ETC-206_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ETC-206_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.206318
AHNAK AHNAK nucleoprotein 0.173926
VIM vimentin 0.150879
POTEF POTE ankyrin domain family, member F 0.140285
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.139122
CALR calreticulin 0.11224
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.106444
PLAT plasminogen activator, tissue 0.0894604
COL3A1 collagen, type III, alpha 1 0.0803703
PODXL podocalyxin-like 0.0764043
ENO1 enolase 1, (alpha) 0.0729317
TPM3 tropomyosin 3 0.0708516
CENPF centromere protein F, 350/400kDa 0.06956
AHNAK2 AHNAK nucleoprotein 2 0.0637699
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.062137
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0612328
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0567876
ACTG1 actin gamma 1 0.0532506
ASPH aspartate beta-hydroxylase 0.0519861
PALM2AKAP2 PALM2 and AKAP2 fusion 0.05128
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0511891
TMSB4X thymosin beta 4, X-linked 0.0503425
LDHA lactate dehydrogenase A 0.049549
CD44 CD44 molecule (Indian blood group) 0.0494705
FSTL1 follistatin-like 1 0.0493772
APP amyloid beta (A4) precursor protein 0.0451417
MYH9 myosin, heavy chain 9, non-muscle 0.044542
AKAP12 A kinase (PRKA) anchor protein 12 0.0445047
NFE2L1 nuclear factor, erythroid 2-like 1 0.0440289
PRRC2C proline-rich coiled-coil 2C 0.0438599
MT2A metallothionein 2A 0.0426584
TPM4 tropomyosin 4 0.0414269
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0411084
SET SET nuclear proto-oncogene 0.0406738
MCL1 myeloid cell leukemia 1 0.0391219
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0390722
EEF2 eukaryotic translation elongation factor 2 0.0384573
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.037048
HDAC9 histone deacetylase 9 0.0359149
HSPA8 heat shock 70kDa protein 8 0.0354903
S100A6 S100 calcium binding protein A6 0.0345739
BZW1 basic leucine zipper and W2 domains 1 0.0329061
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0326151
SRRM2 serine/arginine repetitive matrix 2 0.032492
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0320789
EIF4A1 eukaryotic translation initiation factor 4A1 0.0318569
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.031741
EZR ezrin 0.0307381
RPS3 ribosomal protein S3 0.0305523
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0299696
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0297781
LAMB1 laminin, beta 1 0.0296446
DOCK5 dedicator of cytokinesis 5 0.0290628
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0289892
ERRFI1 ERBB receptor feedback inhibitor 1 0.0289461
SPDL1 spindle apparatus coiled-coil protein 1 0.0288114
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0287473
CSTB cystatin B (stefin B) 0.0286047
NIBAN2 niban apoptosis regulator 2 0.0284346
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.028404
EIF1 eukaryotic translation initiation factor 1 0.0283348
PTMA prothymosin, alpha 0.0280909
GLIS3 GLIS family zinc finger 3 0.0276895
CDH13 cadherin 13 0.0270722
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0264973
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0264625
NEK7 NIMA-related kinase 7 0.0264426
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.026301
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0259733
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0259469
TLN1 talin 1 0.0258346
DNMBP dynamin binding protein 0.0256179
RRM2 ribonucleotide reductase M2 0.0255339
ANKRD11 ankyrin repeat domain 11 0.0253655
PKM pyruvate kinase, muscle 0.0252957
MKI67 marker of proliferation Ki-67 0.0251704
DSPP dentin sialophosphoprotein 0.0250619
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0250578
ALCAM activated leukocyte cell adhesion molecule 0.0242456
MAP1B microtubule-associated protein 1B 0.0238892
SEPTIN7 septin 7 0.0238774
CTSB cathepsin B 0.0238035
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0235904
CAVIN1 caveolae associated protein 1 0.0234531
MSN moesin 0.0232457
EIF5B eukaryotic translation initiation factor 5B 0.0232266
GDI2 GDP dissociation inhibitor 2 0.023212
PDLIM5 PDZ and LIM domain 5 0.0222887
NT5E 5'-nucleotidase, ecto (CD73) 0.021851
AXL AXL receptor tyrosine kinase 0.0215008
ERBIN erbb2 interacting protein 0.0212074
ITGA6 integrin, alpha 6 0.0211088
THBS2 thrombospondin 2 0.0210653
FLNA filamin A, alpha 0.0210019
EFNA5 ephrin-A5 0.0209866
RPS2 ribosomal protein S2 0.0203987
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0203735
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0202912
PDIA6 protein disulfide isomerase family A, member 6 0.0202437
TPR translocated promoter region, nuclear basket protein 0.0202027

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154264
TRIO trio Rho guanine nucleotide exchange factor -0.152064
IGFBP3 insulin-like growth factor binding protein 3 -0.13891
NDRG1 N-myc downstream regulated 1 -0.132781
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.111638
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.102175
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0933201
FNDC3B fibronectin type III domain containing 3B -0.0911864
COL8A1 collagen, type VIII, alpha 1 -0.0850445
ABI3BP ABI family, member 3 (NESH) binding protein -0.0843217
DLG1 discs, large homolog 1 (Drosophila) -0.0820343
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0803157
FBN1 fibrillin 1 -0.0790101
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0758555
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0727352
FN1 fibronectin 1 -0.070579
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0663975
RSAD2 radical S-adenosyl methionine domain containing 2 -0.066108
RIGI RNA sensor RIG-I -0.0635375
SOD2 superoxide dismutase 2, mitochondrial -0.059048
SPAG9 sperm associated antigen 9 -0.0588333
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0583788
ZBTB20 zinc finger and BTB domain containing 20 -0.0569828
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0569315
LOX lysyl oxidase -0.0518916
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0518399
AUTS2 autism susceptibility candidate 2 -0.050615
RTN4 reticulon 4 -0.0502573
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0500177
RUNX1 runt-related transcription factor 1 -0.0498827
SDK1 sidekick cell adhesion molecule 1 -0.0494909
MX2 MX dynamin-like GTPase 2 -0.0494503
MSI2 musashi RNA-binding protein 2 -0.049227
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0485101
UBC ubiquitin C -0.0478699
MEIS2 Meis homeobox 2 -0.0472067
CD109 CD109 molecule -0.0470391
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0468909
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0461152
ELL2 elongation factor, RNA polymerase II, 2 -0.0453338
JAZF1 JAZF zinc finger 1 -0.0443684
SBF2 SET binding factor 2 -0.0423162
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0411973
FNDC3A fibronectin type III domain containing 3A -0.0411551
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0406237
SAMD9 sterile alpha motif domain containing 9 -0.0405308
GPC6 glypican 6 -0.0404168
PDE4D phosphodiesterase 4D, cAMP-specific -0.0396581
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0396506
LOXL2 lysyl oxidase-like 2 -0.0390718
BHLHE40 basic helix-loop-helix family, member e40 -0.0375261
HELZ helicase with zinc finger -0.0374422
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0372939
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0370167
IFIH1 interferon induced with helicase C domain 1 -0.0364528
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.03591
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0352268
WSB1 WD repeat and SOCS box containing 1 -0.0349002
PRELID2 PRELI domain containing 2 -0.034376
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335132
WARS1 tryptophanyl-tRNA synthetase 1 -0.03338
ESYT2 extended synaptotagmin-like protein 2 -0.0329924
OASL 2'-5'-oligoadenylate synthetase-like -0.0324241
GRB10 growth factor receptor-bound protein 10 -0.0323747
FNIP1 folliculin interacting protein 1 -0.0318287
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0318131
ZNF292 zinc finger protein 292 -0.0317637
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0317045
KDM3A lysine (K)-specific demethylase 3A -0.0315023
NAV1 neuron navigator 1 -0.03125
RAB1A RAB1A, member RAS oncogene family -0.0311852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0311083
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0309798
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0309042
ANKRD10 ankyrin repeat domain 10 -0.0306037
HILPDA hypoxia inducible lipid droplet-associated -0.0304921
ADM adrenomedullin -0.0303511
NAV2 neuron navigator 2 -0.029856
SSBP2 single-stranded DNA binding protein 2 -0.0298223
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0297624
DPYSL3 dihydropyrimidinase-like 3 -0.0294445
KMT2E lysine (K)-specific methyltransferase 2E -0.0293804
COL1A2 collagen, type I, alpha 2 -0.0291149
MYOF myoferlin -0.0290671
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0288911
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0288666
AFF4 AF4/FMR2 family, member 4 -0.0288489
RNF24 ring finger protein 24 -0.0287407
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0281045
NT5C2 5'-nucleotidase, cytosolic II -0.0278613
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0272886
SOX9 SRY (sex determining region Y)-box 9 -0.027223
MXI1 MAX interactor 1, dimerization protein -0.0272027
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0270195
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0265534
CUX1 cut-like homeobox 1 -0.0264461
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0263739
DDIT4 DNA-damage-inducible transcript 4 -0.0263071
SEC31A SEC31 homolog A (S. cerevisiae) -0.0262939
DTNA dystrobrevin, alpha -0.0261486