| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | estrogen-related receptor gamma|This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2104) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/2104 |
| Similar Terms | |
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29 interacting proteins for ESRRG from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| APP | amyloid beta (A4) precursor protein |
| ARHGEF15 | Rho guanine nucleotide exchange factor (GEF) 15 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) |
| CREBZF | CREB/ATF bZIP transcription factor |
| DAXX | death-domain associated protein |
| DPF2 | D4, zinc and double PHD fingers family 2 |
| DUT | deoxyuridine triphosphatase |
| EBP | emopamil binding protein (sterol isomerase) |
| EIF3I | eukaryotic translation initiation factor 3, subunit I |
| ESRRA | estrogen-related receptor alpha |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate |
| NCOA1 | nuclear receptor coactivator 1 |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 |
| NR0B2 | nuclear receptor subfamily 0, group B, member 2 |
| NRIP1 | nuclear receptor interacting protein 1 |
| PARK2 | parkin RBR E3 ubiquitin protein ligase |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PNRC2 | proline-rich nuclear receptor coactivator 2 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
| PPARGC1B | peroxisome proliferator-activated receptor gamma, coactivator 1 beta |
| PROX1 | prospero homeobox 1 |
| PSMC5 | proteasome (prosome, macropain) 26S subunit, ATPase, 5 |
| SP1 | Sp1 transcription factor |
| SRA1 | steroid receptor RNA activator 1 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase |
| SRPK1 | SRSF protein kinase 1 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| TULP3 | tubby like protein 3 |
| UBC | ubiquitin C |
