ETC-206_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ETC-206 perturbation in BT-474 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the ETC-206_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.31995
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.182357
FBXL20 F-box and leucine-rich repeat protein 20 0.112832
CLTC clathrin, heavy chain (Hc) 0.100189
ACTG1 actin gamma 1 0.0948873
RPL19 ribosomal protein L19 0.0938782
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0864722
NCOA3 nuclear receptor coactivator 3 0.084689
INTS6 integrator complex subunit 6 0.0843637
CDK12 cyclin-dependent kinase 12 0.0826272
ITCH itchy E3 ubiquitin protein ligase 0.0790646
ENO1 enolase 1, (alpha) 0.0785264
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0753412
VMP1 vacuole membrane protein 1 0.0703979
CEP250 centrosomal protein 250kDa 0.0665793
MCL1 myeloid cell leukemia 1 0.066119
DSPP dentin sialophosphoprotein 0.0640276
ZSWIM6 zinc finger, SWIM-type containing 6 0.0612526
SP100 SP100 nuclear antigen 0.0608951
YAP1 Yes-associated protein 1 0.0608678
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0601587
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0599999
LOC102724023 ES1 protein homolog, mitochondrial 0.0598977
SET SET nuclear proto-oncogene 0.0597887
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0583951
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0572274
HSPA8 heat shock 70kDa protein 8 0.0570108
PDLIM5 PDZ and LIM domain 5 0.0558118
PRRC2C proline-rich coiled-coil 2C 0.0556561
RPL23 ribosomal protein L23 0.0538525
ANKRD12 ankyrin repeat domain 12 0.0531608
MYH9 myosin, heavy chain 9, non-muscle 0.053005
RAD51B RAD51 paralog B 0.0526621
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0523732
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0516113
ADAR adenosine deaminase, RNA-specific 0.0514357
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0512086
RCOR1 REST corepressor 1 0.0508945
USO1 USO1 vesicle transport factor 0.0492501
VCP valosin containing protein 0.0488502
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0484457
LPP LIM domain containing preferred translocation partner in lipoma 0.0483642
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0477936
SRCIN1 SRC kinase signaling inhibitor 1 0.0470509
LDHA lactate dehydrogenase A 0.0459939
PRRC2B proline-rich coiled-coil 2B 0.045283
CEMIP cell migration inducing protein, hyaluronan binding 0.0444954
POTEF POTE ankyrin domain family, member F 0.0441112
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.043441
NRIP1 nuclear receptor interacting protein 1 0.0429774
FNDC3A fibronectin type III domain containing 3A 0.0426714
LIMCH1 LIM and calponin homology domains 1 0.0425495
SAMD12 sterile alpha motif domain containing 12 0.0423693
APLP2 amyloid beta (A4) precursor-like protein 2 0.0416492
ANKRD17 ankyrin repeat domain 17 0.041276
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0406054
SRRM2 serine/arginine repetitive matrix 2 0.040587
BZW1 basic leucine zipper and W2 domains 1 0.0404064
IFI6 interferon, alpha-inducible protein 6 0.0395631
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0394757
MED13 mediator complex subunit 13 0.039217
GOLGB1 golgin B1 0.0384978
DTNA dystrobrevin, alpha 0.0383931
VCL vinculin 0.0383708
BBX bobby sox homolog (Drosophila) 0.0380349
SLFN5 schlafen family member 5 0.0380171
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0379391
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0376124
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0374375
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0372007
DIAPH1 diaphanous-related formin 1 0.0371718
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0370718
APP amyloid beta (A4) precursor protein 0.0364426
RBM47 RNA binding motif protein 47 0.0359902
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0355572
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0352197
ADARB1 adenosine deaminase, RNA-specific, B1 0.0350724
ENAH enabled homolog (Drosophila) 0.0349092
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0347132
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0343175
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0342416
SLC22A23 solute carrier family 22, member 23 0.0341656
HOMER1 homer scaffolding protein 1 0.0340393
ATXN1 ataxin 1 0.0340142
STAU1 staufen double-stranded RNA binding protein 1 0.0338567
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0333499
GIGYF2 GRB10 interacting GYF protein 2 0.03317
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.033061
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0328467
MED13L mediator complex subunit 13-like 0.032842
IFIH1 interferon induced with helicase C domain 1 0.032673
CUL3 cullin 3 0.0324285
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0324049
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0323462
NIPBL Nipped-B homolog (Drosophila) 0.0321632
ZNFX1 zinc finger, NFX1-type containing 1 0.0320215
KMT2C lysine (K)-specific methyltransferase 2C 0.0314918
SERINC3 serine incorporator 3 0.0314864
N4BP2L2 NEDD4 binding protein 2-like 2 0.0313319
KTN1 kinectin 1 (kinesin receptor) 0.0309048

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0913849
CCND1 cyclin D1 -0.0492764
IGFBP5 insulin-like growth factor binding protein 5 -0.0490758
OSMR oncostatin M receptor -0.0455305
NAMPT nicotinamide phosphoribosyltransferase -0.0392219
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0392199
ACACA acetyl-CoA carboxylase alpha -0.0387843
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0382651
ASPH aspartate beta-hydroxylase -0.0379743
THSD4 thrombospondin, type I, domain containing 4 -0.0379693
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0366018
RPL35A ribosomal protein L35a -0.0358005
TRPS1 trichorhinophalangeal syndrome I -0.0345579
NTN4 netrin 4 -0.0330269
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0321994
PTMA prothymosin, alpha -0.0318441
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0307944
FTH1 ferritin, heavy polypeptide 1 -0.0299534
RPS6 ribosomal protein S6 -0.0291541
GRB7 growth factor receptor-bound protein 7 -0.0289408
NCAM2 neural cell adhesion molecule 2 -0.0286753
FASN fatty acid synthase -0.0286722
NCOA7 nuclear receptor coactivator 7 -0.0273534
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0272851
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0268685
KAZN kazrin, periplakin interacting protein -0.0265091
TMSB10 thymosin beta 10 -0.0261819
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.025667
RPS24 ribosomal protein S24 -0.0254921
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0243766
FADS2 fatty acid desaturase 2 -0.0241749
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0237668
S100A14 S100 calcium binding protein A14 -0.0235639
ELOVL5 ELOVL fatty acid elongase 5 -0.0233178
TP53INP2 tumor protein p53 inducible nuclear protein 2 -0.0231407
S100A9 S100 calcium binding protein A9 -0.0230184
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0228951
TMEM123 transmembrane protein 123 -0.0227596
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0225473
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0223494
NT5C2 5'-nucleotidase, cytosolic II -0.0223317
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0221434
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0221374
MSMO1 methylsterol monooxygenase 1 -0.0220811
FNDC3B fibronectin type III domain containing 3B -0.0220511
IER3 immediate early response 3 -0.0218019
GSE1 Gse1 coiled-coil protein -0.0211724
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0209324
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0207663
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0204398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0203264
RPS29 ribosomal protein S29 -0.0195683
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0195635
S100A8 S100 calcium binding protein A8 -0.0194454
EGR1 early growth response 1 -0.0194252
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0192608
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0187569
TMC5 transmembrane channel-like 5 -0.0187353
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.018563
KLF6 Kruppel-like factor 6 -0.018558
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.018351
NRCAM neuronal cell adhesion molecule -0.0180642
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0180107
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0179061
LRP1B low density lipoprotein receptor-related protein 1B -0.0175049
TMEM165 transmembrane protein 165 -0.0172897
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0172189
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0169733
ICAM1 intercellular adhesion molecule 1 -0.0168329
AGR2 anterior gradient 2 -0.0167887
PRR11 proline rich 11 -0.0167427
RPLP1 ribosomal protein, large, P1 -0.0167025
TPT1 tumor protein, translationally-controlled 1 -0.016372
ANKRD30A ankyrin repeat domain 30A -0.0162705
TMEM45B transmembrane protein 45B -0.016102
RAB1B RAB1B, member RAS oncogene family -0.015865
ARHGAP32 Rho GTPase activating protein 32 -0.0157941
TSPAN13 tetraspanin 13 -0.0156901
TMEM41B transmembrane protein 41B -0.0154148
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.015379
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0153342
CNRIP1 cannabinoid receptor interacting protein 1 -0.015207
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0151137
WSB1 WD repeat and SOCS box containing 1 -0.0150934
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0145789
SPTSSB serine palmitoyltransferase, small subunit B -0.0145544
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.01432
TAPBP TAP binding protein (tapasin) -0.0142822
WWC1 WW and C2 domain containing 1 -0.0142774
LMAN1 lectin, mannose-binding, 1 -0.0140219
LOC112694756 uncharaterized LOC112694756 -0.0140043
WWOX WW domain containing oxidoreductase -0.0139875
MDK midkine (neurite growth-promoting factor 2) -0.0139505
ZFAND3 zinc finger, AN1-type domain 3 -0.013841
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0137913
TUBB tubulin, beta class I -0.0137433
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0137146
SKA2 spindle and kinetochore associated complex subunit 2 -0.0136069
HMGB1 high mobility group box 1 -0.0135853
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0134328