ESRRG Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description estrogen-related receptor gamma|This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2104)
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Genes

323 genes differentially expressed following the ESRRG gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IFNK interferon, kappa 3.38277
SAG S-antigen; retina and pineal gland (arrestin) 3.38277
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.38277
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.38277
CELA1 chymotrypsin-like elastase family, member 1 3.38277
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.38277
ZNF556 zinc finger protein 556 3.38277
OR13C3 olfactory receptor, family 13, subfamily C, member 3 3.38277
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.38277
TPSD1 tryptase delta 1 3.38277
FHL5 four and a half LIM domains 5 3.38277
ASB9 ankyrin repeat and SOCS box containing 9 3.38277
MYOM2 myomesin 2 3.38277
NUGGC nuclear GTPase, germinal center associated 3.38277
C19ORF67 chromosome 19 open reading frame 67 3.38277
GYPB glycophorin B (MNS blood group) 3.38277
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.38277
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.38277
PAPOLB poly(A) polymerase beta (testis specific) 3.38277
KRT77 keratin 77, type II 3.38277
ZPLD1 zona pellucida-like domain containing 1 3.38277
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.38277
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.38277
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 3.38277
ICAM5 intercellular adhesion molecule 5, telencephalin 3.38277
ICAM2 intercellular adhesion molecule 2 3.38277
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.38277
PITX1 paired-like homeodomain 1 3.38277
CTRB2 chymotrypsinogen B2 3.38277
BTBD16 BTB (POZ) domain containing 16 3.38277
BOLA2 bolA family member 2 3.38277
FAM9B family with sequence similarity 9, member B 3.38277
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 3.38277
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.38277
NMUR2 neuromedin U receptor 2 3.38277
HMX3 H6 family homeobox 3 3.38277
TRPC5OS TRPC5 opposite strand 3.38277
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.38277
FETUB fetuin B 3.38277
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.38277
GATA5 GATA binding protein 5 3.38277
LIPG lipase, endothelial 3.38277
OR5H6 olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene) 3.38277
FOXD1 forkhead box D1 3.38277
CNTN6 contactin 6 3.38277
LTF lactotransferrin 3.38277
PRB4 proline-rich protein BstNI subfamily 4 3.38277
MAGEB2 melanoma antigen family B2 3.38277
CIMIP4 ciliary microtubule inner protein 4 3.38277
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.38277
CATSPER1 cation channel, sperm associated 1 3.38277
MSX1 msh homeobox 1 3.38277
UTS2 urotensin 2 3.38277
PGC progastricsin (pepsinogen C) 3.38277
FAP fibroblast activation protein, alpha 3.38277
GLP2R glucagon-like peptide 2 receptor 3.38277
TACR2 tachykinin receptor 2 3.38277
CD300E CD300e molecule 3.38277
GRXCR1 glutaredoxin, cysteine rich 1 3.38277
FOXR1 forkhead box R1 3.38277
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.38277
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.38277
AADACL4 arylacetamide deacetylase-like 4 3.38277
EPB42 erythrocyte membrane protein band 4.2 3.38277
SLC25A41 solute carrier family 25, member 41 3.38277
GLYAT glycine-N-acyltransferase 3.38277
GLUD2 glutamate dehydrogenase 2 3.38277
TSGA13 testis specific, 13 3.38277
MUC2 mucin 2, oligomeric mucus/gel-forming 3.38277
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.38277
VWA5B2 von Willebrand factor A domain containing 5B2 3.38277
LY6K lymphocyte antigen 6 complex, locus K 3.38277
KHDC1L KH homology domain containing 1-like 3.38277
CD6 CD6 molecule 3.38277
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.38277
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.38277
SPDYC speedy/RINGO cell cycle regulator family member C 3.38277
SMIM32 small integral membrane protein 32 3.38277
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.38277
H3-7 H3.7 histone (putative) 3.38277
SMIM35 small integral membrane protein 35 3.38277
MYMK myomaker, myoblast fusion factor 3.38277
MAB21L1 mab-21-like 1 (C. elegans) 3.38277
APOC4 apolipoprotein C-IV 3.38277
APOC2 apolipoprotein C-II 3.38277
GLYATL1B glycine-N-acyltransferase like 1B 3.38277
SEBOX SEBOX homeobox 3.38277
BPIFB4 BPI fold containing family B, member 4 3.38277
CHI3L2 chitinase 3-like 2 3.38277
VNN2 vanin 2 3.38277
BTNL3 butyrophilin-like 3 3.38277
CST8 cystatin 8 (cystatin-related epididymal specific) 3.38277
CST2 cystatin SA 3.38277
ARMH2 armadillo like helical domain containing 2 3.38277
HRCT1 histidine rich carboxyl terminus 1 3.38277
C8ORF89 chromosome 8 open reading frame 89 3.38277
COPZ2 coatomer protein complex, subunit zeta 2 3.38277
HOXA10 homeobox A10 3.38277
GOLGA8Q golgin A8 family, member Q 3.38277
LY6S-AS1 LY6S antisense RNA 1 3.38277
CLEC18B C-type lectin domain family 18, member B 3.38277
TM4SF19 transmembrane 4 L six family member 19 3.38277
GJB6 gap junction protein, beta 6, 30kDa 3.38277
HPGDS hematopoietic prostaglandin D synthase 3.38277
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.38277
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.38277
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 3.38277
CTRB1 chymotrypsinogen B1 3.38277
H4C14 H4 clustered histone 14 3.38277
ADORA3 adenosine A3 receptor 3.38277
SIRPG signal-regulatory protein gamma 3.38277
C20ORF144 chromosome 20 open reading frame 144 3.38277
EPGN epithelial mitogen 3.38277
C18ORF63 chromosome 18 open reading frame 63 3.38277
MAGEA10 melanoma antigen family A10 3.38277
PLGLB2 plasminogen-like B2 3.38277
EPX eosinophil peroxidase 3.38277
SLC7A4 solute carrier family 7, member 4 3.38277
DERPC DERPC proline and glycine rich nuclear protein 3.38277
ALPG alkaline phosphatase, germ cell 3.38277
SLC36A3 solute carrier family 36, member 3 3.38277
LST1 leukocyte specific transcript 1 3.38277
MAGEA9B melanoma antigen family A9B 3.38277
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.38277
TCERG1L transcription elongation regulator 1-like 3.38277
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.38277
CETP cholesteryl ester transfer protein, plasma 3.38277
PTCRA pre T-cell antigen receptor alpha 3.38277
RGR retinal G protein coupled receptor 3.38277
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.38277
LRCOL1 leucine rich colipase-like 1 3.38277
CLEC7A C-type lectin domain family 7, member A 3.38277
GK3 glycerol kinase 3 3.38277
ANKRD40CL ANKRD40 C-terminal like 3.38277
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.38277
CCDC197 coiled-coil domain containing 197 3.38277
CIDEA cell death-inducing DFFA-like effector a 3.38277
MAGEB17 melanoma antigen family B17 3.38277
CALML6 calmodulin-like 6 3.38277
FIGLA folliculogenesis specific basic helix-loop-helix 3.38277
DES desmin 3.33393
TACSTD2 tumor-associated calcium signal transducer 2 3.33393
COMMD7 COMM domain containing 7 3.32154
AGMO alkylglycerol monooxygenase 3.30427
OTUD7A OTU deubiquitinase 7A 3.29694
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 3.20642
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.95615
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.82617
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 2.80073
NRCAM neuronal cell adhesion molecule 2.78588
RPS19 ribosomal protein S19 2.72149
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) 2.65563
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.65563
ADISSP adipose secreted signaling protein 2.64623
RRAGA Ras-related GTP binding A 2.55499
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.55499
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 2.49364
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 2.49364
GUCD1 guanylyl cyclase domain containing 1 2.44801
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.41974
KCTD10 potassium channel tetramerization domain containing 10 2.41052
KLF3 Kruppel-like factor 3 (basic) 2.40068
PRH2 proline-rich protein HaeIII subfamily 2 2.37548
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 2.37548
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.37548
BTBD17 BTB (POZ) domain containing 17 2.33147
PCDH9 protocadherin 9 2.32157
CCR6 chemokine (C-C motif) receptor 6 2.31086
ZIC4 Zic family member 4 2.31086
ASCL2 achaete-scute family bHLH transcription factor 2 2.31086
FAM209A family with sequence similarity 209, member A 2.31086
LRRC63 leucine rich repeat containing 63 2.31086
FBXO40 F-box protein 40 2.31086
AMER2 APC membrane recruitment protein 2 2.31086
DAND5 DAN domain family member 5, BMP antagonist 2.31086
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.30949
CAT catalase 2.306
KIF3B kinesin family member 3B 2.25425
DAZAP1 DAZ associated protein 1 2.24924
SCAF11 SR-related CTD-associated factor 11 2.24659
FLOT1 flotillin 1 2.24153
ZNF766 zinc finger protein 766 2.23153
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.22242
NELL2 NEL-like 2 (chicken) 2.21305
ANGPTL5 angiopoietin-like 5 2.21121
FGF10 fibroblast growth factor 10 2.21121
RPSA ribosomal protein SA 2.19666
CYB5R2 cytochrome b5 reductase 2 2.19426
EZR ezrin 2.19272
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.18211
LYPD1 LY6/PLAUR domain containing 1 2.15245
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.14468
HTRA2 HtrA serine peptidase 2 2.1335
MARS2 methionyl-tRNA synthetase 2, mitochondrial 2.12962
KLHL36 kelch-like family member 36 2.11553
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 2.11341
SFN stratifin 2.11115
ARHGAP26 Rho GTPase activating protein 26 2.11115
KRTCAP3 keratinocyte associated protein 3 2.09377
PYCR1 pyrroline-5-carboxylate reductase 1 2.0888
CCDC81 coiled-coil domain containing 81 2.0593
RAB38 RAB38, member RAS oncogene family 2.0593
OSBPL2 oxysterol binding protein-like 2 2.05662
GSDMB gasdermin B 2.04683
PWWP2B PWWP domain containing 2B 2.0189
MRM3 mitochondrial rRNA methyltransferase 3 2.01435

decreased expression

Symbol Name Standardized Value
H4C12 H4 clustered histone 12 -3.38277
RFPL2 ret finger protein-like 2 -3.38277
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -3.38277
GMFG glia maturation factor, gamma -3.38277
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -3.38277
WNT8B wingless-type MMTV integration site family, member 8B -3.38277
MMP28 matrix metallopeptidase 28 -3.38277
TSHZ1 teashirt zinc finger homeobox 1 -3.38277
NOTCH2NLB notch 2 N-terminal like B -3.38277
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 -3.38277
SNAI2 snail family zinc finger 2 -3.38277
PITX3 paired-like homeodomain 3 -3.38277
TRAF3IP3 TRAF3 interacting protein 3 -3.38277
ADRA1D adrenoceptor alpha 1D -3.38277
TBX15 T-box 15 -3.38277
TCHH trichohyalin -3.38277
HCRTR1 hypocretin (orexin) receptor 1 -3.38277
SEPTIN12 septin 12 -3.38277
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -3.38277
PCDHGA9 protocadherin gamma subfamily A, 9 -3.38277
GC group-specific component (vitamin D binding protein) -3.38277
C15ORF62 chromosome 15 open reading frame 62 -3.38277
C7ORF57 chromosome 7 open reading frame 57 -3.38277
BHLHA9 basic helix-loop-helix family, member a9 -3.38277
TLR6 toll-like receptor 6 -3.38277
CLDN9 claudin 9 -3.38277
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 -3.38277
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -3.38277
GNLY granulysin -3.38277
HEATR9 HEAT repeat containing 9 -3.38277
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -3.38277
S100A14 S100 calcium binding protein A14 -3.38277
DUOX2 dual oxidase 2 -3.38277
TESPA1 thymocyte expressed, positive selection associated 1 -3.38277
ADAM7 ADAM metallopeptidase domain 7 -3.38277
TREH trehalase (brush-border membrane glycoprotein) -3.38277
EVPLL envoplakin-like -3.38277
PLA1A phospholipase A1 member A -3.38277
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -3.38277
SOSTDC1 sclerostin domain containing 1 -3.38277
CERKL ceramide kinase-like -3.38277
EFCC1 EF-hand and coiled-coil domain containing 1 -3.38277
FLRT3 fibronectin leucine rich transmembrane protein 3 -3.38277
EVI2A ecotropic viral integration site 2A -3.38277
CCDC121 coiled-coil domain containing 121 -3.28886
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -3.15693
AANAT aralkylamine N-acetyltransferase -2.85365
FN1 fibronectin 1 -2.80072
TMEM263 transmembrane protein 263 -2.80038
SV2B synaptic vesicle glycoprotein 2B -2.79275
TTN titin -2.73558
APOE apolipoprotein E -2.67118
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.64426
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.61199
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.60876
TBC1D2B TBC1 domain family, member 2B -2.55446
BTD biotinidase -2.51384
PUS1 pseudouridylate synthase 1 -2.51151
FOXO4 forkhead box O4 -2.49364
RSPO4 R-spondin 4 -2.47946
CPOX coproporphyrinogen oxidase -2.43779
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -2.42939
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -2.40699
SPACDR sperm acrosome developmental regulator -2.40699
AMN amnion associated transmembrane protein -2.40699
C11ORF86 chromosome 11 open reading frame 86 -2.40699
LKAAEAR1 LKAAEAR motif containing 1 -2.40699
CDC14A cell division cycle 14A -2.40191
SPIRE1 spire-type actin nucleation factor 1 -2.39533
INSYN1 inhibitory synaptic factor 1 -2.31086
POTEJ POTE ankyrin domain family, member J -2.31086
PRAM1 PML-RARA regulated adaptor molecule 1 -2.31086
FHOD1 formin homology 2 domain containing 1 -2.29591
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.26431
SDK2 sidekick cell adhesion molecule 2 -2.25022
SHISA3 shisa family member 3 -2.24924
BUD31 BUD31 homolog (S. cerevisiae) -2.24153
CDC34 cell division cycle 34 -2.24153
EQTN equatorin, sperm acrosome associated -2.24153
GMPS guanine monphosphate synthase -2.24153
CD27 CD27 molecule -2.24153
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.24153
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -2.23897
MST1 macrophage stimulating 1 -2.22403
SLAIN2 SLAIN motif family, member 2 -2.21105
MEPE matrix extracellular phosphoglycoprotein -2.20936
ZNF324B zinc finger protein 324B -2.20936
OTOGL otogelin-like -2.20936
ZFP92 ZFP92 zinc finger protein -2.20936
MYLK4 myosin light chain kinase family, member 4 -2.20936
XPO6 exportin 6 -2.20699
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 -2.20617
SCML2 sex comb on midleg-like 2 (Drosophila) -2.20534
INSR insulin receptor -2.19478
RNF169 ring finger protein 169 -2.18397
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.18264
PET100 PET100 homolog (S. cerevisiae) -2.18264
TRIM45 tripartite motif containing 45 -2.17738
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator -2.14777
DCP2 decapping mRNA 2 -2.14097
ACIN1 apoptotic chromatin condensation inducer 1 -2.14097
TM9SF4 transmembrane 9 superfamily protein member 4 -2.13719
SMOX spermine oxidase -2.11778
SECISBP2L SECIS binding protein 2-like -2.11083
LRRN2 leucine rich repeat neuronal 2 -2.09376
RUFY2 RUN and FYVE domain containing 2 -2.09376
ZNF461 zinc finger protein 461 -2.0888
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -2.06859
TMEM196 transmembrane protein 196 -2.06859
NDOR1 NADPH dependent diflavin oxidoreductase 1 -2.06433
ZNF512 zinc finger protein 512 -2.05911
ZNRF3 zinc and ring finger 3 -2.04683
CTIF CBP80/20-dependent translation initiation factor -2.04683
TBCK TBC1 domain containing kinase -2.04144
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.01986
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.01435
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 -2.00505