein, transcriptional regulator, 1 2.65575
FOXE3 forkhead box E3 2.65575
PCDHGA2 protocadherin gamma subfamily A, 2 2.65575
PCDHGA4 protocadherin gamma subfamily A, 4 2.65575
MAB21L1 mab-21-like 1 (C. elegans) 2.65575
NPBWR1 neuropeptides B/W receptor 1 2.65575
CD5L CD5 molecule-like 2.65575
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.65575
FAM117A family with sequence similarity 117, member A 2.65575
TMPRSS13 transmembrane protease, serine 13 2.65575
TGM5 transglutaminase 5 2.65575
PSD2 pleckstrin and Sec7 domain containing 2 2.65575
OR9K2 olfactory receptor, family 9, subfamily K, member 2 2.65575
OR4E2 olfactory receptor, family 4, subfamily E, member 2 2.65575
LMOD3 leiomodin 3 (fetal) 2.65575
OR5AS1 olfactory receptor, family 5, subfamily AS, member 1 2.65575
DEFB135 defensin, beta 135 2.65575
KLHDC1 kelch domain containing 1 2.65575
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.65575
NWD2 NACHT and WD repeat domain containing 2 2.65575
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.65575
C22ORF31 chromosome 22 open reading frame 31 2.65575
TDO2 tryptophan 2,3-dioxygenase 2.65575
GHRH growth hormone releasing hormone 2.65575
HELZ2 helicase with zinc finger 2, transcriptional coactivator 2.65575
PRSS37 protease, serine, 37 2.65575
SI sucrase-isomaltase (alpha-glucosidase) 2.65575
BANF2 barrier to autointegration factor 2 2.65575
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.65575
TGM1 transglutaminase 1 2.65575
NLRP9 NLR family, pyrin domain containing 9 2.65575
MRPL10 mitochondrial ribosomal protein L10 2.6532
ZIM3 zinc finger, imprinted 3 2.63256
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.63089
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.63089
BAIAP3 BAI1-associated protein 3 2.63089
METTL27 methyltransferase like 27 2.56182
UBALD2 UBA-like domain containing 2 2.49316
GMDS GDP-mannose 4,6-dehydratase 2.45559
ATP5MGL ATP synthase membrane subunit g like 2.37585
TRIP11 thyroid hormone receptor interactor 11 2.37299
NMRAL1 NmrA-like family domain containing 1 2.3555
ZNF525 zinc finger protein 525 2.33902
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.31195
BCL9 B-cell CLL/lymphoma 9 2.30518
HYPK huntingtin interacting protein K 2.30075
ZNF827 zinc finger protein 827 2.27184
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.23437
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.23232
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.23232
KLHL25 kelch-like family member 25 2.23083
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.22956
PDGFD platelet derived growth factor D 2.18897
SMIM17 small integral membrane protein 17 2.17773
GSG1 germ cell associated 1 2.17773
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.15259
SMG7 SMG7 nonsense mediated mRNA decay factor 2.11473
DDIT4 DNA-damage-inducible transcript 4 2.10782
KCNIP4 Kv channel interacting protein 4 2.06423
CNOT10 CCR4-NOT transcription complex, subunit 10 2.06222
SHANK1 SH3 and multiple ankyrin repeat domains 1 2.05655
FZD4 frizzled class receptor 4 2.05636
NTAQ1 N-terminal glutamine amidase 1 2.05489
DMD dystrophin 2.05489
EPS8 epidermal growth factor receptor pathway substrate 8 2.05489
C22ORF39 chromosome 22 open reading frame 39 2.05489
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.05489
OTUD3 OTU deubiquitinase 3 2.03288
KLK6 kallikrein-related peptidase 6 2.01713
SNTG2 syntrophin, gamma 2 2.01322
SDAD1 SDA1 domain containing 1 2.00163

decreased expression

Symbol Name Standardized Value
C8ORF90 chromosome 8 open reading frame 90 -2.65575
NEU4 sialidase 4 -2.65575
GATA2 GATA binding protein 2 -2.65575
PTGFR prostaglandin F receptor (FP) -2.65575
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -2.65575
CEP97 centrosomal protein 97kDa -2.65575
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.65575
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -2.65575
RFPL2 ret finger protein-like 2 -2.65575
SPINT4 serine peptidase inhibitor, Kunitz type 4 -2.65575
SLC25A45 solute carrier family 25, member 45 -2.65575
TNNI1 troponin I type 1 (skeletal, slow) -2.65575
IL1R1 interleukin 1 receptor, type I -2.65575
PLB1 phospholipase B1 -2.65575
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.65575
ACTL10 actin-like 10 -2.65575
ZDBF2 zinc finger, DBF-type containing 2 -2.65575
BTN3A1 butyrophilin, subfamily 3, member A1 -2.65575
SCG2 secretogranin II -2.65575
ADRB2 adrenoceptor beta 2, surface -2.65575
PCDHB6 protocadherin beta 6 -2.65575
VWC2L von Willebrand factor C domain containing protein 2-like -2.65575
PPP1R27 protein phosphatase 1, regulatory subunit 27 -2.65575
TP63 tumor protein p63 -2.65575
EPHA10 EPH receptor A10 -2.65575
ITGA8 integrin, alpha 8 -2.65575
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.65575
PCDH12 protocadherin 12 -2.65575
KLK12 kallikrein-related peptidase 12 -2.65575
NIM1K NIM1 serine/threonine protein kinase -2.65575
EDN3 endothelin 3 -2.65575
GPRC5D G protein-coupled receptor, class C, group 5, member D -2.65575
MPRIP myosin phosphatase Rho interacting protein -2.62175
NUTM2G NUT family member 2G -2.61607
C2CD4D C2 calcium-dependent domain containing 4D -2.61607
IAPP islet amyloid polypeptide -2.61607
HAX1 HCLS1 associated protein X-1 -2.53353
PML promyelocytic leukemia -2.523
SLC48A1 solute carrier family 48 (heme transporter), member 1 -2.49316
SRPK2 SRSF protein kinase 2 -2.47475
RARG retinoic acid receptor, gamma -2.4186
MARCHF11 membrane associated ring-CH-type finger 11 -2.40714
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.33318
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.32562
RPP40 ribonuclease P/MRP 40kDa subunit -2.3072
ADCK2 aarF domain containing kinase 2 -2.30518
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.30075
NAF1 nuclear assembly factor 1 ribonucleoprotein -2.27675
DPY19L1 dpy-19-like 1 (C. elegans) -2.27184
ZNF219 zinc finger protein 219 -2.26996
DOHH deoxyhypusine hydroxylase/monooxygenase -2.23232
DAGLA diacylglycerol lipase, alpha -2.19131
MED26 mediator complex subunit 26 -2.18897
DPF3 D4, zinc and double PHD fingers, family 3 -2.17773
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.17773
BTBD19 BTB (POZ) domain containing 19 -2.17773
USP6 ubiquitin specific peptidase 6 -2.17773
CCM2L cerebral cavernous malformation 2-like -2.15259
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.10782
STAP2 signal transducing adaptor family member 2 -2.07151
ALPK3 alpha-kinase 3 -2.06998
CELA2B chymotrypsin-like elastase family, member 2B -2.06423
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.06423
MED9 mediator complex subunit 9 -2.05489
CREBBP CREB binding protein -2.03288
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.03278
SPTSSB serine palmitoyltransferase, small subunit B -2.02734
BAX BCL2-associated X protein -2.02596